Strain Name:
C57BL/6J-MtgxR8273Btlr/Mmmh
Stock Number:
067696-MU
Citation ID:
RRID:MMRRC_067696-MU
Other Names:
R8273 (G1)
Major Collection:

Strain Information

Mbd5
Name: methyl-CpG binding domain protein 5
Synonyms: 9430004D19Rik, C030040A15Rik, OTTMUSG00000012483
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109241
Homologene: 81861
Wee1
Name: WEE 1 homolog 1 (S. pombe)
Synonyms: Wee1A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22390
Homologene: 31152
Usp28
Name: ubiquitin specific peptidase 28
Synonyms: 9830148O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235323
VEGA: 9
Homologene: 10840
Bend3
Name: BEN domain containing 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 331623
VEGA: 10
Homologene: 19511
Gtf2h1
Name: general transcription factor II H, polypeptide 1
Synonyms: p62, 62kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14884
HGNC: HGNC:4655
Homologene: 3885
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, mBSC2, Nkcc1, sy-ns
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Copa
Name: coatomer protein complex subunit alpha
Synonyms: xenin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12847
HGNC: HGNC:2230
Homologene: 3218
Rbbp6
Name: retinoblastoma binding protein 6, ubiquitin ligase
Synonyms: 4933422O15Rik, C030034J04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19647
HGNC: HGNC:9889
Homologene: 136812
Ccnk
Name: cyclin K
Synonyms: CPR4, CycK
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12454
VEGA: 12
HGNC: HGNC:1596
Homologene: 14748
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57908
Homologene: 22808
Scube2
Name: signal peptide, CUB domain, EGF-like 2
Synonyms: ICRFP703N2430Q5.1, ICRFP703B1614Q5.1, 4932442O19Rik, Cegf1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56788
Homologene: 36383
Gpr89
Name: G protein-coupled receptor 89
Synonyms: SH120, 4933412D19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67549
Homologene: 9475
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: D14Ertd171e, ELKS2alpha, CAST
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 238988
Homologene: 69188
Copg2
Name: coatomer protein complex, subunit gamma 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54160
HGNC: HGNC:2237
Homologene: 56292
Dync2i2
Name: dynein 2 intermediate chain 2
Synonyms: 3200002I06Rik, Wdr34
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71820
Homologene: 14156
Inpp4a
Name: inositol polyphosphate-4-phosphatase, type I
Synonyms: 107kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269180
HGNC: HGNC:6074
Homologene: 2871
Wnt5a
Name: wingless-type MMTV integration site family, member 5A
Synonyms: Wnt-5a, 8030457G12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22418
Homologene: 20720
Haus3
Name: HAUS augmin-like complex, subunit 3
Synonyms: D4S43h, D5H4S43, D5H4S43E
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231123
Homologene: 75209
St6galnac4
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
Synonyms: ST6GalNAc IV, Siat7d
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20448
Homologene: 7939
F7
Name: coagulation factor VII
Synonyms: FVII, Cf7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14068
HGNC: HGNC:3544
Homologene: 7710
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Pdzph1
Name: PDZ and pleckstrin homology domains 1
Synonyms: 2610034M16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69239
Homologene: 130756
Stc2
Name: stanniocalcin 2
Synonyms: mustc2, Stc2l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20856
Homologene: 2753
Nalcn
Name: sodium leak channel, non-selective
Synonyms: A530023G15Rik, Vgcnl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Klc4
Name: kinesin light chain 4
Synonyms: 1200014P03Rik, Knsl8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74764
