Strain Name:
C57BL/6J-MtgxR8401Btlr/Mmmh
Stock Number:
067877-MU
Citation ID:
RRID:MMRRC_067877-MU
Other Names:
R8401 (G1)
Major Collection:

Strain Information

Dct
Name: dopachrome tautomerase
Synonyms: TRP2, Tyrp-2, tyrosinase-related protein-2, TRP-2, Tyrp2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13190
VEGA: 14
HGNC: HGNC:2709
Homologene: 1447
Nes
Name: nestin
Synonyms: Ifaprc2, Marc2, RC2, ESTM46
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNAPDcs, DNA-PKcs, DNA-PK, DOXNPH, XRCC7, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Tspan14
Name: tetraspanin 14
Synonyms: D14Ertd226e, Tm4sf14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52588
VEGA: 14
Homologene: 23717
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Nkx2-1
Name: NK2 homeobox 1
Synonyms: T/EBP, Ttf-1, Titf1, thyroid transcription factor-1, tinman, thyroid-specific enhancer-binding protein
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21869
Homologene: 2488
Ddx56
Name: DEAD box helicase 56
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 56, NOH61, 2600001H07Rik, D11Ertd619e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52513
Homologene: 6498
Hars1
Name: histidyl-tRNA synthetase 1
Synonyms: Hars, MMHRS
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15115
VEGA: 18
HGNC: HGNC:4816
Homologene: 1592
Gan
Name: giant axonal neuropathy
Synonyms: gigaxonin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 209239
HGNC: HGNC:4137
Homologene: 32523
Epb41
Name: erythrocyte membrane protein band 4.1
Synonyms: D4Ertd442e, Elp-1, Epb4.1, 4.1R, Elp1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269587
HGNC: HGNC:3377
Homologene: 44324
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67724
Homologene: 41000
Ogdh
Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms: d1401, alpha-ketoglutarate dehydrogenase, 2210412K19Rik, 2210403E04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18293
HGNC: HGNC:8124
Homologene: 55662
Slitrk6
Name: SLIT and NTRK-like family, member 6
Synonyms: 4832410J21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239250
VEGA: 14
Homologene: 12986
Nol6
Name: nucleolar protein family 6 (RNA-associated)
Synonyms: Nrap
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230082
Homologene: 41505
Ankrd28
Name: ankyrin repeat domain 28
Synonyms: E430019N21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105522
VEGA: 14
Homologene: 35374
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Vps18
Name: VPS18 CORVET/HOPS core subunit
Synonyms: 9930024E13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228545
Homologene: 13302
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Grk6
Name: G protein-coupled receptor kinase 6
Synonyms: Gprk6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26385
VEGA: 13
HGNC: HGNC:4545
Homologene: 37570
Dapk1
Name: death associated protein kinase 1
Synonyms: 2810425C21Rik, DAP-Kinase, D13Ucla1, 2310039H24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Atp2b4
Name: ATPase, Ca++ transporting, plasma membrane 4
Synonyms: PMCA4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381290
HGNC: HGNC:817
Homologene: 48034
Rundc1
Name: RUN domain containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217201
Homologene: 15095
Grk1
Name: G protein-coupled receptor kinase 1
Synonyms: RK, Rhok
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 24013
Homologene: 2197
Orm3
Name: orosomucoid 3
Synonyms: Agp-3, Orm-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18407
Homologene: 130632
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Drc7
Name: dynein regulatory complex subunit 7
Synonyms: Ccdc135, SRG-L, LOC330830
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330830
Homologene: 12996
Brinp3
Name: bone morphogenetic protein/retinoic acid inducible neural specific 3
Synonyms: Fam5c, B830045N13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215378
Homologene: 17786
Setmar
Name: SET domain without mariner transposase fusion
Synonyms: 5830404F24Rik, Etet2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74729
Homologene: 68519
Pnpla8
Name: patatin-like phospholipase domain containing 8
Synonyms: iPLA2 gamma, 1200006O19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67452
Homologene: 12136
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Lmbrd2
Name: LMBR1 domain containing 2
Synonyms: 9930036E21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320506
VEGA: 15
Homologene: 44696
Ube4a
Name: ubiquitination factor E4A
Synonyms: 4732444G18Rik, UFD2b, 9930123J21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 140630
Homologene: 3517
Ano8
Name: anoctamin 8
Synonyms: Tmem16h
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382014
Homologene: 124473
Foxred2
Name: FAD-dependent oxidoreductase domain containing 2
Synonyms: LOC239554, A430097D04Rik, D15Bwg0759e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239554
Homologene: 11800
Pkn3
Name: protein kinase N3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 263803
Homologene: 50980
Zfp672
Name: zinc finger protein 672
