Strain Name:
C57BL/6J-MtgxR7704Btlr/Mmmh
Stock Number:
045765-MU
Citation ID:
RRID:MMRRC_045765-MU
Other Names:
R7704 (G1)
Major Collection:

Strain Information

Prdm16
Name: PR domain containing 16
Synonyms: Mel1, csp1, line 27, 5730557K01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70673
Homologene: 11139
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Kdm5b
Name: lysine demethylase 5B
Synonyms: 2010009J12Rik, D1Ertd202e, Jarid1b, Rb-Bp2, 2210016I17Rik, Plu1, PLU-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Abcc8
Name: ATP-binding cassette, sub-family C member 8
Synonyms: Sur, SUR1, D930031B21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Tbc1d22a
Name: TBC1 domain family, member 22a
Synonyms: D15Ertd781e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223754
VEGA: 15
HGNC: HGNC:1309
Homologene: 105406
Kdm5a
Name: lysine demethylase 5A
Synonyms: RBP2, Rbbp2, Jarid1a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Nop58
Name: NOP58 ribonucleoprotein
Synonyms: SIK similar protein, Nol5, MSSP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 55989
Homologene: 7024
Ncapg2
Name: non-SMC condensin II complex, subunit G2
Synonyms: 5830426I05Rik, Mtb, Luzp5, mCAP-G2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76044
VEGA: 12
Homologene: 9820
Akap12
Name: A kinase anchor protein 12
Synonyms: Tsga12, SSeCKS, Srcs5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83397
VEGA: 10
HGNC: HGNC:370
Homologene: 3740
Tango6
Name: transport and golgi organization 6
Synonyms: Tmco7, Tango6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 272538
Homologene: 52121
Ddx46
Name: DEAD box helicase 46
Synonyms: 2200005K02Rik, 8430438J23Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212880
VEGA: 13
Homologene: 5430
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, Swl, dynein heavy chain, retrograde transport, Dnec1, 9930018I23Rik, Loa, Dnchc1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Med13
Name: mediator complex subunit 13
Synonyms: Trap240, Thrap1, 1110067M05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327987
Homologene: 21067
Nsd2
Name: nuclear receptor binding SET domain protein 2
Synonyms: D030027O06Rik, Whsc1, 5830445G22Rik, Whsc1l, C130020C13Rik, D930023B08Rik, 9430010A17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 107823
Homologene: 26175
Zap70
Name: zeta-chain (TCR) associated protein kinase
Synonyms: Srk, TZK, ZAP-70
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22637
Homologene: 839
Copg1
Name: coatomer protein complex, subunit gamma 1
Synonyms: Copg, D6Wsu16e, D6Ertd71e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54161
HGNC: HGNC:2236
Homologene: 56745
Ddx21
Name: DExD box helicase 21
Synonyms: D10Ertd645e, D10Wsu42e, RH-II/Gualpha, DEAD (Asp-Glu-Ala-Asp) box polypeptide 21, RH II/Gu
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56200
VEGA: 10
HGNC: HGNC:2744
Homologene: 3473
Sox17
Name: SRY (sex determining region Y)-box 17
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20671
Homologene: 7948
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20259
Homologene: 36296
Tnfrsf11b
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Synonyms: osteoclastogenesis inhibitory factor, OCIF, OPG, Opg, TR1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18383
VEGA: 15
Homologene: 1912
Sec14l2
Name: SEC14-like lipid binding 2
Synonyms: 1300013M05Rik, tap, Spf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67815
Homologene: 8245
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, Fath2, LOC245827, mKIAA0811
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Bltp2
Name: bridge-like lipid transfer protein family member 2
Synonyms: 2610507B11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72503
Homologene: 34730
Prss46
Name: serine protease 46
Synonyms: 1700112C13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74306
Homologene: 77706
Ust
Name: uronyl-2-sulfotransferase
Synonyms: D930010O20Rik, UA2OST
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 338362
VEGA: 10
Homologene: 4174
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Vmn1r76
Name: vomeronasal 1 receptor 76
Synonyms: V1rg4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171239
Dennd5a
Name: DENN domain containing 5A
Synonyms: 1500012B19Rik, ORF37, Rab6ip1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19347
Homologene: 14584
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627132
Homologene: 129750
Cfap65
Name: cilia and flagella associated protein 65
Synonyms: B230363K08Rik, Ccdc108
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241116
Homologene: 28093
Or2t35
Name: olfactory receptor family 2 subfamily T member 35
Synonyms: MOR274-4_i, GA_x6K02T2PLTE-6793523-6794528, Olfr721, MOR274-3P
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 257982
Or1e30
Name: olfactory receptor family 1 subfamily E member 30
Synonyms: Olfr390, GA_x6K02T2P1NL-3938806-3939741, MOR135-26
