Strain Name:
C57BL/6J-MtgxR8481Btlr/Mmmh
Stock Number:
067925-MU
Citation ID:
RRID:MMRRC_067925-MU
Other Names:
R8481 (G1)
Major Collection:

Strain Information

Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: Glur2, GluA2, GluR-B, Glur-2, GluR2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Synonyms: IKK-1, IKK 1, IkappaB kinase alpha, IKK[a], IKK alpha, IKK1, Chuk1, IKK-alpha, IKKalpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12675
HGNC: HGNC:1974
Homologene: 979
Rabep1
Name: rabaptin, RAB GTPase binding effector protein 1
Synonyms: neurocrescin, rabaptin-5, RAB5 effector protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54189
Homologene: 3451
Cryzl1
Name: crystallin zeta like 1
Synonyms: 2410006O11Rik, 2210407J23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66609
HGNC: HGNC:2420
Homologene: 3749
Sec24d
Name: SEC24 homolog D, COPII coat complex component
Synonyms: 2310020L09Rik, LOC383951
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69608
Homologene: 40986
Ptpn21
Name: protein tyrosine phosphatase, non-receptor type 21
Synonyms: PTPRL10, PTPD1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 24000
VEGA: 12
HGNC: HGNC:9651
Homologene: 5110
Slu7
Name: SLU7 splicing factor homolog (S. cerevisiae)
Synonyms: D11Ertd730e, D3Bwg0878e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193116
Homologene: 4690
Cul5
Name: cullin 5
Synonyms: 4921514I20Rik, VACM-1, 8430423K24Rik, C030032G03Rik, C330021I08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Got2
Name: glutamatic-oxaloacetic transaminase 2, mitochondrial
Synonyms: plasma membrane fatty acid binding protein, mAspAT, Kyat4, mitochondrial aspartate aminotransferase, FABP-pm
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14719
HGNC: HGNC:4433
Homologene: 1572
Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Synonyms: Pdgfr, CD140b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18596
HGNC: HGNC:8804
Homologene: 1960
Tpbg
Name: trophoblast glycoprotein
Synonyms: 5T4, 5T4 oncofetal antigen
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21983
Homologene: 4859
Hnrnpa2b1
Name: heterogeneous nuclear ribonucleoprotein A2/B1
Synonyms: 9130414A06Rik, Hnrpa2, Hnrpa2b1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 53379
HGNC: HGNC:5033
Homologene: 22992
Tubgcp2
Name: tubulin, gamma complex component 2
Synonyms: 1700022B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74237
Homologene: 55980
Dpp9
Name: dipeptidylpeptidase 9
Synonyms: DPRP2, 6430584G11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224897
VEGA: 17
Homologene: 16385
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1565Clo, b2b3491Clo, Mdnah5, b2b1154Clo, b2b1537Clo, Dnahc5, b2b1134Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, b2b1554Clo, A2mr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Hdhc3, HL19, LOC380889, Dnahc7l, DLP12, Dnahc12, 4921531P07Rik, DHC3, HL-19
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: Acvrinp1, Magi-2, S-SCAM
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50791
Homologene: 8189
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
BC024139
Name: cDNA sequence BC024139
Synonyms: 6230424I18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 271278
Homologene: 129974
Aste1
Name: asteroid homolog 1
Synonyms: 1100001A21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66595
Homologene: 130666
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78317
VEGA: 19
Homologene: 49992
Mprip
Name: myosin phosphatase Rho interacting protein
Synonyms: Rhoip3, Gm34094, p116 Rho interacting protein, RIP3, p116Rip
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26936
Homologene: 9034
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: Spacrcan, PG10.2, IPM200
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224224
Homologene: 9439
Letm2
Name: leucine zipper-EF-hand containing transmembrane protein 2
Synonyms: D030041N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270035
Homologene: 56358
Bpifb9a
Name: BPI fold containing family B, member 9A
Synonyms: vomeromodulin, 4833413D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71425
Homologene: 128535
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Slc13a3
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Synonyms: SDCT2, NaDC-3, NaDC3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 114644
Homologene: 11266
Padi2
Name: peptidyl arginine deiminase, type II
Synonyms: Pdi, Pdi2, PAD type II
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18600
Homologene: 7214
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Sp140
