Strain Name:
C57BL/6J-MtgxR7693Btlr/Mmmh
Stock Number:
045708-MU
Citation ID:
RRID:MMRRC_045708-MU
Other Names:
R7693 (G1)
Major Collection:

Strain Information

Gjd2
Name: gap junction protein, delta 2
Synonyms: Cx36, connexin36, Gja9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14617
Homologene: 7734
Adcy10
Name: adenylate cyclase 10
Synonyms: soluble adenylyl cyclase, Sacy, 4930431D04Rik, sAC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271639
Homologene: 10188
Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: TrkA, Tkr
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18211
HGNC: HGNC:8031
Homologene: 1898
Abcc8
Name: ATP-binding cassette, sub-family C member 8
Synonyms: Sur, SUR1, D930031B21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Cilk1
Name: ciliogenesis associated kinase 1
Synonyms: Ick, 2210420N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56542
Homologene: 69218
Zc3h11a
Name: zinc finger CCCH type containing 11A
Synonyms: G630041M05Rik, 1110003F06Rik, 5730454B08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70579
Homologene: 8888
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, 2610021O03Rik, Apc1, Mcpr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17222
Homologene: 7414
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 3526402J09Rik, 5730590C14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77097
Homologene: 64680
Dnaja2
Name: DnaJ heat shock protein family (Hsp40) member A2
Synonyms: 1500017M13Rik, DNJ3, PRO3015, HIRIP4, 2010206B19Rik, mDj3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56445
Homologene: 21193
Epm2aip1
Name: EPM2A interacting protein 1
Synonyms: A930003G21Rik, EPM2A (laforin) interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77781
Homologene: 8875
Arhgap33
Name: Rho GTPase activating protein 33
Synonyms: Tcgap, Snx26, NOMA-GAP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233071
Homologene: 76448
Cdhr5
Name: cadherin-related family member 5
Synonyms: 1810074H01Rik, Mupcdh, Mucdhl
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72040
HGNC: HGNC:7521
Homologene: 69345
Csnk2b
Name: casein kinase 2, beta polypeptide
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13001
HGNC: HGNC:2460
Homologene: 55572
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Kif13a
Name: kinesin family member 13A
Synonyms: 4930505I07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16553
VEGA: 13
Homologene: 22589
Azi2
Name: 5-azacytidine induced gene 2
Synonyms: AZ2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 27215
Homologene: 8443
Dnaaf10
Name: dynein axonemal assembly factor 10
Synonyms: Wdr92
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103784
Homologene: 16321
Ucp3
Name: uncoupling protein 3 (mitochondrial, proton carrier)
Synonyms: Slc25a9, UCP-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22229
Homologene: 2517
Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Synonyms: M100174, Nmdar, Rgsc174, NR1, NMDAR1, GluRzeta1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14810
HGNC: HGNC:4584
Homologene: 7187
Dusp19
Name: dual specificity phosphatase 19
Synonyms: 5930436K22Rik, SKRP1, C79103, TS-DSP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68082
Homologene: 41565
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Fer1l4
Name: fer-1 like family member 4
Synonyms: 9130402C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74562
Homologene: 19075
Map6
Name: microtubule-associated protein 6
Synonyms: F-STOP, Mtap6, 2810411E12Rik, STOP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17760
HGNC: HGNC:6868
Homologene: 7850
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Rp1h, mG145, oxygen-regulated protein 1, Dcdc3, Orp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Tnfaip3
Name: tumor necrosis factor, alpha-induced protein 3
Synonyms: zinc finger protein A20, Tnfip3, A20
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21929
Homologene: 4582
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: 5730414M22Rik, Slo, MaxiK, BKCa, BK channel alpha subunit, mSlo1, Slo1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Or5m5
Name: olfactory receptor family 5 subfamily M member 5
Synonyms: Olfr1030, MOR196-2, GA_x6K02T2Q125-47462755-47463693
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258581
Homologene: 64892
Rfc4
Name: replication factor C (activator 1) 4
Synonyms: RFC37, A1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106344
HGNC: HGNC:9972
Homologene: 6288
Arhgef4
Name: Rho guanine nucleotide exchange factor 4
Synonyms: 9330140K16Rik, C230030N03Rik, Asef
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Pcnx2
Name: pecanex homolog 2
Synonyms: Pcnxl2, E330039K12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Parp9
Name: poly (ADP-ribose) polymerase family, member 9
