Strain Name:
C57BL/6J-MtgxR8758Btlr/Mmmh
Stock Number:
068598-MU
Citation ID:
RRID:MMRRC_068598-MU
Other Names:
R8758 (G1)
Major Collection:

Strain Information

Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: Wdt4, C130078N17Rik, ANKRD4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228852
Homologene: 9194
Gpm6a
Name: glycoprotein m6a
Synonyms: Gpm6, M6A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234267
HGNC: HGNC:4460
Homologene: 3864
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2810012K13Rik, 2210413N07Rik, SBP2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75420
Homologene: 11415
Ranbp1
Name: RAN binding protein 1
Synonyms: Htf9a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19385
HGNC: HGNC:9847
Homologene: 21600
Skil
Name: SKI-like
Synonyms: sno-dE3, 9130011J04Rik, SnoN2, Skir, SnoN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20482
Homologene: 3948
Dock4
Name: dedicator of cytokinesis 4
Synonyms: EST N28122, 6330411N01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Tmx1
Name: thioredoxin-related transmembrane protein 1
Synonyms: Txndc1, 2810425A04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72736
Homologene: 12482
Tmem135
Name: transmembrane protein 135
Synonyms: 2810439K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72759
Homologene: 11295
Dock7
Name: dedicator of cytokinesis 7
Synonyms: LOC242555, 3110056M06Rik, m
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67299
Homologene: 23566
Rph3a
Name: rabphilin 3A
Synonyms: 2900002P20Rik, Doc2 family
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19894
Homologene: 7921
Ube3b
Name: ubiquitin protein ligase E3B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 117146
Homologene: 13775
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 2A-HUB, 6430549P11Rik, 2310047C04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224170
Homologene: 8771
Ikzf1
Name: IKAROS family zinc finger 1
Synonyms: Ikaros, LyF-1, 5832432G11Rik, Zfpn1a1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22778
Homologene: 55948
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: 9330197E15Rik, A630028O16Rik, LOC380767
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Cwc22
Name: CWC22 spliceosome-associated protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80744
Homologene: 6048
Ssh2
Name: slingshot protein phosphatase 2
Synonyms: SSH-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237860
Homologene: 14116
Kcna4
Name: potassium voltage-gated channel, shaker-related subfamily, member 4
Synonyms: Kv1.4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16492
HGNC: HGNC:6222
Homologene: 20514
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70853
Homologene: 27053
Vmn2r57
Name: vomeronasal 2, receptor 57
Synonyms: EG269902
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269902
Homologene: 104832
Tgfbi
Name: transforming growth factor, beta induced
Synonyms: 68kDa, bIG-h3, Beta-ig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21810
VEGA: 13
Homologene: 37294
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: Cc1, LaXp180, 5930404L04Rik, Fip200, 2900055E04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12421
Homologene: 7659
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Tgfbr3
Name: transforming growth factor, beta receptor III
Synonyms: 1110036H20Rik, TBRIII, betaglycan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21814
Homologene: 2436
Psg21
Name: pregnancy-specific beta-1-glycoprotein 21
Synonyms: cea8, 1600026N13Rik, 1600025N01Rik, 1600019C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72242
Homologene: 110989
Mmrn1
Name: multimerin 1
Synonyms: 4921530G03Rik, Emilin4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70945
HGNC: HGNC:7178
Homologene: 49134
Plxnc1
Name: plexin C1
Synonyms: vespr, CD232, 2510048K12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Slc28a3
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
Synonyms: Cnt3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 114304