Synonyms: 4930511N19Rik, 4930488P06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319475
Homologene: 23493
Skic8
Name: SKI8 subunit of superkiller complex
Synonyms: 2700038L12Rik, 2810418I05Rik, Wdr61
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66317
Homologene: 5884
Zfp62
Name: zinc finger protein 62
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22720
Homologene: 40686
Lca5l
Name: Leber congenital amaurosis 5-like
Synonyms: 4921526F01Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385668
HGNC: HGNC:1255
Homologene: 47978
Prkag2
Name: protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Synonyms: 2410051C13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108099
HGNC: HGNC:9386
Homologene: 136125
Glra3
Name: glycine receptor, alpha 3 subunit
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110304
HGNC: HGNC:4328
Homologene: 142
Klre1
Name: killer cell lectin-like receptor family E member 1
Synonyms: Klre-1, NKG2I
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243655
Homologene: 17794
Stx1b
Name: syntaxin 1B
Synonyms: Stx1b2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56216
Homologene: 69375
Ptgds
Name: prostaglandin D2 synthase (brain)
Synonyms: L-PGDS, PGD2, Ptgs3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19215
HGNC: HGNC:9592
Homologene: 737
Ikzf2
Name: IKAROS family zinc finger 2
Synonyms: Helios, Zfpn1a2, A730095J18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22779
Homologene: 22659
Rnaseh2b
Name: ribonuclease H2, subunit B
Synonyms: Dleu8, 1110019N06Rik, 2610207P08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67153
Homologene: 41572
Or2b28
Name: olfactory receptor family 2 subfamily B member 28
Synonyms: MOR256-16, Olfr1367, GA_x6K02T2QHY8-11899770-11898820, MOR256-65
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258526
Spi1
Name: Spi-1 proto-oncogene
Synonyms: PU.1, Dis-1, Spi-1, Tcfpu1, Sfpi-1, spleen focus forming virus (SFFV) proviral integration oncogene, Tfpu.1, Sfpi1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20375
Homologene: 2346
Prr9
Name: proline rich 9
Synonyms: A030004J04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109314
Homologene: 130379
Nim1k
Name: NIM1 serine/threonine protein kinase
Synonyms: Nim1, E130304F04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 245269
VEGA: 13
Homologene: 25286
Prok1
Name: prokineticin 1
Synonyms: EG-VEGF
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 246691
Homologene: 13023
Trav5-4
Name: T cell receptor alpha variable 5-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21507
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 69,539,095 bp
  • T to G, chromosome 1 at 69,539,096 bp
  • T to A, chromosome 1 at 133,731,836 bp
  • T to C, chromosome 1 at 146,901,446 bp
  • C to T, chromosome 1 at 188,542,865 bp
  • A to G, chromosome 2 at 25,469,657 bp
  • C to A, chromosome 2 at 30,080,059 bp
  • A to G, chromosome 2 at 91,113,305 bp
  • T to C, chromosome 2 at 119,297,492 bp
  • G to T, chromosome 2 at 180,198,787 bp
  • T to C, chromosome 3 at 87,978,081 bp
  • T to G, chromosome 3 at 92,123,049 bp
  • A to G, chromosome 3 at 107,237,197 bp
  • C to A, chromosome 4 at 41,119,548 bp
  • A to G, chromosome 4 at 63,356,230 bp
  • C to T, chromosome 4 at 131,974,707 bp
  • T to C, chromosome 5 at 24,863,870 bp
  • T to A, chromosome 5 at 150,552,352 bp
  • T to C, chromosome 6 at 108,076,163 bp
  • T to A, chromosome 6 at 129,580,026 bp
  • A to T, chromosome 7 at 127,807,773 bp
  • T to C, chromosome 8 at 13,407,846 bp
  • T to C, chromosome 8 at 56,089,089 bp
  • C to T, chromosome 8 at 61,956,243 bp
  • T to C, chromosome 8 at 71,483,367 bp
  • C to T, chromosome 8 at 95,074,135 bp
  • C to A, chromosome 8 at 117,183,503 bp
  • T to C, chromosome 9 at 44,941,229 bp
  • A to T, chromosome 9 at 54,728,255 bp
  • T to C, chromosome 11 at 6,264,199 bp
  • T to A, chromosome 11 at 6,297,174 bp
  • T to A, chromosome 11 at 49,217,391 bp
  • T to C, chromosome 11 at 58,316,802 bp
  • C to T, chromosome 11 at 101,433,557 bp
  • T to A, chromosome 11 at 118,024,659 bp
  • T to A, chromosome 12 at 44,288,308 bp
  • C to A, chromosome 12 at 56,533,056 bp
  • T to A, chromosome 13 at 11,668,935 bp
  • A to T, chromosome 13 at 21,347,827 bp
  • G to A, chromosome 13 at 55,452,168 bp
  • T to C, chromosome 13 at 60,723,090 bp
  • A to G, chromosome 13 at 119,712,677 bp
  • T to C, chromosome 14 at 31,745,294 bp
  • T to C, chromosome 14 at 40,908,092 bp
  • G to A, chromosome 14 at 53,704,293 bp
  • T to A, chromosome 14 at 62,370,489 bp
  • A to G, chromosome 14 at 110,752,021 bp
  • T to C, chromosome 14 at 118,043,203 bp
  • A to T, chromosome 15 at 9,156,207 bp
  • A to T, chromosome 15 at 34,508,609 bp
  • T to C, chromosome 15 at 77,951,991 bp
  • T to A, chromosome 16 at 15,773,613 bp
  • T to C, chromosome 16 at 96,162,560 bp
  • A to G, chromosome 17 at 15,743,211 bp
  • T to C, chromosome 18 at 36,771,190 bp
  • C to A, chromosome 18 at 77,380,460 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8401 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067877-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.