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Strain Name:
C57BL/6J-MtgxR8768Btlr/Mmmh
Stock Number:
068623-MU
Citation ID:
RRID:MMRRC_068623-MU
Other Names:
R8768 (G1)
Major Collection:

Strain Information

Ppp2r2d
Name: protein phosphatase 2, regulatory subunit B, delta
Synonyms: 1300017E19Rik, MDS026, D7Ertd753e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52432
Homologene: 81915
Syt6
Name: synaptotagmin VI
Synonyms: 3110037A08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54524
Homologene: 10301
Dap3
Name: death associated protein 3
Synonyms: 4921514D13Rik, DAP-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 65111
HGNC: HGNC:2673
Homologene: 3404
Dbh
Name: dopamine beta hydroxylase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13166
HGNC: HGNC:2689
Homologene: 615
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Arip4, G630026H09Rik, Srisnf2l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81000
Homologene: 56698
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: Bmn, 2410030O07Rik, B930014J03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Taok1
Name: TAO kinase 1
Synonyms: D130018F14Rik, 2810468K05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216965
Homologene: 27041
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 36,701,507 bp
  • T to C, chromosome 1 at 37,437,163 bp
  • A to G, chromosome 1 at 59,066,153 bp
  • T to C, chromosome 2 at 5,898,722 bp
  • T to A, chromosome 2 at 18,162,772 bp
  • A to G, chromosome 2 at 27,170,316 bp
  • C to T, chromosome 2 at 37,147,004 bp
  • T to A, chromosome 2 at 76,968,446 bp
  • T to A, chromosome 2 at 85,070,636 bp
  • T to C, chromosome 2 at 137,090,788 bp
  • A to C, chromosome 2 at 137,101,601 bp
  • T to G, chromosome 3 at 30,597,843 bp
  • C to A, chromosome 3 at 83,346,285 bp
  • A to G, chromosome 3 at 88,927,027 bp
  • T to C, chromosome 3 at 103,585,534 bp
  • T to C, chromosome 3 at 108,206,934 bp
  • T to A, chromosome 3 at 135,551,234 bp
  • T to C, chromosome 3 at 138,941,760 bp
  • A to T, chromosome 3 at 154,322,249 bp
  • A to G, chromosome 3 at 157,541,690 bp
  • A to G, chromosome 4 at 9,453,417 bp
  • A to C, chromosome 4 at 118,369,416 bp
  • T to C, chromosome 4 at 120,132,324 bp
  • T to A, chromosome 4 at 129,846,506 bp
  • A to T, chromosome 4 at 139,421,765 bp
  • T to A, chromosome 4 at 150,629,749 bp
  • C to A, chromosome 4 at 154,998,867 bp
  • G to T, chromosome 5 at 24,533,692 bp
  • T to A, chromosome 5 at 31,473,538 bp
  • T to A, chromosome 5 at 73,520,967 bp
  • A to C, chromosome 6 at 23,382,939 bp
  • A to T, chromosome 6 at 94,654,859 bp
  • T to G, chromosome 6 at 113,408,988 bp
  • T to A, chromosome 6 at 136,839,981 bp
  • C to T, chromosome 6 at 142,133,171 bp
  • T to C, chromosome 7 at 24,105,736 bp
  • A to G, chromosome 7 at 75,866,611 bp
  • T to C, chromosome 7 at 90,426,585 bp
  • T to A, chromosome 7 at 120,776,076 bp
  • T to G, chromosome 7 at 128,242,611 bp
  • T to G, chromosome 7 at 135,681,577 bp
  • T to A, chromosome 7 at 138,874,168 bp
  • T to A, chromosome 7 at 141,258,738 bp
  • T to C, chromosome 8 at 67,964,351 bp
  • G to A, chromosome 9 at 14,314,668 bp
  • A to C, chromosome 9 at 38,607,145 bp
  • A to G, chromosome 9 at 48,392,750 bp
  • T to G, chromosome 9 at 54,393,821 bp
  • T to G, chromosome 9 at 106,719,610 bp
  • T to A, chromosome 9 at 111,389,276 bp
  • T to C, chromosome 9 at 119,941,220 bp
  • A to T, chromosome 10 at 86,705,305 bp
  • A to G, chromosome 10 at 130,362,158 bp
  • A to G, chromosome 11 at 5,643,763 bp
  • A to T, chromosome 11 at 77,553,886 bp
  • C to A, chromosome 11 at 83,423,173 bp
  • T to C, chromosome 11 at 87,778,371 bp
  • T to C, chromosome 11 at 115,420,453 bp
  • C to T, chromosome 11 at 120,897,962 bp
  • T to A, chromosome 13 at 49,724,626 bp
  • C to T, chromosome 13 at 93,688,610 bp
  • A to T, chromosome 14 at 52,753,786 bp
  • T to A, chromosome 15 at 5,242,657 bp
  • C to T, chromosome 15 at 12,437,166 bp
  • T to A, chromosome 15 at 47,698,176 bp
  • G to A, chromosome 15 at 92,234,466 bp
  • A to C, chromosome 15 at 94,581,229 bp
  • T to A, chromosome 15 at 102,540,889 bp
  • T to C, chromosome 16 at 5,242,552 bp
  • A to T, chromosome 16 at 97,837,688 bp
  • T to C, chromosome 17 at 3,193,074 bp
  • T to C, chromosome 17 at 20,624,682 bp
  • A to G, chromosome 17 at 37,006,185 bp
  • T to C, chromosome 17 at 62,881,130 bp
  • G to T, chromosome 17 at 80,373,719 bp
  • C to T, chromosome 18 at 45,559,435 bp
  • G to A, chromosome 19 at 3,997,303 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8768 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068623-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.