Strain Name:
C57BL/6J-MtgxR8496Btlr/Mmmh
Stock Number:
067938-MU
Citation ID:
RRID:MMRRC_067938-MU
Other Names:
R8496 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: PTPzeta, DSD-1-PG, phosphacan, RPTPz, Ptprz, Ptpz, Rptpbeta, PTPbeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Slc6a5
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Synonyms: Glyt2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 104245
Homologene: 37901
Odc1
Name: ornithine decarboxylase, structural 1
Synonyms: ODC
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18263
VEGA: 12
HGNC: HGNC:8109
Homologene: 1906
Ints6
Name: integrator complex subunit 6
Synonyms: DICE1, Notch2l, 2900075H24Rik, Ddx26
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18130
VEGA: 14
Homologene: 8121
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2210413N07Rik, 2810012K13Rik, SBP2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75420
Homologene: 11415
Gpr88
Name: G-protein coupled receptor 88
Synonyms: Strg
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64378
HGNC: HGNC:4539
Homologene: 11104
Kifap3
Name: kinesin-associated protein 3
Synonyms: KAP3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16579
Homologene: 7799
Ano6
Name: anoctamin 6
Synonyms: 2900059G15Rik, F730003B03Rik, Tmem16f
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Gtse1
Name: G two S phase expressed protein 1
Synonyms: B99, Gtse-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29870
VEGA: 15
Homologene: 8489
Ppm1b
Name: protein phosphatase 1B, magnesium dependent, beta isoform
Synonyms: PP2CB
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19043
VEGA: 17
HGNC: HGNC:9276
Homologene: 2027
Kif1b
Name: kinesin family member 1B
Synonyms: Kif1b alpha, KIF1Bp130, KIF1Bp204, Kif1b beta, A530096N05Rik, N-3 kinesin, D4Mil1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Schip1
Name: schwannomin interacting protein 1
Synonyms: SCHIP-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 30953
Homologene: 130673
Tfap4
Name: transcription factor AP4
Synonyms: D930048N17Rik, AP-4, Tcfap4, bHLHc41
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 83383
VEGA: 16
Homologene: 2424
Pparg
Name: peroxisome proliferator activated receptor gamma
Synonyms: PPARgamma, Ppar-gamma2, PPARgamma2, Nr1c3, PPAR-gamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19016
HGNC: HGNC:9236
Homologene: 7899
Palm
Name: paralemmin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18483
VEGA: 10
HGNC: HGNC:8594
Homologene: 1937
Rab5b
Name: RAB5B, member RAS oncogene family
Synonyms: C030027M18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19344
VEGA: 10
HGNC: HGNC:9784
Homologene: 104027
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CAP-D2, 2810465G24Rik, 2810406C15Rik, CNAP1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68298
Homologene: 6497
Nova1
Name: NOVA alternative splicing regulator 1
Synonyms: Nova-1, 9430099M15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 664883
VEGA: 12
HGNC: HGNC:7886
Homologene: 21296
Atp13a1
Name: ATPase type 13A1
Synonyms: catp, Cgi152, Atp13a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170759
VEGA: 8
Homologene: 5791
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Cemip
Name: cell migration inducing protein, hyaluronan binding
Synonyms: 9930013L23Rik, 6330404C01Rik, 12H19.01.T7, Hybid
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80982
Homologene: 10268
Cd34
Name: CD34 antigen
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12490
HGNC: HGNC:1662
Homologene: 1343
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Lgn1, Birc1e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Gm4847
Name: predicted gene 4847
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226604
Homologene: 101040
Rdh19
Name: retinol dehydrogenase 19
Synonyms: Rdhs, RDH-S
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216453
Homologene: 129514
Afp
Name: alpha fetoprotein
Synonyms: alpha-foetoprotein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11576
HGNC: HGNC:317
Homologene: 36278
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Cadm2
Name: cell adhesion molecule 2
Synonyms: SynCAM2, 2900078E11Rik, A830029E02Rik, Igsf4d, Necl3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239857
Homologene: 17705
Parp10
Name: poly (ADP-ribose) polymerase family, member 10
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 671535
Homologene: 53133
Ctse
Name: cathepsin E
Synonyms: CE, A430072O03Rik, C920004C08Rik, CatE
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13034
HGNC: HGNC:2530
Homologene: 37551
Capn2
Name: calpain 2
Synonyms: Capa-2, Capa2, m-calpain
