Strain Name:
C57BL/6J-MtgxR8445Btlr/Mmmh
Stock Number:
067886-MU
Citation ID:
RRID:MMRRC_067886-MU
Other Names:
R8445 (G1)
Major Collection:

Strain Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: D230017O13Rik, 2610103K11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
Synonyms: MAPKKKK5, KHS, 4432415E19Rik, GCKR
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399510
HGNC: HGNC:6867
Homologene: 38199
Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SW1/SNF, Brg1, b2b508.1Clo, b2b692Clo, SNF2beta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20586
Homologene: 135927
Mc3r
Name: melanocortin 3 receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17201
HGNC: HGNC:6931
Homologene: 7412
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk2, Tsk-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Thbs4
Name: thrombospondin 4
Synonyms: TSP-4, TSP4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21828
Homologene: 20691
Rbpms2
Name: RNA binding protein with multiple splicing 2
Synonyms: 2400008B06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71973
VEGA: 9
Homologene: 49895
Akap13
Name: A kinase anchor protein 13
Synonyms: 5730522G15Rik, 1700026G02Rik, PROTO-LB, Ht31, PROTO-LBC, 5830460E08Rik, AKAP-Lbc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Slc30a7
Name: solute carrier family 30 (zinc transporter), member 7
Synonyms: ZnT7, 1810059J10Rik, 2610034N15Rik, 4833428C12Rik, ZnT-7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66500
Homologene: 11332
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71643
Homologene: 34708
Epha8
Name: Eph receptor A8
Synonyms: EphA8, Hek3, Eek
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
E130308A19Rik
Name: RIKEN cDNA E130308A19 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230259
Homologene: 136157
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: Crpd, vomeroglandin, gp300, CRP-[a], MUCLIN, ebnerin, hensin, CRP-[b]
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Rph3a
Name: rabphilin 3A
Synonyms: 2900002P20Rik, Doc2 family
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19894
Homologene: 7921
Nop2
Name: NOP2 nucleolar protein
Synonyms: 120kDa, Nol1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110109
HGNC: HGNC:7867
Homologene: 135865
Alg12
Name: ALG12 alpha-1,6-mannosyltransferase
Synonyms: ECM39, mannosyltransferase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223774
Homologene: 36269
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: TRPC7, Trrp7, 9830168K16Rik, LTRPC2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28240
Homologene: 20709
Wdr89
Name: WD repeat domain 89
Synonyms: 2600001A11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72338
Homologene: 43791
Spata31d1c
Name: spermatogenesis associated 31 subfamily D, member 1C
Synonyms: Fam75d1c, 4932441B19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238683
VEGA: 13
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Itga4
Name: integrin alpha 4
Synonyms: VLA-4 receptor, alpha 4 subunit
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16401
HGNC: HGNC:6140
Homologene: 37364
Kdm5d
Name: lysine demethylase 5D
Synonyms: Jarid1d, Smcy, HY
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 20592
Homologene: 55838
Insrr
Name: insulin receptor-related receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23920
HGNC: HGNC:6093
Homologene: 56539
Cyp4a10
Name: cytochrome P450, family 4, subfamily a, polypeptide 10
Synonyms: D4Rp1, Cyp4a, Msp-3, RP1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13117
HGNC: HGNC:2642
Homologene: 128044
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56552
Homologene: 135915
Fbxl4
Name: F-box and leucine-rich repeat protein 4
Synonyms: FBL5, FBL4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269514
Homologene: 8128
Zfp623
Name: zinc finger protein 623
Synonyms: 2610029D06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78834
VEGA: 15
Homologene: 15994
St6galnac6
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Synonyms: ST6GalNAcVI, Siat7f
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50935
Homologene: 8390
Or8b12i
Name: olfactory receptor family 8 subfamily B member 12I
Synonyms: MOR141-1, GA_x6K02T2PVTD-13912679-13911744, Olfr870
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57251
Homologene: 138319
Adam10
Name: a disintegrin and metallopeptidase domain 10
Synonyms: kuzbanian, kuz, 1700031C13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11487
HGNC: HGNC:188
Homologene: 865
Zfp879
Name: zinc finger protein 879
Synonyms: 9630041N07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 214779
Homologene: 45452
Cyp2j12
Name: cytochrome P450, family 2, subfamily j, polypeptide 12
Synonyms: Cyp2j12-ps, OTTMUSG00000007939
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242546
HGNC: HGNC:2634
Homologene: 133195
Dytn
Name: dystrotelin
Synonyms: LOC241073
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241073
Homologene: 104042
Vmn2r87
Name: vomeronasal 2, receptor 87