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 80285
Homologene: 12720
Hinfp
Name: histone H4 transcription factor
Synonyms: DKFZp434F162, Mizf
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102423
VEGA: 9
Homologene: 9174
Slc14a2
Name: solute carrier family 14 (urea transporter), member 2
Synonyms: UT-A5, UT-A3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 27411
VEGA: 18
Homologene: 5183
Gmcl1
Name: germ cell-less, spermatogenesis associated 1
Synonyms: 2810049L19Rik, Gcl, mglc-1, Btbd13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23885
Homologene: 8021
Fxyd3
Name: FXYD domain-containing ion transport regulator 3
Synonyms: Mat8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17178
HGNC: HGNC:4027
Homologene: 4356
Iqca1l
Name: IQ motif containing with AAA domain 1 like
Synonyms: 4931409K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231045
Homologene: 18602
Or7a37
Name: olfactory receptor family 7 subfamily A member 37
Synonyms: GA_x6K02T2QGN0-2842591-2841662, MOR139-2, Olfr1353
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259044
Homologene: 131345
Popdc3
Name: popeye domain containing 3
Synonyms: Pop3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78977
Homologene: 32540
Zfp316
Name: zinc finger protein 316
Synonyms: Emzf1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54201
Homologene: 69231
Aoc3
Name: amine oxidase, copper containing 3
Synonyms: VAP1, semicarbazide-sensitive amine oxidase, SSAO
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11754
HGNC: HGNC:550
Homologene: 2770
Alpl
Name: alkaline phosphatase, liver/bone/kidney
Synonyms: ALP, Akp2, TNSALP, Akp-2, TNAP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11647
HGNC: HGNC:438
Homologene: 37314
Tmcc1
Name: transmembrane and coiled coil domains 1
Synonyms: 3632431M01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330401
Homologene: 8995
Gnl1
Name: guanine nucleotide binding protein-like 1
Synonyms: Gna-rs1, Gnal1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14670
HGNC: HGNC:4413
Homologene: 3862
Spx
Name: spexin hormone
Synonyms: B230216G23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319552
Homologene: 79576
Rbm8a
Name: RNA binding motif protein 8a
Synonyms: 2310057C03Rik, Rbm8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 60365
HGNC: HGNC:9905
Homologene: 3744
Noc2l
Name: NOC2 like nucleolar associated transcriptional repressor
Synonyms: NIR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 57741
VEGA: 4
Homologene: 6980
Art2a
Name: ADP-ribosyltransferase 2a
Synonyms: Rt6-1, Art2a-ps, Rt-6, Rt6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11871
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 4,347,403 bp
  • A to G, chromosome 1 at 34,724,141 bp
  • A to T, chromosome 1 at 133,645,737 bp
  • A to G, chromosome 1 at 165,570,771 bp
  • T to A, chromosome 2 at 25,318,667 bp
  • C to T, chromosome 2 at 52,299,569 bp
  • A to G, chromosome 2 at 80,617,561 bp
  • A to T, chromosome 2 at 85,984,635 bp
  • T to C, chromosome 2 at 114,011,828 bp
  • A to G, chromosome 2 at 128,641,537 bp
  • A to G, chromosome 2 at 156,020,431 bp
  • T to C, chromosome 3 at 87,788,426 bp
  • T to C, chromosome 3 at 96,630,308 bp
  • C to T, chromosome 4 at 137,743,809 bp
  • T to A, chromosome 4 at 156,240,307 bp
  • T to C, chromosome 5 at 24,546,628 bp
  • G to A, chromosome 5 at 143,263,412 bp
  • A to G, chromosome 6 at 86,714,257 bp
  • T to C, chromosome 6 at 116,024,882 bp
  • A to G, chromosome 6 at 142,414,790 bp
  • A to T, chromosome 7 at 30,526,112 bp
  • T to A, chromosome 7 at 31,071,173 bp
  • C to A, chromosome 7 at 46,178,544 bp
  • C to T, chromosome 7 at 99,336,292 bp
  • T to C, chromosome 7 at 100,482,592 bp
  • A to T, chromosome 7 at 101,554,849 bp
  • T to C, chromosome 7 at 141,271,778 bp
  • G to T, chromosome 8 at 85,540,310 bp
  • G to A, chromosome 8 at 125,887,125 bp
  • A to G, chromosome 9 at 44,298,345 bp
  • A to G, chromosome 9 at 78,157,726 bp
  • G to A, chromosome 9 at 111,272,375 bp
  • A to T, chromosome 9 at 118,047,593 bp
  • A to G, chromosome 10 at 19,004,780 bp
  • A to G, chromosome 10 at 45,315,131 bp
  • A to T, chromosome 10 at 78,970,303 bp
  • T to C, chromosome 11 at 17,212,064 bp
  • C to A, chromosome 11 at 101,332,512 bp
  • T to A, chromosome 11 at 105,923,467 bp
  • G to T, chromosome 13 at 46,750,613 bp
  • T to A, chromosome 14 at 23,367,612 bp
  • A to G, chromosome 16 at 23,127,413 bp
  • A to G, chromosome 16 at 35,956,912 bp
  • C to A, chromosome 17 at 35,117,996 bp
  • T to C, chromosome 17 at 35,988,220 bp
  • C to T, chromosome 17 at 67,817,031 bp
  • G to A, chromosome 18 at 78,154,003 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7693 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045708-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.