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Strain Name:
C57BL/6J-MtgxR7608Btlr/Mmmh
Stock Number:
045678-MU
Citation ID:
RRID:MMRRC_045678-MU
Other Names:
R7608 (G1)
Major Collection:

Strain Information

Epha7
Name: Eph receptor A7
Synonyms: MDK1, Ebk, Cek11, Ehk3, Hek11, Mdk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13841
HGNC: HGNC:3390
Homologene: 20935
Kdm3a
Name: lysine (K)-specific demethylase 3A
Synonyms: 1700105C21Rik, Tsga, C230043E16Rik, Jmjd1, Jmjd1a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 104263
Homologene: 10196
Mtcl1
Name: microtubule crosslinking factor 1
Synonyms: t8219b25, 1110012J17Rik, Soga2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68617
Homologene: 41017
Trim23
Name: tripartite motif-containing 23
Synonyms: Arfd1, 6330516O20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 81003
HGNC: HGNC:660
Homologene: 1251
Casp3
Name: caspase 3
Synonyms: CPP32, Apopain, Yama, Caspase-3, A830040C14Rik, CC3, mldy, AC-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12367
HGNC: HGNC:1504
Homologene: 37912
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57908
Homologene: 22808
Melk
Name: maternal embryonic leucine zipper kinase
Synonyms: MPK38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17279
Homologene: 32111
Prox1
Name: prospero homeobox 1
Synonyms: A230003G05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19130
HGNC: HGNC:9459
Homologene: 2069
Prpf39
Name: pre-mRNA processing factor 39
Synonyms: Srcs1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328110
Homologene: 32377
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Fgfrl1
Name: fibroblast growth factor receptor-like 1
Synonyms: fibroblast growth factor receptor 5, FGFR5gamma, FGFR5beta, FGFR5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 116701
HGNC: HGNC:3693
Homologene: 11067
Hspbp1
Name: HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Synonyms: 1500019G21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66245
Homologene: 40827
Tsc1
Name: TSC complex subunit 1
Synonyms: hamartin, tuberous sclerosis 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64930
Homologene: 314
Fign
Name: fidgetin
Synonyms: Fgn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60344
Homologene: 5813
Abcb6
Name: ATP-binding cassette, sub-family B member 6
Synonyms: 1200005B17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74104
HGNC: HGNC:47
Homologene: 11375
Slc16a4
Name: solute carrier family 16 (monocarboxylic acid transporters), member 4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229699
Homologene: 74529
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b598Clo, b2b1203Clo, b2b1279Clo, b2b1289Clo, b2b1727Clo, Dnahc11, avc4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Galns
Name: galactosamine (N-acetyl)-6-sulfatase
Synonyms: N-acetylgalactosamine-6-sulfate sulfatase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50917
HGNC: HGNC:4122
Homologene: 55468
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329278
Homologene: 18634
Adamts7
Name: ADAM metallopeptidase with thrombospondin type 1 motif 7
Synonyms: ADAM-TS7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 108153
HGNC: HGNC:223
Homologene: 22803
Duox1
Name: dual oxidase 1
Synonyms: NOXEF1, THOX1, LNOX1, 9930101G15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99439
HGNC: HGNC:3062
Homologene: 68136
Vmn1r67
Name: vomeronasal 1 receptor 67
Synonyms: V1re10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171263
Homologene: 128344
Atosb
Name: atos homolog B
Synonyms: B230312A22Rik, Fam214b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230088
Homologene: 32625
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75172
Homologene: 67159
Vmn1r53
Name: vomeronasal 1 receptor 53
Synonyms: VN5, V1rb3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113853
Homologene: 113975
Idh3b
Name: isocitrate dehydrogenase 3 (NAD+) beta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170718
HGNC: HGNC:5385
Homologene: 5035
Txlnb
Name: taxilin beta
Synonyms: Mdp77, 2310001N14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 378431
Homologene: 44534
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: mDGK[z], E130307B02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226255
VEGA: 19
Homologene: 45809
Pdzrn3
Name: PDZ domain containing RING finger 3
Synonyms: semaphorin cytoplasmic domain-associated protein 3A, 1110020C07Rik, LNX3, Semcap3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 55983
Homologene: 10328
Pop5
Name: processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)
Synonyms: 1500019J17Rik, Rnasep3, 2700077E03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 117109
Homologene: 41076
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Cacna2, Ca(v)alpha2delta1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102747
Homologene: 9782
Ifi44
Name: interferon-induced protein 44
Synonyms: p44, MTAP44, A430056A10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99899
