Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8693Btlr/Mmmh
Stock Number:
068547-MU
Citation ID:
RRID:MMRRC_068547-MU
Other Names:
R8693 (G1)
Major Collection:

Strain Information

Crhr2
Name: corticotropin releasing hormone receptor 2
Synonyms: Crfr2, CRF-R2, CRFR2beta, CRFR2alpha, CRF 2 receptor, CRH-R2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12922
HGNC: HGNC:2358
Homologene: 55612
Med1
Name: mediator complex subunit 1
Synonyms: TRAP 220, TRAP220, CRSP210, DRIP205, Pparbp, l11Jus15, PBP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Scrib
Name: scribbled planar cell polarity
Synonyms: Scrb1, Crc
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Exog
Name: exo/endonuclease G
Synonyms: ENGL-a, ENDOGL2, ENGL-B, Endogl1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208194
VEGA: 9
HGNC: HGNC:3347
Homologene: 3745
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, HTRX1, ALL-1, All1, Cxxc7, Mll, Mll1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Sdad1
Name: SDA1 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231452
Homologene: 6036
Unk
Name: unkempt family zinc finger
Synonyms: B230379M23Rik, Zc3h5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217331
Homologene: 18194
Setdb1
Name: SET domain, bifurcated 1
Synonyms: ESET, KMT1E
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 84505
Homologene: 32157
Top2a
Name: topoisomerase (DNA) II alpha
Synonyms: DNA Topoisomerase II alpha, Top-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21973
Homologene: 830
Chek1
Name: checkpoint kinase 1
Synonyms: Chk1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12649
HGNC: HGNC:1925
Homologene: 975
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Rph3a
Name: rabphilin 3A
Synonyms: 2900002P20Rik, Doc2 family
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19894
Homologene: 7921
Pcx
Name: pyruvate carboxylase
Synonyms: Pc
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18563
VEGA: 19
HGNC: HGNC:8636
Homologene: 5422
Slc17a8
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
Synonyms: Vglut3, Vgt3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216227
Homologene: 13584
Sh3bgrl3
Name: SH3 domain binding glutamic acid-rich protein-like 3
Synonyms: 1110004L05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73723
Homologene: 41824
Cndp1
Name: carnosine dipeptidase 1
Synonyms: Cn1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 338403
Homologene: 57178
Galnt14
Name: polypeptide N-acetylgalactosaminyltransferase 14
Synonyms: 0610033M06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71685
Homologene: 56997
Cdk12
Name: cyclin dependent kinase 12
Synonyms: 1810022J16Rik, Crk7, D11Ertd752e, Crkrs
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69131
Homologene: 128632
Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Synonyms: PERK
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13666
HGNC: HGNC:3255
Homologene: 3557
Wwtr1
Name: WW domain containing transcription regulator 1
Synonyms: 2610021I22Rik, 2310058J06Rik, TAZ, transcriptional coactivator with PDZ binding motif
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 97064
Homologene: 9159
Akap8
Name: A kinase anchor protein 8
Synonyms: AKAP95, 1200016A02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56399
VEGA: 17
HGNC: HGNC:378
Homologene: 4278
Cnot3
Name: CCR4-NOT transcription complex, subunit 3
Synonyms: A930039N10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232791
HGNC: HGNC:7879
Homologene: 133900
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Tnfrsf19
Name: tumor necrosis factor receptor superfamily, member 19
Synonyms: TAJ, Troy, TAJ-ALPHA, TRADE
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 29820
VEGA: 14
Homologene: 8481
Wnt9b
Name: wingless-type MMTV integration site family, member 9B
Synonyms: clf, Wnt14b, Wnt15, clf1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22412
Homologene: 2551
Sox6
Name: SRY (sex determining region Y)-box 6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20679
Homologene: 22631
Dennd5b
Name: DENN domain containing 5B
Synonyms: 9330160C06Rik, D030011O10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320560
Homologene: 44911
Arhgap30
Name: Rho GTPase activating protein 30
Synonyms: 6030405P05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226652
Homologene: 18766
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: b2b012Clo, Jbts17, Hug, 2410089E03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Plcb1
Name: phospholipase C, beta 1
Synonyms: 3110043I21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18795
Homologene: 22876
Fbxl4
Name: F-box and leucine-rich repeat protein 4
Synonyms: FBL5, FBL4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269514
Homologene: 8128
Msto1
Name: misato 1, mitochondrial distribution and morphology regulator
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229524
Homologene: 41228
Alpi
Name: alkaline phosphatase, intestinal
Synonyms: 2010001C14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76768
Homologene: 122414
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 252866
Homologene: 78104
Pygl
Name: liver glycogen phosphorylase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110095
HGNC: HGNC:9725
Homologene: 84371
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Pbld1
Name: phenazine biosynthesis-like protein domain containing 1
Synonyms: 0610038K03Rik, Pbld
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68371
VEGA: 10
Homologene: 41470
