Strain Name:
C57BL/6J-MtgxR8681Btlr/Mmmh
Stock Number:
068536-MU
Citation ID:
RRID:MMRRC_068536-MU
Other Names:
R8681 (G1)
Major Collection:

Strain Information

Ptprf
Name: protein tyrosine phosphatase receptor type F
Synonyms: LAR, RPTP-LAR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Ino80e
Name: INO80 complex subunit E
Synonyms: Ccdc95
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233875
Homologene: 17792
Nsmce2
Name: NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
Synonyms: 1110014D18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68501
VEGA: 15
Homologene: 12271
Pogz
Name: pogo transposable element with ZNF domain
Synonyms: 9530006B08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229584
Homologene: 9022
Tars2
Name: threonyl-tRNA synthetase 2, mitochondrial (putative)
Synonyms: 2610024N01Rik, Tarsl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71807
Homologene: 23520
Mms19
Name: MMS19 cytosolic iron-sulfur assembly component
Synonyms: 2610042O15Rik, Mms19, C86341, Mms19l
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72199
Homologene: 41480
Slc44a1
Name: solute carrier family 44, member 1
Synonyms: CHTL1, CTL1, 4833416H08Rik, Cdw92, 2210409B22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100434
Homologene: 11137
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Adcy1
Name: adenylate cyclase 1
Synonyms: AC1, I-AC, D11Bwg1392e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432530
HGNC: HGNC:232
Homologene: 41419
Adam32
Name: a disintegrin and metallopeptidase domain 32
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 353188
Homologene: 17021
Il17c
Name: interleukin 17C
Synonyms: IL-17C
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234836
HGNC: HGNC:5983
Homologene: 8320
Cntrl
Name: centriolin
Synonyms: IB3/5, 6720467O09Rik, Ma2a8, Cep1, b2b1468Clo, Cep110
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Zfp142
Name: zinc finger protein 142
Synonyms: 9330177B18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77264
Homologene: 3723
Lemd3
Name: LEM domain containing 3
Synonyms: Man1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380664
Homologene: 8633
Slc44a4
Name: solute carrier family 44, member 4
Synonyms: NG22, 2210409B01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70129
Homologene: 11359
Clu
Name: clusterin
Synonyms: testosterone repressed prostate message-2, SP-40, complement lysis inhibitor, Sgp-2, ApoJ, Apolipoprotein J, Sugp-2, Cli, Sgp2, D14Ucla3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12759
HGNC: HGNC:2095
Homologene: 1382
Pkp2
Name: plakophilin 2
Synonyms: 1200012P04Rik, 1200008D14Rik, Pkp2l
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67451
HGNC: HGNC:9024
Homologene: 3364
Fbxo33
Name: F-box protein 33
Synonyms: 5730501N20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70611
Homologene: 16501
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Mdh1b
Name: malate dehydrogenase 1B, NAD (soluble)
Synonyms: 1700124B08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76668
Homologene: 57110
Abcc12
Name: ATP-binding cassette, sub-family C member 12
Synonyms: MRP9, 4930467B22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244562
Homologene: 57211
Dll3
Name: delta like canonical Notch ligand 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13389
HGNC: HGNC:2909
Homologene: 7291
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56552
Homologene: 135915
Spic
Name: Spi-C transcription factor (Spi-1/PU.1 related)
Synonyms: Spi-C, Prf, C76795
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20728
Homologene: 7953
Vmn1r67
Name: vomeronasal 1 receptor 67
Synonyms: V1re10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171263
Homologene: 128344
Slc8a3
Name: solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms: Ncx3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110893
Homologene: 62645
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: merg1a, ether a go-go related, M-erg, LQT, Lqt2, ERG1, merg1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: KA2, GluRgamma2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Dcaf17
Name: DDB1 and CUL4 associated factor 17
Synonyms: 2810055O12Rik, A030004A10Rik, 4833418A01Rik, A930009G19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75763
Homologene: 65979
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2, bapa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Cyp26c1
Name: cytochrome P450, family 26, subfamily c, polypeptide 1
Synonyms: EG546726
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 546726
VEGA: 19
Homologene: 28089
Or11h7
Name: olfactory receptor family 11 subfamily H member 7
Synonyms: GA_x6K02T2PMLR-6372116-6373060, MOR106-12, Olfr746
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258295
Homologene: 134081
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74376
Homologene: 53435
Lrrc25
Name: leucine rich repeat containing 25
Synonyms: Mapa
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211228
Homologene: 51663
Stk36
Name: serine/threonine kinase 36
Synonyms: 1700112N14Rik, Fused
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269209
Homologene: 49432
Klrb1
Name: killer cell lectin-like receptor subfamily B member 1
Synonyms: Ly-55, Ly55, Gm4696, 4930431A04Rik, Nkrp1g