VEGA: 17
Homologene: 12584
Nlrp9b
Name: NLR family, pyrin domain containing 9B
Synonyms: Nalp9b, Nalp-delta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243874
Homologene: 18530
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: Naptb, beta3B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Fmnl1
Name: formin-like 1
Synonyms: 8030453N10Rik, formin-related gene in leukocytes
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57778
HGNC: HGNC:1212
Homologene: 135620
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Atp13a4
Name: ATPase type 13A4
Synonyms: 4631413J11Rik, 9330174J19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224079
Homologene: 75330
Mtus2
Name: microtubule associated tumor suppressor candidate 2
Synonyms: 5730592G18Rik, A730013O20Rik, C130038G02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77521
Homologene: 78141
Or2w6
Name: olfactory receptor family 2 subfamily W member 6
Synonyms: GA_x6K02T2QHY8-11577590-11578528, MOR256-12, Olfr1361
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258534
Homologene: 88362
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Oaz3
Name: ornithine decarboxylase antizyme 3
Synonyms: ornithine decarboxylase antizyme in testis, Oaz-t, AZ-3, antizyme 3, AZ3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53814
HGNC: HGNC:8097
Homologene: 9410
F11
Name: coagulation factor XI
Synonyms: plasma thromboplastin antecedent, FXI, Cf11, 1600027G01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109821
HGNC: HGNC:3529
Homologene: 86654
Plxnc1
Name: plexin C1
Synonyms: vespr, 2510048K12Rik, CD232
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Ano2
Name: anoctamin 2
Synonyms: Tmem16b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243634
HGNC: HGNC:1183
Homologene: 23221
Ccdc57
Name: coiled-coil domain containing 57
Synonyms: 4933434G05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71276
Homologene: 52351
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 636808
Homologene: 43974
Smpdl3b
Name: sphingomyelin phosphodiesterase, acid-like 3B
Synonyms: 1110054A24Rik, Asml3b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100340
Homologene: 8708
Fbxl12
Name: F-box and leucine-rich repeat protein 12
Synonyms: 3110048D16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30843
Homologene: 32198
Wdr27
Name: WD repeat domain 27
Synonyms: 0610012K18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71682
VEGA: 17
Homologene: 18417
Flot2
Name: flotillin 2
Synonyms: Esa, reggie-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14252
HGNC: HGNC:3758
Homologene: 3293
Ttl
Name: tubulin tyrosine ligase
Synonyms: 2410003M22Rik, 2700049H19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69737
Homologene: 32678
Sun5
Name: Sad1 and UNC84 domain containing 5
Synonyms: 1700021O15Rik, Spag4l
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76407
Homologene: 12640
Fars2
Name: phenylalanine-tRNA synthetase 2, mitochondrial
Synonyms: 2810431B21Rik, 6720478K01Rik, Fars1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69955
VEGA: 13
Homologene: 4788
Spata9
Name: spermatogenesis associated 9
Synonyms: 4930599C08Rik, 1700030K01Rik, A930023H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75571
VEGA: 13
Homologene: 12609
Tas2r106
Name: taste receptor, type 2, member 106
Synonyms: T2R06, Tas2r6, mGR06, mt2r44
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387341
Homologene: 130071
Rftn1
Name: raftlin lipid raft linker 1
Synonyms: 2310015N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76438
Homologene: 18745
Pigm
Name: phosphatidylinositol glycan anchor biosynthesis, class M
Synonyms: 4933437L05Rik, C920011G20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67556
Homologene: 6274
Pea15a
Name: proliferation and apoptosis adaptor protein 15A