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12334
HGNC: HGNC:1479
Homologene: 1326
Or10w1
Name: olfactory receptor family 10 subfamily W member 1
Synonyms: MOR266-6P, Olfr1490, GA_x6K02T2RE5P-3987000-3987950
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258098
Homologene: 79418
Cyp4f13
Name: cytochrome P450, family 4, subfamily f, polypeptide 13
Synonyms: leukotriene B4 omega hydroxylase, P450 CYP4F13, 0610030I10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 170716
HGNC: HGNC:2646
Homologene: 73902
Kctd1
Name: potassium channel tetramerisation domain containing 1
Synonyms: 4933402K10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106931
VEGA: 18
Homologene: 65999
A430033K04Rik
Name: RIKEN cDNA A430033K04 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243308
Homologene: 65621
Kctd11
Name: potassium channel tetramerisation domain containing 11
Synonyms: Ren
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216858
Homologene: 17697
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12722
HGNC: HGNC:2017
Homologene: 77224
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
Cel
Name: carboxyl ester lipase
Synonyms: 1810036E18Rik, BAL
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12613
HGNC: HGNC:1848
Homologene: 37529
Zfp326
Name: zinc finger protein 326
Synonyms: ZAN75, 5730470H14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54367
Homologene: 10297
Or1ad8
Name: olfactory receptor family 1 subfamily AD member 8
Synonyms: GA_x6K02T2QP88-4431129-4430206, ID7, MOR129-3, Olfr51
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18351
Homologene: 133578
Ttll12
Name: tubulin tyrosine ligase-like family, member 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223723
Homologene: 9036
Dsn1
Name: DSN1 homolog, MIS12 kinetochore complex component
Synonyms: 1700022L09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66934
Homologene: 49806
Cry2
Name: cryptochrome circadian regulator 2
Synonyms: D130054K12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12953
HGNC: HGNC:2385
Homologene: 56466
Or1s2
Name: olfactory receptor family 1 subfamily S member 1
Synonyms: MOR127-1, Olfr1496, GA_x6K02T2RE5P-4112771-4113718
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258991
Homologene: 17458
Prdx5
Name: peroxiredoxin 5
Synonyms: AOEB166, PrxV, AOPP, PMP20, Prdx6, PrxV, peroxiredoxin V
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54683
HGNC: HGNC:9355
Homologene: 8076
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 131,664,380 bp
  • T to A, chromosome 1 at 163,829,297 bp
  • T to A, chromosome 1 at 166,642,192 bp
  • T to C, chromosome 1 at 182,477,275 bp
  • A to G, chromosome 1 at 194,959,781 bp
  • T to C, chromosome 2 at 28,556,188 bp
  • C to G, chromosome 2 at 92,426,939 bp
  • C to T, chromosome 2 at 156,997,720 bp
  • G to T, chromosome 3 at 68,494,613 bp
  • T to C, chromosome 3 at 116,252,468 bp
  • A to T, chromosome 3 at 144,747,421 bp
  • C to A, chromosome 4 at 149,192,611 bp
  • C to T, chromosome 5 at 90,491,713 bp
  • T to G, chromosome 5 at 105,888,585 bp
  • A to G, chromosome 5 at 138,646,858 bp
  • A to T, chromosome 6 at 22,972,798 bp
  • A to G, chromosome 6 at 115,463,151 bp
  • T to C, chromosome 6 at 125,170,164 bp
  • A to G, chromosome 7 at 28,143,952 bp
  • T to A, chromosome 7 at 49,936,212 bp
  • T to C, chromosome 7 at 83,951,426 bp
  • T to G, chromosome 8 at 69,797,968 bp
  • T to A, chromosome 9 at 42,330,251 bp
  • T to A, chromosome 10 at 5,228,896 bp
  • T to C, chromosome 10 at 5,318,441 bp
  • C to T, chromosome 10 at 79,806,651 bp
  • T to A, chromosome 10 at 127,859,600 bp
  • G to A, chromosome 10 at 128,682,907 bp
  • T to C, chromosome 11 at 51,007,050 bp
  • T to G, chromosome 11 at 69,880,051 bp
  • T to A, chromosome 12 at 17,548,395 bp
  • T to A, chromosome 12 at 46,713,542 bp
  • A to G, chromosome 13 at 48,817,705 bp
  • T to C, chromosome 13 at 51,665,347 bp
  • G to T, chromosome 13 at 100,212,739 bp
  • A to G, chromosome 14 at 62,705,876 bp
  • T to A, chromosome 15 at 76,233,549 bp
  • T to C, chromosome 15 at 83,577,809 bp
  • A to G, chromosome 15 at 85,862,082 bp
  • T to A, chromosome 15 at 95,949,926 bp
  • T to C, chromosome 16 at 4,551,306 bp
  • A to T, chromosome 16 at 66,664,423 bp
  • G to C, chromosome 17 at 32,924,859 bp
  • T to A, chromosome 17 at 84,994,232 bp
  • A to T, chromosome 18 at 14,974,171 bp
  • A to T, chromosome 19 at 6,908,174 bp
  • T to A, chromosome 19 at 13,655,024 bp
  • A to G, chromosome 19 at 13,781,020 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8496 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067938-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.