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Strain Name:
C57BL/6J-MtgxR7808Btlr/Mmmh
Stock Number:
045863-MU
Citation ID:
RRID:MMRRC_045863-MU
Other Names:
R7808 (G1)
Major Collection:

Strain Information

Krt5
Name: keratin 5
Synonyms: 3300001P10Rik, Tfip8, K5, Krt2-5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110308
HGNC: HGNC:6442
Homologene: 55461
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: SHIP, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP-1, SHIP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Ulk2
Name: unc-51 like kinase 2
Synonyms: Unc51.2, A830085I22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 29869
Homologene: 5891
Tal1
Name: T cell acute lymphocytic leukemia 1
Synonyms: SCL/tal-1, Scl, bHLHa17, Hpt
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21349
Homologene: 2400
Clasrp
Name: CLK4-associating serine/arginine rich protein
Synonyms: SWAP2, Srsf16, Sfrs16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53609
Homologene: 134306
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,711,581 bp
  • A to T, chromosome 1 at 71,274,634 bp
  • A to T, chromosome 1 at 87,683,845 bp
  • T to C, chromosome 1 at 135,452,248 bp
  • T to A, chromosome 1 at 138,561,771 bp
  • T to C, chromosome 1 at 163,039,109 bp
  • C to A, chromosome 1 at 174,089,851 bp
  • T to C, chromosome 1 at 193,350,285 bp
  • T to C, chromosome 2 at 52,192,023 bp
  • T to A, chromosome 2 at 71,250,834 bp
  • T to C, chromosome 2 at 91,444,594 bp
  • A to G, chromosome 3 at 59,328,068 bp
  • G to A, chromosome 3 at 60,614,821 bp
  • A to T, chromosome 3 at 92,620,335 bp
  • C to A, chromosome 3 at 107,760,045 bp
  • T to C, chromosome 3 at 123,372,585 bp
  • T to A, chromosome 4 at 46,875,744 bp
  • T to A, chromosome 4 at 48,459,984 bp
  • T to C, chromosome 4 at 115,068,292 bp
  • C to T, chromosome 4 at 130,073,264 bp
  • C to A, chromosome 4 at 135,750,796 bp
  • T to C, chromosome 5 at 20,465,840 bp
  • A to T, chromosome 5 at 21,373,231 bp
  • A to T, chromosome 5 at 72,604,273 bp
  • G to T, chromosome 5 at 120,914,971 bp
  • T to C, chromosome 5 at 124,260,946 bp
  • T to A, chromosome 6 at 18,204,205 bp
  • T to C, chromosome 6 at 84,070,929 bp
  • T to C, chromosome 6 at 122,990,380 bp
  • T to C, chromosome 6 at 140,583,914 bp
  • C to A, chromosome 6 at 148,843,030 bp
  • T to C, chromosome 7 at 5,493,679 bp
  • C to T, chromosome 7 at 15,922,251 bp
  • C to T, chromosome 7 at 19,588,746 bp
  • A to C, chromosome 7 at 45,282,936 bp
  • A to T, chromosome 7 at 51,587,795 bp
  • A to G, chromosome 7 at 65,652,261 bp
  • A to T, chromosome 7 at 89,956,333 bp
  • T to G, chromosome 7 at 92,431,055 bp
  • A to G, chromosome 7 at 102,973,110 bp
  • G to A, chromosome 7 at 105,384,525 bp
  • T to A, chromosome 7 at 118,669,217 bp
  • T to A, chromosome 8 at 69,706,986 bp
  • T to A, chromosome 8 at 86,507,939 bp
  • T to C, chromosome 8 at 110,221,619 bp
  • T to C, chromosome 9 at 44,412,918 bp
  • A to T, chromosome 9 at 72,842,697 bp
  • A to C, chromosome 9 at 109,448,154 bp
  • A to T, chromosome 9 at 110,086,202 bp
  • A to G, chromosome 10 at 10,378,659 bp
  • T to A, chromosome 10 at 79,898,418 bp
  • T to C, chromosome 10 at 87,121,435 bp
  • T to C, chromosome 11 at 35,828,707 bp
  • A to G, chromosome 11 at 61,854,552 bp
  • T to A, chromosome 11 at 66,005,805 bp
  • A to T, chromosome 11 at 74,239,899 bp
  • T to A, chromosome 11 at 90,035,476 bp
  • C to T, chromosome 11 at 118,303,800 bp
  • T to A, chromosome 11 at 119,544,636 bp
  • C to T, chromosome 11 at 120,789,436 bp
  • A to T, chromosome 12 at 28,766,770 bp
  • A to G, chromosome 12 at 75,983,727 bp
  • A to G, chromosome 12 at 101,053,496 bp
  • A to T, chromosome 12 at 104,001,225 bp
  • A to T, chromosome 12 at 110,655,459 bp
  • A to C, chromosome 13 at 23,819,334 bp
  • A to T, chromosome 13 at 40,860,862 bp
  • A to C, chromosome 13 at 55,161,156 bp
  • G to T, chromosome 14 at 30,111,069 bp
  • T to G, chromosome 14 at 56,635,748 bp
  • A to T, chromosome 14 at 63,919,292 bp
  • T to C, chromosome 15 at 5,099,472 bp
  • T to A, chromosome 15 at 75,713,450 bp
  • A to G, chromosome 15 at 76,698,893 bp
  • A to T, chromosome 15 at 89,548,880 bp
  • A to G, chromosome 15 at 100,522,429 bp
  • T to A, chromosome 15 at 101,709,018 bp
  • T to C, chromosome 15 at 101,890,494 bp
  • T to C, chromosome 16 at 8,705,163 bp
  • T to C, chromosome 16 at 85,800,229 bp
  • A to G, chromosome 16 at 88,647,310 bp
  • C to A, chromosome 17 at 21,397,385 bp
  • T to A, chromosome 17 at 65,985,653 bp
  • G to A, chromosome 18 at 3,123,033 bp
  • A to G, chromosome 18 at 4,673,113 bp
  • G to A, chromosome 18 at 36,760,416 bp
  • T to A, chromosome 18 at 49,878,315 bp
  • A to G, chromosome 18 at 58,609,195 bp
  • C to T, chromosome 19 at 12,824,821 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7808 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045863-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.