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Strain Name:
C57BL/6J-MtgxR8048Btlr/Mmmh
Stock Number:
067485-MU
Citation ID:
RRID:MMRRC_067485-MU
Other Names:
R8048 (G1)
Major Collection:

Strain Information

Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Prdm16
Name: PR domain containing 16
Synonyms: Mel1, 5730557K01Rik, line 27, csp1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70673
Homologene: 11139
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Wdr47
Name: WD repeat domain 47
Synonyms: 1810073M12Rik, nemitin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99512
Homologene: 8984
Arhgap12
Name: Rho GTPase activating protein 12
Synonyms: 2810011M08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75415
Homologene: 23089
Ddx4
Name: DEAD box helicase 4
Synonyms: mvh / m'vasa, VASA, Mvh, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13206
VEGA: 13
Homologene: 49227
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66185
Homologene: 41043
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: C87618, 4930570G11Rik, 2600010B19Rik, 3110050K21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67302
VEGA: 14
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Sdad1
Name: SDA1 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231452
Homologene: 6036
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CNAP1, CAP-D2, 2810406C15Rik, 2810465G24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68298
Homologene: 6497
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Ccdc187
Name: coiled-coil domain containing 187
Synonyms: 4932418E24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329366
Homologene: 77630
Sptb
Name: spectrin beta, erythrocytic
Synonyms: Spnb-1, spectrin R, D330027P03Rik, LOC383567, brain erythroid spectrin (235E), Spnb1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20741
Homologene: 295
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: Cngb1, Cngb1b, BC016201
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Tbx1
Name: T-box 1
Synonyms: nmf219
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21380
VEGA: 16
Homologene: 7966
Tespa1
Name: thymocyte expressed, positive selection associated 1
Synonyms: A430001F24Rik, 5830405N20Rik, Itprid3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67596
VEGA: 10
Homologene: 106645
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, POMFIL1, 4732483H20Rik, unc53H3, steerin 3, 9630020C08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 260315
Homologene: 56688
Plpp4
Name: phospholipid phosphatase 4
Synonyms: LOC381925, C030048B12Rik, Ppapdc1a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381925
Homologene: 38751
Arhgap29
Name: Rho GTPase activating protein 29
Synonyms: 6720461J18Rik, Parg1, C76601, B130017I01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214137
Homologene: 3539
Eln
Name: elastin
Synonyms: tropoelastin, E030024M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13717
HGNC: HGNC:3327
Pard3b
Name: par-3 family cell polarity regulator beta
Synonyms: 2810455B10Rik, PAR3beta, PAR3L, PAR3B, 2010002N16Rik, Als2cr19, 1810008K04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72823
Homologene: 35389
Nebl
Name: nebulette
Synonyms: Lnebl, 1200007O21Rik, A630080F05Rik, D830029A09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74103
Homologene: 128431
Or6b6
Name: olfactory receptor family 6 subfamily B member 6
Synonyms: GA_x6K02T2PBJ9-9352783-9351839, MOR103-4, Olfr711
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259037
Homologene: 128111
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75729
Homologene: 123434
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627805
Homologene: 129678
C1qa
Name: complement component 1, q subcomponent, alpha polypeptide
Synonyms: C1q
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12259
HGNC: HGNC:1241
Homologene: 7249
Hpx
Name: hemopexin
Synonyms: hx, Hpxn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15458
