Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8006Btlr/Mmmh
Stock Number:
046046-MU
Citation ID:
RRID:MMRRC_046046-MU
Other Names:
R8006 (G1)
Major Collection:

Strain Information

Vcp
Name: valosin containing protein
Synonyms: CDC48, p97, p97/VCP, AAA ATPase p97
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269523
Homologene: 5168
Jade1
Name: jade family PHD finger 1
Synonyms: D530048A03Rik, Phf17
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269424
Homologene: 18162
Lrrc41
Name: leucine rich repeat containing 41
Synonyms: D730026A16Rik, MUF1, D630045E04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230654
Homologene: 4645
Ankrd13a
Name: ankyrin repeat domain 13a
Synonyms: 1100001D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68420
Homologene: 23814
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: SDRP1, Tiul1, AIP5, 8030445B08Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107568
Homologene: 21385
Tyw1
Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Synonyms: Rsafd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100929
Homologene: 7068
Akap13
Name: A kinase anchor protein 13
Synonyms: AKAP-Lbc, PROTO-LBC, PROTO-LB, Ht31, 5730522G15Rik, 1700026G02Rik, 5830460E08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 32,546,924 bp
  • A to G, chromosome 1 at 91,076,951 bp
  • A to G, chromosome 1 at 97,734,106 bp
  • A to G, chromosome 1 at 139,736,852 bp
  • T to C, chromosome 2 at 85,429,974 bp
  • A to G, chromosome 2 at 181,995,876 bp
  • A to T, chromosome 3 at 41,613,689 bp
  • T to A, chromosome 3 at 88,537,086 bp
  • A to T, chromosome 4 at 19,650,174 bp
  • A to T, chromosome 4 at 42,985,993 bp
  • G to A, chromosome 4 at 116,094,888 bp
  • T to A, chromosome 4 at 148,001,181 bp
  • A to T, chromosome 5 at 21,899,084 bp
  • C to T, chromosome 5 at 90,223,813 bp
  • A to T, chromosome 5 at 109,220,458 bp
  • A to C, chromosome 5 at 114,804,423 bp
  • C to T, chromosome 5 at 130,268,072 bp
  • A to T, chromosome 7 at 10,490,173 bp
  • T to C, chromosome 7 at 41,545,682 bp
  • T to A, chromosome 7 at 51,593,770 bp
  • T to C, chromosome 7 at 75,579,696 bp
  • T to A, chromosome 7 at 103,717,325 bp
  • A to G, chromosome 7 at 109,703,992 bp
  • T to A, chromosome 7 at 130,467,388 bp
  • T to A, chromosome 8 at 40,795,907 bp
  • T to A, chromosome 8 at 105,519,103 bp
  • C to T, chromosome 9 at 7,578,984 bp
  • T to G, chromosome 9 at 40,022,474 bp
  • T to A, chromosome 9 at 66,445,560 bp
  • T to A, chromosome 9 at 82,890,126 bp
  • T to C, chromosome 9 at 89,729,836 bp
  • C to T, chromosome 9 at 108,829,107 bp
  • A to G, chromosome 10 at 63,582,011 bp
  • A to T, chromosome 10 at 93,555,586 bp
  • A to G, chromosome 10 at 127,589,619 bp
  • A to T, chromosome 11 at 50,864,657 bp
  • A to G, chromosome 11 at 101,268,356 bp
  • T to C, chromosome 11 at 104,665,496 bp
  • C to T, chromosome 11 at 119,156,072 bp
  • T to A, chromosome 13 at 119,609,238 bp
  • G to A, chromosome 14 at 55,887,590 bp
  • A to G, chromosome 15 at 55,048,701 bp
  • T to C, chromosome 15 at 71,462,334 bp
  • A to G, chromosome 15 at 79,634,098 bp
  • A to T, chromosome 17 at 35,928,266 bp
  • A to G, chromosome 18 at 36,648,719 bp
  • T to A, chromosome 18 at 44,354,837 bp
  • G to C, chromosome 18 at 60,829,051 bp
  • G to A, chromosome 18 at 67,501,181 bp
  • A to T, chromosome 18 at 73,877,506 bp
  • T to C, chromosome 19 at 9,012,083 bp
  • T to A, chromosome 19 at 44,942,317 bp
  • A to C, chromosome 19 at 46,558,374 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8006 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046046-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.