Strain Name:
C57BL/6J-MtgxR8384Btlr/Mmmh
Stock Number:
067750-MU
Citation ID:
RRID:MMRRC_067750-MU
Other Names:
R8384 (G1)
Major Collection:

Strain Information

Hells
Name: helicase, lymphoid specific
Synonyms: PASG, LSH, Lysh, E130115I21Rik, YFK8, proliferation-associated SNF2-like
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15201
HGNC: HGNC:4861
Homologene: 50037
Zcchc17
Name: zinc finger, CCHC domain containing 17
Synonyms: Ps1d, HSPC251, 2810055E05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 619605
Homologene: 32319
Zfp638
Name: zinc finger protein 638
Synonyms: Zfml, Np220
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18139
Homologene: 7447
Ctnnbl1
Name: catenin, beta like 1
Synonyms: P14L, NYD-SP19, FLJ21108, 5730471K09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66642
Homologene: 12003
Mdn1
Name: midasin AAA ATPase 1
Synonyms: D4Abb1e, 4833432B22Rik, LOC213784
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Lfng
Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: lunatic fringe
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16848
HGNC: HGNC:6560
Homologene: 22475
Eif5
Name: eukaryotic translation initiation factor 5
Synonyms: 2810011H21Rik, D12Ertd549e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217869
VEGA: 12
HGNC: HGNC:3299
Homologene: 49610
Colec11
Name: collectin sub-family member 11
Synonyms: 1010001H16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71693
VEGA: 12
Homologene: 11423
Usp6nl
Name: USP6 N-terminal like
Synonyms: TRE2NL
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98910
Homologene: 6879
Fhdc1
Name: FH2 domain containing 1
Synonyms: 6330505N24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229474
Homologene: 18920
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, Adgrc1, crash
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245026
Homologene: 18260
Ralgds
Name: ral guanine nucleotide dissociation stimulator
Synonyms: Rgds, RalGDS, Gnds
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19730
HGNC: HGNC:9842
Homologene: 4562
Lnx2
Name: ligand of numb-protein X 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140887
Homologene: 17737
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: Rw, LOC384168, Dpp-6, B930011P16Rik, In(5)6H-p, Peplb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Or5p51
Name: olfactory receptor family 5 subfamily P member 51
Synonyms: MOR204-22, GA_x6K02T2PBJ9-10175273-10174329, Olfr470
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258417
Myo5b
Name: myosin VB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
4933427D14Rik
Name: RIKEN cDNA 4933427D14 gene
Synonyms: Gm43951
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74477
Homologene: 8874
Slc7a13
Name: solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
Synonyms: XAT2, 0610009O04Rik, AGT-1, AGT1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74087
Homologene: 23656
Snx14
Name: sorting nexin 14
Synonyms: YR-14, C330035N22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244962
Homologene: 17823
Msh5
Name: mutS homolog 5
Synonyms: G7, Mut5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17687
HGNC: HGNC:7328
Homologene: 8415
Serpinb3c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 3C
Synonyms: ovalbumin, 1110001H02Rik, Scca2, 1110013A16Rik, Serpinb4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381286
Homologene: 131278
Idua
Name: iduronidase, alpha-L
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15932
HGNC: HGNC:5391
Homologene: 170
Rgs22
Name: regulator of G-protein signalling 22
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 626596
Homologene: 75047
Cyp24a1
Name: cytochrome P450, family 24, subfamily a, polypeptide 1
Synonyms: 25-hydroxyvitamin D-24-hydroxylase, 24-OHase, Cyp24, CP24
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13081
HGNC: HGNC:2602
Homologene: 68094
Ugt2b5
Name: UDP glucuronosyltransferase 2 family, polypeptide B5
Synonyms: Udpgt-3, m-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22238
Homologene: 137225
Or6c6
Name: olfactory receptor family 6 subfamily C member 6
Synonyms: GA_x6K02T2PULF-11031172-11032116, MOR110-8, Olfr782
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257985
Homologene: 133581
Hacl1
Name: 2-hydroxyacyl-CoA lyase 1
Synonyms: Hpcl, Phyh2, 1600020H07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56794
Homologene: 5794
Macir
Name: macrophage immunometabolism regulator
Synonyms: D1Ertd622e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 52392
Homologene: 13239
Lsm8
Name: LSM8 homolog, U6 small nuclear RNA associated
Synonyms: Lsm8, 2010003I05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76522
Homologene: 9419
Flvcr2
Name: feline leukemia virus subgroup C cellular receptor 2
Synonyms: Mfsd7c, CCT
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217721
VEGA: 12
Homologene: 9840
Mpst
Name: mercaptopyruvate sulfurtransferase
Synonyms: 3MST
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 246221
VEGA: 15
HGNC: HGNC:7223
Homologene: 31942
Pam16l
Name: presequence translocase associated motor 16 like
Synonyms: Gm9803
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100042179
VEGA: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 97,645,930 bp
  • T to C, chromosome 1 at 107,271,967 bp
  • A to G, chromosome 2 at 6,427,793 bp
  • G to T, chromosome 2 at 28,547,170 bp
  • A to T, chromosome 2 at 157,818,060 bp
  • A to G, chromosome 2 at 170,486,769 bp
  • T to C, chromosome 3 at 84,454,999 bp
  • T to C, chromosome 4 at 19,823,984 bp
  • T to C, chromosome 4 at 32,765,680 bp
  • T to C, chromosome 4 at 130,316,733 bp
  • A to T, chromosome 5 at 27,718,474 bp
  • A to G, chromosome 5 at 87,140,065 bp
  • A to G, chromosome 5 at 108,681,439 bp
  • G to A, chromosome 5 at 140,613,226 bp
  • G to A, chromosome 5 at 147,029,328 bp
  • G to T, chromosome 6 at 48,482,664 bp
  • C to A, chromosome 6 at 83,979,765 bp
  • A to T, chromosome 7 at 107,845,258 bp
  • C to A, chromosome 9 at 88,403,280 bp
  • C to T, chromosome 9 at 105,755,694 bp
  • A to T, chromosome 10 at 43,524,351 bp
  • A to T, chromosome 10 at 129,350,826 bp
  • C to A, chromosome 11 at 59,085,109 bp
  • A to G, chromosome 11 at 69,395,926 bp
  • T to C, chromosome 11 at 72,166,765 bp
  • A to T, chromosome 12 at 28,594,659 bp
  • T to C, chromosome 12 at 85,796,193 bp
  • A to G, chromosome 12 at 111,539,805 bp
  • A to G, chromosome 14 at 31,634,197 bp
  • A to T, chromosome 15 at 36,046,012 bp
  • T to A, chromosome 15 at 78,413,575 bp
  • G to T, chromosome 15 at 86,033,085 bp
  • A to G, chromosome 17 at 35,030,637 bp
  • A to G, chromosome 18 at 74,742,202 bp
  • A to G, chromosome 19 at 38,959,122 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8384 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067750-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.