Strain Name:
C57BL/6J-MtgxR7633Btlr/Mmmh
Stock Number:
045721-MU
Citation ID:
RRID:MMRRC_045721-MU
Other Names:
R7633 (G1)
Major Collection:

Strain Information

Hgs
Name: HGF-regulated tyrosine kinase substrate
Synonyms: tn, Hrs
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15239
HGNC: HGNC:4897
Homologene: 37954
Fam117b
Name: family with sequence similarity 117, member B
Synonyms: 2810425F24Rik, Als2cr13, 6330416D14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72750
Homologene: 18307
Notch3
Name: notch 3
Synonyms: N3, hpbk
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Trim59
Name: tripartite motif-containing 59
Synonyms: Mrf1, 2700022F13Rik, TSBF1, 2310035M22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66949
Homologene: 32644
Ehmt1
Name: euchromatic histone methyltransferase 1
Synonyms: 9230102N17Rik, KMT1D
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77683
Homologene: 11698
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Mov10
Name: Mov10 RISC complex RNA helicase
Synonyms: Mov-10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17454
HGNC: HGNC:7200
Homologene: 10365
Plxdc1
Name: plexin domain containing 1
Synonyms: 2410003I07Rik, Tem7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72324
Homologene: 10700
Tyw5
Name: tRNA-yW synthesizing protein 5
Synonyms: 1110034B05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68736
Homologene: 72085
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Smc4
Name: structural maintenance of chromosomes 4
Synonyms: Smc4l1, 2500002A22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70099
Homologene: 4015
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730555F13Rik, 5730455C01Rik, 9130215G10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Cdc68, Spt16, Fact140, Supt16h
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Yipf1
Name: Yip1 domain family, member 1
Synonyms: C030002N13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230584
Homologene: 5898
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: A530025K05Rik, Acac, Acc1, LOC327983, acetyl-CoA carboxylase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Ppfia1
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Synonyms: Liprin-alpha1, liprin, C030014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233977
HGNC: HGNC:9245
Homologene: 20802
Degs1
Name: delta 4-desaturase, sphingolipid 1
Synonyms: Des1, Mdes
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13244
Homologene: 55770
Ikbkb
Name: inhibitor of kappaB kinase beta
Synonyms: IKKbeta, IKK2, IKK-2, IKK-beta, IKK[b]
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16150
HGNC: HGNC:5960
Homologene: 7782
Stard3nl
Name: STARD3 N-terminal like
Synonyms: 0610035N01Rik, 6530409L22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76205
Homologene: 11501
Clmn
Name: calmin
Synonyms: 9330188N17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 94040
VEGA: 12
Homologene: 11683
Slco1a6
Name: solute carrier organic anion transporter family, member 1a6
Synonyms: organic anion-transporting polypeptide, Oatp-5, Slc21a13, 4930422F19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28254
Homologene: 23416
Vmn2r57
Name: vomeronasal 2, receptor 57
Synonyms: EG269902
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269902
Homologene: 104832
Trpv2
Name: transient receptor potential cation channel, subfamily V, member 2
Synonyms: OTRPC2, Vrl1, VRL-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22368
Homologene: 7993
Intu
Name: inturned planar cell polarity protein
Synonyms: Pdzk6, 9230116I04Rik, 9430087H23Rik, Pdzd6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 380614
Homologene: 41059
Mrgprb1
Name: MAS-related GPR, member B1
Synonyms: MrgB1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233231
Homologene: 24986
C4b
Name: complement C4B (Chido blood group)
Synonyms: Ss, C4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12268
Homologene: 36030
Slc28a2b
Name: solute carrier family 28 member 2b
Synonyms: Gm14085
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381417
Rgs1
Name: regulator of G-protein signaling 1
Synonyms: BL34
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 50778
HGNC: HGNC:9991
Homologene: 2191
Hormad2
Name: HORMA domain containing 2
Synonyms: 4930529M09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75828
Homologene: 45130
Qrich2
Name: glutamine rich 2
Synonyms: LOC217341
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217341
Homologene: 12951
Tmc6
Name: transmembrane channel-like gene family 6
Synonyms: D11Ertd204e, EVER1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217353
Homologene: 5258
Zfp954
Name: zinc finger protein 954
Synonyms: 5730403M16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232853
Homologene: 129792
Cd46
Name: CD46 antigen, complement regulatory protein
Synonyms: CD46, Mcp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17221
HGNC: HGNC:6953
Homologene: 7832
Calhm4
Name: calcium homeostasis modulator family member 4
Synonyms: LOC270711, 4732454E20Rik, Fam26d
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270711
VEGA: 10
Homologene: 19551
Skint7
Name: selection and upkeep of intraepithelial T cells 7
Synonyms: C130057D23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 328505
Homologene: 106613
Usp31
Name: ubiquitin specific peptidase 31
