Strain Name:
C57BL/6J-MtgxR7745Btlr/Mmmh
Stock Number:
045801-MU
Citation ID:
RRID:MMRRC_045801-MU
Other Names:
R7745 (G1)
Major Collection:

Strain Information

Prkar1a
Name: protein kinase, cAMP dependent regulatory, type I, alpha
Synonyms: RIalpha, Tse-1, 1300018C22Rik, Tse1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19084
HGNC: HGNC:9388
Homologene: 37664
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: D630035I23Rik, TRIP8, 5430433L24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Mgll
Name: monoglyceride lipase
Synonyms: Magl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23945
Homologene: 38298
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Aebp2
Name: AE binding protein 2
Synonyms: B230313N05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11569
Homologene: 40690
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lec1, Lphn2, Lphh1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99633
Homologene: 22712
Sbno1
Name: strawberry notch 1
Synonyms: 9330180L10Rik, sno
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243272
Homologene: 10055
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, Casc5, 5730505K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76464
Homologene: 44890
Copa
Name: coatomer protein complex subunit alpha
Synonyms: xenin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12847
HGNC: HGNC:2230
Homologene: 3218
Nedd1
Name: neural precursor cell expressed, developmentally down-regulated gene 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17997
VEGA: 10
HGNC: HGNC:7723
Homologene: 7439
Aars1
Name: alanyl-tRNA synthetase 1
Synonyms: Aars
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234734
HGNC: HGNC:20
Homologene: 1213
Ampd2
Name: adenosine monophosphate deaminase 2
Synonyms: 1200014F01Rik, Ampd-2, m4521Dajl
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109674
HGNC: HGNC:469
Homologene: 2979
Limk2
Name: LIM domain kinase 2
Synonyms: whe, A930024P04Rik, Limk2a, Limk2b, LIM kinase 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16886
HGNC: HGNC:6614
Homologene: 55911
Hnrnph1
Name: heterogeneous nuclear ribonucleoprotein H1
Synonyms: Hnrph1, E430005G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 59013
HGNC: HGNC:5041
Homologene: 31318
Pprc1
Name: peroxisome proliferative activated receptor, gamma, coactivator-related 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226169
Homologene: 9006
Exoc1
Name: exocyst complex component 1
Synonyms: Sec3p, SEC3, Sec3l1, 2810407P21Rik, A730011E05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69940
Homologene: 41241
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: nmf352, Cacnl1a4, Ccha1a, smrl, alpha1A, SCA6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12286
HGNC: HGNC:1388
Homologene: 56383
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: D930026N18Rik, (alpha)1 subunit, L-type Cav1.2, Cchl1a1, Cav1.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: 2900022L05Rik, Dnhd3, Dnahc2, D330014H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Cpne2
Name: copine II
Synonyms: 3322401K10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234577
HGNC: HGNC:2315
Homologene: 27392
Abca15
Name: ATP-binding cassette, sub-family A member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320631
Homologene: 87255
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Pitpnm2
Name: phosphatidylinositol transfer protein, membrane-associated 2
Synonyms: Rdgb2, RDGBA2, NIR3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19679
Homologene: 7915
Aox3
Name: aldehyde oxidase 3
Synonyms: 1200011D03Rik, AOH1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71724
Homologene: 90899
Crybg2
Name: crystallin beta-gamma domain containing 2
Synonyms: Aim1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230806
Homologene: 19232
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mdga2, 6720489L24Rik, Adp, 9330209L04Rik, Mamdc1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320772
Homologene: 45659
Pcnx2
Name: pecanex homolog 2
Synonyms: Pcnxl2, E330039K12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Adck1
Name: aarF domain containing kinase 1
Synonyms: 2610005A10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72113
VEGA: 12
Homologene: 6493
Stmnd1
Name: stathmin domain containing 1
Synonyms: Gm1574, LOC380842
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380842
VEGA: 13
Homologene: 54416
Ccng2
Name: cyclin G2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12452
HGNC: HGNC:1593
Homologene: 3208
Aox4
Name: aldehyde oxidase 4
Synonyms: 2310003G12Rik, AOH2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71872
Homologene: 70273
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, Wdr65, LOC384050, 1110020C03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Fam171a1
Name: family with sequence similarity 171, member A1
Synonyms: 9630050M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269233
Homologene: 19521
Rhbdl3
Name: rhomboid like 3
Synonyms: Rhbdl4, Ventrhoid, Vrho
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246104
Homologene: 34700
Ccdc8
Name: coiled-coil domain containing 8
Synonyms: ENSMUSG00000041117
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434130
Homologene: 49977
Piwil2
Name: piwi-like RNA-mediated gene silencing 2
Synonyms: Miwi like, mili
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57746
VEGA: 14
Homologene: 23071
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 636808
