Strain Name:
C57BL/6J-MtgxR7781Btlr/Mmmh
Stock Number:
045837-MU
Citation ID:
RRID:MMRRC_045837-MU
Other Names:
R7781 (G1)
Major Collection:

Strain Information

Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: Src homology 2 domain-containing inositol-5-phosphatase, SHIP-1, SHIP1, s-SHIP, SHIP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Ndrg3
Name: N-myc downstream regulated gene 3
Synonyms: Ndr3, 4833415O14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29812
Homologene: 40903
Mga
Name: MAX gene associated
Synonyms: D030062C11Rik, Mad5, C130042M01Rik, Mga
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: 5730450D16Rik, Narg1, Tbdn-1, tubedown, mNAT1, ASTBDN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74838
Homologene: 14211
Hdac4
Name: histone deacetylase 4
Synonyms: 4932408F19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208727
Homologene: 55946
Wdr7
Name: WD repeat domain 7
Synonyms: TGF-beta resistance associated gene, TRAG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 104082
VEGA: 18
Homologene: 11408
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: E430008G22Rik, c-Abl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Gabpb1
Name: GA repeat binding protein, beta 1
Synonyms: GABPB1-1, E4TF1, NRF2B2, NRF2B1, E4TF1-53, E4Tf1B, BABPB2, GABPB1-2, E4TF1-47
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14391
HGNC: HGNC:4074
Homologene: 7723
Ate1
Name: arginyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11907
HGNC: HGNC:782
Homologene: 31420
Gls
Name: glutaminase
Synonyms: B230365M23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14660
HGNC: HGNC:4331
Homologene: 22726
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268878
Homologene: 77451
Atp5po
Name: ATP synthase peripheral stalk subunit OSCP
Synonyms: D12Wsu28e, Atp5o
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 28080
HGNC: HGNC:850
Homologene: 1283
Coq7
Name: demethyl-Q 7
Synonyms: clk-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12850
HGNC: HGNC:2244
Homologene: 6953
Atl2
Name: atlastin GTPase 2
Synonyms: Arl6ip2, 2010110I21Rik, Aip-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56298
VEGA: 17
Homologene: 56949
Zcchc2
Name: zinc finger, CCHC domain containing 2
Synonyms: 9930114B20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227449
Homologene: 9808
Dennd2a
Name: DENN domain containing 2A
Synonyms: B930096L08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209773
Homologene: 35238
Lemd3
Name: LEM domain containing 3
Synonyms: Man1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380664
Homologene: 8633
Tmem231
Name: transmembrane protein 231
Synonyms: 4932417I16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234740
Homologene: 78035
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, calcium release channel isoform 1, skrr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Tsc2
Name: TSC complex subunit 2
Synonyms: Nafld, tuberin, tuberous sclerosis 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22084
VEGA: 17
Homologene: 462
Bicdl1
Name: BICD family like cargo adaptor 1
Synonyms: 2210403N09Rik, Ccdc64, BICDR-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75665
Homologene: 18013
Unc13b
Name: unc-13 homolog B
Synonyms: Unc13h2, Munc13-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: Siglec-1, CD169, Sn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20612
Homologene: 124458
Kcp
Name: kielin/chordin-like protein
Synonyms: Crim2, LOC333088, KCP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 333088
Homologene: 87817
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: D430029O09Rik, Polydom, 4833413O10Rik, 1110021D17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Rubcnl
Name: RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms: 5031414D18Rik, LOC380917
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271221
VEGA: 14
Homologene: 57021
Faap100
Name: Fanconi anemia core complex associated protein 100
