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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7673Btlr/Mmmh
Stock Number:
045743-MU
Citation ID:
RRID:MMRRC_045743-MU
Other Names:
R7673 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Dnm2
Name: dynamin 2
Synonyms: Dyn2, b2b2159Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13430
HGNC: HGNC:2974
Homologene: 90883

Additional Resources
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Gene Ontology
BioGPS
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KOMP Phenotyping
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ClinGen
Stx8
Name: syntaxin 8
Synonyms: 1110002H11Rik, 0610007H08Rik, 4930571E13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 55943
Homologene: 37973

Additional Resources
IMPC
Google
Entrez
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IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Il4i1
Name: interleukin 4 induced 1
Synonyms: Fig1-ps, Fig1, H46, H4, H-46, H-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14204
Homologene: 22567

Additional Resources
IMPC
Google
Entrez
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IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Cxcl17
Name: C-X-C motif chemokine ligand 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232983
Homologene: 18875

Additional Resources
IMPC
Google
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PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
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Mouse Phenome DB
Mouse Mine
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ClinGen
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231326
Homologene: 71711

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Fam117a
Name: family with sequence similarity 117, member A
Synonyms: 5730593F17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 215512
Homologene: 12775

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: p1.m, P1, Mcmd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,812,014 bp
  • T to C, chromosome 1 at 66,413,774 bp
  • A to C, chromosome 1 at 72,160,964 bp
  • T to C, chromosome 1 at 75,557,351 bp
  • A to G, chromosome 1 at 129,915,750 bp
  • T to A, chromosome 1 at 153,124,036 bp
  • C to A, chromosome 1 at 167,361,550 bp
  • A to T, chromosome 1 at 179,762,846 bp
  • G to A, chromosome 2 at 26,958,493 bp
  • G to A, chromosome 2 at 52,088,654 bp
  • T to C, chromosome 2 at 67,517,087 bp
  • T to C, chromosome 2 at 85,591,062 bp
  • T to C, chromosome 2 at 86,657,726 bp
  • T to A, chromosome 2 at 112,042,580 bp
  • C to T, chromosome 2 at 153,129,085 bp
  • T to A, chromosome 2 at 181,260,388 bp
  • A to T, chromosome 3 at 75,450,907 bp
  • C to A, chromosome 3 at 98,619,441 bp
  • A to G, chromosome 3 at 100,191,699 bp
  • T to C, chromosome 4 at 43,563,117 bp
  • A to T, chromosome 4 at 52,610,679 bp
  • A to C, chromosome 4 at 88,842,072 bp
  • T to C, chromosome 4 at 119,353,172 bp
  • T to G, chromosome 4 at 155,463,056 bp
  • T to C, chromosome 5 at 3,646,867 bp
  • C to A, chromosome 5 at 76,882,708 bp
  • A to G, chromosome 5 at 123,029,442 bp
  • G to A, chromosome 5 at 124,413,216 bp
  • T to A, chromosome 6 at 34,927,918 bp
  • A to T, chromosome 6 at 35,276,476 bp
  • T to A, chromosome 6 at 90,223,643 bp
  • A to T, chromosome 6 at 124,399,383 bp
  • G to T, chromosome 7 at 6,317,010 bp
  • C to A, chromosome 7 at 25,402,868 bp
  • T to A, chromosome 7 at 27,748,315 bp
  • A to G, chromosome 7 at 44,840,362 bp
  • A to G, chromosome 7 at 45,337,234 bp
  • A to T, chromosome 7 at 78,843,611 bp
  • A to G, chromosome 8 at 72,161,296 bp
  • A to G, chromosome 8 at 72,200,511 bp
  • A to G, chromosome 8 at 91,051,697 bp
  • A to T, chromosome 8 at 91,300,787 bp
  • T to A, chromosome 9 at 21,481,421 bp
  • A to T, chromosome 9 at 38,116,227 bp
  • A to T, chromosome 9 at 104,063,906 bp
  • G to T, chromosome 9 at 104,233,692 bp
  • A to T, chromosome 10 at 69,990,501 bp
  • A to G, chromosome 10 at 80,524,406 bp
  • T to C, chromosome 10 at 127,056,599 bp
  • A to T, chromosome 11 at 48,907,628 bp
  • G to A, chromosome 11 at 59,027,437 bp
  • A to T, chromosome 11 at 67,245,513 bp
  • T to C, chromosome 11 at 67,984,639 bp
  • A to C, chromosome 11 at 69,405,742 bp
  • G to T, chromosome 11 at 70,466,040 bp
  • G to T, chromosome 11 at 95,371,496 bp
  • A to T, chromosome 11 at 96,353,457 bp
  • T to C, chromosome 11 at 115,788,378 bp
  • A to T, chromosome 13 at 19,367,753 bp
  • A to G, chromosome 13 at 49,664,780 bp
  • T to C, chromosome 13 at 55,659,159 bp
  • A to T, chromosome 13 at 93,094,121 bp
  • C to A, chromosome 14 at 55,569,305 bp
  • G to T, chromosome 15 at 3,274,858 bp
  • G to T, chromosome 15 at 63,825,083 bp
  • A to G, chromosome 16 at 4,694,464 bp
  • T to C, chromosome 16 at 27,406,675 bp
  • T to A, chromosome 16 at 32,162,281 bp
  • C to T, chromosome 16 at 36,913,669 bp
  • T to C, chromosome 17 at 20,182,737 bp
  • G to A, chromosome 17 at 78,795,983 bp
  • G to T, chromosome 18 at 37,491,737 bp
  • A to C, chromosome 19 at 4,645,633 bp
  • G to C, chromosome 19 at 33,825,028 bp
  • T to C, chromosome 19 at 44,511,688 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7673 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045743-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.