Strain Name:
C57BL/6J-MtgxR8230Btlr/Mmmh
Stock Number:
067662-MU
Citation ID:
RRID:MMRRC_067662-MU
Other Names:
R8230 (G1)
Major Collection:

Strain Information

Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Etv1
Name: ets variant 1
Synonyms: ER81, Etsrp81
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14009
HGNC: HGNC:3490
Homologene: 3636
Mapk1
Name: mitogen-activated protein kinase 1
Synonyms: Prkm1, MAPK2, Erk2, p42mapk, 9030612K14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26413
HGNC: HGNC:6871
Homologene: 37670
F2r
Name: coagulation factor II thrombin receptor
Synonyms: thrombin receptor, Cf2r, protease-activated receptor 1, ThrR, Par1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14062
VEGA: 13
HGNC: HGNC:3537
Homologene: 1510
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, 4933425K22Rik, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Kat7
Name: K(lysine) acetyltransferase 7
Synonyms: Hboa, Myst2, Hbo1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217127
Homologene: 5134
Clasp2
Name: CLIP associating protein 2
Synonyms: 8030404L10Rik, CLASP2gamma, CLASP2beta, CLASP2, 1500004F14Rik, CLASP2alpha
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76499
VEGA: 9
Homologene: 24944
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Ccdc15
Name: coiled-coil domain containing 15
Synonyms: A630039F14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245902
VEGA: 9
Homologene: 28448
Lmnb2
Name: lamin B2
Synonyms: lamin B3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16907
HGNC: HGNC:6638
Homologene: 7818
Bcl6
Name: B cell leukemia/lymphoma 6
Synonyms: Bcl5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12053
HGNC: HGNC:1001
Homologene: 7640
Fbf1
Name: Fas binding factor 1
Synonyms: 1110033G01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217335
Homologene: 16531
Cbx3
Name: chromobox 3
Synonyms: HP1g, heterochromatin protein 1 gamma, M32
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12417
HGNC: HGNC:1553
Homologene: 40583
Ubxn7
Name: UBX domain protein 7
Synonyms: Ubxd7
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224111
VEGA: 16
Homologene: 45585
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: C730036B14Rik, D12Ertd364e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Zfp870
Name: zinc finger protein 870
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240066
VEGA: 17
Homologene: 48189
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, Itpr-3, tf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Baiap3
Name: BAI1-associated protein 3
Synonyms: LOC381076
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 545192
HGNC: HGNC:948
Homologene: 20844
Shf
Name: Src homology 2 domain containing F
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 435684
Homologene: 44524
Adam15
Name: ADAM metallopeptidase domain 15
Synonyms: MDC15, metargidin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11490
HGNC: HGNC:193
Homologene: 2829
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Ccdc127
Name: coiled-coil domain containing 127
Synonyms: 5430420E17Rik, 0610011N22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67433
Homologene: 11482
Tbx15
Name: T-box 15
Synonyms: Tbx14, de, Tbx8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21384
Homologene: 7967
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: mXin beta, myomaxin, 2310003D02Rik, Cmya3, 2310008C07Rik, A530024P18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Vsig8
Name: V-set and immunoglobulin domain containing 8
Synonyms: EG240916
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240916
Homologene: 18616
Actl7a
Name: actin-like 7a
Synonyms: t-actin 2, Tact2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11470
HGNC: HGNC:161
Homologene: 7613
Or56a4
Name: olfactory receptor family 56 subfamily A member 4
Synonyms: GA_x6K02T2PBJ9-7786441-7785503, Olfr684, MOR40-8P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244187
Homologene: 133596
Hic1
Name: hypermethylated in cancer 1
Synonyms: HIC-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15248
HGNC: HGNC:4909
Homologene: 4740
Plagl2
Name: pleiomorphic adenoma gene-like 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54711
HGNC: HGNC:9047
Homologene: 1994
Or5w13
Name: olfactory receptor family 5 subfamily W member 13
Synonyms: Olfr1136, MOR177-3, GA_x6K02T2Q125-49193051-49192119
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258653
Homologene: 74193
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: 5730435J12Rik, p96, D15Wsu122e, D630005B22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
Gm12790
Name: predicted gene 12790
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 115489970
Ntpcr
Name: nucleoside-triphosphatase, cancer-related
Synonyms: 2310079N02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66566
Homologene: 11989
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76074
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: Nope, 9330155G14Rik, WI-16786, WI-18508
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Ifit1
Name: interferon-induced protein with tetratricopeptide repeats 1
Synonyms: ISG56, Ifi56
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15957
Homologene: 22462
Aaas
Name: achalasia, adrenocortical insufficiency, alacrimia
Synonyms: D030041N15Rik, GL003, Aladin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223921
VEGA: 15
Homologene: 9232
Tapbpl
Name: TAP binding protein-like
Synonyms: TAPBPL-R
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213233
Homologene: 9958
Or10ag54
Name: olfactory receptor family 10 subfamily AG member 54
Synonyms: GA_x6K02T2Q125-48753766-48754734, Olfr1116-ps, Olfr1116, Olfr1521-ps1, MOR264-21P, MOR264-8P
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257875
Homologene: 134077
Vprbp
Name:
Type: Gene
Species: Mouse
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 172,561,511 bp
  • A to G, chromosome 2 at 31,344,473 bp
  • A to G, chromosome 2 at 67,515,665 bp
  • A to T, chromosome 2 at 87,269,201 bp
  • T to A, chromosome 2 at 87,693,361 bp
  • A to G, chromosome 2 at 122,349,487 bp
  • A to G, chromosome 2 at 153,232,319 bp
  • G to A, chromosome 3 at 89,345,610 bp
  • G to T, chromosome 3 at 99,351,989 bp
  • T to A, chromosome 4 at 56,743,768 bp
  • T to C, chromosome 4 at 101,968,083 bp
  • T to C, chromosome 5 at 90,243,976 bp
  • T to C, chromosome 5 at 105,050,869 bp
  • T to C, chromosome 6 at 51,475,301 bp
  • T to A, chromosome 6 at 125,226,721 bp
  • C to A, chromosome 7 at 78,250,770 bp
  • A to G, chromosome 7 at 105,157,424 bp
  • G to T, chromosome 8 at 125,737,420 bp
  • T to C, chromosome 9 at 37,315,259 bp
  • A to G, chromosome 9 at 65,122,738 bp
  • G to A, chromosome 9 at 66,470,316 bp
  • G to A, chromosome 9 at 106,858,715 bp
  • A to G, chromosome 9 at 113,892,414 bp
  • T to C, chromosome 10 at 74,355,875 bp
  • A to T, chromosome 10 at 80,905,148 bp
  • T to C, chromosome 11 at 75,165,585 bp
  • T to C, chromosome 11 at 95,277,589 bp
  • T to C, chromosome 11 at 116,146,739 bp
  • T to C, chromosome 12 at 38,780,936 bp
  • A to G, chromosome 12 at 65,102,650 bp
  • T to C, chromosome 13 at 74,360,632 bp
  • T to A, chromosome 13 at 95,604,739 bp
  • T to A, chromosome 15 at 6,422,343 bp
  • A to G, chromosome 15 at 102,338,469 bp
  • T to C, chromosome 16 at 17,026,066 bp
  • T to C, chromosome 16 at 23,972,902 bp
  • T to C, chromosome 16 at 32,375,276 bp
  • A to G, chromosome 17 at 25,246,853 bp
  • T to C, chromosome 17 at 27,107,737 bp
  • A to G, chromosome 17 at 32,883,689 bp
  • A to G, chromosome 19 at 34,647,668 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8230 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067662-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.