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Strain Name:
C57BL/6J-MtgxR7660Btlr/Mmmh
Stock Number:
045735-MU
Citation ID:
RRID:MMRRC_045735-MU
Other Names:
R7660 (G1)
Major Collection:

Strain Information

Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: pCIP, TRAM-1, AIB1, RAC3, TRAM1, Src3, 2010305B15Rik, KAT13B, bHLHe42
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Glrx3
Name: glutaredoxin 3
Synonyms: PKC interacting cousin of thioredoxin, PICOT, Txnl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30926
Homologene: 4769
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Rgs3
Name: regulator of G-protein signaling 3
Synonyms: 4930506N09Rik, C2pa, PDZ-RGS3, RGS3S, C2PA-RGS3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50780
HGNC: HGNC:9999
Homologene: 32440
Sema4b
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
Synonyms: SemC, Semac
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20352
Homologene: 8426
Cilk1
Name: ciliogenesis associated kinase 1
Synonyms: 2210420N10Rik, Ick
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56542
Homologene: 69218
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218693
Homologene: 4709
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 66,414,377 bp
  • T to C, chromosome 1 at 79,802,905 bp
  • A to G, chromosome 1 at 174,028,248 bp
  • T to C, chromosome 2 at 24,436,561 bp
  • T to G, chromosome 2 at 52,249,439 bp
  • C to T, chromosome 2 at 69,287,594 bp
  • A to T, chromosome 2 at 86,525,830 bp
  • T to C, chromosome 2 at 89,844,443 bp
  • C to T, chromosome 2 at 111,231,615 bp
  • T to C, chromosome 2 at 128,930,822 bp
  • C to T, chromosome 2 at 166,069,321 bp
  • A to T, chromosome 3 at 38,981,160 bp
  • A to G, chromosome 3 at 59,865,268 bp
  • G to C, chromosome 3 at 127,680,967 bp
  • A to T, chromosome 3 at 139,701,697 bp
  • G to T, chromosome 3 at 142,259,185 bp
  • A to T, chromosome 4 at 56,899,170 bp
  • A to T, chromosome 4 at 58,087,782 bp
  • T to A, chromosome 4 at 62,314,341 bp
  • A to G, chromosome 4 at 62,701,112 bp
  • A to T, chromosome 4 at 109,861,837 bp
  • C to A, chromosome 4 at 117,213,741 bp
  • A to T, chromosome 4 at 123,860,719 bp
  • T to A, chromosome 5 at 29,619,631 bp
  • G to A, chromosome 5 at 108,338,619 bp
  • T to C, chromosome 5 at 137,520,969 bp
  • T to A, chromosome 5 at 144,148,340 bp
  • T to C, chromosome 5 at 149,594,480 bp
  • T to A, chromosome 6 at 28,829,817 bp
  • T to C, chromosome 6 at 39,623,641 bp
  • C to A, chromosome 6 at 121,861,220 bp
  • A to G, chromosome 6 at 128,424,746 bp
  • A to T, chromosome 6 at 146,557,338 bp
  • C to T, chromosome 7 at 32,210,458 bp
  • C to T, chromosome 7 at 46,850,257 bp
  • C to A, chromosome 7 at 80,220,247 bp
  • T to G, chromosome 7 at 85,568,922 bp
  • T to C, chromosome 7 at 87,370,022 bp
  • T to C, chromosome 7 at 104,279,362 bp
  • A to G, chromosome 7 at 108,124,834 bp
  • A to G, chromosome 7 at 137,459,225 bp
  • A to T, chromosome 8 at 13,837,995 bp
  • G to T, chromosome 8 at 41,016,211 bp
  • A to G, chromosome 8 at 43,193,320 bp
  • G to A, chromosome 8 at 63,940,074 bp
  • T to A, chromosome 8 at 124,820,285 bp
  • T to C, chromosome 9 at 19,175,508 bp
  • C to T, chromosome 9 at 53,445,507 bp
  • G to C, chromosome 9 at 78,167,620 bp
  • T to C, chromosome 10 at 43,998,835 bp
  • T to C, chromosome 10 at 88,548,854 bp
  • T to A, chromosome 10 at 103,393,380 bp
  • A to G, chromosome 10 at 110,937,763 bp
  • C to A, chromosome 10 at 129,754,563 bp
  • A to G, chromosome 11 at 9,290,678 bp
  • T to C, chromosome 11 at 87,604,580 bp
  • C to G, chromosome 11 at 98,809,873 bp
  • T to A, chromosome 11 at 110,115,452 bp
  • T to C, chromosome 13 at 22,244,597 bp
  • T to C, chromosome 13 at 73,806,089 bp
  • C to T, chromosome 13 at 119,450,770 bp
  • T to G, chromosome 14 at 4,893,349 bp
  • G to A, chromosome 14 at 121,276,922 bp
  • A to G, chromosome 15 at 34,402,946 bp
  • T to A, chromosome 15 at 34,423,728 bp
  • T to C, chromosome 16 at 11,087,929 bp
  • C to T, chromosome 16 at 55,844,327 bp
  • T to A, chromosome 17 at 3,482,605 bp
  • T to C, chromosome 17 at 21,434,239 bp
  • T to A, chromosome 17 at 23,077,032 bp
  • T to G, chromosome 17 at 25,051,824 bp
  • C to T, chromosome 17 at 43,478,977 bp
  • T to A, chromosome 18 at 37,005,851 bp
  • C to T, chromosome 18 at 37,757,130 bp
  • G to A, chromosome 18 at 52,475,599 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7660 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045735-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.