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Strain Name:
C57BL/6J-MtgxR7774Btlr/Mmmh
Stock Number:
045830-MU
Citation ID:
RRID:MMRRC_045830-MU
Other Names:
R7774 (G1)
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, elf3, elf1, spectrin G, brain spectrin, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Ly6a
Name: lymphocyte antigen 6 family member A
Synonyms: Sca-1, TAP, Ly-6A/E, Ly-6E.1, Ly-6A.2, Sca1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110454
Homologene: 113718
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Tlr6
Name: toll-like receptor 6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21899
Homologene: 21223
Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Smarcad1
Name: SNF2 related chromatin remodeling ATPase with DExD box 1
Synonyms: D6Pas1, Etl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13990
Homologene: 5301
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm, Shrm3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27428
Homologene: 9263
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 5033407O22Rik, 4833414K03Rik, Ltpr7, CHAK1, CHAK, TRP-PLIK, 2310022G15Rik, LTRPC7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Clasp2
Name: CLIP associating protein 2
Synonyms: 1500004F14Rik, CLASP2gamma, CLASP2beta, CLASP2alpha, CLASP2, 8030404L10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76499
VEGA: 9
Homologene: 24944
Ipo13
Name: importin 13
Synonyms: Kap13, Imp13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230673
Homologene: 40968
Nifk
Name: nucleolar protein interacting with the FHA domain of MKI67
Synonyms: C130020J04Rik, Mki67ip
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67949
Homologene: 49862
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: RPA2, RPA116, 128kDa, D630020H17Rik, Rpo1-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20017
Homologene: 7133
Opn3
Name: opsin 3
Synonyms: ERO, Ecpn, panopsin, encephalopsin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13603
Homologene: 40707
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4930515K21Rik, 4933435G09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98403
Homologene: 9188
Sec24b
Name: SEC24 homolog B, COPII coat complex component
Synonyms: SEC24
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99683
Homologene: 55968
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Fzd2
Name: frizzled class receptor 2
Synonyms: Mfz10a, Mfz10, Fz10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57265
HGNC: HGNC:4040
Homologene: 20377
Ldlrad4
Name: low density lipoprotein receptor class A domain containing 4
Synonyms: D330030L18Rik, A430108L08Rik, 8230401C20Rik, D18Ertd653e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52662
VEGA: 18
HGNC: HGNC:1224
Homologene: 3202
Pdk4
Name: pyruvate dehydrogenase kinase, isoenzyme 4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27273
HGNC: HGNC:8812
Homologene: 129720
Zfp418
Name: zinc finger protein 418
Synonyms: A230102I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232854
Homologene: 119890
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Itga9
Name: integrin alpha 9
Synonyms: 2610002H11Rik, D9Ertd428e, 6720458D17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104099
HGNC: HGNC:6145
Homologene: 1664
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Ints11
Name: integrator complex subunit 11
Synonyms: 2410006F12Rik, Cpsf3l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71957
Homologene: 9894
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: LaXp180, 2900055E04Rik, Cc1, 5930404L04Rik, Fip200
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12421
Homologene: 7659
Exoc7
Name: exocyst complex component 7
Synonyms: sec70, 70kDa, Exo70
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53413
Homologene: 41019
Tcp11l2
Name: t-complex 11 (mouse) like 2
Synonyms: E430026E19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216198