Or10d1
Name: olfactory receptor family 10 subfamily D member 1
Synonyms: GA_x6K02T2PVTD-33270211-33269276, MOR224-3, Olfr959
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258501
VEGA: 9
Homologene: 71989
Lgals4
Name: lectin, galactose binding, soluble 4
Synonyms: galectin-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16855
HGNC: HGNC:6565
Homologene: 21239
Dctd
Name: dCMP deaminase
Synonyms: 6030466N05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320685
HGNC: HGNC:2710
Homologene: 55618
Abcc2
Name: ATP-binding cassette, sub-family member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Pcdhb12
Name: protocadherin beta 12
Synonyms: Pcdhb5F, PcdhbL, Pcdh3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93883
HGNC: HGNC:8690
Homologene: 87126
Trappc3l
Name: trafficking protein particle complex 3 like
Synonyms: ENSMUSG00000071340, Bet3l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 692132
VEGA: 10
Homologene: 82663
Armh1
Name: armadillo-like helical domain containing 1
Synonyms: LOC381544, LOC381543, Ncrna00082, Gm1661
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381544
Homologene: 28727
Psme3
Name: proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
Synonyms: Ki, pa28g, PA28gamma, REGgamma
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19192
HGNC: HGNC:9570
Homologene: 2111
Dhrs13
Name: dehydrogenase/reductase 13
Synonyms: 2610209N15Rik, dehydrogenase/reductase (SDR family) member 13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70451
Homologene: 64807
Tmem30c
Name: transmembrane protein 30C
Synonyms: 4933409A18Rik, 4933401B01Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71027
Homologene: 78138
Frmd3
Name: FERM domain containing 3
Synonyms: EPB41L4O, P410, 4.1O, 9430066I12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242506
Homologene: 16012
Ccdc177
Name: coiled-coil domain containing 177
Synonyms: LOC380768, Gm1568
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380768
VEGA: 12
Homologene: 128326
Lpo
Name: lactoperoxidase
Synonyms: 5830499B15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76113
HGNC: HGNC:6678
Homologene: 21240
Fndc11
Name: fibronectin type III domain containing 11
Synonyms: 1700026M20Rik, BC051628
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 332713
Homologene: 11442
Vamp1
Name: vesicle-associated membrane protein 1
Synonyms: VAMP-1, Syb-1, Syb1, lew
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22317
Homologene: 40678
Igkv5-48
Name: immunoglobulin kappa variable 5-48
Synonyms: ENSMUSG00000029975, Gm10881
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 619846
Igkv4-63
Name: immunoglobulin kappa variable 4-63
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 628571
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 87,098,683 bp
  • T to C, chromosome 1 at 171,397,526 bp
  • T to A, chromosome 2 at 118,432,237 bp
  • T to A, chromosome 2 at 119,963,926 bp
  • A to G, chromosome 2 at 135,252,776 bp
  • A to C, chromosome 2 at 181,222,071 bp
  • T to A, chromosome 3 at 57,462,524 bp
  • T to A, chromosome 3 at 83,285,324 bp
  • T to C, chromosome 3 at 88,911,877 bp
  • T to C, chromosome 3 at 95,341,730 bp
  • T to C, chromosome 4 at 22,403,704 bp
  • T to A, chromosome 4 at 74,162,049 bp
  • T to C, chromosome 4 at 117,231,763 bp
  • T to C, chromosome 4 at 134,127,805 bp
  • C to A, chromosome 5 at 92,304,998 bp
  • A to G, chromosome 5 at 114,226,783 bp
  • A to T, chromosome 5 at 120,962,438 bp
  • A to G, chromosome 6 at 55,102,794 bp
  • A to G, chromosome 6 at 69,378,067 bp
  • G to A, chromosome 6 at 69,726,795 bp
  • A to T, chromosome 6 at 70,881,551 bp
  • T to C, chromosome 6 at 84,111,970 bp
  • G to A, chromosome 6 at 125,240,425 bp
  • A to T, chromosome 6 at 149,009,774 bp
  • T to C, chromosome 7 at 3,653,523 bp
  • C to T, chromosome 7 at 28,841,496 bp
  • T to A, chromosome 7 at 115,662,397 bp
  • T to C, chromosome 8 at 43,651,604 bp
  • T to A, chromosome 8 at 48,112,011 bp
  • A to G, chromosome 9 at 36,713,844 bp
  • G to T, chromosome 9 at 39,572,504 bp
  • T to C, chromosome 9 at 44,810,684 bp
  • A to G, chromosome 9 at 119,447,042 bp
  • T to C, chromosome 10 at 5,140,928 bp
  • G to A, chromosome 10 at 34,098,921 bp
  • A to T, chromosome 10 at 63,075,111 bp
  • G to A, chromosome 10 at 89,592,896 bp
  • G to C, chromosome 11 at 78,032,666 bp
  • T to C, chromosome 11 at 87,809,240 bp
  • T to C, chromosome 11 at 98,155,773 bp
  • C to T, chromosome 11 at 98,250,307 bp
  • T to A, chromosome 11 at 99,010,042 bp
  • T to C, chromosome 11 at 101,320,596 bp
  • T to C, chromosome 11 at 103,733,661 bp
  • C to T, chromosome 11 at 116,047,814 bp
  • A to T, chromosome 12 at 70,197,406 bp
  • A to G, chromosome 12 at 80,757,808 bp
  • G to T, chromosome 12 at 82,169,743 bp
  • C to T, chromosome 14 at 44,338,558 bp
  • T to C, chromosome 14 at 60,971,002 bp
  • T to C, chromosome 15 at 8,229,008 bp
  • C to A, chromosome 15 at 76,064,505 bp
  • T to A, chromosome 16 at 34,034,514 bp
  • G to A, chromosome 16 at 57,266,492 bp
  • A to T, chromosome 17 at 32,310,651 bp
  • A to T, chromosome 17 at 73,526,262 bp
  • G to A, chromosome 18 at 37,437,421 bp
  • T to C, chromosome 18 at 84,628,813 bp
  • G to T, chromosome 19 at 4,602,011 bp
  • T to C, chromosome 19 at 43,822,035 bp
  • T to C, chromosome 19 at 56,321,952 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8693 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068547-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.