Strain Name:
C57BL/6J-MtgxR7862Btlr/Mmmh
Stock Number:
045915-MU
Citation ID:
RRID:MMRRC_045915-MU
Other Names:
R7862 (G1)
Major Collection:

Strain Information

Slc12a1
Name: solute carrier family 12, member 1
Synonyms: mBSC1, urehr3, D630042G03Rik, Nkcc2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20495
Homologene: 286
Myo10
Name: myosin X
Synonyms: D15Ertd600e, myosin-X
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Fkbp11
Name: FK506 binding protein 11
Synonyms: 1110002O23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66120
VEGA: 15
Homologene: 9581
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20321
Homologene: 40653
Med1
Name: mediator complex subunit 1
Synonyms: TRAP220, l11Jus15, PBP, Pparbp, TRAP 220, CRSP210, DRIP205
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd257e, D7Ertd237e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Fkbp5
Name: FK506 binding protein 5
Synonyms: Dit1, D17Ertd592e, FKBP51
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14229
HGNC: HGNC:3721
Homologene: 3038
Cep97
Name: centrosomal protein 97
Synonyms: 4932439K18Rik, Lrriq2, E130116N02Rik, 2810403B08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74201
Homologene: 11579
Mllt6
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms: Af17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246198
HGNC: HGNC:7138
Homologene: 31347
Rpap1
Name: RNA polymerase II associated protein 1
Synonyms: 1190005L06Rik, A730023M06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68925
Homologene: 32269
Tle1
Name: transducin-like enhancer of split 1
Synonyms: Grg1, Tle4l, C230057C06Rik, Estm14
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21885
Homologene: 21058
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, XAP8, Hbxap, C030033M12Rik, p325
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17847
Homologene: 40978
Ep300
Name: E1A binding protein p300
Synonyms: p300, KAT3B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328572
HGNC: HGNC:3373
Homologene: 1094
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 9130215G10Rik, 5730455C01Rik, 5730555F13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Fh1
Name: fumarate hydratase 1
Synonyms: fumarase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14194
HGNC: HGNC:3700
Homologene: 115
Krit1
Name: KRIT1, ankyrin repeat containing
Synonyms: Krit1A, Ccm1, Krit1B, A630036P20Rik, Krit1, 2010007K12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 79264
HGNC: HGNC:1573
Homologene: 12746
Chd8
Name: chromodomain helicase DNA binding protein 8
Synonyms: 5830451P18Rik, Duplin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67772
Homologene: 72405
Stk3
Name: serine/threonine kinase 3
Synonyms: Ste20, Mst2, 0610042I06Rik, mess1, MST
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56274
Homologene: 48420
Glud1
Name: glutamate dehydrogenase 1
Synonyms: Glud, Gdh-X
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14661
Homologene: 55885
Spag9
Name: sperm associated antigen 9
Synonyms: 3110018C07Rik, 4733401I23Rik, 4831406C20Rik, syd1, JLP, JIP4, Mapk8ip4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70834
Homologene: 2954
Rasa1
Name: RAS p21 protein activator 1
Synonyms: p120-rasGAP, Gap
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218397
HGNC: HGNC:9871
Homologene: 2168
Tgfbr1
Name: transforming growth factor, beta receptor I
Synonyms: Alk-5, TbetaR-I, ALK5, TbetaRI
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21812
Homologene: 3177
Haus2
Name: HAUS augmin-like complex, subunit 2
Synonyms: 2410007P03Rik, 1700101G24Rik, Cep27
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66296
Homologene: 10001
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: erythroid, Spna-1, ihj, Spna1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Chmp6
Name: charged multivesicular body protein 6
Synonyms: chromatin modifying protein 6, 2400004G01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 208092
Homologene: 11607
Pnp2
Name: purine-nucleoside phosphorylase 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 667034
