Strain Name:
C57BL/6J-MtgxR7631Btlr/Mmmh
Stock Number:
045692-MU
Citation ID:
RRID:MMRRC_045692-MU
Other Names:
R7631 (G1)
Major Collection:

Strain Information

Eno2
Name: enolase 2, gamma neuronal
Synonyms: Eno-2, D6Ertd375e, NSE
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13807
HGNC: HGNC:3353
Homologene: 74414
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Ifi203
Name: interferon activated gene 203
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15950
HGNC: HGNC:5395
Homologene: 115929
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd1, Edd
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Pabpc4
Name: poly(A) binding protein, cytoplasmic 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230721
HGNC: HGNC:8557
Homologene: 37855
Smchd1
Name: SMC hinge domain containing 1
Synonyms: 4931400A14Rik, MommeD1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Naa25
Name: N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms: 4833422K13Rik, C330023M02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231713
Homologene: 6891
Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms: D730028O18Rik, ARFGEP1, P200, BIG1, D130059B05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211673
Homologene: 4687
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730455C01Rik, 9130215G10Rik, 5730555F13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Scaf4
Name: SR-related CTD-associated factor 4
Synonyms: Sra4, Sfrs15, Srsf15
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224432
VEGA: 16
Homologene: 16227
Lifr
Name: LIF receptor alpha
Synonyms: soluble differentiation-stimulating factor receptor, A230075M04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16880
VEGA: 15
HGNC: HGNC:6597
Homologene: 1735
Slc25a20
Name: solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
Synonyms: mCAC, Cact, 1110007P09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57279
HGNC: HGNC:1421
Homologene: 331
Zfp473
Name: zinc finger protein 473
Synonyms: D030014N22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243963
Homologene: 18698
Tmem204
Name: transmembrane protein 204
Synonyms: Clp24
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 407831
Homologene: 36419
Gpr155
Name: G protein-coupled receptor 155
Synonyms: DEPDC3, PGR22, 1110017O10Rik, F730029F15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68526
Homologene: 16584
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: mtrp6, Trrp6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Klc2
Name: kinesin light chain 2
Synonyms: 8030455F02Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16594
Homologene: 22468
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC6, SPC6, PC5A, PC5/6A, b2b585Clo, b2b1549Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Or2r3
Name: olfactory receptor family 2 subfamily R member 3
Synonyms: GA_x6K02T2P3E9-5088893-5089834, MOR257-1, Olfr457
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258989
Homologene: 133701
Cyb5d1
Name: cytochrome b5 domain containing 1
Synonyms: LOC327951
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327951
Homologene: 15945
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241589
Homologene: 115928
Or8c13
Name: olfactory receptor family 8 subfamily C member 13
Synonyms: GA_x6K02T2PVTD-31862167-31861217, MOR170-9, Olfr891
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258471
Homologene: 74210
Fer1l4
Name: fer-1 like family member 4
Synonyms: 9130402C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74562
Homologene: 19075
Agbl3
Name: ATP/GTP binding protein-like 3
Synonyms: 2900053G10Rik, 6530406M24Rik, 4930431N21Rik, Ccp3, Ccp3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76223
Homologene: 35330
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: mGluR5, Gprc1e, 6430542K11Rik, Glu5R
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Lingo4
Name: leucine rich repeat and Ig domain containing 4
Synonyms: A530050P17Rik, Lrrn6d, LERN4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320747
Homologene: 18563
Albfm1
Name: albumin superfamily member 1
Synonyms: ARG, Gm17754, 5830473C10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622307
Homologene: 129803
Spem1
Name: spermatid maturation 1
Synonyms: 1700095G12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74288
Homologene: 45717
Cpne9
Name: copine family member IX
Synonyms: A730016F12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211232
Homologene: 84686
Dcaf7
Name: DDB1 and CUL4 associated factor 7
Synonyms: 2610037L01Rik, 1700012F10Rik, Wdr68
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71833
Homologene: 55930
Strip1
Name: striatin interacting protein 1
Synonyms: 6530401O14Rik, 6330569M22Rik, Fam40a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229707
Homologene: 35064
Onecut2
Name: one cut domain, family member 2
Synonyms: OC-2, Oc2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225631
HGNC: HGNC:8139
Homologene: 113592
Lrrc74a
Name: leucine rich repeat containing 74A
Synonyms: Gm6772, Lrrc74
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 627607
VEGA: 12
Homologene: 19331
Tubb2a
Name: tubulin, beta 2A class IIA
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22151
VEGA: 13
Homologene: 134314
Fndc7
Name: fibronectin type III domain containing 7
Synonyms: E230011A21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320181
Homologene: 18551
Pgm2
Name: phosphoglucomutase 2