Homologene: 17129
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Mgat3
Name: mannoside acetylglucosaminyltransferase 3
Synonyms: GnT-III, 1110038J12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17309
VEGA: 15
HGNC: HGNC:7046
Homologene: 31088
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: CMR1, TRPP8, Trp-p8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171382
Homologene: 23433
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215772
Homologene: 100289
Dnaaf11
Name: dynein axonemal assembly factor 11
Synonyms: LRTP, Lrrc6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54562
Homologene: 34534
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: PLA2-I receptor, M-type receptor, Pla2g1br
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226255
VEGA: 19
Homologene: 45809
Defa34
Name: defensin, alpha, 34
Synonyms: ENSMUSG00000063206, Gm15315
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100041952
Homologene: 113382
Zfp521
Name: zinc finger protein 521
Synonyms: B930086A16Rik, Evi3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225207
VEGA: 18
Homologene: 9151
Fbxw21
Name: F-box and WD-40 domain protein 21
Synonyms: E330009P21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320082
Homologene: 110776
H1f6
Name: H1.6 linker histone, cluster member
Synonyms: H1ft, Hist1h1t, H1t
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107970
HGNC: HGNC:4720
Homologene: 3889
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Or52ad1
Name: olfactory receptor family 52 subfamily AD member 1
Synonyms: GA_x6K02T2PBJ9-6056235-6055291, MOR39-1, Olfr600
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259048
Homologene: 17476
Rgl1
Name: ral guanine nucleotide dissociation stimulator,-like 1
Synonyms: Rgl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19731
Homologene: 9039
Adprhl1
Name: ADP-ribosylhydrolase like 1
Synonyms: Arh2, D330008N11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234072
Homologene: 16311
Or5ae1
Name: olfactory receptor family 5 subfamily AE member 1
Synonyms: GA_x6K02T2NHDJ-11170115-11169168, MOR254-1, Olfr290
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258411
Homologene: 83130
Fitm2
Name: fat storage-inducing transmembrane protein 2
Synonyms: Fit2, D930001I22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228859
Homologene: 35254
Krt39
Name: keratin 39
Synonyms: 4732494G06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237934
Homologene: 19078
Zfp174
Name: zinc finger protein 174
Synonyms: LOC385674
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385674
Homologene: 55755
Or8c17
Name: olfactory receptor family 8 subfamily C member 17
Synonyms: GA_x6K02T2PVTD-31962461-31963411, MOR170-1, Olfr895
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258875
Homologene: 74253
Adgra1
Name: adhesion G protein-coupled receptor A1
Synonyms: 2900059M17Rik, D7Ertd680e, Gpr123
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52389
Homologene: 18582
Gm5592
Name: predicted gene 5592
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434172
Homologene: 45597
Ccdc122
Name: coiled-coil domain containing 122
Synonyms: 4933415L06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108811
Homologene: 51651
Krtap13-1
Name: keratin associated protein 13-1
Synonyms: KAP13.1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268905
VEGA: 16
Homologene: 138459
Dhrs7c
Name: dehydrogenase/reductase 7C
Synonyms: 1110001P11Rik, dehydrogenase/reductase (SDR family) member 7C
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68460
Homologene: 19108
Tvp23a
Name: trans-golgi network vesicle protein 23A
Synonyms: Fam18a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 383103
Homologene: 19919
Tnfrsf4
Name: tumor necrosis factor receptor superfamily, member 4
Synonyms: CD134, ACT35, Ox40, Txgp1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22163
Homologene: 2496
H4c16
Name: H4 histone 16