Synonyms: 6330567E21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76179
Homologene: 44504
Or4k41
Name: olfactory receptor family 4 subfamily K member 41
Synonyms: MOR248-15, GA_x6K02T2Q125-72500603-72501520, Olfr1287
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257935
Chrnb1
Name: cholinergic receptor nicotinic beta 1 subunit
Synonyms: Acrb, Achr-2, AChR beta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11443
HGNC: HGNC:1961
Homologene: 594
Synpo
Name: synaptopodin
Synonyms: 9030217H17Rik, 9330140I15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 104027
Homologene: 5274
Chp1
Name: calcineurin-like EF hand protein 1
Synonyms: 1500003O03Rik, vac, Sid470p
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56398
Homologene: 5235
Or8s5
Name: olfactory receptor family 8 subfamily S member 5
Synonyms: GA_x6K02T2NBG7-5395976-5396893, MOR160-4, Olfr284
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 258278
Homologene: 74250
Dedd
Name: death effector domain-containing
Synonyms: KE05, DEFT, CASP8IP1, FLDED1, Dedpro1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21945
HGNC: HGNC:2755
Homologene: 7980
A530084C06Rik
Name: RIKEN cDNA A530084C06 gene
Type: Gene
Species: Mouse
Chromosome: 13
Prdm11
Name: PR domain containing 11
Synonyms: 8030443D09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100042784
Homologene: 82511
Dcxr
Name: dicarbonyl L-xylulose reductase
Synonyms: 1810027P18Rik, 0610038K04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67880
Homologene: 22964
Cracd
Name: capping protein inhibiting regulator of actin
Synonyms: C530008M17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320827
Homologene: 136278
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: AIDA-1b, LOC380650, E530015N03Rik, Gm10937, C030032C09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77531
Homologene: 51570
Vmn1r159
Name: vomeronasal 1 receptor 159
Synonyms: Gm16507
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 670857
Homologene: 104166
Slc25a3
Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
Synonyms: 5730556H19Rik, Phc
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18674
Homologene: 37649
Lypd9
Name: LY6/PLAUR domain containing 9
Synonyms: 4930504O13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 403200
Homologene: 87298
Tcstv7b
Name: Tcstv family member 7B
Synonyms: Gm21731
Type: Gene
Species: Mouse
Chromosome: 13
Spock2
Name: sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
Synonyms: testican-2, Gcap26
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 94214
Homologene: 8854
Igkv8-19
Name: immunoglobulin kappa variable 8-19
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232065
HGNC: HGNC:5834
Gm6882
Name: predicted gene 6882
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628475
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 57,393,485 bp
  • A to G, chromosome 1 at 59,981,534 bp
  • A to G, chromosome 1 at 144,248,477 bp
  • C to T, chromosome 1 at 171,338,910 bp
  • A to G, chromosome 1 at 182,279,698 bp
  • A to T, chromosome 1 at 195,083,619 bp
  • T to C, chromosome 2 at 24,815,780 bp
  • G to A, chromosome 2 at 92,980,654 bp
  • A to G, chromosome 2 at 111,449,622 bp
  • A to G, chromosome 2 at 119,560,745 bp
  • A to T, chromosome 2 at 122,486,680 bp
  • G to A, chromosome 3 at 40,654,253 bp
  • CTA to CTATA, chromosome 3 at 69,018,067 bp
  • T to A, chromosome 3 at 69,037,926 bp
  • A to G, chromosome 3 at 104,797,065 bp
  • A to G, chromosome 4 at 107,318,996 bp
  • T to A, chromosome 4 at 111,984,140 bp
  • A to G, chromosome 5 at 76,857,520 bp
  • C to T, chromosome 6 at 70,341,399 bp
  • A to T, chromosome 6 at 142,145,755 bp
  • A to T, chromosome 7 at 7,115,824 bp
  • A to G, chromosome 7 at 21,427,652 bp
  • T to A, chromosome 7 at 22,843,023 bp
  • C to T, chromosome 7 at 41,425,089 bp
  • A to G, chromosome 7 at 48,447,583 bp
  • T to C, chromosome 7 at 104,861,147 bp
  • T to C, chromosome 7 at 121,658,962 bp
  • T to C, chromosome 7 at 144,552,436 bp
  • T to C, chromosome 8 at 22,671,741 bp
  • C to G, chromosome 9 at 70,586,673 bp
  • T to A, chromosome 9 at 95,947,118 bp
  • G to A, chromosome 10 at 34,043,908 bp
  • G to A, chromosome 10 at 60,126,180 bp
  • A to C, chromosome 10 at 90,948,584 bp
  • A to T, chromosome 10 at 91,118,042 bp
  • T to C, chromosome 11 at 4,346,662 bp
  • C to A, chromosome 11 at 58,447,478 bp
  • G to A, chromosome 11 at 62,591,006 bp
  • T to A, chromosome 11 at 69,792,873 bp
  • A to G, chromosome 11 at 84,372,639 bp
  • A to T, chromosome 11 at 97,956,151 bp
  • A to T, chromosome 11 at 116,456,629 bp
  • G to T, chromosome 11 at 117,769,220 bp
  • A to T, chromosome 11 at 120,474,302 bp
  • A to C, chromosome 11 at 120,726,453 bp
  • G to A, chromosome 12 at 104,782,112 bp
  • T to G, chromosome 13 at 19,367,838 bp
  • G to T, chromosome 13 at 31,558,995 bp
  • G to A, chromosome 13 at 120,240,840 bp
  • A to G, chromosome 14 at 52,197,099 bp
  • C to G, chromosome 15 at 8,109,453 bp
  • A to G, chromosome 15 at 98,340,086 bp
  • A to T, chromosome 17 at 32,158,622 bp
  • C to T, chromosome 17 at 34,729,399 bp
  • G to A, chromosome 18 at 60,603,428 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7633 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045721-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.