Strain Name:
C57BL/6J-MtgxR8050Btlr/Mmmh
Stock Number:
067487-MU
Citation ID:
RRID:MMRRC_067487-MU
Other Names:
R8050 (G1)
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Myo5a
Name: myosin VA
Synonyms: 9630007J19Rik, Myo5, MyoVA, Dbv, flail, MVa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Stam2
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: 1200004O12Rik, 5730456G07Rik, Hbp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56324
Homologene: 68490
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Usp1
Name: ubiquitin specific peptidase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230484
Homologene: 2528
Nbea
Name: neurobeachin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Cipp, Inadl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12695
Homologene: 72199
Bnc2
Name: basonuclin zinc finger protein 2
Synonyms: 5031434M05Rik, 8430420F16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242509
Homologene: 18243
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66185
Homologene: 41043
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17847
Homologene: 40978
E130308A19Rik
Name: RIKEN cDNA E130308A19 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230259
Homologene: 136157
Hsf1
Name: heat shock factor 1
Synonyms: heat shock transcription factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15499
VEGA: 15
HGNC: HGNC:5224
Homologene: 74556
Tacc1
Name: transforming, acidic coiled-coil containing protein 1
Synonyms: 4833447E04Rik, Tacc1, B230378H13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320165
Homologene: 4575
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: Solo, 6720464I07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Zp3
Name: zona pellucida glycoprotein 3
Synonyms: Zp-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22788
Homologene: 5178
Bnip3l
Name: BCL2/adenovirus E1B interacting protein 3-like
Synonyms: D14Ertd719e, Nip3L, Nix
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12177
HGNC: HGNC:1085
Homologene: 3195
Zfp931
Name: zinc finger protein 931
Synonyms: 2810021G02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 353208
Homologene: 136272
Btnl9
Name: butyrophilin-like 9
Synonyms: D330012D11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237754
Homologene: 68540
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216766
Homologene: 9155
Eif1ad8
Name: eukaryotic translation initiation factor 1A domain containing 8
Synonyms: Gm8300
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 666806
Homologene: 103865
Esrp1
Name: epithelial splicing regulatory protein 1
Synonyms: Rbm35a, 2210008M09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 207920
Homologene: 9785
Spp1
Name: secreted phosphoprotein 1
Synonyms: Ric, bone sialoprotein 1, 44kDa bone phosphoprotein, osteopontin, Opnl, BNSP, ETA-1, Opn, osteopontin-like protein, minopontin, OP, 2ar, Spp-1, Apl-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20750
Homologene: 20156
Fabp1
Name: fatty acid binding protein 1, liver
Synonyms: L-FABP, Fabpl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14080
HGNC: HGNC:3555
Homologene: 1106
Hps3
Name: HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Synonyms: Hermansky-Pudlak syndrome 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12807
Homologene: 13019
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: 3110001A05Rik, A230065J02Rik, Ugcgl2, 1810064L21Rik, 3110027P15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66435
Homologene: 56875
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213262
Homologene: 10584
Enpep
Name: glutamyl aminopeptidase
Synonyms: 6030431M22Rik, Bp-1/6C3, Ly51, aminopeptidase-A, Ly-51, APA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Pcyt2
Name: phosphate cytidylyltransferase 2, ethanolamine
Synonyms: 1110033E03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68671
HGNC: HGNC:8756
Homologene: 2143
Dnase1
Name: deoxyribonuclease I
Synonyms: Dnl1, DNaseI
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13419
HGNC: HGNC:2956
Homologene: 3826
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Fa2h
Name: fatty acid 2-hydroxylase
Synonyms: G630055L08Rik, Faxdc1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 338521
Homologene: 56284
