Strain Name:
C57BL/6J-MtgxR8531Btlr/Mmmh
Stock Number:
068501-MU
Citation ID:
RRID:MMRRC_068501-MU
Other Names:
R8531 (G1)
Major Collection:

Strain Information

Npc2
Name: NPC intracellular cholesterol transporter 2
Synonyms: 2700012J19Rik, HE1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67963
VEGA: 12
Homologene: 4697
Fiz1
Name: Flt3 interacting zinc finger protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23877
Homologene: 22663
Map2k6
Name: mitogen-activated protein kinase kinase 6
Synonyms: SAPKK3, MAP kinase kinase 6, Prkmk6, MKK6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26399
HGNC: HGNC:6846
Homologene: 55686
Serpinb6a
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6a
Synonyms: D330015H01Rik, Spi3, ovalbumin, 4930482L21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20719
HGNC: HGNC:8950
Homologene: 20956
Rabep1
Name: rabaptin, RAB GTPase binding effector protein 1
Synonyms: neurocrescin, rabaptin-5, RAB5 effector protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54189
Homologene: 3451
Dhx9
Name: DExH-box helicase 9
Synonyms: leukophysin, RHA, Ddx9, nuclear DNA helicase II, RNA helicase, NDH II, NDHII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13211
HGNC: HGNC:2750
Homologene: 1039
Tut7
Name: terminal uridylyl transferase 7
Synonyms: Zcchc6, Tent3b, 6030448M23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214290
VEGA: 13
Homologene: 51941
Flnb
Name: filamin, beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Dennd4c
Name: DENN domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329877
Homologene: 23057
Rttn
Name: rotatin
Synonyms: C530033I08Rik, 4921538A15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246102
VEGA: 18
Homologene: 65275
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Spt16, Fact140, Cdc68, Supt16h
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Mphosph10
Name: M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
Synonyms: 2810453H10Rik, 5730405D16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67973
HGNC: HGNC:7213
Homologene: 134741
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, par, Emv66
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Tmem259
Name: transmembrane protein 259
Synonyms: ORF61, membralin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216157
Homologene: 14122
Gucy1a1
Name: guanylate cyclase 1, soluble, alpha 1
Synonyms: 1200016O07Rik, Gucy1a3, sGC-alpha1, alpha 1 sGC
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 60596
HGNC: HGNC:4685
Homologene: 37360
Ifnar1
Name: interferon (alpha and beta) receptor 1
Synonyms: Ifrc, IFN-alpha/betaR, Ifar
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15975
HGNC: HGNC:5432
Homologene: 524
Lepr
Name: leptin receptor
Synonyms: OB-RGRP, Leprb, Obr, LEPROT, obese-like, obl, Modb1, leptin receptor gene-related protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Osbpl9
Name: oxysterol binding protein-like 9
Synonyms: 2600011I06Rik, ORP-9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100273
Homologene: 69380
Dmp1
Name: dentin matrix protein 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13406
HGNC: HGNC:2932
Homologene: 68396
Alb
Name: albumin
Synonyms: Alb-1, Alb1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11657
HGNC: HGNC:399
Homologene: 405
Dlk1
Name: delta like non-canonical Notch ligand 1
Synonyms: ZOG, DlkI, pref-1, SCP1, pG2, Peg9, FA1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13386
HGNC: HGNC:2907
Homologene: 2846
Serpind1
Name: serine (or cysteine) peptidase inhibitor, clade D, member 1
Synonyms: HC II, heparin cofactor II, Hcf2, HCII
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15160
HGNC: HGNC:4838
Homologene: 36018
Skor2
Name: SKI family transcriptional corepressor 2
Synonyms: Fussel18, Corl2, Gm7348
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 664805
VEGA: 18
Homologene: 64797
Sult3a2
Name: sulfotransferase family 3A, member 2
Synonyms: Gm4794
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215895
VEGA: 10
Homologene: 111031
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627537
Homologene: 129750