Synonyms: 2310003H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71885
Homologene: 69394
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Egflam
Name: EGF-like, fibronectin type III and laminin G domains
Synonyms: pikachurin, nectican
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268780
Homologene: 65044
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 1110004O12Rik, 9130019P20Rik, 4933432B13Rik, A530027J04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108857
Homologene: 87006
Abcc6
Name: ATP-binding cassette, sub-family C member 6
Synonyms: DCC, Dyscalc1, Mrp6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Zfp607a
Name: zinc finger protein 607A
Synonyms: 4732475C15Rik, Zfp607
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545938
Homologene: 134321
Cntn4
Name: contactin 4
Synonyms: Axcam, BIG-2A
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269784
HGNC: HGNC:2174
Homologene: 14257
BC005537
Name: cDNA sequence BC005537
Synonyms: 8030460C05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 79555
Homologene: 11551
Wdr90
Name: WD repeat domain 90
Synonyms: 3230401M21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106618
Homologene: 27066
Csf2rb
Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Synonyms: AIC2B, common beta chain, Il3r, Csf2rb1, CDw131, beta c, Il5rb, Il3rb1, Bc
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12983
VEGA: 15
HGNC: HGNC:2436
Homologene: 339
Grm8
Name: glutamate receptor, metabotropic 8
Synonyms: Gprc1h, mGluR8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14823
HGNC: HGNC:4600
Homologene: 654
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244668
Homologene: 18956
Asb15
Name: ankyrin repeat and SOCS box-containing 15
Synonyms: 4930400E23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78910
Homologene: 43797
Slc24a4
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Synonyms: NCKX4, A930002M03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238384
Homologene: 17798
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238405
Homologene: 128362
Epb42
Name: erythrocyte membrane protein band 4.2
Synonyms: Epb4.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13828
HGNC: HGNC:3381
Homologene: 93
Lamp3
Name: lysosomal-associated membrane protein 3
Synonyms: 1200002D17Rik, DC-LAMP, Cd208, TSC403
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239739
VEGA: 16
Homologene: 8670
Cilp2
Name: cartilage intermediate layer protein 2
Synonyms: 1110031K21Rik, CLIP-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68709
Homologene: 17713
Tlr1
Name: toll-like receptor 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21897
Homologene: 20694
Cyp3a13
Name: cytochrome P450, family 3, subfamily a, polypeptide 13
Synonyms: IIIAm2, steroid inducible
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13113
Homologene: 133564
Fbxw15
Name: F-box and WD-40 domain protein 15
Synonyms: Fbxo12J
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382105
Homologene: 110776
Catsperd
Name: cation channel sperm associated auxiliary subunit delta
Synonyms: Gm6095, 4933402B14Rik, Tmem146, 4921529N20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106757
VEGA: 17
Homologene: 51896
Repin1
Name: replication initiator 1
Synonyms: AP4, E430037F08Rik, Zfp464
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
Bnipl
Name: BCL2/adenovirus E1B 19kD interacting protein like
Synonyms: 1700128A13Rik, BNIPL, PP753, BNIPL1, BNIPL-2, BNIPL-1, BNIPL2, BNIP-S
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 171388
Homologene: 15900
Vmn1r7
Name: vomeronasal 1 receptor 7
Synonyms: Gm5568, V1rc31
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434016
Homologene: 83427
Klk15
Name: kallikrein related-peptidase 15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 317652
Homologene: 77571
Alx1
Name: ALX homeobox 1
Synonyms: Cart1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216285
HGNC: HGNC:1494
Homologene: 5075
Slc4a1ap
Name: solute carrier family 4 (anion exchanger), member 1, adaptor protein