Homologene: 43974
Stt3a
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
Synonyms: Itm1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16430
HGNC: HGNC:6172
Homologene: 40617
Tchh
Name: trichohyalin
Synonyms: AHF, Thh
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99681
Homologene: 136273
Aadac
Name: arylacetamide deacetylase
Synonyms: Aada, 5033417E09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67758
HGNC: HGNC:17
Homologene: 37436
Vmn1r171
Name: vomeronasal 1 receptor 171
Synonyms: V1rd7, V3R7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81012
Homologene: 128341
Rsph3a
Name: radial spoke 3A homolog (Chlamydomonas)
Synonyms: Rshl2, 4930524H12Rik, Rshl2a, 1700012G05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66832
VEGA: 17
Homologene: 12043
Fastkd5
Name: FAST kinase domains 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 380601
Homologene: 36400
Tgfbr3l
Name: transforming growth factor, beta receptor III-like
Synonyms: Gm14378, LOC100039590
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100044509
Homologene: 130375
Exoc8
Name: exocyst complex component 8
Synonyms: Exo84p, EXO84, SEC84
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102058
Homologene: 44545
Car8
Name: carbonic anhydrase 8
Synonyms: wdl, CA-RP VIII, Carp, Cals1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12319
HGNC: HGNC:1382
Homologene: 20861
Gdf7
Name: growth differentiation factor 7
Synonyms: BMP12
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238057
VEGA: 12
HGNC: HGNC:4222
Homologene: 32177
Adck5
Name: aarF domain containing kinase 5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268822
Homologene: 34378
Med24
Name: mediator complex subunit 24
Synonyms: D11Ertd307e, 100kDa, Trap100, Pparb2, R75526, Gse2, Thrap4, DRIP100
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23989
Homologene: 40795
Or5k1b
Name: olfactory receptor family 5 subfamily K member 1B
Synonyms: Olfr172, MOR184-2, GA_x54KRFPKG5P-54930346-54929417
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259003
Homologene: 45084
Pecr
Name: peroxisomal trans-2-enoyl-CoA reductase
Synonyms: 2400003B18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 111175
Homologene: 69255
Tas2r114
Name: taste receptor, type 2, member 114
Synonyms: Tas2r14, T2R14, mGR14, mt2r46
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387346
Homologene: 128355
Igkv8-27
Name: immunoglobulin kappa chain variable 8-27
Synonyms: Gm16944
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434041
HGNC: HGNC:5834
Prl2c3
Name: prolactin family 2, subfamily c, member 3
Synonyms: MRP-2, Prl2c4, Mrpplf3, mrp/plf3, PLF-2, Plf2, PLF-3, MRP-3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18812
VEGA: 13
Homologene: 40763
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 30,804,224 bp
  • T to C, chromosome 1 at 58,176,517 bp
  • A to G, chromosome 1 at 58,240,707 bp
  • T to C, chromosome 1 at 72,266,998 bp
  • A to G, chromosome 1 at 116,442,283 bp
  • A to T, chromosome 1 at 172,111,942 bp
  • T to A, chromosome 2 at 3,225,446 bp
  • T to A, chromosome 2 at 76,767,800 bp
  • T to G, chromosome 2 at 119,071,556 bp
  • T to C, chromosome 2 at 125,303,195 bp
  • A to T, chromosome 2 at 130,615,068 bp
  • A to C, chromosome 3 at 60,038,472 bp
  • G to T, chromosome 3 at 93,444,777 bp
  • C to A, chromosome 3 at 108,080,116 bp
  • A to G, chromosome 3 at 148,836,458 bp
  • A to G, chromosome 4 at 8,237,939 bp
  • C to T, chromosome 4 at 118,614,931 bp
  • A to G, chromosome 4 at 134,088,845 bp
  • A to G, chromosome 4 at 141,890,939 bp
  • A to T, chromosome 5 at 76,561,512 bp
  • C to G, chromosome 5 at 93,273,343 bp
  • A to T, chromosome 5 at 96,726,895 bp
  • C to G, chromosome 5 at 124,128,705 bp
  • A to T, chromosome 5 at 124,392,899 bp
  • T to A, chromosome 6 at 70,172,015 bp
  • T to C, chromosome 6 at 88,725,788 bp
  • T to C, chromosome 6 at 119,052,626 bp
  • A to T, chromosome 6 at 131,689,438 bp
  • T to A, chromosome 6 at 140,623,858 bp
  • G to T, chromosome 7 at 16,995,689 bp
  • A to G, chromosome 7 at 23,632,610 bp
  • A to G, chromosome 7 at 120,332,217 bp
  • T to C, chromosome 8 at 4,250,622 bp
  • A to G, chromosome 8 at 15,932,461 bp
  • C to A, chromosome 8 at 84,559,394 bp
  • T to G, chromosome 8 at 94,568,684 bp
  • T to A, chromosome 8 at 111,041,657 bp
  • T to C, chromosome 8 at 124,895,819 bp
  • T to C, chromosome 8 at 125,851,107 bp
  • A to T, chromosome 9 at 36,751,239 bp
  • T to C, chromosome 10 at 67,217,045 bp
  • C to T, chromosome 10 at 92,714,172 bp
  • C to T, chromosome 11 at 3,355,896 bp
  • A to T, chromosome 11 at 50,379,497 bp
  • A to C, chromosome 11 at 59,060,855 bp
  • A to T, chromosome 11 at 69,451,318 bp
  • T to A, chromosome 11 at 80,323,579 bp
  • A to T, chromosome 11 at 98,704,967 bp
  • T to A, chromosome 11 at 109,653,847 bp
  • G to T, chromosome 12 at 8,301,854 bp
  • G to A, chromosome 12 at 66,689,350 bp
  • C to A, chromosome 12 at 66,689,351 bp
  • A to T, chromosome 12 at 88,456,800 bp
  • A to T, chromosome 13 at 12,798,297 bp
  • T to A, chromosome 13 at 46,299,601 bp
  • T to A, chromosome 14 at 70,394,189 bp
  • A to T, chromosome 15 at 76,594,548 bp
  • A to T, chromosome 16 at 58,760,419 bp
  • T to G, chromosome 17 at 7,979,243 bp
  • T to C, chromosome 19 at 46,065,342 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7745 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045801-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.