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100043861
HGNC: HGNC:6373
Homologene: 135763
A430078G23Rik
Name: RIKEN cDNA A430078G23 gene
Type: Gene
Species: Mouse
Chromosome: 8
Lilra5
Name: leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
Synonyms: Gm4878
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232801
Homologene: 83297
Cyp2c38
Name: cytochrome P450, family 2, subfamily c, polypeptide 38
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13097
Homologene: 117948
Zfp773
Name: zinc finger protein 773
Synonyms: 2810409K11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76373
Homologene: 137393
Or5aq6
Name: olfactory receptor family 5 subfamily AQ member 6
Synonyms: GA_x6K02T2Q125-48586461-48585523, MOR172-5, Olfr1109
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258762
Homologene: 86672
Aebp1
Name: AE binding protein 1
Synonyms: ACLP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11568
HGNC: HGNC:303
Homologene: 878
Cep112
Name: centrosomal protein 112
Synonyms: 1700001M19Rik, 1700029K01Rik, 8430407H02Rik, Macoco, Ccdc46
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76380
Homologene: 44915
Col23a1
Name: collagen, type XXIII, alpha 1
Synonyms: 2810458L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237759
Homologene: 72101
Gm10118
Name: predicted gene 10118
Type: Gene
Species: Mouse
Chromosome: 10
Odad1
Name: outer dynein arm docking complex subunit 1
Synonyms: Ccdc114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 211535
Homologene: 128610
Syce1
Name: synaptonemal complex central element protein 1
Synonyms: 4933406J07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74075
Homologene: 77044
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: LOC380650, C030032C09Rik, E530015N03Rik, AIDA-1b, Gm10937
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77531
Homologene: 51570
Cyp4a30b
Name: cytochrome P450, family 4, subfamily a, polypeptide 30b
Synonyms: OTTMUSG00000008626, Cyp4a30b-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435802
Tmem9b
Name: TMEM9 domain family, member B
Synonyms: D7H11orf15, ICRFP703N2430Q5.3, ICRFP703B1614Q5.3, 2310004K06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56786
HGNC: HGNC:1168
Homologene: 23191
Rps6kl1
Name: ribosomal protein S6 kinase-like 1
Synonyms: A830084F09Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238323
VEGA: 12
Homologene: 12874
Gm9611
Name: predicted gene 9611
Type: Gene
Species: Mouse
Chromosome: 14
Msx3
Name: msh homeobox 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17703
Homologene: 101667
Prrx2
Name: paired related homeobox 2
Synonyms: Prx2, S8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20204
Homologene: 7524
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 63,715,201 bp
  • T to C, chromosome 1 at 74,571,588 bp
  • T to C, chromosome 1 at 74,622,233 bp
  • G to T, chromosome 2 at 30,845,507 bp
  • T to C, chromosome 2 at 35,148,588 bp
  • T to C, chromosome 2 at 52,237,036 bp
  • T to A, chromosome 2 at 71,056,569 bp
  • A to T, chromosome 2 at 87,093,046 bp
  • T to A, chromosome 3 at 94,860,923 bp
  • G to A, chromosome 3 at 95,750,887 bp
  • A to T, chromosome 4 at 6,271,207 bp
  • A to T, chromosome 4 at 53,481,510 bp
  • G to A, chromosome 4 at 115,457,745 bp
  • T to C, chromosome 4 at 118,231,647 bp
  • G to T, chromosome 5 at 24,331,983 bp
  • T to A, chromosome 5 at 112,873,563 bp
  • C to T, chromosome 6 at 124,024,918 bp
  • A to C, chromosome 6 at 128,710,049 bp
  • T to C, chromosome 7 at 4,238,217 bp
  • T to C, chromosome 7 at 7,136,483 bp
  • A to G, chromosome 7 at 10,447,201 bp
  • G to A, chromosome 7 at 25,010,472 bp
  • T to C, chromosome 7 at 28,294,845 bp
  • A to G, chromosome 7 at 45,941,839 bp
  • A to G, chromosome 7 at 109,745,320 bp
  • A to G, chromosome 7 at 126,861,721 bp
  • T to A, chromosome 7 at 140,048,987 bp
  • G to A, chromosome 7 at 140,782,074 bp
  • A to G, chromosome 8 at 3,389,074 bp
  • G to A, chromosome 8 at 24,837,795 bp
  • G to A, chromosome 8 at 70,617,664 bp
  • A to G, chromosome 8 at 86,505,279 bp
  • A to G, chromosome 8 at 122,423,468 bp
  • G to A, chromosome 9 at 59,868,111 bp
  • C to T, chromosome 10 at 63,926,977 bp
  • T to A, chromosome 10 at 88,675,985 bp
  • T to A, chromosome 10 at 90,050,006 bp
  • T to C, chromosome 10 at 120,931,823 bp
  • A to G, chromosome 11 at 5,867,899 bp
  • T to C, chromosome 11 at 7,161,328 bp
  • A to T, chromosome 11 at 51,567,929 bp
  • A to C, chromosome 11 at 67,352,134 bp
  • T to C, chromosome 11 at 108,425,652 bp
  • A to G, chromosome 12 at 59,219,044 bp
  • T to C, chromosome 12 at 81,315,140 bp
  • T to A, chromosome 12 at 85,147,855 bp
  • T to C, chromosome 13 at 63,190,559 bp
  • T to C, chromosome 14 at 42,296,069 bp
  • A to T, chromosome 14 at 50,653,344 bp
  • T to C, chromosome 14 at 65,980,957 bp
  • A to G, chromosome 15 at 59,601,359 bp
  • T to A, chromosome 15 at 98,846,067 bp
  • A to T, chromosome 16 at 16,230,681 bp
  • A to G, chromosome 17 at 34,928,277 bp
  • A to T, chromosome 19 at 37,686,617 bp
  • A to C, chromosome 19 at 39,401,691 bp
  • G to A, chromosome 19 at 41,949,476 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8681 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068536-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.