Homologene: 4683
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219140
Homologene: 19482
Scg2
Name: secretogranin II
Synonyms: SgII, Chgc
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20254
Homologene: 2591
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: SNS2, NaN, NaT, NSS2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
Zfp819
Name: zinc finger protein 819
Synonyms: 4930427I11Rik, 4933405K07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74400
Homologene: 128446
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231591
Homologene: 129606
Asz1
Name: ankyrin repeat, SAM and basic leucine zipper domain containing 1
Synonyms: ORF3, 4933400N19Rik, Gasz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74068
HGNC: HGNC:1350
Homologene: 11374
Tas2r129
Name: taste receptor, type 2, member 129
Synonyms: T2R29, Tas2r29, mGR29, mt2r60
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387354
Homologene: 130074
Akr1b7
Name: aldo-keto reductase family 1, member B7
Synonyms: MVDP, Avdp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11997
Homologene: 122176
Cfap61
Name: cilia and flagella associated protein 61
Synonyms: 4930529M08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78774
Or5b119
Name: olfactory receptor family 5 subfamily B member 119
Synonyms: GA_x6K02T2RE5P-3812807-3811863, MOR202-36, Olfr1475
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258298
Homologene: 77370
Zfp760
Name: zinc finger protein 760
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240034
VEGA: 17
Or8d2
Name: olfactory receptor family 8 subfamily D member 2
Synonyms: GA_x6K02T2PVTD-32543982-32544908, MOR171-27P, MOR171-47, MOR171-27P, Olfr1520-ps1, Olfr924
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 404322
VEGA: 9
HGNC: HGNC:8482
Homologene: 128215
Ldaf1
Name: lipid droplet assembly factor 1
Synonyms: 8430420C20Rik, Tmem159
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233806
Homologene: 10705
Slc4a1ap
Name: solute carrier family 4 (anion exchanger), member 1, adaptor protein
Synonyms: kanadaptin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20534
Homologene: 7543
Or4a79
Name: olfactory receptor family 4 subfamily A member 79
Synonyms: GA_x6K02T2Q125-51162884-51161940, MOR231-22_p, Olfr1252
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404331
Homologene: 128094
Or51f23c-ps1
Name: olfactory receptor family 51 subfamily F member 23C, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-5498153-5499103, MOR14-5, Olfr562-ps1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259090
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 75,177,703 bp
  • T to C, chromosome 1 at 79,436,181 bp
  • A to T, chromosome 1 at 160,088,414 bp
  • T to A, chromosome 1 at 190,153,445 bp
  • A to T, chromosome 2 at 28,658,736 bp
  • T to C, chromosome 2 at 63,978,719 bp
  • A to G, chromosome 2 at 89,721,298 bp
  • A to T, chromosome 2 at 91,934,054 bp
  • C to A, chromosome 2 at 122,326,135 bp
  • A to T, chromosome 2 at 130,280,980 bp
  • G to A, chromosome 2 at 145,963,531 bp
  • A to T, chromosome 3 at 107,303,127 bp
  • A to G, chromosome 3 at 151,732,408 bp
  • C to T, chromosome 4 at 28,871,937 bp
  • A to G, chromosome 4 at 43,036,533 bp
  • T to A, chromosome 4 at 44,325,571 bp
  • T to C, chromosome 5 at 16,359,024 bp
  • C to T, chromosome 5 at 21,301,452 bp
  • T to A, chromosome 5 at 31,536,189 bp
  • A to T, chromosome 5 at 108,705,345 bp
  • A to G, chromosome 5 at 109,221,410 bp
  • A to G, chromosome 5 at 115,237,872 bp
  • G to A, chromosome 6 at 18,077,253 bp
  • A to G, chromosome 6 at 34,420,522 bp
  • T to A, chromosome 6 at 71,600,747 bp
  • C to T, chromosome 6 at 90,224,122 bp
  • T to C, chromosome 6 at 101,151,752 bp
  • A to G, chromosome 6 at 132,951,193 bp
  • C to A, chromosome 7 at 4,660,822 bp
  • G to A, chromosome 7 at 10,447,363 bp
  • T to C, chromosome 7 at 43,616,933 bp
  • A to T, chromosome 7 at 64,354,231 bp
  • A to G, chromosome 7 at 102,781,925 bp
  • A to G, chromosome 7 at 120,104,788 bp
  • T to A, chromosome 8 at 46,634,333 bp
  • A to G, chromosome 8 at 122,591,445 bp
  • T to A, chromosome 9 at 38,848,510 bp
  • C to T, chromosome 9 at 60,602,722 bp
  • C to A, chromosome 9 at 90,173,773 bp
  • A to T, chromosome 9 at 119,815,313 bp
  • A to G, chromosome 10 at 17,815,398 bp
  • G to A, chromosome 12 at 65,053,446 bp
  • G to T, chromosome 12 at 118,140,770 bp
  • T to C, chromosome 13 at 104,192,033 bp
  • A to G, chromosome 14 at 60,692,507 bp
  • A to G, chromosome 17 at 21,722,816 bp
  • T to G, chromosome 17 at 46,400,009 bp
  • T to C, chromosome 17 at 66,343,305 bp
  • T to C, chromosome 18 at 44,491,227 bp
  • G to A, chromosome 19 at 13,479,592 bp
  • T to A, chromosome 19 at 57,714,687 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7608 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045678-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.