Strain Name:
C57BL/6J-MtgxR7852Btlr/Mmmh
Stock Number:
045905-MU
Citation ID:
RRID:MMRRC_045905-MU
Other Names:
R7852 (G1)
Major Collection:

Strain Information

Stx8
Name: syntaxin 8
Synonyms: 4930571E13Rik, 1110002H11Rik, 0610007H08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 55943
Homologene: 37973
Mpc1
Name: mitochondrial pyruvate carrier 1
Synonyms: 0610006G08Rik, Brp44l, 3830411I18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 55951
Homologene: 9384
S100a1
Name: S100 calcium binding protein A1
Synonyms: S100, S100a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20193
Homologene: 4566
Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74200
Homologene: 41761
Slc25a13
Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
Synonyms: Ctrn, citrin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50799
Homologene: 22800
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Agrn
Name: agrin
Synonyms: Agrin, nmf380, NMF380
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Zc3h4
Name: zinc finger CCCH-type containing 4
Synonyms: Bwq1, Kiaa1064-hp, LOC330474
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330474
Homologene: 87150
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: lectomedin-2, Lphn1, Lec2, 2900070I05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330814
Homologene: 8951
Aco1
Name: aconitase 1
Synonyms: Irebp, Irp1, Aco-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11428
HGNC: HGNC:117
Homologene: 1657
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Fam193a
Name: family with sequence homology 193, member A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231128
Homologene: 2746
Atp6v1b1
Name: ATPase, H+ transporting, lysosomal V1 subunit B1
Synonyms: D630039P21Rik, lysosomal 56/58kDa, D630030L16Rik, Vpp-3, Atp6b1, Vpp3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110935
HGNC: HGNC:853
Homologene: 68198
Prcp
Name: prolylcarboxypeptidase (angiotensinase C)
Synonyms: 2610104A14Rik, 2510048K03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72461
HGNC: HGNC:9344
Homologene: 55867
Cep152
Name: centrosomal protein 152
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99100
Homologene: 37159
Ppip5k2
Name: diphosphoinositol pentakisphosphate kinase 2
Synonyms: Hisppd1, Vip2, Cfap160
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227399
Homologene: 49409
Nkx2-2
Name: NK2 homeobox 2
Synonyms: tinman, Nkx2.2, Nkx-2.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18088
HGNC: HGNC:7835
Homologene: 1879
Sox6
Name: SRY (sex determining region Y)-box 6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20679
Homologene: 22631
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213262
Homologene: 10584
Patl2
Name: protein associated with topoisomerase II homolog 2 (yeast)
Synonyms: Pat1a, 4930424G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67578
Homologene: 12155
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637896
Homologene: 115466
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: 4930505G06Rik, A930002K18Rik, 4930401L23Rik, nmf247
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 77945
Homologene: 10679
Mto1
Name: mitochondrial tRNA translation optimization 1
Synonyms: 5730419A02Rik, 2310039H01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68291
Homologene: 5876
Nlrp10
Name: NLR family, pyrin domain containing 10
Synonyms: Nalp10, 6430548I20Rik, Pynod
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244202
Homologene: 18468
4933415A04Rik
Name: RIKEN cDNA 4933415A04 gene
Type: Gene
Species: Mouse
Chromosome: 11
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mamdc1, Mdga2, 9330209L04Rik, Adp, 6720489L24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320772
Homologene: 45659
Flnc
Name: filamin C, gamma
Synonyms: actin binding protein 280, 1110055E19Rik, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: ojoplano, Opo
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Vmn2r52
Name: vomeronasal 2, receptor 52
Synonyms: EG384534
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384534
