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Strain Name:
C57BL/6J-MtgxR8747Btlr/Mmmh
Stock Number:
068618-MU
Citation ID:
RRID:MMRRC_068618-MU
Other Names:
R8747 (G1)
Major Collection:

Strain Information

Casp8
Name: caspase 8
Synonyms: Mch5, MACH, FLICE, Caspase-8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12370
HGNC: HGNC:1509
Homologene: 7657
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: PARP, sPARP-1, Adprp, parp-1, 5830444G22Rik, Adprt1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11545
HGNC: HGNC:270
Homologene: 1222
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: 6330503C17Rik, Zfp262
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67785
Homologene: 35470
Vmp1
Name: vacuole membrane protein 1
Synonyms: 4930579A11Rik, 3110098I04Rik, Tmem49, Tango5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75909
Homologene: 23686
Kat7
Name: K(lysine) acetyltransferase 7
Synonyms: Hbo1, Hboa, Myst2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217127
Homologene: 5134
Rnf121
Name: ring finger protein 121
Synonyms: 4930544L10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75212
Homologene: 10132
Cmas
Name: cytidine monophospho-N-acetylneuraminic acid synthetase
Synonyms: CMP-Neu5Ac synthase, D6Bwg0250e, CMP-sialic acid synthetase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12764
Homologene: 7670
Zfp180
Name: zinc finger protein 180
Synonyms: D130011P11, HHZ168, 2310040I01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210135
Homologene: 8306
Nbn
Name: nibrin
Synonyms: Nbs1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27354
HGNC: HGNC:7652
Homologene: 1858
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230249
Homologene: 6056
Snap91
Name: synaptosomal-associated protein 91
Synonyms: F1-20, 91kDa, AP180
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20616
Homologene: 8429
Steap2
Name: six transmembrane epithelial antigen of prostate 2
Synonyms: 4921538B17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74051
Homologene: 17682
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
Gtpbp1
Name: GTP binding protein 1
Synonyms: GP-1, GTPBP1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14904
VEGA: 15
HGNC: HGNC:4669
Homologene: 3165
Slc12a7
Name: solute carrier family 12, member 7
Synonyms: Kcc4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20499
VEGA: 13
Homologene: 21312
Cachd1
Name: cache domain containing 1
Synonyms: 1190007F10Rik, Vwcd1, B430218L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320508
Homologene: 10854
Tgm3
Name: transglutaminase 3, E polypeptide
Synonyms: TG E, we
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21818
Homologene: 20690
Akap6
Name: A kinase anchor protein 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Ets1
Name: E26 avian leukemia oncogene 1, 5' domain
Synonyms: Ets-1, Tpl1, p51Ets-1, p42Ets-1, vs
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23871
HGNC: HGNC:3488
Homologene: 3837
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Ift140
Name: intraflagellar transport 140
Synonyms: Wdtc2, Tce5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106633
Homologene: 40979
Efcab14
Name: EF-hand calcium binding domain 14
Synonyms: 4732418C07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230648
Homologene: 8858
Bok
Name: BCL2-related ovarian killer
Synonyms: matador, mtd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 51800
HGNC: HGNC:1087
Homologene: 9632
Zfp781a
Name: zinc finger protein 781A
Synonyms: D130040H23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211135
Homologene: 138403
Slc28a1
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
Synonyms: Cnt1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434203
Homologene: 37902
Vmn1r52
Name: vomeronasal 1 receptor 52
Synonyms: VN3, V1ra7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113849
Lipk
Name: lipase, family member K
Synonyms: Lipl2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240633
VEGA: 19
Homologene: 75666
Pbld2
Name: phenazine biosynthesis-like protein domain containing 2
Synonyms: 3110049J23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67307
Prss54
Name: serine protease 54
Synonyms: 4931432M23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70993
Homologene: 19278
Lum
Name: lumican
Synonyms: Ldc, SLRR2D
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17022
VEGA: 10
HGNC: HGNC:6724
Homologene: 37614
Amn
Name: amnionless
Synonyms: 5033428N14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 93835
VEGA: 12
Homologene: 12804
Fbln5
Name: fibulin 5
Synonyms: EVEC
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23876
VEGA: 12
HGNC: HGNC:3602
Homologene: 38170
Tas1r2
Name: taste receptor, type 1, member 2
Synonyms: TR2, T1r2, Gpr71
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83770
Homologene: 75323
Prkag2
Name: protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Synonyms: 2410051C13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108099
HGNC: HGNC:9386
Homologene: 136125
Zfp827
