Strain Name:
C57BL/6J-MtgxR8532Btlr/Mmmh
Stock Number:
068502-MU
Citation ID:
RRID:MMRRC_068502-MU
Other Names:
R8532 (G1)
Major Collection:

Strain Information

Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: Zfp403, D330017P12Rik, DIF-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217039
Homologene: 11750
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, 4933425K22Rik, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Rcbtb1
Name: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
Synonyms: 5430409I18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71330
Homologene: 10061
Cep78
Name: centrosomal protein 78
Synonyms: 5730599I05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 208518
VEGA: 19
Homologene: 11030
Chek1
Name: checkpoint kinase 1
Synonyms: Chk1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12649
HGNC: HGNC:1925
Homologene: 975
Slitrk5
Name: SLIT and NTRK-like family, member 5
Synonyms: 2610019D03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75409
VEGA: 14
Homologene: 9193
Anxa2
Name: annexin A2
Synonyms: 36-kDa calelectrin, Cal1h, annexin II, lipocortin II
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12306
Homologene: 20857
Brms1l
Name: breast cancer metastasis-suppressor 1-like
Synonyms: 0710008O11Rik, BRMS1, D12Ertd407e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52592
VEGA: 12
Homologene: 9123
Dennd1b
Name: DENN domain containing 1B
Synonyms: F730008N07Rik, 6820401H01Rik, 4930467M19Rik, 4632404N19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
Zfp57
Name: zinc finger protein 57
Synonyms: G19
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22715
Homologene: 7603
Gtf2e2
Name: general transcription factor II E, polypeptide 2 (beta subunit)
Synonyms: C330006J08Rik, 34kDa
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68153
HGNC: HGNC:4651
Homologene: 37573
Zbtb11
Name: zinc finger and BTB domain containing 11
Synonyms: ZNF-U69274, 9230110G02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 271377
Homologene: 8678
Enpep
Name: glutamyl aminopeptidase
Synonyms: Ly51, aminopeptidase-A, 6030431M22Rik, APA, Bp-1/6C3, Ly-51
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Pramel1
Name: PRAME like 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83491
Homologene: 87078
Abcb11
Name: ATP-binding cassette, sub-family B member 11
Synonyms: ABC16, Lith1, PFIC2, sister of P-glycoprotein, Bsep, PGY4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Tdrd7
Name: tudor domain containing 7
Synonyms: 5730495N10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100121
Homologene: 8618
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212392
Homologene: 17668
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19886
Homologene: 2207
Adam2
Name: a disintegrin and metallopeptidase domain 2
Synonyms: Ftnb, Ph30-beta, fertilin beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11495
VEGA: 14
HGNC: HGNC:198
Homologene: 1127
Mical2
Name: microtubule associated monooxygenase, calponin and LIM domain containing 2
Synonyms: Micalcl, Ebitein1, 4921517J23Rik, 5330438E18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320878
Homologene: 8760
Tcaf1
Name: TRPM8 channel-associated factor 1
Synonyms: 3321401G04Rik, 2810407D09Rik, A230020K05Rik, Fam115a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77574
Homologene: 8815
Or13a17
Name: olfactory receptor family 13 subfamily A member 17
Synonyms: GA_x6K02T2PBJ9-42837030-42837962, MOR253-2, IB6, Olfr45
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18344
Homologene: 79416
Fam149a
Name: family with sequence similarity 149, member A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212326
Homologene: 27540
Tbc1d16
Name: TBC1 domain family, member 16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207592
Homologene: 10380
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: alpha1E, Cchra1, Cav2.3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
Syt10
Name: synaptotagmin X
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54526
Homologene: 10303
