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Strain Name:
C57BL/6J-MtgxR8770Btlr/Mmmh
Stock Number:
068625-MU
Citation ID:
RRID:MMRRC_068625-MU
Other Names:
R8770 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Atn1
Name: atrophin 1
Synonyms: atrophin-1, Atr1, Drpla
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13498
HGNC: HGNC:3033
Homologene: 1461
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Cdyl2
Name: chromodomain protein, Y chromosome-like 2
Synonyms: 1700029M19Rik, 4930453I21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75796
Homologene: 41779
Smarcad1
Name: SNF2 related chromatin remodeling ATPase with DExD box 1
Synonyms: D6Pas1, Etl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13990
Homologene: 5301
Laptm4b
Name: lysosomal-associated protein transmembrane 4B
Synonyms: C330023P13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 114128
VEGA: 15
Homologene: 10182
Ogdh
Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms: alpha-ketoglutarate dehydrogenase, 2210412K19Rik, 2210403E04Rik, d1401
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18293
HGNC: HGNC:8124
Homologene: 55662
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 36,799,105 bp
  • A to T, chromosome 1 at 58,339,604 bp
  • T to G, chromosome 1 at 59,845,525 bp
  • T to A, chromosome 1 at 130,876,062 bp
  • G to A, chromosome 1 at 180,962,396 bp
  • A to G, chromosome 2 at 89,590,827 bp
  • A to T, chromosome 2 at 120,323,067 bp
  • A to G, chromosome 2 at 126,154,807 bp
  • T to C, chromosome 2 at 126,342,995 bp
  • C to T, chromosome 2 at 164,428,902 bp
  • C to A, chromosome 3 at 90,118,543 bp
  • T to A, chromosome 3 at 94,429,133 bp
  • T to C, chromosome 3 at 146,046,543 bp
  • T to G, chromosome 4 at 43,770,813 bp
  • T to C, chromosome 5 at 32,247,509 bp
  • A to G, chromosome 5 at 110,648,892 bp
  • A to G, chromosome 5 at 124,775,346 bp
  • T to A, chromosome 6 at 37,957,500 bp
  • T to A, chromosome 6 at 48,474,272 bp
  • T to C, chromosome 6 at 65,052,734 bp
  • T to A, chromosome 6 at 102,277,316 bp
  • C to T, chromosome 6 at 124,745,638 bp
  • C to A, chromosome 6 at 124,934,296 bp
  • T to C, chromosome 6 at 149,518,950 bp
  • C to A, chromosome 7 at 27,351,886 bp
  • T to C, chromosome 7 at 45,006,705 bp
  • A to G, chromosome 7 at 97,713,910 bp
  • G to A, chromosome 7 at 105,771,738 bp
  • T to A, chromosome 8 at 34,807,784 bp
  • T to G, chromosome 8 at 40,899,230 bp
  • T to A, chromosome 8 at 85,364,831 bp
  • T to C, chromosome 8 at 116,595,083 bp
  • C to T, chromosome 8 at 124,334,286 bp
  • T to C, chromosome 9 at 54,404,014 bp
  • T to A, chromosome 9 at 67,323,022 bp
  • A to G, chromosome 9 at 80,264,199 bp
  • A to G, chromosome 9 at 85,326,750 bp
  • A to T, chromosome 9 at 109,217,528 bp
  • C to A, chromosome 9 at 111,390,824 bp
  • A to T, chromosome 9 at 123,177,861 bp
  • T to C, chromosome 10 at 43,160,792 bp
  • T to G, chromosome 10 at 85,965,265 bp
  • T to C, chromosome 11 at 6,355,336 bp
  • T to C, chromosome 11 at 72,318,459 bp
  • T to A, chromosome 11 at 75,469,804 bp
  • A to G, chromosome 11 at 83,588,832 bp
  • T to A, chromosome 11 at 87,159,849 bp
  • A to G, chromosome 11 at 102,255,150 bp
  • T to C, chromosome 11 at 115,897,117 bp
  • T to C, chromosome 12 at 103,653,939 bp
  • A to G, chromosome 13 at 23,855,624 bp
  • A to G, chromosome 13 at 67,140,353 bp
  • A to C, chromosome 13 at 77,046,647 bp
  • A to T, chromosome 14 at 56,206,494 bp
  • T to C, chromosome 15 at 34,258,697 bp
  • A to G, chromosome 15 at 51,968,353 bp
  • A to G, chromosome 16 at 38,004,612 bp
  • T to C, chromosome 16 at 96,654,906 bp
  • T to C, chromosome 17 at 13,883,937 bp
  • T to A, chromosome 17 at 21,745,814 bp
  • T to C, chromosome 17 at 22,200,999 bp
  • A to G, chromosome 17 at 26,431,913 bp
  • C to T, chromosome 18 at 31,981,071 bp
  • A to T, chromosome 18 at 62,653,461 bp
  • A to G, chromosome 19 at 41,328,160 bp
  • A to G, chromosome 19 at 43,963,769 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8770 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068625-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.