HGNC: HGNC:7892
Homologene: 227
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74711
Homologene: 41769
Dpy19l1
Name: dpy-19 like C-mannosyltransferase 1
Synonyms: 1100001I19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244745
Homologene: 14762
Fmnl1
Name: formin-like 1
Synonyms: 8030453N10Rik, formin-related gene in leukocytes
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57778
HGNC: HGNC:1212
Homologene: 135620
Ush1c
Name: USH1 protein network component harmonin
Synonyms: Usher syndrome 1C, 2010016F01Rik, harmonin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72088
Homologene: 77476
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Chaf1b
Name: chromatin assembly factor 1, subunit B
Synonyms: CAF-I 60 kDa subunit, CAF-IP60, CAF1P60, CAF1A, CAF1, 2600017H24Rik, MPHOSPH7, CAF-1 subunit B
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110749
HGNC: HGNC:1911
Homologene: 48346
Dmrta1
Name: doublesex and mab-3 related transcription factor like family A1
Synonyms: Dmrt4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242523
Homologene: 18477
Gsdmc
Name: gasdermin C
Synonyms: Gsdmc1, Mlze
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83492
HGNC: HGNC:7151
Homologene: 69487
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Abtb2
Name: ankyrin repeat and BTB domain containing 2
Synonyms: BPOZ-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99382
Homologene: 15904
Pcdhb2
Name: protocadherin beta 2
Synonyms: PcdhbB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93873
HGNC: HGNC:8687
Homologene: 69266
Togaram2
Name: TOG array regulator of axonemal microtubules 2
Synonyms: 4632412N22Rik, Fam179a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320159
Homologene: 65315
Slc6a13
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 13
Synonyms: Gat2, Gabt3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14412
Homologene: 9592
Kcnh1
Name: potassium voltage-gated channel, subfamily H (eag-related), member 1
Synonyms: ether a go-go, Kv10.1, Eag1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16510
HGNC: HGNC:6250
Homologene: 68242
Jmy
Name: junction-mediating and regulatory protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 57748
VEGA: 13
Homologene: 10955
2410004B18Rik
Name: RIKEN cDNA 2410004B18 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66421
Homologene: 11968
Dhx34
Name: DExH-box helicase 34
Synonyms: 1200013B07Rik, 1810012L18Rik, Ddx34
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71723
Homologene: 69171
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665255
Homologene: 129605
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Ehbp1l1
Name: EH domain binding protein 1-like 1
Synonyms: G430002G23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 114601
VEGA: 19
Homologene: 136059
Abcc10
Name: ATP-binding cassette, sub-family C member 10
Synonyms: Mrp7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Or7g25
Name: olfactory receptor family 7 subfamily G member 25
Synonyms: MOR155-2, Olfr843, GA_x6K02T2PVTD-12986331-12985390
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258560
HGNC: HGNC:8466
Homologene: 74251
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627367
Homologene: 115024
Ighe
Name: Immunoglobulin heavy constant epsilon
Synonyms: LOC380792, Gm900
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380792
HGNC: HGNC:5522
Or8b3b
Name: olfactory receptor family 8 subfamily B member 3B
Synonyms: GA_x6K02T2PVTD-32375756-32374818, Olfr918, MOR164-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258372
VEGA: 9
Zfp873
Name: zinc finger protein 873
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 408062
Homologene: 134319
Or6c214
Name: olfactory receptor family 6 subfamily C member 214
Synonyms: MOR117-1, GA_x6K02T2PULF-11434134-11433199, Olfr807
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258931
Homologene: 27300
Kctd20
Name: potassium channel tetramerisation domain containing 20
Synonyms: 2410004N11Rik, D17Ertd562e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66989
Homologene: 12063
Or4a47