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Tmem62
Name: transmembrane protein 62
Synonyms: B830009D23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 96957
Homologene: 11801
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Flad1
Name: flavin adenine dinucleotide synthetase 1
Synonyms: A930017E24Rik, Pp591
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319945
Homologene: 115598
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328573
VEGA: 15
Homologene: 130065
Pnpla8
Name: patatin-like phospholipase domain containing 8
Synonyms: 1200006O19Rik, iPLA2 gamma
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67452
Homologene: 12136
Cyp2d11
Name: cytochrome P450, family 2, subfamily d, polypeptide 11
Synonyms: P450-2D, Cyp2d
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545123
VEGA: 15
Homologene: 86099
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: 6430542K11Rik, Glu5R, mGluR5, Gprc1e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Egr4
Name: early growth response 4
Synonyms: pAT133, NGF1-C, NGFI-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13656
HGNC: HGNC:3241
Homologene: 1485
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94229
Homologene: 23340
Adam6a
Name: a disintegrin and metallopeptidase domain 6A
Synonyms: Adam6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238406
HGNC: HGNC:213
Homologene: 128362
Olfm5
Name: olfactomedin 5
Synonyms: E030002O03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244180
Homologene: 18253
Or5k14
Name: olfactory receptor family 5 subfamily K member 14
Synonyms: MOR184-8, GA_x54KRFPKG5P-55091371-55090442, MOR184-7, GA_x54KRFPKG5P-55043245-55042289, Olfr176, Olfr177
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258998
Homologene: 121500
Dsc3
Name: desmocollin 3
Synonyms: 5430426I24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13507
VEGA: 18
HGNC: HGNC:3037
Homologene: 1462
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381352
Homologene: 17102
Glp1r
Name: glucagon-like peptide 1 receptor
Synonyms: GLP1Rc, GLP-1R
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14652
VEGA: 17
HGNC: HGNC:4324
Homologene: 1558
Rwdd3
Name: RWD domain containing 3
Synonyms: 2510027J23Rik, RSUME, 3110037C01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66568
Homologene: 22899
Slc26a4
Name: solute carrier family 26, member 4
Synonyms: pendrin, Pds
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23985
VEGA: 12
HGNC: HGNC:8818
Homologene: 20132
Pramel27
Name: PRAME like 27
Synonyms: Gm13103
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194225
Homologene: 129883
Arhgef19
Name: Rho guanine nucleotide exchange factor 19
Synonyms: 6430573B13Rik, WGEF
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 213649
Homologene: 17710
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: SKIP, A930009L15Rik, 4930544G21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77629
Homologene: 18172
Rigi
Name: RNA sensor RIG-I
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, Ddx58, RIG-I, 6430573D20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230073
Homologene: 32215
Txk
Name: TXK tyrosine kinase
Synonyms: A130089B16Rik, PTK4, Btkl, Rlk
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22165
Homologene: 2497
Plppr4
Name: phospholipid phosphatase related 4
Synonyms: Lppr4, D3Bwg0562e, PRG-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229791
Homologene: 8895
Acox2
Name: acyl-Coenzyme A oxidase 2, branched chain
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93732
HGNC: HGNC:120
Homologene: 74473
Ube2w
Name: ubiquitin-conjugating enzyme E2W (putative)
Synonyms: 6130401J04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66799
Homologene: 10119
Btnl2
Name: butyrophilin-like 2
Synonyms: NG9, butyrophylin-like MHC class II associated, BTL-II, BTLN2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 547431
HGNC: HGNC:1142
Homologene: 10482
Tnfrsf13b
Name: tumor necrosis factor receptor superfamily, member 13b
Synonyms: Taci, 1200009E08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57916
Homologene: 49320
Nherf4
Name: NHERF family PDZ scaffold protein 4
