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Strain Name:
C57BL/6J-MtgxR8056Btlr/Mmmh
Stock Number:
067493-MU
Citation ID:
RRID:MMRRC_067493-MU
Other Names:
R8056 (G1)
Major Collection:

Strain Information

Msx1
Name: msh homeobox 1
Synonyms: Hox7, Hox7.1, muscle-segment homeobox, msh, Hox-7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17701
HGNC: HGNC:7391
Homologene: 1836
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, beta-MHC, B-MHC, MYH-beta/slow, MyHC-I, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Neurog1
Name: neurogenin 1
Synonyms: neurogenin, Math4C, ngn1, neurogenin 1, Neurod3, bHLHa6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18014
VEGA: 13
HGNC: HGNC:7764
Homologene: 4490
Bmerb1
Name: bMERB domain containing 1
Synonyms: MINP, 2900011O08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67254
Homologene: 13236
Topors
Name: topoisomerase I binding, arginine/serine-rich
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 106021
Homologene: 4237
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LRP7, LR3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16973
HGNC: HGNC:6697
Homologene: 1746
Plxdc1
Name: plexin domain containing 1
Synonyms: Tem7, 2410003I07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72324
Homologene: 10700
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 66,415,620 bp
  • C to T, chromosome 1 at 78,681,894 bp
  • G to C, chromosome 1 at 93,054,701 bp
  • G to A, chromosome 2 at 11,743,630 bp
  • A to G, chromosome 2 at 26,007,897 bp
  • C to A, chromosome 2 at 76,948,230 bp
  • A to T, chromosome 2 at 93,956,675 bp
  • A to G, chromosome 2 at 142,712,842 bp
  • G to C, chromosome 2 at 153,330,059 bp
  • A to T, chromosome 3 at 62,488,591 bp
  • A to C, chromosome 3 at 145,314,164 bp
  • A to G, chromosome 4 at 19,532,426 bp
  • T to C, chromosome 4 at 40,262,221 bp
  • A to G, chromosome 4 at 63,359,357 bp
  • C to T, chromosome 4 at 86,342,032 bp
  • A to G, chromosome 4 at 86,844,976 bp
  • A to G, chromosome 4 at 112,715,813 bp
  • G to A, chromosome 4 at 140,702,275 bp
  • A to G, chromosome 4 at 156,170,411 bp
  • A to T, chromosome 5 at 3,565,744 bp
  • G to A, chromosome 5 at 37,824,200 bp
  • A to C, chromosome 5 at 65,294,093 bp
  • T to C, chromosome 5 at 93,167,576 bp
  • A to G, chromosome 5 at 96,744,774 bp
  • A to C, chromosome 5 at 119,853,613 bp
  • T to A, chromosome 5 at 120,520,617 bp
  • T to C, chromosome 5 at 142,992,861 bp
  • T to C, chromosome 5 at 150,569,306 bp
  • C to T, chromosome 6 at 35,268,952 bp
  • A to T, chromosome 6 at 43,217,044 bp
  • T to A, chromosome 6 at 70,193,722 bp
  • G to A, chromosome 6 at 125,171,043 bp
  • A to T, chromosome 7 at 3,912,552 bp
  • C to T, chromosome 7 at 4,124,623 bp
  • G to T, chromosome 7 at 25,290,941 bp
  • T to C, chromosome 7 at 26,385,687 bp
  • A to G, chromosome 7 at 118,160,366 bp
  • A to G, chromosome 8 at 22,129,343 bp
  • G to T, chromosome 8 at 70,772,367 bp
  • G to A, chromosome 8 at 94,860,267 bp
  • A to G, chromosome 8 at 105,890,484 bp
  • A to T, chromosome 8 at 106,424,480 bp
  • A to T, chromosome 8 at 119,603,463 bp
  • T to C, chromosome 9 at 79,599,938 bp
  • A to G, chromosome 9 at 103,266,224 bp
  • T to C, chromosome 9 at 108,105,307 bp
  • A to G, chromosome 9 at 122,851,967 bp
  • T to A, chromosome 10 at 41,481,172 bp
  • G to A, chromosome 10 at 129,473,192 bp
  • T to C, chromosome 11 at 49,020,082 bp
  • T to A, chromosome 11 at 50,985,541 bp
  • T to C, chromosome 11 at 63,083,959 bp
  • T to A, chromosome 11 at 97,978,517 bp
  • C to A, chromosome 11 at 103,697,704 bp
  • A to G, chromosome 11 at 104,909,070 bp
  • T to C, chromosome 11 at 121,245,344 bp
  • A to T, chromosome 12 at 103,817,878 bp
  • C to G, chromosome 13 at 21,369,322 bp
  • T to C, chromosome 13 at 21,958,838 bp
  • T to A, chromosome 13 at 22,328,218 bp
  • G to T, chromosome 13 at 56,251,410 bp
  • T to C, chromosome 13 at 92,030,813 bp
  • G to A, chromosome 14 at 54,973,319 bp
  • T to C, chromosome 15 at 83,836,462 bp
  • C to A, chromosome 15 at 96,414,817 bp
  • T to A, chromosome 16 at 14,038,316 bp
  • T to C, chromosome 16 at 16,213,400 bp
  • T to A, chromosome 16 at 93,845,176 bp
  • T to C, chromosome 17 at 40,828,788 bp
  • T to C, chromosome 17 at 65,717,508 bp
  • C to A, chromosome 17 at 71,803,592 bp
  • C to T, chromosome 17 at 81,647,923 bp
  • A to G, chromosome 18 at 56,594,691 bp
  • A to G, chromosome 19 at 3,597,337 bp
  • A to C, chromosome 19 at 10,676,797 bp
  • A to G, chromosome 19 at 39,142,041 bp
  • T to C, chromosome 19 at 46,670,591 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8056 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067493-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.