Synonyms: Pkcs15, Mat1, PEA-15, Pea15, phosphoprotein enriched in astrocytes 15A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18611
HGNC: HGNC:8822
Homologene: 7884
Gtf2e1
Name: general transcription factor II E, polypeptide 1 (alpha subunit)
Synonyms: TFIIE-A, FE, 2610024P03Rik, 56kDa
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74197
HGNC: HGNC:4650
Homologene: 38062
Lzts3
Name: leucine zipper, putative tumor suppressor family member 3
Synonyms: Prosapip1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241638
Homologene: 8824
Pcdhgb5
Name: protocadherin gamma subfamily B, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93702
HGNC: HGNC:8712
Homologene: 55773
Ccl22
Name: C-C motif chemokine ligand 22
Synonyms: ABCD-1, MDC, Scya22
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20299
Homologene: 7529
Sgol2b
Name:
Type: Gene
Species: Mouse
Chromosome: 8
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,537,420 bp
  • A to G, chromosome 1 at 37,368,439 bp
  • A to G, chromosome 1 at 105,589,078 bp
  • C to T, chromosome 1 at 116,571,541 bp
  • T to C, chromosome 1 at 172,118,979 bp
  • T to A, chromosome 1 at 172,199,245 bp
  • T to A, chromosome 1 at 172,377,957 bp
  • A to T, chromosome 2 at 30,031,891 bp
  • A to G, chromosome 2 at 32,587,655 bp
  • T to A, chromosome 2 at 49,278,879 bp
  • A to T, chromosome 2 at 76,907,377 bp
  • A to G, chromosome 2 at 129,068,933 bp
  • C to T, chromosome 2 at 130,634,881 bp
  • A to T, chromosome 2 at 153,865,323 bp
  • A to G, chromosome 3 at 94,435,127 bp
  • G to A, chromosome 3 at 96,905,189 bp
  • G to A, chromosome 3 at 138,066,450 bp
  • T to A, chromosome 4 at 132,738,401 bp
  • A to G, chromosome 5 at 34,154,091 bp
  • A to G, chromosome 5 at 144,791,165 bp
  • A to G, chromosome 5 at 148,107,005 bp
  • C to T, chromosome 6 at 30,816,126 bp
  • T to C, chromosome 6 at 73,076,599 bp
  • T to A, chromosome 6 at 73,195,681 bp
  • G to A, chromosome 6 at 125,982,720 bp
  • T to C, chromosome 6 at 131,678,055 bp
  • G to A, chromosome 7 at 20,024,061 bp
  • G to A, chromosome 7 at 46,805,050 bp
  • A to G, chromosome 7 at 81,463,242 bp
  • A to T, chromosome 7 at 109,809,176 bp
  • A to G, chromosome 7 at 110,124,484 bp
  • G to A, chromosome 7 at 122,990,324 bp
  • T to A, chromosome 7 at 141,640,528 bp
  • T to C, chromosome 8 at 13,033,981 bp
  • G to A, chromosome 8 at 23,085,652 bp
  • T to A, chromosome 8 at 45,248,607 bp
  • C to A, chromosome 8 at 63,924,701 bp
  • T to C, chromosome 8 at 94,746,991 bp
  • C to A, chromosome 9 at 20,638,864 bp
  • T to C, chromosome 9 at 49,026,882 bp
  • T to G, chromosome 10 at 43,510,903 bp
  • T to C, chromosome 10 at 51,631,274 bp
  • T to C, chromosome 10 at 94,813,243 bp
  • T to A, chromosome 11 at 31,369,777 bp
  • A to G, chromosome 11 at 78,059,195 bp
  • T to C, chromosome 11 at 103,186,699 bp
  • G to A, chromosome 11 at 120,921,773 bp
  • A to G, chromosome 12 at 108,186,499 bp
  • A to G, chromosome 12 at 109,592,715 bp
  • A to G, chromosome 13 at 21,659,207 bp
  • A to G, chromosome 13 at 36,410,110 bp
  • C to A, chromosome 13 at 75,977,547 bp
  • A to G, chromosome 14 at 27,777,139 bp
  • T to C, chromosome 14 at 28,522,605 bp
  • C to A, chromosome 14 at 123,317,024 bp
  • T to G, chromosome 16 at 29,471,902 bp
  • T to A, chromosome 16 at 37,522,851 bp
  • A to G, chromosome 17 at 14,829,576 bp
  • G to A, chromosome 17 at 46,412,375 bp
  • A to T, chromosome 17 at 46,642,154 bp
  • G to T, chromosome 17 at 50,047,380 bp
  • A to T, chromosome 17 at 58,973,014 bp
  • T to C, chromosome 18 at 37,732,187 bp
  • G to T, chromosome 18 at 57,914,266 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8273 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067696-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.