HGNC: HGNC:5171
Homologene: 511
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Il3ra
Name: interleukin 3 receptor, alpha chain
Synonyms: IL-3 receptor alpha chain, CD123, SUT-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16188
VEGA: 14
HGNC: HGNC:6012
Homologene: 48088
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Or5m3
Name: olfactory receptor family 5 subfamily M member 3
Synonyms: GA_x6K02T2Q125-47485813-47486745, MOR199-1, Olfr1032
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258572
Homologene: 17299
Or8j3c
Name: olfactory receptor family 8 subfamily J member 3C
Synonyms: GA_x6K02T2Q125-47892992-47892045, MOR185-1, Olfr1062
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259082
Homologene: 83135
Or2n1
Name: olfactory receptor family 2 subfamily N member 1
Synonyms: GA_x6K02T2PSCP-2623613-2624551, MOR256-5, Olfr134
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258829
Homologene: 110603
Or5an6
Name: olfactory receptor family 5 subfamily AN member 6
Synonyms: GA_x6K02T2RE5P-2725206-2726153, MOR215-1, Olfr1440
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258679
Homologene: 128133
Sh3bp1
Name: SH3-domain binding protein 1
Synonyms: 3BP-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20401
Homologene: 7534
Ivl
Name: involucrin
Synonyms: 1110019C06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16447
HGNC: HGNC:6187
Homologene: 137207
Prob1
Name: proline rich basic protein 1
Synonyms: LOC381148, Gm1614
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381148
Homologene: 83773
Pramel14
Name: PRAME like 14
Synonyms: Gm13107, Pramef17
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 626943
Homologene: 129642
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: MRP, Mdrap, Mrp1, Abcc1b, Abcc1a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Tmem8b
Name: transmembrane protein 8B
Synonyms: 4930500O05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242409
Homologene: 72894
Zc3h6
Name: zinc finger CCCH type containing 6
Synonyms: 4631426G04Rik, 4833425H18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78751
Homologene: 35328
Oas1f
Name: 2'-5' oligoadenylate synthetase 1F
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243262
HGNC: HGNC:8086
Homologene: 86720
Or5j3
Name: olfactory receptor family 5 subfamily J member 3
Synonyms: GA_x6K02T2Q125-47777498-47778436, MOR172-1, Olfr1052
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259012
Homologene: 79679
Or5t18
Name: olfactory receptor family 5 subfamily T member 18
Synonyms: K17, GA_x6K02T2Q125-48299679-48298702, MOR179-5, Olfr141
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257913
Homologene: 28042
Ffar1
Name: free fatty acid receptor 1
Synonyms: Gpr40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233081
HGNC: HGNC:4498
Homologene: 3876
Fez2
Name: fasciculation and elongation protein zeta 2
Synonyms: zygin 2, D17Ertd315e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225020
HGNC: HGNC:3660
Homologene: 3742
Tubgcp4
Name: tubulin, gamma complex component 4
Synonyms: 4932441P04Rik, D2Ertd435e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51885
Homologene: 8690
Or8b52
Name: olfactory receptor family 8 subfamily B member 52
Synonyms: GA_x6K02T2PVTD-32368166-32367237, MOR168-2P, Olfr917
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258183
VEGA: 9
Or2ab1
Name: olfactory receptor family 2 subfamily AB member 1
Synonyms: GA_x6K02T2NKPP-822947-822000, MOR102-2, Olfr324
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257892
Homologene: 79395
Bsg
Name: basigin
Synonyms: neurothelin, CD147, 5A11/Basigin, EMMPRIN, HT-7, gp 42
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12215
HGNC: HGNC:1116
Homologene: 1308
Or11g7
Name: olfactory receptor family 11 subfamily G member 7
Synonyms: GA_x6K02T2PMLR-6167145-6168080, MOR106-4, Olfr740
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258661
Tmc7
Name: transmembrane channel-like gene family 7
