Strain Name:
C57BL/6J-MtgxR7624Btlr/Mmmh
Stock Number:
045689-MU
Citation ID:
RRID:MMRRC_045689-MU
Other Names:
R7624 (G1)
Major Collection:

Strain Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Slc6a5
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Synonyms: Glyt2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 104245
Homologene: 37901
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330286
Homologene: 19782
Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 1810041E18Rik, 5830410F13Rik, 2310047O13Rik, Fam188a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66960
Homologene: 11478
Zfp934
Name: zinc finger protein 934
Synonyms: 6720457D02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77117
VEGA: 13
Ctnna1
Name: catenin alpha 1
Synonyms: alpha(E)-catenin, alpha E catenin, Catna1, 2010010M04Rik, catenin (cadherin associated protein), alpha 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12385
VEGA: 18
HGNC: HGNC:2509
Homologene: 1433
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Dnajc21
Name: DnaJ heat shock protein family (Hsp40) member C21
Synonyms: 9930116P15Rik, 4930461P20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78244
Homologene: 6752
Taf15
Name: TATA-box binding protein associated factor 15
Synonyms: TAFII68, 2610111C21Rik, Taf2n, 68kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70439
Homologene: 131088
Ilf3
Name: interleukin enhancer binding factor 3
Synonyms: NF90
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16201
VEGA: 9
HGNC: HGNC:6038
Homologene: 7785
Xpo1
Name: exportin 1
Synonyms: Crm1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103573
Homologene: 2554
Caprin1
Name: cell cycle associated protein 1
Synonyms: MMGPIP137, caprin-1, Gpiap1, RNG105
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53872
HGNC: HGNC:6743
Homologene: 4310
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Sqle
Name: squalene epoxidase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20775
Homologene: 2355
Cripto
Name: cripto, EGF-CFC family member
Synonyms: CR1, Tdgf1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21667
Homologene: 2416
Prr14l
Name: proline rich 14-like
Synonyms: 6030436E02Rik, C330019G07Rik, Prl14l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215476
Homologene: 65866
Eya3
Name: EYA transcriptional coactivator and phosphatase 3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14050
HGNC: HGNC:3521
Homologene: 1508
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, l7Rn3, ELM2, Odz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Lcorl
Name: ligand dependent nuclear receptor corepressor-like
Synonyms: Mlr1, A830039H10Rik, Gm3414
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041576
Homologene: 82325
Rundc1
Name: RUN domain containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217201
Homologene: 15095
Col4a3
Name: collagen, type IV, alpha 3
Synonyms: alpha3(IV), tumstatin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12828
HGNC: HGNC:2204
Homologene: 68033
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, 9430076A06Rik, D430038H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Lcn5
Name: lipocalin 5
Synonyms: MEP10, mE-RABP, Erabp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13863
Homologene: 7305
Zkscan2
Name: zinc finger with KRAB and SCAN domains 2
Synonyms: 9430065N20Rik, Zfp694
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210162
Homologene: 19671
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: N-3 kinesin, Kif16a, 4831403C07Rik, E230025N21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Or5h18
Name: olfactory receptor family 5 subfamily H member 18
Synonyms: GA_x54KRFPKG5P-55257214-55256285, MOR183-9, Olfr186
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258318
Homologene: 133671
Letm2
Name: leucine zipper-EF-hand containing transmembrane protein 2
Synonyms: D030041N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270035
Homologene: 56358
Il4ra
Name: interleukin 4 receptor, alpha
Synonyms: IL-4 receptor alpha chain, CD124, Il4r
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16190
HGNC: HGNC:6015
Homologene: 7784