Name: Sp140 nuclear body protein
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 434484
Homologene: 128391
Dnm1
Name: dynamin 1
Synonyms: dynamin 1, Ftfl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13429
HGNC: HGNC:2972
Homologene: 123905
Pon3
Name: paraoxonase 3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269823
HGNC: HGNC:9206
Homologene: 37371
Nek4
Name: NIMA (never in mitosis gene a)-related expressed kinase 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 23955
VEGA: 14
Homologene: 2376
Vmn1r19
Name: vomeronasal 1 receptor 19
Synonyms: V1rc27
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171200
Homologene: 134034
Or11a4
Name: olfactory receptor family 11 subfamily A member 4
Synonyms: Olfr96, MOR121-1, GA_x6K02T2PSCP-1665046-1665987
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258507
HGNC: HGNC:8176
Homologene: 27189
Nrsn1
Name: neurensin 1
Synonyms: Neuro-p24, Neurensin-1, Vmp
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22360
Homologene: 7597
Rgs7bp
Name: regulator of G-protein signalling 7 binding protein
Synonyms: A930030I01Rik, R7bp, D13Bwg1146e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 52882
VEGA: 13
Homologene: 78705
Or4k40
Name: olfactory receptor family 4 subfamily K member 40
Synonyms: GA_x6K02T2Q125-72472405-72471488, MOR248-21, Olfr1286
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277562
Homologene: 73992
Prlhr
Name: prolactin releasing hormone receptor
Synonyms: PrRPR, GR3, LOC226278, Gpr10
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226278
VEGA: 19
HGNC: HGNC:4464
Homologene: 3134
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: ACAS, AceCS1, Acas1, Acas2, acetyl-CoA synthetase 1, Acs1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60525
Homologene: 6469
Tex36
Name: testis expressed 36
Synonyms: 4930404H21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73808
Homologene: 67014
Sppl2b
Name: signal peptide peptidase like 2B
Synonyms: 3110056O03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73218
VEGA: 10
Homologene: 10605
Cept1
Name: choline/ethanolaminephosphotransferase 1
Synonyms: 9930118K05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99712
Homologene: 81624
Evi2
Name: ecotropic viral integration site 2
Synonyms: Gm21975
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 101488212
HGNC: HGNC:3500
Homologene: 48438
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 85,641,791 bp
  • A to G, chromosome 2 at 32,340,478 bp
  • T to C, chromosome 2 at 52,224,585 bp
  • T to A, chromosome 2 at 111,420,649 bp
  • T to C, chromosome 2 at 154,269,479 bp
  • T to A, chromosome 2 at 155,556,461 bp
  • T to C, chromosome 2 at 165,434,038 bp
  • A to T, chromosome 3 at 80,801,691 bp
  • A to G, chromosome 3 at 106,505,253 bp
  • T to A, chromosome 3 at 123,353,424 bp
  • A to G, chromosome 4 at 140,933,253 bp
  • A to T, chromosome 5 at 20,389,154 bp
  • C to T, chromosome 6 at 5,221,715 bp
  • C to T, chromosome 6 at 51,467,411 bp
  • T to C, chromosome 6 at 57,404,947 bp
  • A to T, chromosome 7 at 133,587,460 bp
  • C to A, chromosome 7 at 140,033,675 bp
  • T to C, chromosome 8 at 25,580,359 bp
  • T to A, chromosome 8 at 95,888,524 bp
  • A to T, chromosome 9 at 53,646,823 bp
  • T to C, chromosome 9 at 75,301,444 bp
  • T to C, chromosome 9 at 85,844,085 bp
  • G to A, chromosome 9 at 105,396,990 bp
  • G to A, chromosome 9 at 119,143,267 bp
  • TGTCACAGGT to TGT, chromosome 10 at 80,866,069 bp
  • T to C, chromosome 10 at 127,568,910 bp
  • C to A, chromosome 11 at 43,437,493 bp
  • T to A, chromosome 11 at 43,437,494 bp
  • T to A, chromosome 11 at 59,758,156 bp
  • T to C, chromosome 11 at 70,887,127 bp
  • T to A, chromosome 11 at 79,515,462 bp
  • T to A, chromosome 12 at 7,994,807 bp
  • T to C, chromosome 12 at 98,688,894 bp
  • T to C, chromosome 13 at 25,253,615 bp
  • A to G, chromosome 13 at 105,054,208 bp
  • A to G, chromosome 14 at 26,853,796 bp
  • A to G, chromosome 14 at 30,964,034 bp
  • T to A, chromosome 15 at 28,419,795 bp
  • T to C, chromosome 15 at 76,120,682 bp
  • A to G, chromosome 16 at 56,252,266 bp
  • C to A, chromosome 16 at 91,707,273 bp
  • T to A, chromosome 17 at 37,225,404 bp
  • C to A, chromosome 17 at 56,194,467 bp
  • C to T, chromosome 18 at 61,065,742 bp
  • A to T, chromosome 19 at 6,854,532 bp
  • G to T, chromosome 19 at 44,096,239 bp
  • A to G, chromosome 19 at 60,467,687 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8481 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067925-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.