Name: olfactory receptor family 4 subfamily A member 47
Synonyms: Olfr1256, GA_x6K02T2Q125-51276848-51275928, MOR231-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258985
Homologene: 128157
Cst12
Name: cystatin 12
Synonyms: cystatin TE-1, 1700006F03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69362
Homologene: 17808
Thpo
Name: thrombopoietin
Synonyms: TPO-1, myeloproliferative leukemia virus oncogene ligand, TPO-4, TPO, Mpllg, TPO-2, TPO-3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21832
Homologene: 398
D1Pas1
Name: DNA segment, Chr 1, Pasteur Institute 1
Synonyms: Pl10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110957
HGNC: HGNC:2745
Homologene: 135966
Klhl38
Name: kelch-like 38
Synonyms: 8230402K04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268807
Homologene: 18622
Hacd1
Name: 3-hydroxyacyl-CoA dehydratase 1
Synonyms: Ptpla
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 30963
HGNC: HGNC:9639
Homologene: 69153
Myl7
Name: myosin, light polypeptide 7, regulatory
Synonyms: MLC2a, MLC-2alpha, Mylc2a, RLC-A
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17898
Homologene: 23290
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 150,806,421 bp
  • G to A, chromosome 1 at 174,197,785 bp
  • A to T, chromosome 1 at 175,614,834 bp
  • G to A, chromosome 1 at 186,968,152 bp
  • G to T, chromosome 1 at 192,190,859 bp
  • T to C, chromosome 2 at 14,045,202 bp
  • T to C, chromosome 2 at 89,835,124 bp
  • C to T, chromosome 2 at 103,702,281 bp
  • C to T, chromosome 2 at 119,775,412 bp
  • T to A, chromosome 2 at 120,613,089 bp
  • A to G, chromosome 2 at 125,161,094 bp
  • T to C, chromosome 2 at 148,789,575 bp
  • C to T, chromosome 2 at 153,006,975 bp
  • T to C, chromosome 3 at 116,891,880 bp
  • A to C, chromosome 3 at 145,943,869 bp
  • A to T, chromosome 4 at 47,403,489 bp
  • A to C, chromosome 4 at 72,199,315 bp
  • C to A, chromosome 4 at 89,688,324 bp
  • A to G, chromosome 5 at 3,812,788 bp
  • A to G, chromosome 6 at 121,335,630 bp
  • A to T, chromosome 7 at 5,490,614 bp
  • C to A, chromosome 7 at 16,210,523 bp
  • T to C, chromosome 7 at 46,221,424 bp
  • C to T, chromosome 7 at 80,743,888 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,923 bp
  • C to A, chromosome 9 at 19,249,440 bp
  • T to C, chromosome 9 at 24,475,434 bp
  • C to T, chromosome 9 at 38,673,328 bp
  • G to T, chromosome 9 at 70,572,164 bp
  • T to A, chromosome 10 at 82,060,275 bp
  • T to C, chromosome 10 at 129,755,355 bp
  • A to G, chromosome 11 at 5,897,157 bp
  • T to C, chromosome 11 at 23,464,718 bp
  • T to C, chromosome 11 at 94,112,066 bp
  • T to C, chromosome 11 at 97,665,805 bp
  • A to T, chromosome 11 at 98,161,210 bp
  • A to G, chromosome 11 at 103,180,930 bp
  • G to A, chromosome 11 at 119,917,010 bp
  • A to T, chromosome 12 at 113,271,808 bp
  • G to A, chromosome 13 at 85,255,411 bp
  • T to C, chromosome 13 at 93,499,195 bp
  • G to A, chromosome 14 at 24,245,212 bp
  • T to G, chromosome 14 at 34,325,522 bp
  • A to T, chromosome 14 at 50,963,559 bp
  • T to C, chromosome 14 at 52,214,277 bp
  • A to G, chromosome 14 at 64,028,027 bp
  • T to C, chromosome 15 at 8,325,752 bp
  • T to C, chromosome 15 at 25,666,436 bp
  • A to G, chromosome 15 at 35,115,586 bp
  • A to T, chromosome 15 at 58,314,999 bp
  • A to T, chromosome 15 at 63,777,996 bp
  • T to G, chromosome 15 at 81,650,753 bp
  • A to G, chromosome 15 at 89,505,445 bp
  • G to A, chromosome 15 at 98,726,508 bp
  • C to T, chromosome 16 at 20,728,790 bp
  • T to C, chromosome 16 at 55,905,721 bp
  • T to C, chromosome 16 at 93,749,963 bp
  • T to C, chromosome 16 at 93,888,095 bp
  • T to C, chromosome 17 at 18,947,154 bp
  • C to T, chromosome 17 at 28,412,039 bp
  • C to T, chromosome 17 at 28,962,875 bp
  • G to T, chromosome 17 at 46,315,532 bp
  • T to C, chromosome 17 at 71,689,173 bp
  • C to T, chromosome 18 at 37,296,060 bp
  • C to T, chromosome 19 at 5,720,823 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7862 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045915-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.