Wnk4
Name: WNK lysine deficient protein kinase 4
Synonyms: 2010002J11Rik, Prkwnk4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69847
Homologene: 13020
Scarf1
Name: scavenger receptor class F, member 1
Synonyms: SREC, SREC-I
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380713
Homologene: 2741
Tm6sf1
Name: transmembrane 6 superfamily member 1
Synonyms: C630016D09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 107769
Homologene: 11305
Cpa3
Name: carboxypeptidase A3, mast cell
Synonyms: MC-CPA, mMC-CPA, mast cell carboxypeptidase A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12873
HGNC: HGNC:2298
Homologene: 122138
Serpinb1b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 1b
Synonyms: 6330533H24Rik, ovalbumin, EIB
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 282663
HGNC: HGNC:3311
Homologene: 138408
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: mDGK[z], E130307B02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Zfp366
Name: zinc finger protein 366
Synonyms: DC-SCRIPT
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238803
Homologene: 17637
Tmprss9
Name: transmembrane protease, serine 9
Synonyms: Serase-1B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432478
VEGA: 10
Homologene: 115302
Ficd
Name: FIC domain containing
Synonyms: D5Ertd40e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231630
Homologene: 5139
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Rln1
Name: relaxin 1
Synonyms: rlx
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19773
Homologene: 55524
Trim62
Name: tripartite motif-containing 62
Synonyms: 6330414G21Rik, Dear1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67525
Homologene: 10071
Ccdc78
Name: coiled-coil domain containing 78
Synonyms: LOC381146, LOC381077
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381077
VEGA: 17
Homologene: 105408
Cryba1
Name: crystallin, beta A1
Synonyms: Cryb, BA3/A1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12957
HGNC: HGNC:2394
Homologene: 3815
Or8u9
Name: olfactory receptor family 8 subfamily U member 9
Synonyms: GA_x6K02T2Q125-47640742-47639798, MOR185-4, Olfr1044
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259013
Homologene: 100542
Gfra1
Name: glial cell line derived neurotrophic factor family receptor alpha 1
Synonyms: GDNFR-alpha, GFR alpha-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14585
HGNC: HGNC:4243
Homologene: 3855
Slc22a19
Name: solute carrier family 22 (organic anion transporter), member 19
Synonyms: Oat5, D630043A20Rik, Slc22a9
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 207151
Homologene: 133125
Nfe2l3
Name: nuclear factor, erythroid derived 2, like 3
Synonyms: Nrf3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18025
HGNC: HGNC:7783
Homologene: 3168
Usp16
Name: ubiquitin specific peptidase 16
Synonyms: 2810483I07Rik, UBP-M, 1200004E02Rik, 6330514E22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74112
Homologene: 38183
Pom121l2
Name: POM121 transmembrane nucleoporin like 2
Synonyms: LOC195236
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195236
Homologene: 123536
Gsc
Name: goosecoid homeobox
Synonyms: goosecoid
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14836
HGNC: HGNC:4612
Homologene: 7744
Vmn1r62
Name: vomeronasal 1 receptor 62
Synonyms: V3R2, V1rd8, V1rd2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81016
Homologene: 41799
Vmn1r199
Name: vomeronasal 1 receptor 199
Synonyms: V1rh4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171247
Homologene: 110880
Or8b3b
Name: olfactory receptor family 8 subfamily B member 3B
Synonyms: GA_x6K02T2PVTD-32375756-32374818, MOR164-3, Olfr918
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258372
VEGA: 9
Ugt2b34
Name: UDP glucuronosyltransferase 2 family, polypeptide B34
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100727
Homologene: 117389
Or9r7
Name: olfactory receptor family 9 subfamily R member 7
Synonyms: GA_x6K02T2PULF-11797746-11796799, MOR210-3, Olfr824
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258669
Homologene: 45026
Or14a256
Name: olfactory receptor family 14 subfamily A member 256
