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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7768Btlr/Mmmh
Stock Number:
045824-MU
Citation ID:
RRID:MMRRC_045824-MU
Other Names:
R7768 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Ap4e1
Name: adaptor-related protein complex AP-4, epsilon 1
Synonyms: 2310033A20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108011
HGNC: HGNC:573
Homologene: 22397

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Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: 1110006F08Rik, D12Ertd7e, Dicer1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251

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Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21366
Homologene: 2291

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Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
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Mouse Phenome DB
Mouse Mine
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Slc2a1
Name: solute carrier family 2 (facilitated glucose transporter), member 1
Synonyms: Glut-1, Glut1, M100200, Rgsc200
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20525
Homologene: 68520

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Gpr26
Name: G protein-coupled receptor 26
Synonyms: 9630036A11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233919
HGNC: HGNC:4481
Homologene: 17764

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Bclaf1
Name: BCL2-associated transcription factor 1
Synonyms: 2700025J07Rik, 2810454G14Rik, 2610102K23Rik, 5730534O06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72567
Homologene: 8832

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 46,137,474 bp
  • A to G, chromosome 1 at 66,414,483 bp
  • T to C, chromosome 1 at 66,510,595 bp
  • A to G, chromosome 1 at 89,928,984 bp
  • A to G, chromosome 2 at 22,241,143 bp
  • G to T, chromosome 2 at 60,448,946 bp
  • T to A, chromosome 2 at 84,856,871 bp
  • T to C, chromosome 2 at 87,635,313 bp
  • A to G, chromosome 2 at 90,700,116 bp
  • A to C, chromosome 2 at 111,499,853 bp
  • A to G, chromosome 2 at 126,751,123 bp
  • A to T, chromosome 2 at 127,046,934 bp
  • A to T, chromosome 2 at 130,667,916 bp
  • T to C, chromosome 2 at 150,408,321 bp
  • A to T, chromosome 2 at 155,506,501 bp
  • T to C, chromosome 2 at 155,986,009 bp
  • A to G, chromosome 3 at 63,947,618 bp
  • T to A, chromosome 3 at 154,748,331 bp
  • A to G, chromosome 3 at 157,988,647 bp
  • A to C, chromosome 4 at 101,911,813 bp
  • A to G, chromosome 4 at 119,132,447 bp
  • G to T, chromosome 4 at 155,886,939 bp
  • A to G, chromosome 5 at 34,465,791 bp
  • C to A, chromosome 5 at 38,768,158 bp
  • C to A, chromosome 5 at 86,152,920 bp
  • G to A, chromosome 5 at 109,220,220 bp
  • G to A, chromosome 5 at 117,363,722 bp
  • A to T, chromosome 5 at 130,000,405 bp
  • A to T, chromosome 5 at 143,098,444 bp
  • A to G, chromosome 6 at 53,896,491 bp
  • T to A, chromosome 6 at 91,739,965 bp
  • C to T, chromosome 6 at 132,803,522 bp
  • T to C, chromosome 6 at 133,036,849 bp
  • A to T, chromosome 7 at 3,841,697 bp
  • G to A, chromosome 7 at 10,037,371 bp
  • A to T, chromosome 7 at 18,346,028 bp
  • A to T, chromosome 7 at 28,782,859 bp
  • T to C, chromosome 7 at 59,288,777 bp
  • T to C, chromosome 7 at 105,567,088 bp
  • C to A, chromosome 7 at 105,721,095 bp
  • T to A, chromosome 7 at 131,974,348 bp
  • T to A, chromosome 8 at 22,695,236 bp
  • T to A, chromosome 8 at 22,903,212 bp
  • C to T, chromosome 8 at 23,097,997 bp
  • C to A, chromosome 8 at 94,629,841 bp
  • A to G, chromosome 8 at 117,054,860 bp
  • T to C, chromosome 8 at 123,214,407 bp
  • T to A, chromosome 9 at 7,697,748 bp
  • T to A, chromosome 9 at 21,029,994 bp
  • C to T, chromosome 9 at 44,820,603 bp
  • T to C, chromosome 9 at 54,380,939 bp
  • G to A, chromosome 9 at 106,433,618 bp
  • T to A, chromosome 9 at 119,815,272 bp
  • A to T, chromosome 10 at 14,431,666 bp
  • T to A, chromosome 10 at 20,339,771 bp
  • C to A, chromosome 10 at 88,542,372 bp
  • A to G, chromosome 10 at 120,038,397 bp
  • T to G, chromosome 10 at 130,418,693 bp
  • G to T, chromosome 11 at 54,626,588 bp
  • A to T, chromosome 11 at 58,542,640 bp
  • A to T, chromosome 11 at 58,542,867 bp
  • T to C, chromosome 11 at 70,105,416 bp
  • G to A, chromosome 11 at 80,330,621 bp
  • T to C, chromosome 12 at 34,390,240 bp
  • C to A, chromosome 12 at 104,706,697 bp
  • A to G, chromosome 13 at 12,282,594 bp
  • A to G, chromosome 13 at 49,557,395 bp
  • T to C, chromosome 14 at 31,616,480 bp
  • A to T, chromosome 14 at 118,879,498 bp
  • T to C, chromosome 15 at 79,297,314 bp
  • G to A, chromosome 15 at 80,381,188 bp
  • G to T, chromosome 15 at 85,932,409 bp
  • A to C, chromosome 15 at 97,008,664 bp
  • A to C, chromosome 16 at 32,756,194 bp
  • A to G, chromosome 16 at 59,632,336 bp
  • A to G, chromosome 16 at 62,822,204 bp
  • G to A, chromosome 16 at 87,436,745 bp
  • A to G, chromosome 17 at 19,812,052 bp
  • T to C, chromosome 17 at 32,396,793 bp
  • C to T, chromosome 17 at 71,411,911 bp
  • T to C, chromosome 17 at 73,939,836 bp
  • A to G, chromosome 18 at 36,932,167 bp
  • T to C, chromosome 18 at 37,022,351 bp
  • T to A, chromosome 18 at 77,384,941 bp
  • A to T, chromosome 19 at 3,902,900 bp
  • A to G, chromosome 19 at 6,481,379 bp
  • GCGAACG to GCG, chromosome 19 at 25,411,205 bp
  • A to T, chromosome 19 at 58,792,742 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7768 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045824-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.