Synonyms: Pgm-1, 3230402E02Rik, Pgm1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66681
HGNC: HGNC:8906
Homologene: 6693
Alcam
Name: activated leukocyte cell adhesion molecule
Synonyms: DM-GRASP, CD166, MuSC, SC1, BEN
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11658
HGNC: HGNC:400
Homologene: 1229
Mcm8
Name: minichromosome maintenance 8 homologous recombination repair factor
Synonyms: 5730432L01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66634
Homologene: 12001
Or5m11
Name: olfactory receptor family 5 subfamily M member 11
Synonyms: MOR198-3P, GA_x6K02T2Q125-47430129-47431103, MOR198-3P, MOR198-6_p, MOR198-4, Olfr1534-ps1, Olfr1028
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257936
Homologene: 73972
Vmn1r71
Name: vomeronasal 1 receptor 71
Synonyms: V1re13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252910
Homologene: 74352
Fbxw19
Name: F-box and WD-40 domain protein 19
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235612
Homologene: 110776
Zfp82
Name: zinc finger protein 82
Synonyms: KRAB16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330502
Homologene: 51177
Tcirg1
Name: T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
Synonyms: V-ATPase a3, OC-116, TIRC7, ATP6a3, Atp6i
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 27060
Homologene: 4392
Septin12
Name: septin 12
Synonyms: 1700028G04Rik, 4933413B09Rik, Septin12, Sept12
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71089
VEGA: 16
Homologene: 69435
Polr2m
Name: polymerase (RNA) II (DNA directed) polypeptide M
Synonyms: D9Wsu138e, Grinl1a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 28015
Homologene: 9181
Tma7
Name: translational machinery associated 7
Synonyms: 1110017O22Rik, Ccdc72
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66167
Homologene: 41078
Myl10
Name: myosin, light chain 10, regulatory
Synonyms: PLRLC-C, PLRLC-B, PLRLC-A, PLRLC, 1700027I08Rik, Mylc2pl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59310
Homologene: 69341
Defa27
Name: defensin, alpha, 27
Synonyms: ENSMUSG00000074438, Gm15299
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100041811
Homologene: 113382
Vmn2r40
Name: vomeronasal 2, receptor 40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042781
Homologene: 113703
Ankrd31
Name: ankyrin repeat domain 31
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 625662
Homologene: 110355
Or1p4-ps1
Name: olfactory receptor family 1 subfamily P member 4, pseudogene 1
Synonyms: GA_x6K02T2P1NL-4449217-4450187, MOR133-2, Olfr409-ps1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258131
Gm14305
Name: predicted gene 14305
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100043387
Homologene: 134324
Scgb1b19
Name: secretoglobin, family 1B, member 19
Synonyms: Gm5632, Abpa19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434676
Homologene: 114479
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,232,469 bp
  • G to A, chromosome 1 at 173,927,122 bp
  • T to C, chromosome 2 at 73,382,947 bp
  • A to T, chromosome 2 at 85,951,874 bp
  • A to C, chromosome 2 at 104,149,018 bp
  • A to G, chromosome 2 at 132,828,043 bp
  • A to T, chromosome 2 at 156,048,275 bp
  • A to G, chromosome 2 at 176,718,997 bp
  • A to C, chromosome 3 at 94,399,460 bp
  • C to T, chromosome 3 at 107,616,931 bp
  • G to A, chromosome 3 at 108,869,252 bp
  • T to A, chromosome 4 at 6,272,763 bp
  • T to G, chromosome 4 at 123,288,970 bp
  • T to C, chromosome 5 at 21,971,935 bp
  • A to G, chromosome 5 at 64,108,179 bp
  • T to C, chromosome 5 at 90,579,672 bp
  • A to G, chromosome 5 at 121,438,728 bp
  • G to C, chromosome 5 at 136,697,971 bp
  • T to A, chromosome 6 at 34,857,671 bp
  • T to A, chromosome 6 at 42,471,936 bp
  • T to C, chromosome 6 at 113,302,118 bp
  • T to C, chromosome 6 at 124,767,056 bp
  • C to T, chromosome 7 at 8,908,120 bp
  • A to T, chromosome 7 at 10,748,451 bp
  • A to T, chromosome 7 at 30,056,426 bp
  • C to T, chromosome 7 at 33,287,359 bp
  • T to C, chromosome 7 at 44,733,704 bp
  • A to G, chromosome 7 at 87,975,305 bp
  • T to C, chromosome 7 at 105,759,238 bp
  • T to A, chromosome 8 at 21,315,641 bp
  • A to G, chromosome 9 at 8,626,701 bp
  • A to T, chromosome 9 at 38,180,706 bp
  • C to G, chromosome 9 at 70,586,673 bp
  • G to C, chromosome 9 at 71,483,475 bp
  • T to A, chromosome 9 at 108,662,292 bp
  • T to A, chromosome 9 at 109,082,439 bp
  • T to A, chromosome 9 at 109,482,001 bp
  • G to A, chromosome 11 at 21,999,458 bp
  • A to T, chromosome 11 at 69,395,039 bp
  • T to C, chromosome 11 at 69,821,583 bp
  • A to C, chromosome 11 at 74,317,531 bp
  • T to C, chromosome 11 at 106,053,753 bp
  • A to T, chromosome 12 at 86,749,110 bp
  • A to G, chromosome 13 at 34,075,244 bp
  • A to G, chromosome 13 at 96,878,954 bp
  • A to G, chromosome 15 at 7,184,777 bp
  • C to A, chromosome 15 at 38,029,507 bp
  • T to A, chromosome 16 at 4,996,456 bp
  • C to T, chromosome 16 at 52,288,913 bp
  • T to C, chromosome 16 at 90,229,557 bp
  • A to G, chromosome 17 at 25,080,440 bp
  • A to G, chromosome 17 at 71,398,689 bp
  • T to A, chromosome 18 at 64,340,975 bp
  • G to T, chromosome 19 at 3,897,160 bp
  • A to G, chromosome 19 at 5,108,619 bp
  • T to A, chromosome 19 at 6,481,795 bp
  • A to T, chromosome 19 at 17,564,780 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7631 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045692-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.