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258344
Homologene: 115483
Adamts10
Name: ADAM metallopeptidase with thrombospondin type 1 motif 10
Synonyms: ZnMP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224697
Homologene: 81940
Zfp932
Name: zinc finger protein 932
Synonyms: 2310001H12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69504
Homologene: 137770
Agbl2
Name: ATP/GTP binding protein-like 2
Synonyms: Ccp2, Ccp2, A430081C19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271813
Homologene: 11715
Ifi44
Name: interferon-induced protein 44
Synonyms: MTAP44, p44, A430056A10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99899
Homologene: 4683
Ctsf
Name: cathepsin F
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56464
VEGA: 19
HGNC: HGNC:2531
Homologene: 31194
Galc
Name: galactosylceramidase
Synonyms: 2310068B06Rik, Gacy, A930008M05Rik, galactocerebrosidase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14420
VEGA: 12
HGNC: HGNC:4115
Homologene: 124
Mterf1a
Name: mitochondrial transcription termination factor 1a
Synonyms: Mterf1, 4931431L11Rik, Mterf, 9230106K09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 545725
Homologene: 5073
Tmem8b
Name: transmembrane protein 8B
Synonyms: 4930500O05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242409
Homologene: 72894
Ecm1
Name: extracellular matrix protein 1
Synonyms: p85
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13601
HGNC: HGNC:3153
Homologene: 3260
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: Gpd-1, Gpd1, G6pd1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Redic1
Name: regulator of DNA class I crossover intermediates 1
Synonyms: Gm5807, CN725425
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545126
Gask1a
Name: golgi associated kinase 1A
Synonyms: Fam198a, C730027P07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245050
VEGA: 9
Homologene: 18620
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434117
Homologene: 113703
Pramel29
Name: PRAME like 29
Synonyms: C87977
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 97187
Homologene: 103830
Lipt1
Name: lipoyltransferase 1
Synonyms: EG623661
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 623661
Homologene: 50569
Or52ab2
Name: olfactory receptor family 52 subfamily AB member 2
Synonyms: Olfr597, MOR23-2, GA_x6K02T2PBJ9-6029614-6030561
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258135
Homologene: 132401
Tdpoz8
Name: TD and POZ domain containing 8
Synonyms: Gm4858
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229571
Homologene: 130121
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 4,493,672 bp
  • T to C, chromosome 1 at 36,779,314 bp
  • T to A, chromosome 1 at 37,875,962 bp
  • T to C, chromosome 1 at 59,705,595 bp
  • T to A, chromosome 1 at 74,928,368 bp
  • C to T, chromosome 1 at 134,587,931 bp
  • A to C, chromosome 2 at 90,789,005 bp
  • A to G, chromosome 3 at 93,074,445 bp
  • A to C, chromosome 3 at 95,736,531 bp
  • A to G, chromosome 3 at 151,732,424 bp
  • T to C, chromosome 4 at 43,689,461 bp
  • C to T, chromosome 4 at 144,208,521 bp
  • T to C, chromosome 4 at 149,982,903 bp
  • C to T, chromosome 4 at 154,341,490 bp
  • A to G, chromosome 5 at 3,891,845 bp
  • T to C, chromosome 5 at 33,871,467 bp
  • A to G, chromosome 5 at 110,009,764 bp
  • T to A, chromosome 6 at 87,907,958 bp
  • T to G, chromosome 6 at 120,427,064 bp
  • T to C, chromosome 7 at 10,047,738 bp
  • A to G, chromosome 7 at 11,930,417 bp
  • A to T, chromosome 7 at 28,897,042 bp
  • C to A, chromosome 7 at 46,106,644 bp
  • T to A, chromosome 7 at 103,320,771 bp
  • A to G, chromosome 7 at 109,896,967 bp
  • A to G, chromosome 8 at 106,698,989 bp
  • T to A, chromosome 9 at 73,699,212 bp
  • T to C, chromosome 9 at 110,849,997 bp
  • C to T, chromosome 9 at 121,951,085 bp
  • A to T, chromosome 10 at 4,356,082 bp
  • C to T, chromosome 10 at 8,330,223 bp
  • T to C, chromosome 10 at 62,594,086 bp
  • T to C, chromosome 11 at 4,108,574 bp
  • T to C, chromosome 11 at 55,284,347 bp
  • T to G, chromosome 11 at 73,787,790 bp
  • C to A, chromosome 11 at 78,268,744 bp
  • G to A, chromosome 11 at 86,345,918 bp
  • T to C, chromosome 12 at 40,124,688 bp
  • T to A, chromosome 12 at 98,208,843 bp
  • T to A, chromosome 12 at 110,665,766 bp
  • A to T, chromosome 12 at 116,419,277 bp
  • C to T, chromosome 13 at 55,674,019 bp
  • T to A, chromosome 14 at 14,407,867 bp
  • T to A, chromosome 15 at 54,260,101 bp
  • T to A, chromosome 15 at 86,366,675 bp
  • T to A, chromosome 15 at 91,235,790 bp
  • T to C, chromosome 17 at 15,767,475 bp
  • T to C, chromosome 17 at 18,316,648 bp
  • T to C, chromosome 17 at 33,551,152 bp
  • T to G, chromosome 19 at 4,856,539 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7704 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045765-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.