Targeted JM8A3.N1 embryonic stem cells (C57BL/6N-derived) heterozygous for the targeted mutation, clone EPD0613_4_G07 were ordered from the Knockout Mouse Project (KOMP, project ID:79596, UC Davis, CA, USA). Chimeras were bred to albino B6. Subsequent breeding to an Flp deleter strain of unknown genetic background (Bap-flp) removed the frt-pgk-neo-frt sequences. Backcross to C57BL/6J for more than 10 generations.
Mukerjee S, Gao H, Xu J, Sato R, Zsombok A, Lazartigues E. ACE2 and ADAM17Interaction Regulates the Activity of Presympathetic Neurons. Hypertension. 2019 Nov;74(5):1181-1191. doi: 10.1161/HYPERTENSIONAHA.119.13133. Epub 2019 Sep 30.(Medline PMID: 31564162)
Colony Surveillance Program and Current Health Reports
For more information about this colony's health status contact mmrrc@ucdavis.eduViability and Fertility: | Female | Male | Comments |
---|---|---|---|
Homozygotes are viable: | Undetermined | Undetermined | |
Homozygotes are fertile: | Undetermined | Undetermined | |
Hetero/Hemizygotes are fertile: | Undetermined | Undetermined | |
Age Reproductive Decline: | Undetermined | Undetermined |
When this strain becomes available, Limited quantities of breeder mice (up to 2 males and 2 females or 4 mice) per investigator per month are available from a live colony, usually available to ship in under 12 weeks. Larger quantities may be available, please contact the distributing center directly at mmrrc@ucdavis.edu for more details.
Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.