Synonyms: C630024K23Rik, 1700030H01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209760
Homologene: 36424
Plekha2
Name: pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
Synonyms: TAPP2, 6430512N22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 83436
Homologene: 41822
Trib3
Name: tribbles pseudokinase 3
Synonyms: Trb3, Nipk, SKIP3, Ifld2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228775
Homologene: 10902
Ptcd1
Name: pentatricopeptide repeat domain 1
Synonyms: 1110069M14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71799
Homologene: 33161
Prok1
Name: prokineticin 1
Synonyms: EG-VEGF
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 246691
Homologene: 13023
Pcdha2
Name: protocadherin alpha 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353234
HGNC: HGNC:8668
Homologene: 135719
Trbv13-2
Name: T cell receptor beta, variable 13-2
Synonyms: Tcrb-V8.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124675
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,190,636 bp
  • T to A, chromosome 1 at 62,153,989 bp
  • T to C, chromosome 1 at 158,688,638 bp
  • T to C, chromosome 2 at 17,424,522 bp
  • T to A, chromosome 2 at 26,293,514 bp
  • T to G, chromosome 2 at 86,008,180 bp
  • C to T, chromosome 2 at 86,298,328 bp
  • T to A, chromosome 2 at 86,423,307 bp
  • T to A, chromosome 2 at 86,806,171 bp
  • A to T, chromosome 2 at 91,154,448 bp
  • T to C, chromosome 2 at 121,183,500 bp
  • T to A, chromosome 2 at 129,017,014 bp
  • A to T, chromosome 2 at 152,338,633 bp
  • T to A, chromosome 3 at 92,571,924 bp
  • T to C, chromosome 3 at 107,237,092 bp
  • T to C, chromosome 3 at 108,618,968 bp
  • C to T, chromosome 3 at 121,992,901 bp
  • T to A, chromosome 4 at 11,539,918 bp
  • A to G, chromosome 4 at 43,689,476 bp
  • G to T, chromosome 4 at 136,896,610 bp
  • T to A, chromosome 4 at 143,991,607 bp
  • A to G, chromosome 4 at 145,155,567 bp
  • A to G, chromosome 4 at 154,320,882 bp
  • C to A, chromosome 5 at 92,300,089 bp
  • G to T, chromosome 5 at 120,847,537 bp
  • A to T, chromosome 5 at 120,848,416 bp
  • CTCCAGCTCCGAT to C, chromosome 5 at 134,729,149 bp
  • A to G, chromosome 5 at 145,155,077 bp
  • A to G, chromosome 6 at 23,838,863 bp
  • A to T, chromosome 6 at 41,121,559 bp
  • T to G, chromosome 6 at 68,121,802 bp
  • T to A, chromosome 6 at 85,641,334 bp
  • G to T, chromosome 6 at 125,179,698 bp
  • A to T, chromosome 7 at 30,860,578 bp
  • C to T, chromosome 7 at 105,595,478 bp
  • C to T, chromosome 7 at 106,972,464 bp
  • T to C, chromosome 7 at 110,315,082 bp
  • T to C, chromosome 7 at 118,566,245 bp
  • C to T, chromosome 7 at 129,379,477 bp
  • A to T, chromosome 8 at 25,063,989 bp
  • T to A, chromosome 8 at 95,263,210 bp
  • C to T, chromosome 9 at 38,665,812 bp
  • T to C, chromosome 10 at 79,709,746 bp
  • T to C, chromosome 10 at 109,764,918 bp
  • T to A, chromosome 10 at 130,347,339 bp
  • A to G, chromosome 11 at 58,597,407 bp
  • T to C, chromosome 12 at 76,628,559 bp
  • A to G, chromosome 13 at 13,687,645 bp
  • G to A, chromosome 13 at 112,622,172 bp
  • A to G, chromosome 14 at 14,348,903 bp
  • T to C, chromosome 14 at 50,453,916 bp
  • T to A, chromosome 14 at 75,324,537 bp
  • G to T, chromosome 15 at 78,910,072 bp
  • CATTGTCTTGA to CA, chromosome 15 at 79,649,758 bp
  • A to T, chromosome 16 at 14,410,844 bp
  • A to G, chromosome 16 at 17,303,127 bp
  • A to G, chromosome 16 at 18,588,019 bp
  • T to C, chromosome 17 at 20,471,500 bp
  • T to C, chromosome 17 at 38,175,528 bp
  • T to C, chromosome 17 at 78,387,053 bp
  • G to A, chromosome 18 at 6,052,883 bp
  • A to T, chromosome 18 at 20,274,767 bp
  • G to A, chromosome 18 at 35,653,551 bp
  • T to A, chromosome 18 at 36,939,460 bp
  • A to G, chromosome 19 at 12,394,355 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8048 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067485-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.