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Strain Name:
C57BL/6J-MtgxR8061Btlr/Mmmh
Stock Number:
067497-MU
Citation ID:
RRID:MMRRC_067497-MU
Other Names:
R8061 (G1)
Major Collection:

Strain Information

Mitf
Name: melanogenesis associated transcription factor
Synonyms: mi, wh, BCC2, bHLHe32, Gsfbcc2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17342
HGNC: HGNC:7105
Homologene: 4892
Myo5a
Name: myosin VA
Synonyms: MVa, MyoVA, Myo5, flail, 9630007J19Rik, Dbv
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: 1110006F08Rik, D12Ertd7e, Dicer1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, beta-MHC, B-MHC, MYH-beta/slow, MyHC-I, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Chrm1
Name: cholinergic receptor, muscarinic 1, CNS
Synonyms: M1, muscarinic acetylcholine receptor 1, Chrm-1, M1R, AW495047
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12669
HGNC: HGNC:1950
Homologene: 20189
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 65,343,501 bp
  • C to T, chromosome 1 at 87,596,911 bp
  • C to T, chromosome 1 at 119,691,600 bp
  • G to A, chromosome 1 at 158,504,350 bp
  • C to T, chromosome 1 at 183,087,587 bp
  • C to T, chromosome 2 at 3,409,203 bp
  • T to A, chromosome 2 at 66,692,594 bp
  • T to C, chromosome 2 at 120,344,211 bp
  • T to C, chromosome 2 at 128,648,488 bp
  • A to T, chromosome 2 at 135,346,396 bp
  • T to C, chromosome 3 at 86,813,674 bp
  • T to C, chromosome 3 at 89,946,220 bp
  • T to C, chromosome 3 at 92,456,877 bp
  • T to A, chromosome 3 at 109,111,045 bp
  • A to G, chromosome 3 at 155,087,266 bp
  • A to G, chromosome 4 at 43,422,492 bp
  • A to T, chromosome 4 at 62,191,428 bp
  • G to A, chromosome 4 at 156,178,954 bp
  • T to A, chromosome 5 at 44,480,270 bp
  • G to A, chromosome 5 at 115,117,651 bp
  • T to A, chromosome 5 at 137,436,631 bp
  • A to G, chromosome 6 at 43,346,844 bp
  • A to C, chromosome 6 at 97,993,298 bp
  • C to A, chromosome 6 at 120,492,103 bp
  • A to G, chromosome 7 at 96,852,456 bp
  • A to G, chromosome 7 at 101,503,972 bp
  • A to T, chromosome 7 at 102,098,249 bp
  • A to T, chromosome 7 at 118,152,387 bp
  • C to T, chromosome 7 at 134,772,323 bp
  • C to T, chromosome 7 at 143,702,724 bp
  • A to C, chromosome 8 at 64,758,223 bp
  • A to G, chromosome 8 at 70,708,575 bp
  • A to G, chromosome 8 at 95,765,027 bp
  • A to G, chromosome 9 at 8,042,671 bp
  • A to G, chromosome 9 at 15,045,001 bp
  • T to A, chromosome 9 at 75,122,957 bp
  • T to G, chromosome 9 at 86,521,193 bp
  • T to C, chromosome 9 at 95,405,171 bp
  • A to G, chromosome 9 at 123,459,497 bp
  • T to C, chromosome 10 at 11,212,333 bp
  • T to C, chromosome 10 at 22,819,863 bp
  • G to A, chromosome 11 at 5,061,785 bp
  • A to G, chromosome 11 at 30,998,447 bp
  • A to G, chromosome 11 at 58,902,747 bp
  • A to T, chromosome 11 at 74,083,514 bp
  • A to T, chromosome 11 at 105,106,449 bp
  • T to A, chromosome 12 at 9,034,953 bp
  • A to T, chromosome 12 at 11,261,076 bp
  • G to T, chromosome 12 at 12,362,027 bp
  • G to A, chromosome 12 at 104,702,818 bp
  • A to G, chromosome 12 at 116,426,577 bp
  • C to A, chromosome 13 at 22,395,283 bp
  • T to C, chromosome 13 at 67,620,089 bp
  • A to T, chromosome 13 at 70,603,732 bp
  • T to A, chromosome 13 at 89,657,290 bp
  • T to C, chromosome 13 at 100,828,911 bp
  • A to G, chromosome 14 at 54,990,941 bp
  • T to C, chromosome 15 at 59,651,555 bp
  • T to C, chromosome 15 at 97,761,520 bp
  • T to C, chromosome 16 at 18,411,290 bp
  • T to C, chromosome 16 at 91,617,170 bp
  • T to C, chromosome 16 at 93,749,996 bp
  • G to A, chromosome 17 at 17,443,676 bp
  • T to C, chromosome 17 at 34,905,927 bp
  • T to C, chromosome 17 at 35,161,186 bp
  • A to G, chromosome 17 at 37,169,901 bp
  • C to T, chromosome 18 at 20,032,274 bp
  • T to A, chromosome 18 at 22,524,243 bp
  • G to A, chromosome 18 at 48,047,658 bp
  • T to C, chromosome 19 at 8,679,154 bp
  • G to A, chromosome 19 at 46,740,543 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8061 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067497-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.