Strain Name:
C57BL/6J-MtgxR7701Btlr/Mmmh
Stock Number:
045762-MU
Citation ID:
RRID:MMRRC_045762-MU
Other Names:
R7701 (G1)
Major Collection:

Strain Information

Rgs14
Name: regulator of G-protein signaling 14
Synonyms: Rap1/rap2 interacting protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 51791
HGNC: HGNC:9996
Homologene: 4735
Psmb1
Name: proteasome (prosome, macropain) subunit, beta type 1
Synonyms: Lmpc5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19170
VEGA: 17
HGNC: HGNC:9537
Homologene: 2087
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: Zfat1, Zfp406, LOC380993
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380993
Homologene: 16829
Zfp341
Name: zinc finger protein 341
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228807
Homologene: 13127
Naa25
Name: N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms: C330023M02Rik, 4833422K13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231713
Homologene: 6891
Mcm5
Name: minichromosome maintenance complex component 5
Synonyms: Cdc46, Mcmd5, mCD46
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17218
HGNC: HGNC:6948
Homologene: 4904
Actn1
Name: actinin, alpha 1
Synonyms: 3110023F10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109711
VEGA: 12
HGNC: HGNC:163
Homologene: 55553
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Loa, dynein heavy chain, retrograde transport, Dnchc1, Swl, MAP1C, 9930018I23Rik, Dnec1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: 2810429C13Rik, 1110031N14Rik, D430026L04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235559
Homologene: 38262
Gas2
Name: growth arrest specific 2
Synonyms: Gas-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14453
HGNC: HGNC:4167
Homologene: 31301
Ccdc3
Name: coiled-coil domain containing 3
Synonyms: 2310045O21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74186
Homologene: 12870
Arhgef1
Name: Rho guanine nucleotide exchange factor 1
Synonyms: Lbcl2, Lsc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16801
HGNC: HGNC:681
Homologene: 3454
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik, sao
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68750
Homologene: 2218
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: A930031B09Rik, D330024H06Rik, Ankrd15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107351
Homologene: 17706
Zfp54
Name: zinc finger protein 54
Synonyms: clone 18, Zfp-54, Zfp76, KRAB10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22712
Homologene: 129791
Eif2a
Name: eukaryotic translation initiation factor 2A
Synonyms: D3Ertd194e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229317
HGNC: HGNC:3254
Homologene: 5969
Mapk8ip3
Name: mitogen-activated protein kinase 8 interacting protein 3
Synonyms: JSAP1, Jip3, JNK-interacting protein 3, JUN/SAPK-associated protein 1, Syd2, sunday driver 2, D17Wsu15e, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, JSAP1a, JSAP1b, JSAP1c, JSAP1d
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 30957
HGNC: HGNC:6884
Homologene: 22790
Tspan3
Name: tetraspanin 3
Synonyms: Tspan-3, Tm4sf8, tetraspanin TM4-A homolog, tetraspanin, 1700055K04Rik, TM4-A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56434
VEGA: 9
Homologene: 21168
Tubgcp3
Name: tubulin, gamma complex component 3
Synonyms: Spc98p, GCP3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 259279
Homologene: 4609
Dach1
Name: dachshund family transcription factor 1
Synonyms: E130112M23Rik, Dac
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Col24a1
Name: collagen, type XXIV, alpha 1
Synonyms: 5430404K19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71355
Homologene: 65061
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: MSF, DOL54, SZP, lubricin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Lnx2
Name: ligand of numb-protein X 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140887
Homologene: 17737
Iqcm
Name: IQ motif containing M
Synonyms: 1700007B14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71831
Homologene: 53050
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: 1110001D15Rik, EG235580, Vwa6, Dvwa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Bbs10
Name: Bardet-Biedl syndrome 10
Synonyms: 1300007O09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71769
VEGA: 10
Homologene: 49781
Or8g4
Name: olfactory receptor family 8 subfamily G member 4
Synonyms: Olfr967, GA_x6K02T2PVTD-33447884-33448816, MOR171-30P
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258086
VEGA: 9
HGNC: HGNC:8484
Homologene: 115535
Miip
Name: migration and invasion inhibitory protein
Synonyms: D4Wsu114e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 28010
Homologene: 15879
Spock1
Name: sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
Synonyms: Ticn1, testican 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20745
Homologene: 80193
Pdlim3
Name: PDZ and LIM domain 3
Synonyms: ALP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 53318
Homologene: 75063
Mob3a
Name: MOB kinase activator 3A
Synonyms: Mobkl2a, 5330417K06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208228
VEGA: 10
Homologene: 41587
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75721
Homologene: 138468
Flot2
Name: flotillin 2
Synonyms: reggie-2, Esa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14252
HGNC: HGNC:3758
Homologene: 3293