Homologene: 129605
Arhgef40
Name: Rho guanine nucleotide exchange factor 40
Synonyms: E130112L23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268739
Homologene: 19560
Micu2
Name: mitochondrial calcium uptake 2
Synonyms: 1110008L20Rik, 4833427E09Rik, Efha1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68514
VEGA: 14
Homologene: 12516
Gys2
Name: glycogen synthase 2
Synonyms: LGS, glycogen synthase, liver
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232493
HGNC: HGNC:4707
Homologene: 56580
Or2ag16
Name: olfactory receptor family 2 subfamily AG member 16
Synonyms: MOR283-3, Olfr698, GA_x6K02T2PBJ9-9130754-9129519
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258595
Homologene: 133598
Grk5
Name: G protein-coupled receptor kinase 5
Synonyms: Gprk5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14773
VEGA: 19
HGNC: HGNC:4544
Homologene: 3879
Krt16
Name: keratin 16
Synonyms: Krt1-16, K16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16666
HGNC: HGNC:6423
Homologene: 21145
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Lrfn2
Name: leucine rich repeat and fibronectin type III domain containing 2
Synonyms: SALM1, 5730420O05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70530
Homologene: 19182
Pde8b
Name: phosphodiesterase 8B
Synonyms: B230331L10Rik, C030047E14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218461
HGNC: HGNC:8794
Homologene: 2758
Or11a4
Name: olfactory receptor family 11 subfamily A member 4
Synonyms: Olfr96, GA_x6K02T2PSCP-1665046-1665987, MOR121-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258507
HGNC: HGNC:8176
Homologene: 27189
Kif12
Name: kinesin family member 12
Synonyms: N-9 kinesin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16552
Homologene: 7796
Masp2
Name: MBL associated serine protease 2
Synonyms: MASP-2, MAp19
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17175
HGNC: HGNC:6902
Homologene: 4819
Dpysl2
Name: dihydropyrimidinase-like 2
Synonyms: Crmp2, DRP2, TOAD-64, Ulip2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12934
HGNC: HGNC:3014
Homologene: 74392
Cd38
Name: CD38 antigen
Synonyms: Cd38-rs1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12494
HGNC: HGNC:1667
Homologene: 1345
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: 9330155G14Rik, Nope, WI-16786, WI-18508
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Agmo
Name: alkylglycerol monooxygenase
Synonyms: Tmem195, A530016O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319660
Homologene: 45620
Cfhr1
Name: complement factor H-related 1
Synonyms: Cfhl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 50702
Homologene: 55632
Med22
Name: mediator complex subunit 22
Synonyms: Surf5, Surf-5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20933
Homologene: 4913
Rsl1d1
Name: ribosomal L1 domain containing 1
Synonyms: 2410005K20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66409
Homologene: 41052
Slc35f6
Name: solute carrier family 35, member F6
Synonyms: p40, 4930471M23Rik, 5730478O19Rik, Tango9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74919
Homologene: 9896
Or6c38
Name: olfactory receptor family 6 subfamily C member 38
Synonyms: Olfr768, MOR114-4, GA_x6K02T2PULF-10779441-10778503
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258863
Homologene: 17159
Mfsd4b1
Name: major facilitator superfamily domain containing 4B1
Synonyms: AI317395
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215929
Homologene: 77426
Vmn2r130
Name: vomeronasal 2, receptor 130
Synonyms: Vmn2r-ps130
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100042225
Napepld
Name: N-acyl phosphatidylethanolamine phospholipase D
Synonyms: NAPE-PLD
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242864
Homologene: 7094
Or10q12
Name: olfactory receptor family 10 subfamily Q member 12
Synonyms: MOR266-9, GA_x6K02T2RE5P-4101369-4102328, Olfr1495
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258341
Homologene: 73965
Slc35f3
Name: solute carrier family 35, member F3