Synonyms: B130044J01Rik, Hist4h4, H4-16, H4f16
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320332
Homologene: 134493
Ran
Name: RAN, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19384
HGNC: HGNC:9846
Homologene: 68143
Pcdha2
Name: protocadherin alpha 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353234
HGNC: HGNC:8668
Homologene: 135719
Mucl1
Name: mucin-like 1
Synonyms: Spt-2, Spt2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20771
Homologene: 137219
Mfsd4b4
Name: major facilitator superfamily domain containing 4B4
Synonyms: AA474331
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213332
Tmem218
Name: transmembrane protein 218
Synonyms: 1810021J13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66279
VEGA: 9
Homologene: 11941
Cc2d2b
Name: coiled-coil and C2 domain containing 2B
Synonyms: EG668310
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 668310
Homologene: 141114
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 6,248,085 bp
  • T to A, chromosome 1 at 33,805,393 bp
  • A to C, chromosome 1 at 80,269,294 bp
  • A to T, chromosome 1 at 88,330,841 bp
  • G to A, chromosome 1 at 118,327,661 bp
  • T to A, chromosome 1 at 152,554,350 bp
  • C to T, chromosome 1 at 175,662,905 bp
  • A to T, chromosome 2 at 60,530,458 bp
  • A to G, chromosome 2 at 126,813,238 bp
  • C to A, chromosome 2 at 129,125,544 bp
  • T to A, chromosome 2 at 163,470,066 bp
  • T to C, chromosome 2 at 181,233,991 bp
  • C to A, chromosome 3 at 129,984,197 bp
  • G to T, chromosome 4 at 117,914,297 bp
  • C to T, chromosome 4 at 143,697,106 bp
  • A to G, chromosome 4 at 155,885,683 bp
  • C to T, chromosome 4 at 156,014,338 bp
  • T to G, chromosome 5 at 64,953,385 bp
  • A to T, chromosome 5 at 73,083,384 bp
  • T to C, chromosome 5 at 92,950,489 bp
  • G to A, chromosome 5 at 129,022,810 bp
  • T to A, chromosome 6 at 5,492,757 bp
  • T to A, chromosome 6 at 65,107,830 bp
  • T to C, chromosome 6 at 121,223,389 bp
  • G to T, chromosome 6 at 136,804,283 bp
  • G to A, chromosome 7 at 7,182,777 bp
  • A to T, chromosome 7 at 41,289,859 bp
  • T to A, chromosome 7 at 84,916,531 bp
  • T to C, chromosome 7 at 103,346,530 bp
  • T to A, chromosome 7 at 119,951,752 bp
  • A to T, chromosome 7 at 139,847,712 bp
  • G to A, chromosome 7 at 141,842,379 bp
  • C to T, chromosome 8 at 13,248,682 bp
  • G to A, chromosome 8 at 21,665,962 bp
  • T to A, chromosome 9 at 37,222,568 bp
  • T to C, chromosome 9 at 38,269,359 bp
  • T to C, chromosome 9 at 109,143,840 bp
  • T to A, chromosome 9 at 113,848,736 bp
  • T to A, chromosome 9 at 118,871,900 bp
  • C to A, chromosome 10 at 10,339,660 bp
  • T to C, chromosome 10 at 39,892,411 bp
  • T to C, chromosome 10 at 76,709,876 bp
  • T to C, chromosome 10 at 84,604,983 bp
  • T to C, chromosome 10 at 107,643,669 bp
  • A to T, chromosome 11 at 30,142,142 bp
  • A to G, chromosome 11 at 67,809,815 bp
  • T to C, chromosome 11 at 99,514,611 bp
  • A to T, chromosome 11 at 102,605,488 bp
  • T to C, chromosome 11 at 116,295,316 bp
  • A to G, chromosome 12 at 110,933,172 bp
  • A to G, chromosome 13 at 23,696,200 bp
  • T to C, chromosome 14 at 77,067,939 bp
  • A to G, chromosome 15 at 44,540,907 bp
  • T to G, chromosome 15 at 66,449,552 bp
  • A to T, chromosome 15 at 74,997,567 bp
  • C to T, chromosome 15 at 80,211,542 bp
  • G to T, chromosome 15 at 98,596,533 bp
  • G to T, chromosome 15 at 103,753,684 bp
  • G to A, chromosome 16 at 3,849,351 bp
  • A to G, chromosome 16 at 10,427,381 bp
  • C to T, chromosome 16 at 88,729,173 bp
  • T to C, chromosome 18 at 13,845,781 bp
  • A to G, chromosome 18 at 36,941,526 bp
  • G to T, chromosome 18 at 68,235,792 bp
  • A to G, chromosome 19 at 40,765,717 bp
  • G to T, chromosome 19 at 57,699,671 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7774 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045830-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.