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: 6430517E21Rik, Fam5b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240843
Homologene: 10905
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Cd276
Name: CD276 antigen
Synonyms: 6030411F23Rik, B7-H3, B7RP-2, B7h3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102657
VEGA: 9
Homologene: 11892
Mrpl38
Name: mitochondrial ribosomal protein L38
Synonyms: 4733401F03Rik, MRP-L3, 1110036N21Rik, Rpml3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 60441
Homologene: 11476
Or5b102
Name: olfactory receptor family 5 subfamily B member 102
Synonyms: Olfr1454, MOR202-14, GA_x6K02T2RE5P-3390804-3391727
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258687
HGNC: HGNC:8324
Homologene: 120159
Pcdhb6
Name: protocadherin beta 6
Synonyms: PcdhbF, Pcdhb5B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93877
HGNC: HGNC:8690
Homologene: 62177
Duxf1
Name: double homeobox family member 1
Synonyms: AW822073
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100504180
Homologene: 134545
Scly
Name: selenocysteine lyase
Synonyms: Scly1, SCL, A930015N15Rik, Scly2, Selenocysteine reductase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 50880
Homologene: 9548
Aup1
Name: ancient ubiquitous protein 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11993
HGNC: HGNC:891
Homologene: 7239
Ska1
Name: spindle and kinetochore associated complex subunit 1
Synonyms: 2810433K01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66468
VEGA: 18
Homologene: 11975
Slc35b3
Name: solute carrier family 35, member B3
Synonyms: PAPST2, 4921526O06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108652
VEGA: 13
Homologene: 9313
Or2z9
Name: olfactory receptor family 2 subfamily Z member 9
Synonyms: MOR282-1, GA_x6K02T2NUPS-231686-232630, MOR282-2, Olfr373
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 258532
Homologene: 17287
Phpt1
Name: phosphohistidine phosphatase 1
Synonyms: 1700008C22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75454
Homologene: 8573
Rsph14
Name: radial spoke head homolog 14 (Chlamydomonas)
Synonyms: Rtdr1, 4933431K05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71236
Homologene: 49382
Gm5111
Name: predicted gene 5111
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330305
Smok2b
Name: sperm motility kinase 2B
Synonyms: LOC236574
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 236574
Homologene: 128738
Rab14
Name: RAB14, member RAS oncogene family
Synonyms: 2810475J17Rik, D030017L14Rik, A830021G03Rik, 0610030G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68365
Homologene: 48679
4930470P17Rik
Name: RIKEN cDNA 4930470P17 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67637
Pcdha8
Name: protocadherin alpha 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353235
HGNC: HGNC:8675
Homologene: 129614
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 91,308,308 bp
  • T to C, chromosome 1 at 150,457,542 bp
  • A to G, chromosome 1 at 158,266,460 bp
  • A to G, chromosome 2 at 5,138,057 bp
  • A to G, chromosome 2 at 25,574,787 bp
  • A to G, chromosome 2 at 35,183,415 bp
  • G to A, chromosome 2 at 68,731,204 bp
  • T to G, chromosome 2 at 76,729,684 bp
  • T to A, chromosome 2 at 154,634,080 bp
  • T to C, chromosome 2 at 170,601,305 bp
  • A to T, chromosome 3 at 58,552,570 bp
  • A to G, chromosome 3 at 83,346,206 bp
  • T to A, chromosome 3 at 145,315,011 bp
  • A to G, chromosome 3 at 145,366,901 bp
  • A to T, chromosome 4 at 147,862,914 bp
  • A to G, chromosome 5 at 121,425,979 bp
  • A to T, chromosome 5 at 147,024,523 bp
  • A to G, chromosome 6 at 48,590,093 bp
  • T to C, chromosome 6 at 83,055,927 bp
  • CAAAGTAA to CAAAGTAAAGTAA, chromosome 6 at 113,399,157 bp
  • T to C, chromosome 7 at 24,912,578 bp
  • T to G, chromosome 7 at 51,993,353 bp
  • A to G, chromosome 8 at 12,655,974 bp
  • A to G, chromosome 8 at 45,908,539 bp
  • T to A, chromosome 8 at 72,100,186 bp
  • C to A, chromosome 8 at 75,123,923 bp
  • A to G, chromosome 8 at 75,554,911 bp
  • A to G, chromosome 9 at 39,751,301 bp
  • A to T, chromosome 9 at 56,147,519 bp
  • T to C, chromosome 9 at 58,535,527 bp
  • T to C, chromosome 9 at 103,332,985 bp
  • A to C, chromosome 9 at 106,082,888 bp
  • G to T, chromosome 10 at 43,989,143 bp
  • A to G, chromosome 10 at 58,223,063 bp
  • A to T, chromosome 10 at 74,957,776 bp
  • G to A, chromosome 10 at 80,689,934 bp
  • A to G, chromosome 10 at 111,300,013 bp
  • A to G, chromosome 11 at 78,038,116 bp
  • G to A, chromosome 11 at 116,135,278 bp
  • A to T, chromosome 12 at 80,174,554 bp
  • G to A, chromosome 12 at 110,618,646 bp
  • C to T, chromosome 13 at 37,930,116 bp
  • T to C, chromosome 13 at 38,944,635 bp
  • A to G, chromosome 13 at 55,379,325 bp
  • G to A, chromosome 13 at 57,587,659 bp
  • C to T, chromosome 14 at 97,903,234 bp
  • C to A, chromosome 15 at 68,180,908 bp
  • A to G, chromosome 17 at 13,234,880 bp
  • A to G, chromosome 17 at 15,477,247 bp
  • A to G, chromosome 17 at 21,434,095 bp
  • G to T, chromosome 17 at 24,901,404 bp
  • A to T, chromosome 18 at 36,993,811 bp
  • A to T, chromosome 18 at 37,334,509 bp
  • A to T, chromosome 18 at 74,202,643 bp
  • A to G, chromosome 19 at 13,064,081 bp
  • G to A, chromosome 19 at 25,411,765 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7701 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045762-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.