Name: zinc finger protein 827
Synonyms: 2810449M09Rik, D630040G17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 622675
Homologene: 45622
Nfu1
Name: NFU1 iron-sulfur cluster scaffold
Synonyms: 0610006G17Rik, CGI-33, Hirip5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56748
Homologene: 6369
Asic2
Name: acid-sensing ion channel 2
Synonyms: Mdeg, BNaC1a, BNC1, Accn1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11418
HGNC: HGNC:99
Homologene: 137202
Gmppa
Name: GDP-mannose pyrophosphorylase A
Synonyms: 1810012N01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69080
Homologene: 8346
Or7a39
Name: olfactory receptor family 7 subfamily A member 39
Synonyms: GA_x6K02T2QGN0-2932609-2931677, MOR139-6, Olfr1355
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257734
Homologene: 136441
Vmn1r238
Name: vomeronasal 1 receptor, 238
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100312476
Homologene: 128342
Or51f1
Name: olfactory receptor family 51 subfamily F member 1
Synonyms: GA_x6K02T2PBJ9-5560696-5559746, MOR14-7P, Olfr566
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258168
Homologene: 133721
Depp1
Name: DEPP1 autophagy regulator
Synonyms: Depp, 8430408G22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213393
Homologene: 48491
Slc35a3
Name: solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
Synonyms: 2310050P13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229782
Homologene: 40826
Ccdc87
Name: coiled-coil domain containing 87
Synonyms: 4931419P11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 399599
VEGA: 19
Homologene: 49531
Tagap
Name: T cell activation Rho GTPase activating protein
Synonyms: tcs-1, Tcd-1, tcs1, TRD, Tcd1, Tcd1a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72536
Homologene: 44943
1700109H08Rik
Name: RIKEN cDNA 1700109H08 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77036
Homologene: 130776
Abhd11
Name: abhydrolase domain containing 11
Synonyms: 1110054D16Rik, A630008N09Rik, Wbscr21
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68758
Homologene: 5961
Tuba3a
Name: tubulin, alpha 3A
Synonyms: M[a]3, Tuba3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22144
Homologene: 128229
Cavin3
Name: caveolae associated 3
Synonyms: 3110015B12Rik, 6330514M23Rik, cavin 3, Prkcdbp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109042
HGNC: HGNC:9400
Homologene: 12490
Ctxn3
Name: cortexin 3
Synonyms: ENSMUSG00000069372
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 629147
Homologene: 85473
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,844,458 bp
  • G to A, chromosome 1 at 75,439,381 bp
  • T to C, chromosome 1 at 93,694,942 bp
  • T to C, chromosome 1 at 180,594,710 bp
  • T to C, chromosome 2 at 130,044,532 bp
  • T to C, chromosome 3 at 116,694,570 bp
  • G to T, chromosome 4 at 15,981,555 bp
  • C to T, chromosome 4 at 58,828,632 bp
  • T to A, chromosome 4 at 101,002,848 bp
  • A to G, chromosome 4 at 115,746,596 bp
  • C to A, chromosome 4 at 123,355,151 bp
  • A to G, chromosome 4 at 126,893,405 bp
  • A to G, chromosome 4 at 139,660,007 bp
  • A to T, chromosome 4 at 148,008,897 bp
  • A to G, chromosome 5 at 3,582,240 bp
  • A to G, chromosome 5 at 5,673,539 bp
  • A to G, chromosome 5 at 24,880,682 bp
  • A to G, chromosome 5 at 135,011,906 bp
  • T to C, chromosome 6 at 87,019,418 bp
  • A to G, chromosome 6 at 90,179,469 bp
  • T to A, chromosome 6 at 116,652,161 bp
  • A to G, chromosome 6 at 125,281,055 bp
  • T to C, chromosome 6 at 142,771,201 bp
  • A to G, chromosome 7 at 24,105,262 bp
  • C to T, chromosome 7 at 81,124,971 bp
  • T to C, chromosome 7 at 102,029,109 bp
  • T to C, chromosome 7 at 102,856,932 bp
  • G to T, chromosome 7 at 105,481,947 bp
  • C to A, chromosome 8 at 69,303,053 bp
  • A to G, chromosome 8 at 79,028,687 bp
  • A to G, chromosome 8 at 95,559,723 bp
  • G to A, chromosome 9 at 32,730,178 bp
  • A to G, chromosome 9 at 86,804,524 bp
  • G to T, chromosome 10 at 63,052,290 bp
  • A to G, chromosome 10 at 78,879,321 bp
  • A to T, chromosome 10 at 97,568,489 bp
  • T to C, chromosome 11 at 65,927,990 bp
  • A to T, chromosome 11 at 81,152,407 bp
  • A to G, chromosome 11 at 86,602,059 bp
  • G to C, chromosome 11 at 95,294,566 bp
  • A to T, chromosome 11 at 103,969,149 bp
  • T to G, chromosome 12 at 53,142,216 bp
  • G to A, chromosome 12 at 101,768,495 bp
  • C to A, chromosome 12 at 111,275,006 bp
  • G to A, chromosome 13 at 73,785,122 bp
  • A to C, chromosome 14 at 33,152,654 bp
  • T to A, chromosome 15 at 4,935,300 bp
  • A to G, chromosome 15 at 79,719,281 bp
  • T to A, chromosome 17 at 7,928,770 bp
  • T to A, chromosome 17 at 25,035,835 bp
  • T to G, chromosome 18 at 3,123,232 bp
  • G to A, chromosome 18 at 37,962,982 bp
  • A to T, chromosome 18 at 57,477,306 bp
  • A to G, chromosome 19 at 4,841,618 bp
  • T to A, chromosome 19 at 34,018,784 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8747 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068618-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.