Zfp715
Name: zinc finger protein 715
Synonyms: 2610041B18Rik, mszf15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69930
Homologene: 74591
Kif12
Name: kinesin family member 12
Synonyms: N-9 kinesin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16552
Homologene: 7796
Timm44
Name: translocase of inner mitochondrial membrane 44
Synonyms: 0710005E20Rik, Tim44, Mimt44, D8Ertd118e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21856
Homologene: 4631
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: A330035H04Rik, Facl6, Lacsl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216739
Homologene: 100939
Or9m2
Name: olfactory receptor family 9 subfamily M member 2
Synonyms: GA_x6K02T2Q125-49480812-49481753, MOR173-3, Olfr1158
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258639
Eif2b5
Name: eukaryotic translation initiation factor 2B, subunit 5 epsilon
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224045
HGNC: HGNC:3261
Homologene: 2903
Rps6kb2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: S6K2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58988
Homologene: 68374
Or52e8b
Name: olfactory receptor family 52 subfamily E member 8B
Synonyms: MOR32-9P, Olfr675, GA_x6K02T2PBJ9-7653782-7652841
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258147
Homologene: 133595
Snrpa
Name: small nuclear ribonucleoprotein polypeptide A
Synonyms: C430021M15Rik, U1A, U1 snRNP, Rnu1a1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53607
Homologene: 133537
Slc17a4
Name: solute carrier family 17 (sodium phosphate), member 4
Synonyms: 9130214H05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319848
Homologene: 21127
Tbc1d30
Name: TBC1 domain family, member 30
Synonyms: 4930505D03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74694
VEGA: 10
Homologene: 18930
Xcl1
Name: chemokine (C motif) ligand 1
Synonyms: lymphotactin, Lptn, SCM-1, SCM-1a, LTN, ATAC, Scyc1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16963
Homologene: 2250
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 139,170,174 bp
  • A to T, chromosome 1 at 154,465,764 bp
  • T to A, chromosome 1 at 164,931,946 bp
  • C to A, chromosome 2 at 69,259,691 bp
  • A to G, chromosome 2 at 87,990,569 bp
  • C to T, chromosome 3 at 86,757,483 bp
  • A to T, chromosome 3 at 129,276,653 bp
  • A to G, chromosome 4 at 46,016,920 bp
  • G to A, chromosome 4 at 63,169,419 bp
  • A to G, chromosome 4 at 143,398,555 bp
  • A to T, chromosome 5 at 90,264,820 bp
  • A to T, chromosome 6 at 42,678,131 bp
  • G to C, chromosome 6 at 70,588,722 bp
  • A to G, chromosome 7 at 27,191,602 bp
  • A to C, chromosome 7 at 43,299,405 bp
  • A to T, chromosome 7 at 43,299,710 bp
  • T to C, chromosome 7 at 105,024,566 bp
  • C to A, chromosome 7 at 112,318,544 bp
  • T to C, chromosome 7 at 140,691,799 bp
  • A to T, chromosome 8 at 4,260,549 bp
  • T to C, chromosome 8 at 33,758,605 bp
  • T to A, chromosome 8 at 45,348,954 bp
  • T to C, chromosome 8 at 45,942,995 bp
  • T to C, chromosome 9 at 36,719,692 bp
  • T to C, chromosome 9 at 69,467,312 bp
  • T to G, chromosome 10 at 52,098,756 bp
  • A to T, chromosome 10 at 121,267,430 bp
  • T to A, chromosome 11 at 54,327,175 bp
  • C to T, chromosome 11 at 84,837,989 bp
  • A to G, chromosome 11 at 119,155,167 bp
  • T to C, chromosome 12 at 55,844,479 bp
  • T to C, chromosome 12 at 115,495,650 bp
  • C to A, chromosome 13 at 23,904,735 bp
  • A to T, chromosome 13 at 62,368,955 bp
  • T to A, chromosome 14 at 59,210,524 bp
  • C to A, chromosome 14 at 66,056,521 bp
  • A to T, chromosome 14 at 111,679,477 bp
  • C to A, chromosome 15 at 34,316,553 bp
  • C to T, chromosome 15 at 89,792,686 bp
  • T to C, chromosome 16 at 20,505,206 bp
  • A to T, chromosome 16 at 55,990,889 bp
  • A to G, chromosome 17 at 37,009,901 bp
  • A to T, chromosome 19 at 4,159,244 bp
  • T to A, chromosome 19 at 15,959,584 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8532 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068502-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.