Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8048Btlr/Mmmh
Stock Number:
067485-MU
Citation ID:
RRID:MMRRC_067485-MU
Other Names:
R8048 (G1)
Major Collection:

Strain Information

Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Prdm16
Name: PR domain containing 16
Synonyms: Mel1, 5730557K01Rik, line 27, csp1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70673
Homologene: 11139
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Wdr47
Name: WD repeat domain 47
Synonyms: 1810073M12Rik, nemitin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99512
Homologene: 8984
Arhgap12
Name: Rho GTPase activating protein 12
Synonyms: 2810011M08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75415
Homologene: 23089
Ddx4
Name: DEAD box helicase 4
Synonyms: mvh / m'vasa, VASA, Mvh, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13206
VEGA: 13
Homologene: 49227
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,190,636 bp
  • T to A, chromosome 1 at 62,153,989 bp
  • T to C, chromosome 1 at 158,688,638 bp
  • T to C, chromosome 2 at 17,424,522 bp
  • T to A, chromosome 2 at 26,293,514 bp
  • T to G, chromosome 2 at 86,008,180 bp
  • C to T, chromosome 2 at 86,298,328 bp
  • T to A, chromosome 2 at 86,423,307 bp
  • T to A, chromosome 2 at 86,806,171 bp
  • A to T, chromosome 2 at 91,154,448 bp
  • T to C, chromosome 2 at 121,183,500 bp
  • T to A, chromosome 2 at 129,017,014 bp
  • A to T, chromosome 2 at 152,338,633 bp
  • T to A, chromosome 3 at 92,571,924 bp
  • T to C, chromosome 3 at 107,237,092 bp
  • T to C, chromosome 3 at 108,618,968 bp
  • C to T, chromosome 3 at 121,992,901 bp
  • T to A, chromosome 4 at 11,539,918 bp
  • A to G, chromosome 4 at 43,689,476 bp
  • G to T, chromosome 4 at 136,896,610 bp
  • T to A, chromosome 4 at 143,991,607 bp
  • A to G, chromosome 4 at 145,155,567 bp
  • A to G, chromosome 4 at 154,320,882 bp
  • C to A, chromosome 5 at 92,300,089 bp
  • G to T, chromosome 5 at 120,847,537 bp
  • A to T, chromosome 5 at 120,848,416 bp
  • CTCCAGCTCCGAT to C, chromosome 5 at 134,729,149 bp
  • A to G, chromosome 5 at 145,155,077 bp
  • A to G, chromosome 6 at 23,838,863 bp
  • A to T, chromosome 6 at 41,121,559 bp
  • T to G, chromosome 6 at 68,121,802 bp
  • T to A, chromosome 6 at 85,641,334 bp
  • G to T, chromosome 6 at 125,179,698 bp
  • A to T, chromosome 7 at 30,860,578 bp
  • C to T, chromosome 7 at 105,595,478 bp
  • C to T, chromosome 7 at 106,972,464 bp
  • T to C, chromosome 7 at 110,315,082 bp
  • T to C, chromosome 7 at 118,566,245 bp
  • C to T, chromosome 7 at 129,379,477 bp
  • A to T, chromosome 8 at 25,063,989 bp
  • T to A, chromosome 8 at 95,263,210 bp
  • C to T, chromosome 9 at 38,665,812 bp
  • T to C, chromosome 10 at 79,709,746 bp
  • T to C, chromosome 10 at 109,764,918 bp
  • T to A, chromosome 10 at 130,347,339 bp
  • A to G, chromosome 11 at 58,597,407 bp
  • T to C, chromosome 12 at 76,628,559 bp
  • A to G, chromosome 13 at 13,687,645 bp
  • G to A, chromosome 13 at 112,622,172 bp
  • A to G, chromosome 14 at 14,348,903 bp
  • T to C, chromosome 14 at 50,453,916 bp
  • T to A, chromosome 14 at 75,324,537 bp
  • G to T, chromosome 15 at 78,910,072 bp
  • CATTGTCTTGA to CA, chromosome 15 at 79,649,758 bp
  • A to T, chromosome 16 at 14,410,844 bp
  • A to G, chromosome 16 at 17,303,127 bp
  • A to G, chromosome 16 at 18,588,019 bp
  • T to C, chromosome 17 at 20,471,500 bp
  • T to C, chromosome 17 at 38,175,528 bp
  • T to C, chromosome 17 at 78,387,053 bp
  • G to A, chromosome 18 at 6,052,883 bp
  • A to T, chromosome 18 at 20,274,767 bp
  • G to A, chromosome 18 at 35,653,551 bp
  • T to A, chromosome 18 at 36,939,460 bp
  • A to G, chromosome 19 at 12,394,355 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8048 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067485-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.