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Vmn2r3
Name: vomeronasal 2, receptor 3
Synonyms: EG637004
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 637004
Kif9
Name: kinesin family member 9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16578
Homologene: 65620
Cdhr2
Name: cadherin-related family member 2
Synonyms: LOC268663, Pcdh24
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268663
Homologene: 134510
Tbx3
Name: T-box 3
Synonyms: D5Ertd189e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21386
Homologene: 4371
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235505
Homologene: 25183
Arhgef38
Name: Rho guanine nucleotide exchange factor 38
Synonyms: D630013G24Rik, 9130221D24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77669
Homologene: 137396
Ecsit
Name: ECSIT signalling integrator
Synonyms: Sitpec
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26940
Homologene: 8080
Dgkb
Name: diacylglycerol kinase, beta
Synonyms: C630029D13Rik, DGK-beta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217480
VEGA: 12
HGNC: HGNC:2850
Homologene: 37875
Serpinb1c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 1c
Synonyms: ovalbumin, EIC
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380839
HGNC: HGNC:3311
Homologene: 137840
Bbof1
Name: basal body orientation factor 1
Synonyms: Ccdc176, 2900006K08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72873
Homologene: 75215
Pappa2
Name: pappalysin 2
Synonyms: PAPP-A2, placenta-specific 3, pregnancy-associated plasma protein-E, pregnancy-associated plasma preproprotein-A2, PLAC3, Pappe
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23850
Homologene: 10661
Mmut
Name: methylmalonyl-Coenzyme A mutase
Synonyms: Mut, D230010K02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17850
VEGA: 17
HGNC: HGNC:7526
Homologene: 20097
Slc22a27
Name: solute carrier family 22, member 27
Synonyms: mOAT6 related protein, AB056442
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 171405
Homologene: 77136
Kbtbd3
Name: kelch repeat and BTB (POZ) domain containing 3
Synonyms: Bklhd3, 2200003A07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69149
Homologene: 12300
Qrsl1
Name: glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Synonyms: GatA, 2700038P16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76563
Homologene: 6699
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: 4932408B21Rik, Trs4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214704
Homologene: 44790
Or7e178
Name: olfactory receptor family 7 subfamily E member 178
Synonyms: GA_x6K02T2PVTD-14054886-14053957, Olfr18, MOR145-1, MTPCR34
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18315
HGNC: HGNC:8396
Homologene: 138313
Kif28
Name: kinesin family member 28
Synonyms: Gm1305, LOC383592
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383592
Homologene: 130945
Opcml
Name: opioid binding protein/cell adhesion molecule-like
Synonyms: Obcam, B930023M13Rik, LOC235104, 2900075O15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330908
HGNC: HGNC:8143
Homologene: 55663
Klhl18
Name: kelch-like 18
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270201
Homologene: 14805
Or2g7
Name: olfactory receptor family 2 subfamily G member 7
Synonyms: GA_x6K02T2PSCP-2515350-2516303, Olfr130, MOR256-19
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258480
Homologene: 105876
Asb7
Name: ankyrin repeat and SOCS box-containing 7
Synonyms: Asb-7, D030055C23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 117589
Homologene: 34130
Psme1
Name: proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
Synonyms: PA28a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19186
HGNC: HGNC:9568
Homologene: 4560
Parp12
Name: poly (ADP-ribose) polymerase family, member 12
Synonyms: Zc3hdc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243771
Homologene: 11236
Pcyox1
Name: prenylcysteine oxidase 1
Synonyms: Pcly, PCL1, 1200015P13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66881
Homologene: 9458
Kctd20
Name: potassium channel tetramerisation domain containing 20
Synonyms: D17Ertd562e, 2410004N11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66989
Homologene: 12063
Bin1
Name: bridging integrator 1