Synonyms: Pdzk2, Pdzd3, sodium-phosphate cotransporter IIa C-terminal-associated protein 2, NaPi-Cap2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 170761
VEGA: 9
Homologene: 11719
Or5aq6
Name: olfactory receptor family 5 subfamily AQ member 6
Synonyms: MOR172-5, GA_x6K02T2Q125-48586461-48585523, Olfr1109
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258762
Homologene: 86672
Vmn1r16
Name: vomeronasal 1 receptor 16
Synonyms: V1rc29
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171202
Homologene: 123821
Serpinb9g
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9g
Synonyms: 1600002F03Rik, ovalbumin, NK21B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 93806
HGNC: HGNC:8955
Homologene: 69093
Tmem176b
Name: transmembrane protein 176B
Synonyms: Clast1, Lr8, 1810009M01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 65963
Homologene: 8521
Zfp260
Name: zinc finger protein 260
Synonyms: Zfp63, PEX1, Ozrf1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26466
Homologene: 40802
Pom121l12
Name: POM121 membrane glycoprotein-like 12
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432536
Homologene: 136280
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 16,602,318 bp
  • A to G, chromosome 1 at 83,277,188 bp
  • C to A, chromosome 1 at 153,458,436 bp
  • G to T, chromosome 2 at 25,567,718 bp
  • T to A, chromosome 2 at 52,291,062 bp
  • T to C, chromosome 2 at 62,267,507 bp
  • G to T, chromosome 2 at 87,093,326 bp
  • G to T, chromosome 2 at 121,007,052 bp
  • A to G, chromosome 3 at 82,111,161 bp
  • A to C, chromosome 3 at 89,403,210 bp
  • T to C, chromosome 3 at 117,321,943 bp
  • T to C, chromosome 3 at 121,159,139 bp
  • A to G, chromosome 4 at 40,225,596 bp
  • T to C, chromosome 4 at 86,826,082 bp
  • A to T, chromosome 4 at 101,765,415 bp
  • T to C, chromosome 4 at 109,156,711 bp
  • T to C, chromosome 4 at 141,249,592 bp
  • T to A, chromosome 4 at 143,853,031 bp
  • C to A, chromosome 5 at 72,736,377 bp
  • A to G, chromosome 5 at 90,464,014 bp
  • A to C, chromosome 5 at 104,212,403 bp
  • A to G, chromosome 6 at 48,834,604 bp
  • A to G, chromosome 6 at 57,322,915 bp
  • T to C, chromosome 6 at 85,512,124 bp
  • A to T, chromosome 7 at 5,009,164 bp
  • T to A, chromosome 7 at 30,105,459 bp
  • C to T, chromosome 7 at 46,252,049 bp
  • T to C, chromosome 7 at 64,384,328 bp
  • A to T, chromosome 7 at 88,130,516 bp
  • A to T, chromosome 7 at 104,153,822 bp
  • T to C, chromosome 7 at 119,951,368 bp
  • T to C, chromosome 9 at 44,248,373 bp
  • T to C, chromosome 10 at 33,777,243 bp
  • A to G, chromosome 10 at 79,977,985 bp
  • A to T, chromosome 11 at 14,599,932 bp
  • T to C, chromosome 11 at 61,140,951 bp
  • T to C, chromosome 11 at 70,908,506 bp
  • A to G, chromosome 11 at 110,399,349 bp
  • C to G, chromosome 11 at 119,474,205 bp
  • C to T, chromosome 12 at 31,549,912 bp
  • T to A, chromosome 12 at 44,311,585 bp
  • C to A, chromosome 12 at 84,760,838 bp
  • A to T, chromosome 12 at 103,047,663 bp
  • T to A, chromosome 12 at 103,083,596 bp
  • A to G, chromosome 12 at 109,458,140 bp
  • A to G, chromosome 12 at 113,545,297 bp
  • A to T, chromosome 13 at 33,492,913 bp
  • A to T, chromosome 13 at 33,931,479 bp
  • A to T, chromosome 13 at 59,789,260 bp
  • T to C, chromosome 14 at 7,929,939 bp
  • T to C, chromosome 14 at 8,247,960 bp
  • A to T, chromosome 14 at 52,172,563 bp
  • A to T, chromosome 15 at 82,066,421 bp
  • A to G, chromosome 15 at 82,389,228 bp
  • A to T, chromosome 16 at 17,342,983 bp
  • A to C, chromosome 16 at 58,872,653 bp
  • T to A, chromosome 16 at 91,495,456 bp
  • A to T, chromosome 17 at 19,522,197 bp
  • T to C, chromosome 17 at 30,924,557 bp
  • T to C, chromosome 17 at 34,358,054 bp
  • T to C, chromosome 18 at 19,968,392 bp
  • C to T, chromosome 18 at 19,981,217 bp
  • T to C, chromosome 18 at 67,407,369 bp
  • T to C, chromosome 18 at 76,858,874 bp
  • C to A, chromosome 18 at 89,113,343 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8531 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068501-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.