Synonyms: EG625131
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625131
Homologene: 129606
Tcp11l1
Name: t-complex 11 like 1
Synonyms: C130096D04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320554
Homologene: 41260
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp4e, 4930406H16Rik, Nalp-epsilon
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 446099
Homologene: 75315
Tfpt
Name: TCF3 (E2A) fusion partner
Synonyms: Amida, 2400004F01Rik, FB1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69714
Homologene: 8349
Nfatc4
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
Synonyms: 3110041H08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 73181
VEGA: 14
HGNC: HGNC:7778
Homologene: 3349
Fmod
Name: fibromodulin
Synonyms: SLRR2E
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14264
HGNC: HGNC:3774
Homologene: 1530
Zfp952
Name: zinc finger protein 952
Synonyms: C920016K16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240067
Homologene: 128790
Or2a52
Name: olfactory receptor family 2 subfamily A member 52
Synonyms: Olfr437, MOR261-11, GA_x6K02T2P3E9-4391088-4390156
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258293
HGNC: HGNC:8230
Homologene: 122778
Tspyl4
Name: TSPY-like 4
Synonyms: 2610102M01Rik, B230210I21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72480
Homologene: 15872
Shisa7
Name: shisa family member 7
Synonyms: D430041B17Rik, CKAMP59
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232813
Homologene: 122129
Klra7
Name: killer cell lectin-like receptor, subfamily A, member 7
Synonyms: Ly-49G.3, Ly49g2, Ly49g1, LGL-1, Ly-49G.2, Ly49g, Ly-49G.1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16638
Homologene: 110821
Fam53c
Name: family with sequence similarity 53, member C
Synonyms: 2810012G03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66306
VEGA: 18
HGNC: HGNC:1336
Homologene: 9586
Nipa1
Name: non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human)
Synonyms: A830014A18Rik, 1110027G09Rik, Spg6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233280
Homologene: 42327
Lbx1
Name: ladybird homeobox 1
Synonyms: Lbx1h
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16814
Homologene: 4784
Prelid3a
Name: PRELI domain containing 3A
Synonyms: A230074A19Rik, Slmo1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225655
VEGA: 18
Homologene: 90953
C330018D20Rik
Name: RIKEN cDNA C330018D20 gene
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 77422
Homologene: 35412
Prl4a1
Name: prolactin family 4, subfamily a, member 1
Synonyms: PLP-A, Prlpa
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19110
Homologene: 7900
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 45,341,180 bp
  • T to A, chromosome 1 at 63,647,514 bp
  • G to A, chromosome 1 at 134,040,998 bp
  • A to G, chromosome 2 at 32,608,520 bp
  • A to G, chromosome 2 at 79,281,781 bp
  • C to A, chromosome 2 at 104,681,933 bp
  • A to G, chromosome 2 at 172,249,317 bp
  • T to C, chromosome 3 at 87,813,584 bp
  • C to T, chromosome 3 at 116,007,346 bp
  • T to C, chromosome 3 at 127,586,205 bp
  • C to A, chromosome 4 at 22,385,983 bp
  • T to A, chromosome 4 at 59,720,526 bp
  • T to A, chromosome 4 at 96,133,022 bp
  • T to A, chromosome 4 at 115,525,594 bp
  • T to C, chromosome 4 at 136,932,289 bp
  • T to C, chromosome 5 at 120,973,370 bp
  • A to G, chromosome 6 at 43,167,297 bp
  • A to G, chromosome 6 at 124,026,036 bp
  • A to G, chromosome 6 at 125,134,604 bp
  • A to T, chromosome 6 at 130,227,115 bp
  • G to A, chromosome 7 at 3,620,929 bp
  • A to T, chromosome 7 at 4,836,353 bp
  • A to T, chromosome 7 at 23,340,540 bp
  • A to T, chromosome 7 at 55,979,718 bp
  • G to A, chromosome 7 at 75,730,465 bp
  • A to C, chromosome 7 at 118,136,977 bp
  • T to A, chromosome 7 at 131,090,380 bp
  • T to A, chromosome 9 at 20,171,098 bp
  • CGAGGAGGAGGAGGAGG to CGAGGAGGAGGAGG, chromosome 9 at 21,700,943 bp
  • C to T, chromosome 9 at 65,651,021 bp
  • T to G, chromosome 9 at 70,766,921 bp
  • C to T, chromosome 10 at 11,181,569 bp
  • C to T, chromosome 10 at 34,297,746 bp
  • T to C, chromosome 10 at 77,910,252 bp
  • A to T, chromosome 10 at 130,477,466 bp
  • A to G, chromosome 11 at 50,833,386 bp
  • T to A, chromosome 12 at 69,850,967 bp
  • T to C, chromosome 12 at 75,632,862 bp
  • T to C, chromosome 13 at 28,021,462 bp
  • G to T, chromosome 13 at 65,033,177 bp
  • C to A, chromosome 13 at 92,790,841 bp
  • A to C, chromosome 14 at 55,826,418 bp
  • C to A, chromosome 15 at 75,947,553 bp
  • C to T, chromosome 15 at 88,814,486 bp
  • C to A, chromosome 16 at 49,120,018 bp
  • T to G, chromosome 17 at 33,003,578 bp
  • T to C, chromosome 18 at 34,768,315 bp
  • G to A, chromosome 18 at 56,957,890 bp
  • A to G, chromosome 18 at 67,473,778 bp
  • T to A, chromosome 19 at 45,234,212 bp
  • A to G, chromosome Y at 916,874 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8445 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067886-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.