Strain Name:
C57BL/6J-MtgxR8205Btlr/Mmmh
Stock Number:
067628-MU
Citation ID:
RRID:MMRRC_067628-MU
Other Names:
R8205 (G1)
Major Collection:

Strain Information

Aldh7a1
Name: aldehyde dehydrogenase family 7, member A1
Synonyms: D18Wsu181e, Atq1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 110695
HGNC: HGNC:877
Homologene: 913
Dst
Name: dystonin
Synonyms: A830042E19Rik, nmf339, bullous pemphigoid antigen 1, Bpag1, 2310001O04Rik, Bpag, Macf2, BPAG1, BPAG1-n, athetoid, bullous pemphigoid antigen 1, ah, nmf203
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
Synonyms: site-1 protease, S1P, 0610038M03Rik, subtilisin/kexin isozyme-1, SKI-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56453
Homologene: 2808
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 9630045K08Rik, 4733401D09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 52184
Homologene: 12011
Smad7
Name: SMAD family member 7
Synonyms: Madh7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17131
HGNC: HGNC:6773
Homologene: 4314
Brd7
Name: bromodomain containing 7
Synonyms: CELTIX1, BP75, bromodomain protein 75 kDa
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26992
Homologene: 8085
Sacm1l
Name: SAC1 suppressor of actin mutations 1-like (yeast)
Synonyms: SAC1, Sac1p
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83493
VEGA: 9
Homologene: 6320
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Tacc1
Name: transforming, acidic coiled-coil containing protein 1
Synonyms: 4833447E04Rik, Tacc1, B230378H13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320165
Homologene: 4575
Smap1
Name: small ArfGAP 1
Synonyms: 1700056O10Rik, 4921514B13Rik, 4921525H11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98366
Homologene: 134676
Trim2
Name: tripartite motif-containing 2
Synonyms: neural activity-related ring finger protein, narf
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80890
Homologene: 22882
Adamtsl1
Name: ADAMTS-like 1
Synonyms: 6720426B09Rik, 5930437A14Rik, punctin-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77739
Homologene: 64642
Eif4ebp2
Name: eukaryotic translation initiation factor 4E binding protein 2
Synonyms: PHAS-II, 2810011I19Rik, 4E-BP2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13688
VEGA: 10
HGNC: HGNC:3289
Homologene: 3022
Eif2a
Name: eukaryotic translation initiation factor 2A
Synonyms: D3Ertd194e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229317
HGNC: HGNC:3254
Homologene: 5969
Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms: LH2, D530025C14Rik, Plod-2, lysyl hydroxylase 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26432
HGNC: HGNC:9082
Homologene: 22681
Rnf6
Name: ring finger protein (C3H2C3 type) 6
Synonyms: 1200013I08Rik, 5730419H05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74132
Homologene: 14036
Glt1d1
Name: glycosyltransferase 1 domain containing 1
Synonyms: 5730455A04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319804
Homologene: 16965
Mex3a
Name: mex3 RNA binding family member A
Synonyms: 2700083E18Rik, Rkhd4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72640
Homologene: 18950
Gpatch8
Name: G patch domain containing 8
Synonyms: Gpatc8, ENSMUSG00000075516, 5430405G24Rik, Fbm1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237943
Homologene: 46117
Fgd3
Name: FYVE, RhoGEF and PH domain containing 3
Synonyms: ZFYVE5, 5830461L01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 30938
Homologene: 22925
Adgrd1
Name: adhesion G protein-coupled receptor D1
Synonyms: Gpr133, E230012M21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243277
Homologene: 34616
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy3, hyrh, hy-3, 1700034M11Rik, 4930545D19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Nlrp4a
Name: NLR family, pyrin domain containing 4A
Synonyms: Nalp4a, E330028A19Rik, Nalp-eta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243880
Homologene: 79696
Zbtb41
Name: zinc finger and BTB domain containing 41
Synonyms: 9830132G07Rik, 8430415N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226470
Homologene: 27795
Scgb2b26
Name: secretoglobin, family 2B, member 26
Synonyms: Abpbg26, C2d, Scgb2b4, Abpg, Abpbg4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110187
Homologene: 83171
Add2
Name: adducin 2
Synonyms: 2900072M03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11519
HGNC: HGNC:244
Homologene: 1221
Cracdl
Name: capping protein inhibiting regulator of actin like
Synonyms: 2010300C02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72097
Homologene: 19208
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Ptgfr
Name: prostaglandin F receptor
Synonyms: PGF, FP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19220
HGNC: HGNC:9600
Homologene: 741
Cap2
Name: cyclase associated actin cytoskeleton regulatory protein 2
Synonyms: 2810452G09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67252
Homologene: 101397
Pxdn
Name: peroxidasin
Synonyms: 2310075M15Rik, VPO1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69675
Homologene: 33907
Adam39
Name: a disintegrin and metallopeptidase domain 39
Synonyms: testase 9, 1700056P18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546055
HGNC: HGNC:199
Homologene: 128364
Col22a1
Name: collagen, type XXII, alpha 1
Synonyms: 2310067L16Rik, C80743
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69700
Homologene: 43567