Synonyms: GA_x6K02T2NHDJ-9504525-9505532, MOR219-5, Olfr294
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257904
Kcnf1
Name: potassium voltage-gated channel, subfamily F, member 1
Synonyms: LOC382571
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 382571
HGNC: HGNC:6246
Homologene: 124236
Or12e10
Name: olfactory receptor family 12 subfamily E member 10
Synonyms: GA_x6K02T2Q125-49311440-49312384, MOR264-19, Olfr1145
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258317
Homologene: 27123
Pcdha9
Name: protocadherin alpha 9
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192161
HGNC: HGNC:8664
Homologene: 130700
Kiss1
Name: KiSS-1 metastasis-suppressor
Synonyms: metastin, kisspeptin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 280287
HGNC: HGNC:6341
Homologene: 1701
Rpl3l
Name: ribosomal protein L3-like
Synonyms: 1110057H16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66211
Homologene: 68434
Gm43517
Name: predicted gene 43517
Type: Gene
Species: Mouse
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 82,718,884 bp
  • A to G, chromosome 1 at 133,329,422 bp
  • A to G, chromosome 2 at 12,419,189 bp
  • A to G, chromosome 2 at 25,661,414 bp
  • A to T, chromosome 2 at 86,171,220 bp
  • A to G, chromosome 2 at 87,810,339 bp
  • C to A, chromosome 2 at 91,942,674 bp
  • T to A, chromosome 2 at 103,772,677 bp
  • T to C, chromosome 2 at 120,688,146 bp
  • T to C, chromosome 3 at 20,225,143 bp
  • T to A, chromosome 3 at 96,652,953 bp
  • A to T, chromosome 4 at 128,883,678 bp
  • A to G, chromosome 4 at 132,672,951 bp
  • T to A, chromosome 5 at 32,829,623 bp
  • T to C, chromosome 5 at 45,701,965 bp
  • C to T, chromosome 5 at 86,891,282 bp
  • A to T, chromosome 5 at 113,274,335 bp
  • T to C, chromosome 5 at 113,738,690 bp
  • T to G, chromosome 6 at 17,558,835 bp
  • T to C, chromosome 6 at 38,149,563 bp
  • T to C, chromosome 6 at 51,458,272 bp
  • A to G, chromosome 6 at 83,152,177 bp
  • A to T, chromosome 7 at 5,675,601 bp
  • A to C, chromosome 7 at 49,941,866 bp
  • T to A, chromosome 7 at 64,372,486 bp
  • A to G, chromosome 7 at 81,868,710 bp
  • A to G, chromosome 7 at 86,616,561 bp
  • A to G, chromosome 7 at 96,895,985 bp
  • A to G, chromosome 7 at 123,498,771 bp
  • T to C, chromosome 7 at 125,569,108 bp
  • A to T, chromosome 8 at 25,592,537 bp
  • T to G, chromosome 8 at 95,751,819 bp
  • T to C, chromosome 9 at 15,959,869 bp
  • T to C, chromosome 9 at 21,398,044 bp
  • C to T, chromosome 9 at 38,672,623 bp
  • C to A, chromosome 9 at 53,454,768 bp
  • G to T, chromosome 9 at 79,645,794 bp
  • C to T, chromosome 9 at 110,945,949 bp
  • T to A, chromosome 10 at 80,892,219 bp
  • A to C, chromosome 10 at 130,126,586 bp
  • T to A, chromosome 11 at 23,282,584 bp
  • T to A, chromosome 11 at 75,514,416 bp
  • T to C, chromosome 11 at 77,722,717 bp
  • A to T, chromosome 11 at 83,505,023 bp
  • G to T, chromosome 11 at 101,264,354 bp
  • G to C, chromosome 11 at 101,433,479 bp
  • T to C, chromosome 12 at 17,176,136 bp
  • T to A, chromosome 12 at 49,391,178 bp
  • A to T, chromosome 12 at 104,473,051 bp
  • A to T, chromosome 13 at 21,983,529 bp
  • T to A, chromosome 13 at 22,382,736 bp
  • T to A, chromosome 13 at 33,091,639 bp
  • T to C, chromosome 13 at 62,518,524 bp
  • A to T, chromosome 13 at 93,090,357 bp
  • A to G, chromosome 13 at 99,246,296 bp
  • G to A, chromosome 15 at 4,917,131 bp
  • G to A, chromosome 15 at 10,461,232 bp
  • A to T, chromosome 15 at 10,461,234 bp
  • G to A, chromosome 15 at 59,330,754 bp
  • T to A, chromosome 16 at 59,027,019 bp
  • T to A, chromosome 16 at 87,476,805 bp
  • T to C, chromosome 16 at 96,610,324 bp
  • A to T, chromosome 17 at 24,732,427 bp
  • A to G, chromosome 17 at 25,787,152 bp
  • T to A, chromosome 18 at 35,244,844 bp
  • T to A, chromosome 18 at 36,999,796 bp
  • T to A, chromosome 19 at 7,673,303 bp
  • T to C, chromosome 19 at 7,693,818 bp
  • A to T, chromosome 19 at 29,332,099 bp
  • A to T, chromosome 19 at 58,238,446 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7624 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045689-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.