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Strain Name:
C57BL/6J-MtgxR7781Btlr/Mmmh
Stock Number:
045837-MU
Citation ID:
RRID:MMRRC_045837-MU
Other Names:
R7781 (G1)
Major Collection:

Strain Information

Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: SHIP, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP-1, SHIP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Ndrg3
Name: N-myc downstream regulated gene 3
Synonyms: Ndr3, 4833415O14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29812
Homologene: 40903
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: tubedown, Tbdn-1, mNAT1, 5730450D16Rik, Narg1, ASTBDN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74838
Homologene: 14211
Hdac4
Name: histone deacetylase 4
Synonyms: 4932408F19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208727
Homologene: 55946
Wdr7
Name: WD repeat domain 7
Synonyms: TGF-beta resistance associated gene, TRAG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 104082
VEGA: 18
Homologene: 11408
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: c-Abl, E430008G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 52,212,333 bp
  • T to C, chromosome 1 at 87,699,672 bp
  • C to A, chromosome 1 at 91,975,665 bp
  • T to C, chromosome 1 at 106,004,165 bp
  • A to T, chromosome 2 at 31,790,697 bp
  • A to G, chromosome 2 at 89,721,535 bp
  • T to A, chromosome 2 at 119,917,357 bp
  • T to G, chromosome 2 at 121,034,435 bp
  • C to T, chromosome 2 at 126,639,200 bp
  • A to G, chromosome 2 at 131,081,338 bp
  • A to T, chromosome 2 at 150,267,657 bp
  • C to A, chromosome 2 at 156,928,813 bp
  • G to A, chromosome 3 at 19,628,542 bp
  • A to G, chromosome 3 at 51,471,483 bp
  • C to A, chromosome 3 at 95,244,175 bp
  • T to G, chromosome 4 at 43,259,546 bp
  • T to G, chromosome 4 at 58,069,251 bp
  • T to C, chromosome 5 at 31,527,478 bp
  • T to C, chromosome 5 at 64,926,736 bp
  • A to T, chromosome 5 at 89,228,932 bp
  • T to A, chromosome 5 at 112,370,522 bp
  • T to C, chromosome 5 at 115,661,487 bp
  • C to T, chromosome 5 at 137,898,874 bp
  • A to G, chromosome 6 at 24,562,645 bp
  • G to T, chromosome 6 at 27,285,787 bp
  • T to C, chromosome 6 at 29,497,765 bp
  • A to G, chromosome 6 at 39,493,066 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • A to G, chromosome 6 at 57,024,568 bp
  • A to C, chromosome 6 at 106,523,614 bp
  • C to T, chromosome 7 at 27,865,575 bp
  • T to C, chromosome 7 at 29,067,630 bp
  • T to C, chromosome 7 at 43,939,556 bp
  • C to T, chromosome 7 at 46,005,606 bp
  • A to T, chromosome 7 at 118,525,888 bp
  • A to T, chromosome 7 at 130,519,427 bp
  • T to C, chromosome 8 at 69,882,347 bp
  • G to T, chromosome 8 at 71,375,951 bp
  • C to T, chromosome 8 at 111,918,290 bp
  • A to G, chromosome 8 at 125,491,827 bp
  • T to A, chromosome 9 at 109,557,262 bp
  • A to T, chromosome 10 at 103,009,192 bp
  • A to G, chromosome 10 at 120,925,773 bp
  • G to A, chromosome 11 at 78,182,828 bp
  • T to C, chromosome 11 at 120,374,263 bp
  • C to A, chromosome 12 at 74,976,681 bp
  • T to C, chromosome 12 at 102,234,853 bp
  • T to C, chromosome 12 at 113,491,342 bp
  • C to T, chromosome 13 at 24,803,399 bp
  • T to C, chromosome 14 at 51,204,011 bp
  • A to G, chromosome 14 at 75,032,090 bp
  • C to A, chromosome 15 at 7,253,746 bp
  • T to A, chromosome 15 at 78,344,571 bp
  • T to A, chromosome 15 at 89,157,022 bp
  • A to T, chromosome 16 at 19,699,690 bp
  • A to G, chromosome 16 at 29,297,408 bp
  • A to T, chromosome 16 at 91,926,529 bp
  • T to C, chromosome 17 at 22,570,733 bp
  • C to A, chromosome 17 at 24,608,115 bp
  • C to T, chromosome 17 at 25,846,326 bp
  • A to T, chromosome 17 at 56,664,072 bp
  • A to T, chromosome 17 at 79,859,831 bp
  • A to T, chromosome 18 at 36,625,205 bp
  • A to T, chromosome 18 at 63,777,789 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7781 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045837-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.