Trav7-6
Name: T cell receptor alpha variable 7-6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213480
Or14j2
Name: olfactory receptor family 14 subfamily J member 2
Synonyms: GA_x6K02T2PSCP-2034880-2033942, MOR218-9, Olfr113
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258286
Tent5c
Name: terminal nucleotidyltransferase 5C
Synonyms: Fam46c, 4930431B09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74645
Homologene: 56783
Or1o11
Name: olfactory receptor family 1 subfamily O member 11
Synonyms: Olfr108, GA_x6K02T2PSCP-1893605-1894534, MOR156-5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258457
Homologene: 44985
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224552
Homologene: 115024
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209683
Homologene: 41023
Or4c104
Name: olfactory receptor family 4 subfamily C member 104
Synonyms: Olfr1199, GA_x6K02T2Q125-50231574-50230642, MOR230-8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258450
Homologene: 128092
Zfp109
Name: zinc finger protein 109
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56869
Steap4
Name: STEAP family member 4
Synonyms: Tiarp, Tnfaip9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 117167
Homologene: 36422
Tmem117
Name: transmembrane protein 117
Synonyms: B930062P21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320709
VEGA: 15
Homologene: 12992
Slfn5
Name: schlafen 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327978
Homologene: 18839
Ndufaf7
Name: NADH:ubiquinone oxidoreductase complex assembly factor 7
Synonyms: 2410091C18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73694
VEGA: 17
Homologene: 12508
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76074
Ankrd13d
Name: ankyrin repeat domain 13 family, member D
Synonyms: 0710001P18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68423
Homologene: 27612
Wfikkn1
Name: WAP, FS, Ig, KU, and NTR-containing protein 1
Synonyms: Gasp2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 215001
Homologene: 14244
Socs5
Name: suppressor of cytokine signaling 5
Synonyms: 1810018L08Rik, Cish5, SOCS-5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56468
VEGA: 17
Homologene: 10495
Slc1a7
Name: solute carrier family 1 (glutamate transporter), member 7
Synonyms: A930031E15Rik, EAAT5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242607
Homologene: 21327
Msantd5f1
Name: Myb/SANT DNA binding domain containing 5 family member 1
Synonyms: Gm428, LOC242502
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242502
Homologene: 128423
Crisp2
Name: cysteine-rich secretory protein 2
Synonyms: Tpx1, CRISP-2, GAPDL5, Tpx-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22024
Homologene: 37756
Mup2
Name: major urinary protein 2
Synonyms: Mup-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17841
Homologene: 74304
Gm4955
Name:
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 23,849,426 bp
  • T to G, chromosome 1 at 34,214,604 bp
  • T to C, chromosome 1 at 37,624,966 bp
  • T to A, chromosome 1 at 139,429,181 bp
  • T to C, chromosome 1 at 173,481,884 bp
  • A to T, chromosome 2 at 88,756,672 bp
  • A to C, chromosome 3 at 58,548,735 bp
  • C to A, chromosome 3 at 84,193,339 bp
  • T to C, chromosome 3 at 88,536,852 bp
  • A to G, chromosome 3 at 100,472,822 bp
  • A to G, chromosome 3 at 145,150,734 bp
  • A to G, chromosome 3 at 151,835,781 bp
  • T to A, chromosome 4 at 60,137,659 bp
  • G to A, chromosome 4 at 73,687,305 bp
  • A to G, chromosome 4 at 86,199,413 bp
  • A to G, chromosome 4 at 108,008,311 bp
  • A to T, chromosome 5 at 7,976,795 bp
  • T to A, chromosome 5 at 105,050,980 bp
  • A to G, chromosome 5 at 111,225,730 bp
  • A to G, chromosome 5 at 127,691,016 bp
  • A to G, chromosome 5 at 129,115,111 bp
  • A to G, chromosome 5 at 146,210,904 bp
  • A to G, chromosome 6 at 86,086,917 bp
  • G to A, chromosome 7 at 24,229,210 bp
  • A to G, chromosome 7 at 26,450,794 bp
  • T to C, chromosome 7 at 33,944,408 bp
  • G to A, chromosome 8 at 25,182,787 bp
  • T to C, chromosome 8 at 40,825,043 bp
  • A to G, chromosome 8 at 88,343,615 bp
  • A to T, chromosome 8 at 110,592,638 bp
  • A to G, chromosome 8 at 119,520,338 bp
  • G to T, chromosome 9 at 92,542,318 bp
  • G to A, chromosome 9 at 123,586,659 bp
  • A to T, chromosome 10 at 61,434,925 bp
  • T to A, chromosome 11 at 59,007,871 bp
  • T to C, chromosome 11 at 82,960,718 bp
  • T to C, chromosome 11 at 102,480,387 bp
  • T to G, chromosome 12 at 30,006,567 bp
  • T to A, chromosome 12 at 51,959,009 bp
  • T to C, chromosome 13 at 12,416,047 bp
  • G to A, chromosome 13 at 46,615,263 bp
  • T to C, chromosome 13 at 49,296,347 bp
  • G to A, chromosome 14 at 53,717,093 bp
  • A to T, chromosome 15 at 71,861,069 bp
  • G to A, chromosome 15 at 95,094,798 bp
  • T to C, chromosome 17 at 19,081,163 bp
  • T to A, chromosome 17 at 25,878,097 bp
  • T to C, chromosome 17 at 37,446,289 bp
  • A to T, chromosome 17 at 37,575,001 bp
  • T to C, chromosome 17 at 40,785,078 bp
  • G to A, chromosome 17 at 78,947,032 bp
  • G to T, chromosome 17 at 87,133,710 bp
  • A to T, chromosome 18 at 56,544,998 bp
  • C to A, chromosome 18 at 75,394,048 bp
  • A to T, chromosome 19 at 4,280,981 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8205 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067628-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.