Homologene: 32533
Evi5l
Name: ecotropic viral integration site 5 like
Synonyms: 3110007G05Rik, B130050I23Rik, 2310039H16Rik, 1700084G18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 213027
Homologene: 134635
1700009N14Rik
Name: RIKEN cDNA 1700009N14 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75471
Homologene: 128450
Amer2
Name: APC membrane recruitment 2
Synonyms: 2600011E07Rik, Amer2, Fam123a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72125
VEGA: 14
Homologene: 45141
Gimd1
Name: GIMAP family P-loop NTPase domain containing 1
Synonyms: Gm5549
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433653
Homologene: 47516
Arl8a
Name: ADP-ribosylation factor-like 8A
Synonyms: 1110033P22Rik, Arl10b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68724
Homologene: 23600
D930048N14Rik
Name: RIKEN cDNA D930048N14 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 97775
Fibp
Name: fibroblast growth factor (acidic) intracellular binding protein
Synonyms: 2010005N21Rik, 3010027N18Rik, 2010004G08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58249
VEGA: 19
HGNC: HGNC:3705
Homologene: 3106
Ddx25
Name: DEAD box helicase 25
Synonyms: GRTH, DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30959
Homologene: 8310
Glra1
Name: glycine receptor, alpha 1 subunit
Synonyms: B230397M16Rik, ot, oscillator, nmf11
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14654
HGNC: HGNC:4326
Homologene: 20083
Lipt2
Name: lipoyl(octanoyl) transferase 2 (putative)
Synonyms: 2610209A20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67164
Homologene: 41659
Gm49359
Name: predicted gene, 49359
Type: Gene
Species: Mouse
Chromosome: 13
Igkv4-74
Name: immunoglobulin kappa variable 4-74
Synonyms: Gm10880, 236047
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236047
Gm30191
Name: predicted gene, 30191
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 115489946
Homologene: 139639
AC157566.4
Name:
Type: Gene
Species: Mouse
Chromosome: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 6,240,227 bp
  • A to G, chromosome 1 at 37,137,792 bp
  • A to T, chromosome 1 at 135,154,451 bp
  • T to C, chromosome 2 at 77,917,097 bp
  • T to A, chromosome 2 at 107,296,149 bp
  • G to A, chromosome 2 at 158,751,178 bp
  • C to T, chromosome 3 at 31,118,537 bp
  • T to A, chromosome 3 at 132,635,038 bp
  • G to A, chromosome 4 at 39,450,811 bp
  • C to T, chromosome 4 at 99,061,318 bp
  • A to G, chromosome 4 at 134,249,788 bp
  • G to A, chromosome 5 at 107,149,884 bp
  • A to T, chromosome 5 at 114,415,200 bp
  • A to T, chromosome 5 at 120,959,302 bp
  • T to A, chromosome 6 at 40,729,043 bp
  • A to G, chromosome 6 at 60,987,209 bp
  • AG to A, chromosome 6 at 69,185,327 bp
  • T to C, chromosome 7 at 18,650,753 bp
  • G to T, chromosome 7 at 41,428,739 bp
  • A to T, chromosome 7 at 89,305,513 bp
  • GGCGCCCGCGCGCG to GGCG, chromosome 7 at 100,159,681 bp
  • G to T, chromosome 8 at 4,205,860 bp
  • T to C, chromosome 8 at 55,058,798 bp
  • T to A, chromosome 9 at 35,542,004 bp
  • A to C, chromosome 10 at 94,922,745 bp
  • A to G, chromosome 11 at 11,761,359 bp
  • A to G, chromosome 11 at 51,653,741 bp
  • T to A, chromosome 11 at 55,527,365 bp
  • T to A, chromosome 11 at 77,454,017 bp
  • A to T, chromosome 12 at 40,788,232 bp
  • A to G, chromosome 12 at 70,456,014 bp
  • A to G, chromosome 12 at 79,264,309 bp
  • G to A, chromosome 13 at 51,679,833 bp
  • C to T, chromosome 13 at 56,632,081 bp
  • T to C, chromosome 13 at 58,572,610 bp
  • A to T, chromosome 13 at 62,454,336 bp
  • C to T, chromosome 14 at 60,378,877 bp
  • A to G, chromosome 15 at 47,606,197 bp
  • T to C, chromosome 15 at 76,534,182 bp
  • T to C, chromosome 16 at 18,241,795 bp
  • T to C, chromosome 16 at 48,977,937 bp
  • A to G, chromosome 19 at 5,464,942 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8758 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068598-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.