Synonyms: kanadaptin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20534
Homologene: 7543
Or4a79
Name: olfactory receptor family 4 subfamily A member 79
Synonyms: MOR231-22_p, GA_x6K02T2Q125-51162884-51161940, Olfr1252
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404331
Homologene: 128094
Hps4
Name: HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
Synonyms: C130020P05Rik, BLOC-3, 2010205O06Rik, Hermansky-Pudlak syndrome 4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 192232
Homologene: 11123
Nr2f6
Name: nuclear receptor subfamily 2, group F, member 6
Synonyms: Erbal2, COUP-TF3, EAR2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13864
HGNC: HGNC:7977
Homologene: 7706
Rpl23a
Name: ribosomal protein L23A
Synonyms: MDA20
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268449
Homologene: 110453
Ear14
Name: eosinophil-associated, ribonuclease A family, member 14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 503847
VEGA: 14
1700064H15Rik
Name: RIKEN cDNA 1700064H15 gene
Type: Gene
Species: Mouse
Chromosome: 3
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 52,212,333 bp
  • T to C, chromosome 1 at 87,699,672 bp
  • C to A, chromosome 1 at 91,975,665 bp
  • T to C, chromosome 1 at 106,004,165 bp
  • A to T, chromosome 2 at 31,790,697 bp
  • A to G, chromosome 2 at 89,721,535 bp
  • T to A, chromosome 2 at 119,917,357 bp
  • T to G, chromosome 2 at 121,034,435 bp
  • C to T, chromosome 2 at 126,639,200 bp
  • A to G, chromosome 2 at 131,081,338 bp
  • A to T, chromosome 2 at 150,267,657 bp
  • C to A, chromosome 2 at 156,928,813 bp
  • G to A, chromosome 3 at 19,628,542 bp
  • A to G, chromosome 3 at 51,471,483 bp
  • C to A, chromosome 3 at 95,244,175 bp
  • T to G, chromosome 4 at 43,259,546 bp
  • T to G, chromosome 4 at 58,069,251 bp
  • T to C, chromosome 5 at 31,527,478 bp
  • T to C, chromosome 5 at 64,926,736 bp
  • A to T, chromosome 5 at 89,228,932 bp
  • T to A, chromosome 5 at 112,370,522 bp
  • T to C, chromosome 5 at 115,661,487 bp
  • C to T, chromosome 5 at 137,898,874 bp
  • A to G, chromosome 6 at 24,562,645 bp
  • G to T, chromosome 6 at 27,285,787 bp
  • T to C, chromosome 6 at 29,497,765 bp
  • A to G, chromosome 6 at 39,493,066 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • A to G, chromosome 6 at 57,024,568 bp
  • A to C, chromosome 6 at 106,523,614 bp
  • C to T, chromosome 7 at 27,865,575 bp
  • T to C, chromosome 7 at 29,067,630 bp
  • T to C, chromosome 7 at 43,939,556 bp
  • C to T, chromosome 7 at 46,005,606 bp
  • A to T, chromosome 7 at 118,525,888 bp
  • A to T, chromosome 7 at 130,519,427 bp
  • T to C, chromosome 8 at 69,882,347 bp
  • G to T, chromosome 8 at 71,375,951 bp
  • C to T, chromosome 8 at 111,918,290 bp
  • A to G, chromosome 8 at 125,491,827 bp
  • T to A, chromosome 9 at 109,557,262 bp
  • A to T, chromosome 10 at 103,009,192 bp
  • A to G, chromosome 10 at 120,925,773 bp
  • G to A, chromosome 11 at 78,182,828 bp
  • T to C, chromosome 11 at 120,374,263 bp
  • C to A, chromosome 12 at 74,976,681 bp
  • T to C, chromosome 12 at 102,234,853 bp
  • T to C, chromosome 12 at 113,491,342 bp
  • C to T, chromosome 13 at 24,803,399 bp
  • T to C, chromosome 14 at 51,204,011 bp
  • A to G, chromosome 14 at 75,032,090 bp
  • C to A, chromosome 15 at 7,253,746 bp
  • T to A, chromosome 15 at 78,344,571 bp
  • T to A, chromosome 15 at 89,157,022 bp
  • A to T, chromosome 16 at 19,699,690 bp
  • A to G, chromosome 16 at 29,297,408 bp
  • A to T, chromosome 16 at 91,926,529 bp
  • T to C, chromosome 17 at 22,570,733 bp
  • C to A, chromosome 17 at 24,608,115 bp
  • C to T, chromosome 17 at 25,846,326 bp
  • A to T, chromosome 17 at 56,664,072 bp
  • A to T, chromosome 17 at 79,859,831 bp
  • A to T, chromosome 18 at 36,625,205 bp
  • A to T, chromosome 18 at 63,777,789 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7781 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045837-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.