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Strain Name:
C57BL/6J-MtgxR7762Btlr/Mmmh
Stock Number:
045818-MU
Citation ID:
RRID:MMRRC_045818-MU
Other Names:
R7762 (G1)
Major Collection:

Strain Information

Figla
Name: folliculogenesis specific basic helix-loop-helix
Synonyms: FIG alpha, bHLHc8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26910
Homologene: 49294
Shh
Name: sonic hedgehog
Synonyms: Hhg1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20423
Homologene: 30961
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Cep55
Name: centrosomal protein 55
Synonyms: 2700032M20Rik, 1200008O12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74107
VEGA: 19
HGNC: HGNC:1161
Homologene: 10019
Egr1
Name: early growth response 1
Synonyms: TIS8, NGFIA, Krox24, Zenk, Zif268, ETR103, Krox-24, Krox-1, Egr-1, Zfp-6, NGF1-A, A530045N19Rik, NGFI-A
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13653
HGNC: HGNC:3238
Homologene: 56394
Itga5
Name: integrin alpha 5 (fibronectin receptor alpha)
Synonyms: Fnra, Cd49e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16402
VEGA: 15
HGNC: HGNC:6141
Homologene: 20508
Serpina9
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
Synonyms: Centerin, 2310014L03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71907
Homologene: 23633
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 37,124,045 bp
  • A to T, chromosome 1 at 50,979,416 bp
  • C to T, chromosome 1 at 58,349,104 bp
  • A to T, chromosome 1 at 75,503,523 bp
  • A to T, chromosome 2 at 36,787,010 bp
  • T to A, chromosome 2 at 90,296,631 bp
  • T to C, chromosome 2 at 91,628,696 bp
  • T to C, chromosome 2 at 103,456,858 bp
  • C to T, chromosome 2 at 125,768,193 bp
  • A to T, chromosome 3 at 55,649,705 bp
  • T to A, chromosome 3 at 86,532,201 bp
  • G to A, chromosome 3 at 89,167,191 bp
  • G to T, chromosome 3 at 93,332,199 bp
  • T to A, chromosome 3 at 131,323,249 bp
  • T to C, chromosome 4 at 32,734,421 bp
  • C to A, chromosome 4 at 99,657,125 bp
  • A to G, chromosome 4 at 111,890,174 bp
  • T to A, chromosome 5 at 15,030,992 bp
  • T to G, chromosome 5 at 28,466,666 bp
  • A to T, chromosome 5 at 36,613,381 bp
  • T to C, chromosome 5 at 38,768,141 bp
  • T to A, chromosome 5 at 124,374,666 bp
  • T to C, chromosome 5 at 127,554,696 bp
  • G to A, chromosome 6 at 48,932,686 bp
  • A to G, chromosome 6 at 83,061,032 bp
  • T to C, chromosome 6 at 83,976,272 bp
  • A to G, chromosome 6 at 86,017,326 bp
  • A to G, chromosome 6 at 129,095,128 bp
  • C to A, chromosome 6 at 142,303,396 bp
  • T to C, chromosome 7 at 30,720,036 bp
  • C to A, chromosome 7 at 45,415,819 bp
  • C to A, chromosome 7 at 99,468,440 bp
  • G to A, chromosome 7 at 127,773,571 bp
  • T to C, chromosome 8 at 45,023,322 bp
  • T to A, chromosome 8 at 45,037,337 bp
  • G to T, chromosome 8 at 47,522,376 bp
  • A to T, chromosome 8 at 63,926,497 bp
  • T to C, chromosome 9 at 7,129,719 bp
  • T to C, chromosome 9 at 8,653,149 bp
  • G to A, chromosome 9 at 38,976,194 bp
  • A to G, chromosome 9 at 54,709,210 bp
  • C to A, chromosome 9 at 58,220,173 bp
  • A to G, chromosome 9 at 76,492,432 bp
  • T to C, chromosome 9 at 105,931,324 bp
  • A to T, chromosome 9 at 123,779,957 bp
  • T to A, chromosome 10 at 80,643,556 bp
  • C to T, chromosome 10 at 81,390,435 bp
  • T to C, chromosome 10 at 96,028,439 bp
  • A to G, chromosome 10 at 130,017,181 bp
  • G to A, chromosome 11 at 36,023,306 bp
  • T to A, chromosome 11 at 49,564,761 bp
  • A to T, chromosome 11 at 58,345,928 bp
  • G to T, chromosome 11 at 73,254,222 bp
  • A to G, chromosome 11 at 78,074,533 bp
  • A to G, chromosome 11 at 85,835,901 bp
  • A to T, chromosome 12 at 79,164,946 bp
  • A to T, chromosome 12 at 79,268,635 bp
  • G to T, chromosome 12 at 85,268,284 bp
  • A to T, chromosome 12 at 104,001,316 bp
  • A to T, chromosome 12 at 112,775,680 bp
  • G to A, chromosome 13 at 13,489,045 bp
  • G to T, chromosome 13 at 22,187,675 bp
  • T to A, chromosome 13 at 54,214,039 bp
  • G to T, chromosome 13 at 89,692,937 bp
  • T to A, chromosome 14 at 14,100,467 bp
  • C to A, chromosome 14 at 73,178,466 bp
  • T to G, chromosome 14 at 103,051,340 bp
  • A to G, chromosome 15 at 5,105,338 bp
  • A to T, chromosome 15 at 76,183,623 bp
  • T to C, chromosome 15 at 103,349,757 bp
  • T to A, chromosome 16 at 44,370,501 bp
  • T to A, chromosome 16 at 97,818,273 bp
  • A to G, chromosome 17 at 12,210,322 bp
  • A to G, chromosome 17 at 35,428,101 bp
  • G to A, chromosome 17 at 35,622,085 bp
  • G to A, chromosome 17 at 38,067,675 bp
  • T to A, chromosome 18 at 34,863,545 bp
  • T to G, chromosome 18 at 37,435,924 bp
  • A to T, chromosome 18 at 61,110,500 bp
  • A to T, chromosome 19 at 5,464,174 bp
  • A to T, chromosome 19 at 13,781,286 bp
  • T to G, chromosome 19 at 38,069,069 bp
  • T to C, chromosome 19 at 41,583,667 bp
  • A to G, chromosome 19 at 45,940,443 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7762 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045818-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.