Strain Name:
C57BL/6J-MtgxR8476Btlr/Mmmh
Stock Number:
067920-MU
Citation ID:
RRID:MMRRC_067920-MU
Other Names:
R8476 (G1)
Major Collection:

Strain Information

Atn1
Name: atrophin 1
Synonyms: atrophin-1, Atr1, Drpla
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13498
HGNC: HGNC:3033
Homologene: 1461
Pik3cd
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Synonyms: p110delta, 2410099E07Rik, 2610208K16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18707
HGNC: HGNC:8977
Homologene: 3686
Slit3
Name: slit guidance ligand 3
Synonyms: b2b2362.1Clo, Slit1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Pum1
Name: pumilio RNA-binding family member 1
Synonyms: Pumm
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 80912
Homologene: 22830
Anks1
Name: ankyrin repeat and SAM domain containing 1
Synonyms: Odin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224650
Homologene: 9068
Kdm3a
Name: lysine (K)-specific demethylase 3A
Synonyms: Jmjd1a, Jmjd1, Tsga, C230043E16Rik, 1700105C21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 104263
Homologene: 10196
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: Hpve6a, A130086L21Rik, 5830462N02Rik, E6-AP ubiquitin protein ligase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22215
Homologene: 7988
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, TIF1alpha, D430004I05Rik, A130082H20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21848
Homologene: 20830
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: D530014O03Rik, Zfp291
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Aen
Name: apoptosis enhancing nuclease
Synonyms: Isg20l1, 2700083B06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68048
Homologene: 23382
Ptprm
Name: protein tyrosine phosphatase receptor type M
Synonyms: RPTPmu
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Gpr165
Name: G protein-coupled receptor 165
Synonyms: 6530406P05Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 76206
Homologene: 85287
Clec4e
Name: C-type lectin domain family 4, member e
Synonyms: Mincle, Clecsf9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56619
Homologene: 22809
Mta2
Name: metastasis-associated gene family, member 2
Synonyms: Mta1l1, mmta2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 23942
HGNC: HGNC:7411
Homologene: 3480
Pask
Name: PAS domain containing serine/threonine kinase
Synonyms: Paskin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269224
Homologene: 9038
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, D330038K10Rik, 4930516E05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Sall3
Name: spalt like transcription factor 3
Synonyms: Salt, Spalt, Msal, Msal-1, B130022O04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20689
VEGA: 18
Homologene: 18142
Smarcd1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Synonyms: Baf60a, D15Kz1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83797
VEGA: 15
Homologene: 20670
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Dclk1
Name: doublecortin-like kinase 1
Synonyms: Click-I, 1700113D08Rik, Dcl, DCLK, CPG16, Dcamkl1, 2810480F11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13175
HGNC: HGNC:2700
Homologene: 130530
Or6d13
Name: olfactory receptor family 6 subfamily D member 13
Synonyms: MOR119-3, Olfr213, GA_x54KRFPKN04-58174409-58175392
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258020
Homologene: 74186
Pcdhb13
Name: protocadherin beta 13
Synonyms: Pcdbh6, PcdhbM
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93884
HGNC: HGNC:8691
Homologene: 10338
Morc2b
Name: microrchidia 2B
Synonyms: 4932411A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240069
Homologene: 18615
Krt72
Name: keratin 72
Synonyms: Krt72-ps, K6irs2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105866
Homologene: 25876
Klhdc7a
Name: kelch domain containing 7A
Synonyms: B230308G19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242721
Homologene: 17567
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72371
Homologene: 89234
Gba2
Name: glucosidase beta 2
Synonyms: bile acid
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230101
Homologene: 10859
Lax1
Name: lymphocyte transmembrane adaptor 1
Synonyms: E430019B13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240754
Homologene: 49504
Rabep2
Name: rabaptin, RAB GTPase binding effector protein 2
Synonyms: 2610011A08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70314
Homologene: 23489
Ccdc172
Name: coiled-coil domain containing 172
Synonyms: 1700011F14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75645
VEGA: 19
Homologene: 36871
Or51f1
Name: olfactory receptor family 51 subfamily F member 1
Synonyms: Olfr566, MOR14-7P, GA_x6K02T2PBJ9-5560696-5559746
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258168
Homologene: 133721
Rfxank
Name: regulatory factor X-associated ankyrin-containing protein
Synonyms: Tvl1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19727
HGNC: HGNC:9987
Homologene: 2760
Bola1
Name: bolA family member 1
Synonyms: 1810037G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69168
Homologene: 41103
Ceacam11
Name: CEA cell adhesion molecule 11
Synonyms: Ceacam11-C4, Ceacam11-C1, Ceacam11-C3, 1600015D01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66996
HGNC: HGNC:1819
Homologene: 135962
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 93,321,639 bp
  • T to A, chromosome 1 at 133,683,588 bp
  • A to T, chromosome 3 at 55,533,679 bp
  • G to A, chromosome 3 at 96,197,257 bp
  • C to T, chromosome 4 at 43,569,944 bp
  • A to G, chromosome 4 at 130,752,713 bp
  • A to C, chromosome 4 at 139,965,740 bp
  • A to T, chromosome 4 at 149,651,820 bp
  • C to T, chromosome 6 at 37,945,643 bp
  • T to C, chromosome 6 at 71,611,709 bp
  • T to A, chromosome 6 at 116,540,546 bp
  • A to G, chromosome 6 at 123,286,276 bp
  • C to A, chromosome 6 at 124,746,453 bp
  • T to C, chromosome 7 at 17,973,693 bp
  • C to T, chromosome 7 at 59,304,827 bp
  • A to G, chromosome 7 at 78,907,199 bp
  • A to T, chromosome 7 at 102,856,945 bp
  • A to G, chromosome 7 at 105,758,808 bp
  • C to T, chromosome 7 at 126,435,743 bp
  • T to C, chromosome 8 at 70,138,178 bp
  • T to A, chromosome 9 at 55,762,291 bp
  • G to A, chromosome 11 at 35,629,769 bp
  • C to T, chromosome 12 at 112,782,991 bp
  • A to T, chromosome 13 at 77,261,901 bp
  • G to T, chromosome 15 at 99,702,424 bp
  • A to T, chromosome 15 at 101,778,266 bp
  • T to A, chromosome 17 at 28,054,318 bp
  • T to A, chromosome 17 at 33,135,859 bp
  • T to C, chromosome 17 at 66,944,322 bp
  • A to T, chromosome 18 at 37,444,084 bp
  • G to T, chromosome 18 at 80,972,118 bp
  • T to A, chromosome 19 at 8,950,988 bp
  • T to C, chromosome 19 at 16,722,457 bp
  • T to A, chromosome 19 at 58,552,838 bp
  • C to A, chromosome X at 96,714,017 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8476 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067920-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.