Strain Name:
C57BL/6J-MtgxR8130Btlr/Mmmh
Stock Number:
067559-MU
Citation ID:
RRID:MMRRC_067559-MU
Other Names:
R8130 (G1)
Major Collection:

Strain Information

Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Zfp934
Name: zinc finger protein 934
Synonyms: 6720457D02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77117
VEGA: 13
Arfgef2
Name: ADP ribosylation factor guanine nucleotide exchange factor 2
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99371
Homologene: 111880
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Taok1
Name: TAO kinase 1
Synonyms: D130018F14Rik, 2810468K05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216965
Homologene: 27041
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103554
Homologene: 113742
Armc8
Name: armadillo repeat containing 8
Synonyms: HSPC056, 1200015K23Rik, Gid5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74125
Homologene: 9121
Nploc4
Name: NPL4 homolog, ubiquitin recognition factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217365
Homologene: 5403
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki67, Ki-67, D630048A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Nemf
Name: nuclear export mediator factor
Synonyms: 4933405E14Rik, Sdccag1, 1500011I12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66244
VEGA: 12
Homologene: 3458
Cemip
Name: cell migration inducing protein, hyaluronan binding
Synonyms: Hybid, 6330404C01Rik, 12H19.01.T7, 9930013L23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80982
Homologene: 10268
Lpin1
Name: lipin 1
Synonyms: Lipin1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14245
VEGA: 12
Homologene: 9266
Usp8
Name: ubiquitin specific peptidase 8
Synonyms: Ubpy
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 84092
Homologene: 3782
1700123K08Rik
Name: RIKEN cDNA 1700123K08 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76658
Homologene: 86127
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Kdm5d
Name: lysine demethylase 5D
Synonyms: Jarid1d, Smcy, HY
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 20592
Homologene: 55838
Cdh8
Name: cadherin 8
Synonyms: cad8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12564
HGNC: HGNC:1767
Homologene: 55604
Gm4847
Name: predicted gene 4847
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226604
Homologene: 101040
Ormdl1
Name: ORM1-like 1 (S. cerevisiae)
Synonyms: C730042F17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227102
Homologene: 41135
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Il17ra
Name: interleukin 17 receptor A
Synonyms: Il17r, VDw217
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16172
HGNC: HGNC:5985
Homologene: 7378
Ctrb1
Name: chymotrypsinogen B1
Synonyms: 2200008D09Rik, Prt-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66473
Homologene: 88564
Zfp329
Name: zinc finger protein 329
Synonyms: 2810439M05Rik, 4632409L22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67230
Homologene: 23459
Mndal
Name: myeloid nuclear differentiation antigen like
Synonyms: Ifi212
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040462
HGNC: HGNC:5395
Homologene: 115929
Necab1
Name: N-terminal EF-hand calcium binding protein 1
Synonyms: 1700003H21Rik, STIP-1, Efcbp1, NECAB1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69352
Homologene: 11172
Speg
Name: SPEG complex locus
Synonyms: D1Bwg1450e, BPEG, Apeg1, SPEG, SPEGalpha, SPEGbeta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
I830077J02Rik
Name: RIKEN cDNA I830077J02 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433638
Homologene: 45482
Col15a1
Name: collagen, type XV, alpha 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12819
HGNC: HGNC:2192
Homologene: 1396
Mmrn1
Name: multimerin 1
Synonyms: Emilin4, 4921530G03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70945
HGNC: HGNC:7178
Homologene: 49134
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72277
F830016B08Rik
Name: RIKEN cDNA F830016B08 gene
Synonyms: Ifgga4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240328
VEGA: 18
Homologene: 129714
Dpep1
Name: dipeptidase 1
Synonyms: MBD
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13479
HGNC: HGNC:3002
Homologene: 80192
Kcnip3
Name: Kv channel interacting protein 3, calsenilin
Synonyms: 4933407H12Rik, DREAM, Csen, R74849, KChIP3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56461
Homologene: 8382
Slc22a18
Name: solute carrier family 22 (organic cation transporter), member 18
Synonyms: Impt1, BWSCR1A, IMPT1, TSSC5, Slc22a1l, Orctl2, BWR1A, p45-BWR1A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18400
Homologene: 1918
Ttll6
Name: tubulin tyrosine ligase-like family, member 6
Synonyms: D11Moh44e, 4932418K24Rik, D11Moh43e, t8130b59
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237930
Homologene: 18229
Abcb10
Name: ATP-binding cassette, sub-family B member 10
Synonyms: ABC-me
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56199
HGNC: HGNC:41
Homologene: 6474
Matcap1
Name: microtubule associated tyrosine carboxypeptidase 1
Synonyms: MATCAP, 4931428F04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74356
Homologene: 47588
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: pheromone recepter, V2rf2, EC1-VR2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216144
