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Strain Name:
C57BL/6J-MtgxR7807Btlr/Mmmh
Stock Number:
045862-MU
Citation ID:
RRID:MMRRC_045862-MU
Other Names:
R7807 (G1)
Major Collection:

Strain Information

Hgs
Name: HGF-regulated tyrosine kinase substrate
Synonyms: Hrs, tn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15239
HGNC: HGNC:4897
Homologene: 37954
Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, HGF/SF, NK2, C230052L06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Synonyms: Int-5, Int5, aromatase, Ar, Cyp19, ArKO, p450arom
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13075
VEGA: 9
HGNC: HGNC:2594
Homologene: 30955
Mad1l1
Name: MAD1 mitotic arrest deficient 1-like 1
Synonyms: Mad1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17120
HGNC: HGNC:6762
Homologene: 74500
Zmym1
Name: zinc finger, MYM domain containing 1
Synonyms: 5830412B09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68310
Homologene: 32904
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, Zap3, A930013E17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Slc25a13
Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
Synonyms: Ctrn, citrin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50799
Homologene: 22800
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 46,214,367 bp
  • A to T, chromosome 1 at 54,792,476 bp
  • A to G, chromosome 1 at 65,269,942 bp
  • T to A, chromosome 1 at 107,604,727 bp
  • T to A, chromosome 1 at 125,584,541 bp
  • T to C, chromosome 1 at 164,053,893 bp
  • T to C, chromosome 2 at 88,101,565 bp
  • C to A, chromosome 2 at 106,744,740 bp
  • T to C, chromosome 2 at 130,710,865 bp
  • C to T, chromosome 3 at 10,335,469 bp
  • A to G, chromosome 3 at 122,014,332 bp
  • T to C, chromosome 3 at 133,486,541 bp
  • A to G, chromosome 3 at 158,160,487 bp
  • A to G, chromosome 4 at 6,393,688 bp
  • A to C, chromosome 4 at 42,793,885 bp
  • A to G, chromosome 4 at 106,463,895 bp
  • A to G, chromosome 4 at 124,658,281 bp
  • A to C, chromosome 4 at 127,047,874 bp
  • A to G, chromosome 5 at 16,577,011 bp
  • A to T, chromosome 5 at 76,243,135 bp
  • A to T, chromosome 5 at 103,876,066 bp
  • T to A, chromosome 5 at 140,088,786 bp
  • G to A, chromosome 6 at 6,117,164 bp
  • A to G, chromosome 6 at 42,310,348 bp
  • T to A, chromosome 6 at 85,622,976 bp
  • A to G, chromosome 6 at 89,870,237 bp
  • T to C, chromosome 7 at 3,719,865 bp
  • T to C, chromosome 7 at 34,163,213 bp
  • T to A, chromosome 7 at 41,872,486 bp
  • T to C, chromosome 7 at 102,427,141 bp
  • C to A, chromosome 8 at 45,041,973 bp
  • T to G, chromosome 8 at 68,282,381 bp
  • T to A, chromosome 8 at 118,283,855 bp
  • C to A, chromosome 9 at 21,535,980 bp
  • C to A, chromosome 9 at 22,360,880 bp
  • C to G, chromosome 9 at 35,566,725 bp
  • T to C, chromosome 9 at 37,315,382 bp
  • T to C, chromosome 9 at 54,166,842 bp
  • T to A, chromosome 9 at 58,150,161 bp
  • T to C, chromosome 9 at 58,990,494 bp
  • T to C, chromosome 9 at 65,133,795 bp
  • T to A, chromosome 10 at 78,879,209 bp
  • C to T, chromosome 10 at 80,550,136 bp
  • T to A, chromosome 10 at 85,976,250 bp
  • T to A, chromosome 10 at 86,776,631 bp
  • A to G, chromosome 11 at 70,220,562 bp
  • A to G, chromosome 11 at 76,946,214 bp
  • A to G, chromosome 11 at 105,867,654 bp
  • T to G, chromosome 11 at 116,863,907 bp
  • G to T, chromosome 11 at 120,479,934 bp
  • G to A, chromosome 12 at 51,745,388 bp
  • A to T, chromosome 12 at 56,697,065 bp
  • C to T, chromosome 12 at 85,014,081 bp
  • T to C, chromosome 12 at 86,962,125 bp
  • T to C, chromosome 12 at 109,038,930 bp
  • T to C, chromosome 13 at 77,046,704 bp
  • T to A, chromosome 14 at 3,134,925 bp
  • G to T, chromosome 14 at 54,942,440 bp
  • T to A, chromosome 14 at 70,652,507 bp
  • T to C, chromosome 15 at 38,934,017 bp
  • T to C, chromosome 15 at 93,391,121 bp
  • C to T, chromosome 16 at 14,153,889 bp
  • T to C, chromosome 16 at 33,107,131 bp
  • A to G, chromosome 17 at 25,746,777 bp
  • G to T, chromosome 17 at 34,876,371 bp
  • A to G, chromosome 17 at 85,063,943 bp
  • T to A, chromosome 18 at 46,290,759 bp
  • T to A, chromosome 18 at 66,066,757 bp
  • A to G, chromosome 18 at 78,047,481 bp
  • G to A, chromosome 19 at 12,714,634 bp
  • C to A, chromosome 19 at 13,619,921 bp
  • T to C, chromosome 19 at 18,829,856 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7807 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045862-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.