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Strain Name:
C57BL/6J-MtgxR7862Btlr/Mmmh
Stock Number:
045915-MU
Citation ID:
RRID:MMRRC_045915-MU
Other Names:
R7862 (G1)
Major Collection:

Strain Information

Slc12a1
Name: solute carrier family 12, member 1
Synonyms: Nkcc2, mBSC1, D630042G03Rik, urehr3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20495
Homologene: 286
Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Fkbp11
Name: FK506 binding protein 11
Synonyms: 1110002O23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66120
VEGA: 15
Homologene: 9581
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20321
Homologene: 40653
Med1
Name: mediator complex subunit 1
Synonyms: TRAP 220, TRAP220, CRSP210, DRIP205, Pparbp, l11Jus15, PBP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 150,806,421 bp
  • G to A, chromosome 1 at 174,197,785 bp
  • A to T, chromosome 1 at 175,614,834 bp
  • G to A, chromosome 1 at 186,968,152 bp
  • G to T, chromosome 1 at 192,190,859 bp
  • T to C, chromosome 2 at 14,045,202 bp
  • T to C, chromosome 2 at 89,835,124 bp
  • C to T, chromosome 2 at 103,702,281 bp
  • C to T, chromosome 2 at 119,775,412 bp
  • T to A, chromosome 2 at 120,613,089 bp
  • A to G, chromosome 2 at 125,161,094 bp
  • T to C, chromosome 2 at 148,789,575 bp
  • C to T, chromosome 2 at 153,006,975 bp
  • T to C, chromosome 3 at 116,891,880 bp
  • A to C, chromosome 3 at 145,943,869 bp
  • A to T, chromosome 4 at 47,403,489 bp
  • A to C, chromosome 4 at 72,199,315 bp
  • C to A, chromosome 4 at 89,688,324 bp
  • A to G, chromosome 5 at 3,812,788 bp
  • A to G, chromosome 6 at 121,335,630 bp
  • A to T, chromosome 7 at 5,490,614 bp
  • C to A, chromosome 7 at 16,210,523 bp
  • T to C, chromosome 7 at 46,221,424 bp
  • C to T, chromosome 7 at 80,743,888 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,923 bp
  • C to A, chromosome 9 at 19,249,440 bp
  • T to C, chromosome 9 at 24,475,434 bp
  • C to T, chromosome 9 at 38,673,328 bp
  • G to T, chromosome 9 at 70,572,164 bp
  • T to A, chromosome 10 at 82,060,275 bp
  • T to C, chromosome 10 at 129,755,355 bp
  • A to G, chromosome 11 at 5,897,157 bp
  • T to C, chromosome 11 at 23,464,718 bp
  • T to C, chromosome 11 at 94,112,066 bp
  • T to C, chromosome 11 at 97,665,805 bp
  • A to T, chromosome 11 at 98,161,210 bp
  • A to G, chromosome 11 at 103,180,930 bp
  • G to A, chromosome 11 at 119,917,010 bp
  • A to T, chromosome 12 at 113,271,808 bp
  • G to A, chromosome 13 at 85,255,411 bp
  • T to C, chromosome 13 at 93,499,195 bp
  • G to A, chromosome 14 at 24,245,212 bp
  • T to G, chromosome 14 at 34,325,522 bp
  • A to T, chromosome 14 at 50,963,559 bp
  • T to C, chromosome 14 at 52,214,277 bp
  • A to G, chromosome 14 at 64,028,027 bp
  • T to C, chromosome 15 at 8,325,752 bp
  • T to C, chromosome 15 at 25,666,436 bp
  • A to G, chromosome 15 at 35,115,586 bp
  • A to T, chromosome 15 at 58,314,999 bp
  • A to T, chromosome 15 at 63,777,996 bp
  • T to G, chromosome 15 at 81,650,753 bp
  • A to G, chromosome 15 at 89,505,445 bp
  • G to A, chromosome 15 at 98,726,508 bp
  • C to T, chromosome 16 at 20,728,790 bp
  • T to C, chromosome 16 at 55,905,721 bp
  • T to C, chromosome 16 at 93,749,963 bp
  • T to C, chromosome 16 at 93,888,095 bp
  • T to C, chromosome 17 at 18,947,154 bp
  • C to T, chromosome 17 at 28,412,039 bp
  • C to T, chromosome 17 at 28,962,875 bp
  • G to T, chromosome 17 at 46,315,532 bp
  • T to C, chromosome 17 at 71,689,173 bp
  • C to T, chromosome 18 at 37,296,060 bp
  • C to T, chromosome 19 at 5,720,823 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7862 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045915-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.