Synonyms: Amphl, Amphiphysin 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 30948
VEGA: 18
HGNC: HGNC:1052
Homologene: 113707
Prl3d1
Name: prolactin family 3, subfamily d, member 1
Synonyms: PL-Ia, Csh1, Pl-1, Pl1, prolactin-like 2, placental lactogen 1, mPL-I
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18775
Homologene: 137215
2410002F23Rik
Name: RIKEN cDNA 2410002F23 gene
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668661
Homologene: 105477
Tmem233
Name: transmembrane protein 233
Synonyms: Gm13843
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 545798
Homologene: 54444
Napepld
Name: N-acyl phosphatidylethanolamine phospholipase D
Synonyms: NAPE-PLD
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242864
Homologene: 7094
Or2r11
Name: olfactory receptor family 2 subfamily R member 11
Synonyms: Olfr458, GA_x6K02T2P3E9-5100053-5100994, MOR257-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258436
Homologene: 133704
H2bc8
Name: H2B clustered histone 8
Synonyms: Hist1h2bg
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319181
Homologene: 136774
Igkv3-2
Name: immunoglobulin kappa variable 3-2
Synonyms: V(kappa)21A
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 626583
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 158,848,400 bp
  • C to T, chromosome 1 at 179,709,449 bp
  • T to A, chromosome 2 at 52,221,726 bp
  • T to A, chromosome 2 at 52,719,773 bp
  • T to C, chromosome 2 at 178,068,096 bp
  • T to C, chromosome 3 at 20,003,328 bp
  • A to G, chromosome 3 at 55,987,981 bp
  • A to T, chromosome 3 at 64,271,293 bp
  • T to A, chromosome 3 at 76,707,503 bp
  • A to T, chromosome 3 at 129,305,516 bp
  • T to A, chromosome 3 at 133,137,562 bp
  • A to T, chromosome 4 at 11,338,767 bp
  • T to A, chromosome 4 at 11,528,643 bp
  • T to C, chromosome 4 at 59,719,767 bp
  • C to A, chromosome 4 at 84,292,336 bp
  • C to A, chromosome 4 at 98,538,964 bp
  • A to G, chromosome 4 at 98,928,913 bp
  • C to A, chromosome 5 at 21,665,321 bp
  • T to A, chromosome 5 at 104,440,414 bp
  • G to T, chromosome 5 at 116,083,082 bp
  • A to G, chromosome 5 at 119,683,067 bp
  • T to A, chromosome 5 at 135,982,750 bp
  • T to A, chromosome 6 at 24,503,785 bp
  • T to A, chromosome 6 at 39,089,104 bp
  • A to T, chromosome 6 at 42,460,830 bp
  • T to A, chromosome 6 at 70,699,004 bp
  • G to A, chromosome 6 at 71,199,972 bp
  • T to A, chromosome 6 at 86,389,146 bp
  • T to A, chromosome 7 at 44,251,253 bp
  • T to A, chromosome 7 at 66,679,184 bp
  • T to C, chromosome 8 at 25,169,214 bp
  • T to A, chromosome 8 at 111,348,185 bp
  • A to T, chromosome 9 at 4,330,408 bp
  • C to T, chromosome 9 at 20,314,645 bp
  • C to T, chromosome 9 at 22,076,296 bp
  • T to C, chromosome 9 at 28,813,344 bp
  • T to A, chromosome 9 at 75,181,946 bp
  • T to C, chromosome 9 at 78,664,351 bp
  • A to T, chromosome 9 at 88,840,337 bp
  • T to C, chromosome 9 at 110,428,761 bp
  • T to C, chromosome 9 at 110,519,140 bp
  • G to A, chromosome 10 at 43,874,635 bp
  • A to G, chromosome 10 at 58,479,619 bp
  • A to G, chromosome 11 at 23,446,787 bp
  • A to G, chromosome 11 at 49,175,615 bp
  • G to A, chromosome 11 at 58,128,860 bp
  • T to C, chromosome 11 at 120,610,939 bp
  • G to A, chromosome 12 at 38,124,217 bp
  • G to A, chromosome 12 at 84,411,217 bp
  • G to A, chromosome 12 at 87,517,141 bp
  • T to C, chromosome 13 at 23,571,667 bp
  • T to A, chromosome 13 at 27,100,028 bp
  • T to A, chromosome 13 at 32,882,069 bp
  • G to A, chromosome 13 at 54,734,222 bp
  • T to C, chromosome 13 at 81,413,177 bp
  • A to T, chromosome 14 at 55,579,599 bp
  • A to G, chromosome 14 at 66,989,202 bp
  • A to T, chromosome 14 at 119,026,422 bp
  • A to G, chromosome 15 at 27,891,454 bp
  • T to A, chromosome 15 at 76,498,281 bp
  • A to T, chromosome 16 at 4,037,997 bp
  • A to T, chromosome 17 at 24,565,643 bp
  • G to T, chromosome 17 at 28,952,758 bp
  • T to C, chromosome 17 at 38,067,479 bp
  • T to A, chromosome 17 at 40,943,893 bp
  • T to G, chromosome 18 at 32,406,145 bp
  • A to T, chromosome 19 at 7,880,167 bp
  • T to C, chromosome 19 at 29,298,332 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8050 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067487-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.