Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7981Btlr/Mmmh
Stock Number:
046022-MU
Citation ID:
RRID:MMRRC_046022-MU
Other Names:
R7981 (G1)
Major Collection:

Strain Information

Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: tubedown, Tbdn-1, mNAT1, 5730450D16Rik, Narg1, ASTBDN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74838
Homologene: 14211
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Rab11fip3
Name: RAB11 family interacting protein 3 (class II)
Synonyms: Rab11-FIP3, D030060O14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 215445
Homologene: 49396
Tasor
Name: transcription activation suppressor
Synonyms: 4933409E02Rik, D14Abb1e, MommeD6, Fam208a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218850
VEGA: 14
Homologene: 9062
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Crh
Name: corticotropin releasing hormone
Synonyms: CRF, corticotropin releasing factor, LOC383938, corticotropin-releasing factor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12918
HGNC: HGNC:2355
Homologene: 599
Ankrd28
Name: ankyrin repeat domain 28
Synonyms: E430019N21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105522
VEGA: 14
Homologene: 35374
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 54,368,392 bp
  • A to T, chromosome 1 at 133,075,809 bp
  • A to G, chromosome 2 at 26,421,372 bp
  • T to A, chromosome 2 at 37,436,875 bp
  • A to G, chromosome 2 at 89,112,056 bp
  • T to A, chromosome 3 at 19,694,052 bp
  • T to C, chromosome 3 at 51,458,671 bp
  • T to A, chromosome 3 at 59,876,939 bp
  • A to G, chromosome 3 at 159,520,851 bp
  • G to T, chromosome 4 at 12,070,592 bp
  • T to G, chromosome 4 at 130,086,554 bp
  • T to G, chromosome 4 at 139,058,461 bp
  • T to G, chromosome 4 at 143,726,882 bp
  • C to T, chromosome 5 at 65,812,142 bp
  • G to A, chromosome 5 at 107,725,677 bp
  • G to A, chromosome 5 at 144,357,890 bp
  • G to A, chromosome 6 at 28,419,141 bp
  • A to G, chromosome 6 at 48,468,494 bp
  • A to G, chromosome 6 at 108,152,225 bp
  • G to T, chromosome 6 at 116,640,257 bp
  • A to T, chromosome 6 at 121,881,764 bp
  • T to C, chromosome 6 at 134,610,311 bp
  • T to C, chromosome 7 at 21,162,989 bp
  • A to G, chromosome 7 at 76,444,840 bp
  • A to T, chromosome 7 at 102,477,829 bp
  • A to G, chromosome 7 at 114,829,067 bp
  • T to C, chromosome 7 at 118,689,041 bp
  • A to G, chromosome 8 at 43,625,813 bp
  • G to T, chromosome 8 at 83,681,008 bp
  • A to C, chromosome 8 at 84,257,163 bp
  • T to C, chromosome 8 at 92,855,554 bp
  • A to G, chromosome 8 at 94,842,657 bp
  • C to T, chromosome 8 at 95,763,169 bp
  • A to T, chromosome 9 at 71,263,820 bp
  • T to C, chromosome 10 at 5,229,248 bp
  • A to G, chromosome 10 at 18,218,379 bp
  • T to C, chromosome 11 at 58,145,405 bp
  • T to C, chromosome 11 at 58,651,312 bp
  • T to C, chromosome 11 at 110,089,913 bp
  • T to C, chromosome 11 at 115,606,861 bp
  • C to T, chromosome 12 at 70,042,817 bp
  • T to C, chromosome 14 at 24,158,145 bp
  • T to C, chromosome 14 at 27,446,416 bp
  • T to C, chromosome 14 at 31,702,157 bp
  • T to C, chromosome 14 at 34,065,881 bp
  • T to C, chromosome 16 at 89,419,674 bp
  • T to A, chromosome 17 at 18,107,625 bp
  • C to T, chromosome 17 at 25,997,989 bp
  • T to C, chromosome 17 at 56,631,562 bp
  • T to C, chromosome 18 at 78,009,714 bp
  • C to A, chromosome 19 at 30,239,337 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7981 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046022-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.