Homologene: 83483
Repin1
Name: replication initiator 1
Synonyms: AP4, E430037F08Rik, Zfp464
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
Or8k24
Name: olfactory receptor family 8 subfamily K member 24
Synonyms: Olfr1058, MOR190-2, GA_x6K02T2Q125-47855818-47854868
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258386
Homologene: 74093
Zfp119a
Name: zinc finger protein 119a
Synonyms: Zfp119, Mzf13
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 104349
Or4k44
Name: olfactory receptor family 4 subfamily K member 44
Synonyms: GA_x6K02T2Q125-72589785-72588847, Olfr1294, MOR248-7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258887
Homologene: 74216
4921539E11Rik
Name: RIKEN cDNA 4921539E11 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70941
Homologene: 52843
Ldlrad1
Name: low density lipoprotein receptor class A domain containing 1
Synonyms: OTTMUSG00000008594
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546840
Homologene: 54473
Caps2
Name: calcyphosphine 2
Synonyms: D630005B03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353025
Homologene: 72278
Gcm1
Name: glial cells missing homolog 1
Synonyms: glial cell deficient, Gcm 1, Gcm a, Gcm1-rs1, glide, GCMa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14531
VEGA: 9
HGNC: HGNC:4197
Homologene: 2702
Or5aq1b
Name: olfactory receptor family 5 subfamily AQ member 1B
Synonyms: GA_x6K02T2Q125-48565383-48564445, Olfr1107, MOR172-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258841
Homologene: 131138
Disp1
Name: dispatched RND transporter family member 1
Synonyms: DispA, 1190008H24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68897
Homologene: 14133
Krtap9-20
Name: keratin associated protein 9-20
Synonyms: Gm11559
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100415785
Homologene: 136354
Psmb3
Name: proteasome (prosome, macropain) subunit, beta type 3
Synonyms: C10-II
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26446
HGNC: HGNC:9540
Homologene: 2089
Hypk
Name: huntingtin interacting protein K
Synonyms: 2310003F16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67693
Homologene: 9498
Cmtm1
Name: CKLF-like MARVEL transmembrane domain containing 1
Synonyms: CHLFH1a, CKLFH1, Cklfsf1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100504164
Homologene: 134399
Krtap19-2
Name: keratin associated protein 19-2
Synonyms: Krtap16-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 170651
VEGA: 16
Igkv4-86
Name: immunoglobulin kappa variable 4-86
Synonyms: LOC243451
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243451
Kif19b
Name: kinesin family member 19B
Synonyms: Gm4869
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 101055939
Homologene: 82478
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 53,298,980 bp
  • T to A, chromosome 1 at 75,415,596 bp
  • C to T, chromosome 1 at 166,638,348 bp
  • T to A, chromosome 1 at 173,871,545 bp
  • T to C, chromosome 1 at 183,135,635 bp
  • T to A, chromosome 2 at 86,385,567 bp
  • T to C, chromosome 2 at 87,071,226 bp
  • A to T, chromosome 2 at 111,537,480 bp
  • A to G, chromosome 2 at 121,456,378 bp
  • A to T, chromosome 2 at 126,717,998 bp
  • C to T, chromosome 2 at 127,510,908 bp
  • T to A, chromosome 2 at 166,836,250 bp
  • C to T, chromosome 3 at 105,926,917 bp
  • A to T, chromosome 4 at 15,005,073 bp
  • C to T, chromosome 4 at 47,312,196 bp
  • T to C, chromosome 4 at 103,235,698 bp
  • G to A, chromosome 4 at 107,209,491 bp
  • A to T, chromosome 5 at 93,636,738 bp
  • T to C, chromosome 5 at 138,563,009 bp
  • C to T, chromosome 5 at 140,474,961 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • A to T, chromosome 6 at 60,960,723 bp
  • T to C, chromosome 6 at 68,910,666 bp
  • G to A, chromosome 6 at 84,137,376 bp
  • A to G, chromosome 6 at 120,478,455 bp
  • C to A, chromosome 7 at 12,810,386 bp
  • T to C, chromosome 7 at 83,947,176 bp
  • C to T, chromosome 7 at 135,697,564 bp
  • T to C, chromosome 7 at 141,647,087 bp
  • G to A, chromosome 7 at 143,499,174 bp
  • A to T, chromosome 8 at 99,031,044 bp
  • C to A, chromosome 8 at 104,309,456 bp
  • G to A, chromosome 8 at 105,285,513 bp
  • A to G, chromosome 8 at 111,689,191 bp
  • T to C, chromosome 8 at 123,200,226 bp
  • C to T, chromosome 8 at 123,965,018 bp
  • T to A, chromosome 9 at 78,064,534 bp
  • C to T, chromosome 9 at 99,551,547 bp
  • A to T, chromosome 10 at 77,074,450 bp
  • T to A, chromosome 10 at 79,274,704 bp
  • A to T, chromosome 10 at 112,182,476 bp
  • T to A, chromosome 11 at 30,842,026 bp
  • C to A, chromosome 11 at 59,124,613 bp
  • G to A, chromosome 11 at 77,579,833 bp
  • T to C, chromosome 11 at 96,156,599 bp
  • A to G, chromosome 11 at 97,703,897 bp
  • A to G, chromosome 11 at 99,864,590 bp
  • A to G, chromosome 11 at 120,389,414 bp
  • A to T, chromosome 12 at 16,579,964 bp
  • A to T, chromosome 12 at 69,356,052 bp
  • C to A, chromosome 13 at 62,520,171 bp
  • CGG to CG, chromosome 15 at 99,944,033 bp
  • C to T, chromosome 16 at 88,874,015 bp
  • A to T, chromosome 17 at 55,865,971 bp
  • A to G, chromosome 18 at 60,299,980 bp
  • T to A, chromosome Y at 940,658 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8130 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067559-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.