Synonyms: B230375D17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 210027
Homologene: 62481
Gnpnat1
Name: glucosamine-phosphate N-acetyltransferase 1
Synonyms: EMeg32
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54342
VEGA: 14
Homologene: 41323
Eif1ad3
Name: eukaryotic translation initiation factor 1A domain containing 3
Synonyms: Gm2016
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039042
Homologene: 103865
Pgls
Name: 6-phosphogluconolactonase
Synonyms: 1110030K05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66171
HGNC: HGNC:8903
Homologene: 6037
Dnajb1
Name: DnaJ heat shock protein family (Hsp40) member B1
Synonyms: Hsp40, 0610007I11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 81489
HGNC: HGNC:5270
Homologene: 55957
Eif1ad10
Name: eukaryotic translation initiation factor 1A domain containing 10
Synonyms: Gm8332
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 666862
VEGA: 12
Gm36864
Name: predicted gene, 36864
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102640913
Homologene: 141046
Gm29394
Name: predicted gene 29394
Type: Gene
Species: Mouse
Chromosome: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 97,741,171 bp
  • A to C, chromosome 1 at 139,556,427 bp
  • A to T, chromosome 2 at 26,910,364 bp
  • C to T, chromosome 2 at 122,179,109 bp
  • A to T, chromosome 2 at 125,590,113 bp
  • A to T, chromosome 2 at 147,184,269 bp
  • T to A, chromosome 3 at 59,247,911 bp
  • A to G, chromosome 3 at 76,707,968 bp
  • T to A, chromosome 3 at 88,696,736 bp
  • C to A, chromosome 3 at 90,512,085 bp
  • A to G, chromosome 4 at 40,180,263 bp
  • G to C, chromosome 4 at 63,167,989 bp
  • G to A, chromosome 4 at 148,602,732 bp
  • A to T, chromosome 4 at 156,169,057 bp
  • C to T, chromosome 5 at 21,683,173 bp
  • T to C, chromosome 5 at 30,656,815 bp
  • C to A, chromosome 5 at 34,410,817 bp
  • C to A, chromosome 5 at 43,901,448 bp
  • G to A, chromosome 5 at 110,306,829 bp
  • A to G, chromosome 6 at 6,152,461 bp
  • G to T, chromosome 6 at 29,440,898 bp
  • A to T, chromosome 6 at 83,752,470 bp
  • A to T, chromosome 6 at 142,430,333 bp
  • T to C, chromosome 7 at 10,158,968 bp
  • A to G, chromosome 7 at 16,422,467 bp
  • ATCAGAAGTTTC to ATC, chromosome 7 at 44,236,937 bp
  • T to A, chromosome 7 at 86,920,170 bp
  • A to T, chromosome 7 at 92,928,692 bp
  • A to T, chromosome 7 at 106,752,638 bp
  • A to G, chromosome 7 at 108,925,074 bp
  • A to T, chromosome 7 at 115,801,604 bp
  • A to G, chromosome 7 at 116,417,458 bp
  • T to A, chromosome 8 at 71,595,203 bp
  • T to A, chromosome 8 at 83,610,205 bp
  • T to G, chromosome 8 at 83,935,558 bp
  • T to C, chromosome 8 at 126,394,480 bp
  • G to A, chromosome 9 at 65,120,258 bp
  • G to T, chromosome 9 at 78,449,538 bp
  • T to C, chromosome 10 at 40,003,415 bp
  • T to A, chromosome 10 at 129,093,516 bp
  • GTGT to GTGTTTGT, chromosome 11 at 43,587,426 bp
  • G to A, chromosome 11 at 67,969,785 bp
  • A to T, chromosome 11 at 100,246,766 bp
  • C to T, chromosome 12 at 37,242,052 bp
  • T to C, chromosome 12 at 66,470,950 bp
  • G to A, chromosome 12 at 87,876,972 bp
  • A to C, chromosome 12 at 88,249,818 bp
  • T to A, chromosome 13 at 40,180,439 bp
  • T to G, chromosome 13 at 95,107,697 bp
  • G to A, chromosome 14 at 45,384,653 bp
  • C to T, chromosome 14 at 51,991,797 bp
  • T to A, chromosome 14 at 52,145,880 bp
  • T to C, chromosome 14 at 55,871,429 bp
  • A to T, chromosome 14 at 57,932,253 bp
  • T to C, chromosome 14 at 66,862,643 bp
  • T to C, chromosome 15 at 58,048,776 bp
  • A to G, chromosome 16 at 11,203,234 bp
  • C to T, chromosome 17 at 8,296,908 bp
  • A to G, chromosome 17 at 23,063,814 bp
  • T to C, chromosome 17 at 37,225,272 bp
  • G to A, chromosome 17 at 49,069,944 bp
  • A to G, chromosome 18 at 20,046,285 bp
  • A to G, chromosome 19 at 13,768,510 bp
  • T to C, chromosome 19 at 61,080,945 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7852 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045905-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.