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Strain Name:
C57BL/6J-MtgxR8795Btlr/Mmmh
Stock Number:
068636-MU
Citation ID:
RRID:MMRRC_068636-MU
Other Names:
R8795 (G1)
Major Collection:

Strain Information

Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: alpha13.2, Cav3.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Pzp
Name: PZP, alpha-2-macroglobulin like
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11287
Homologene: 104112
Rab6b
Name: RAB6B, member RAS oncogene family
Synonyms: C330006L04Rik, D9Bwg0185e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270192
Homologene: 39749
Smarcad1
Name: SNF2 related chromatin remodeling ATPase with DExD box 1
Synonyms: D6Pas1, Etl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13990
Homologene: 5301
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Dsk9, Mhdadsk9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: 6330503C17Rik, Zfp262
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67785
Homologene: 35470
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 24,194,731 bp
  • A to T, chromosome 1 at 44,163,929 bp
  • CA to CAA, chromosome 1 at 65,165,188 bp
  • A to T, chromosome 1 at 79,776,257 bp
  • A to G, chromosome 1 at 88,107,072 bp
  • A to G, chromosome 1 at 161,083,014 bp
  • C to G, chromosome 2 at 25,297,456 bp
  • A to G, chromosome 2 at 31,425,381 bp
  • T to A, chromosome 2 at 60,653,285 bp
  • T to G, chromosome 2 at 88,499,511 bp
  • T to A, chromosome 2 at 111,328,536 bp
  • A to G, chromosome 2 at 157,225,573 bp
  • A to G, chromosome 2 at 167,017,810 bp
  • G to A, chromosome 3 at 96,187,080 bp
  • A to G, chromosome 3 at 151,510,779 bp
  • T to A, chromosome 4 at 24,536,245 bp
  • T to A, chromosome 4 at 33,161,756 bp
  • A to G, chromosome 4 at 42,792,992 bp
  • T to A, chromosome 4 at 43,446,070 bp
  • C to T, chromosome 4 at 43,495,514 bp
  • A to T, chromosome 4 at 59,737,676 bp
  • G to T, chromosome 4 at 124,856,690 bp
  • A to T, chromosome 4 at 126,906,026 bp
  • G to A, chromosome 5 at 31,476,790 bp
  • A to T, chromosome 5 at 37,649,139 bp
  • T to C, chromosome 5 at 115,614,395 bp
  • C to T, chromosome 5 at 135,635,131 bp
  • A to T, chromosome 5 at 137,299,976 bp
  • C to T, chromosome 5 at 137,398,260 bp
  • A to T, chromosome 6 at 3,374,221 bp
  • T to A, chromosome 6 at 35,283,295 bp
  • T to C, chromosome 6 at 39,592,652 bp
  • T to G, chromosome 6 at 40,386,920 bp
  • T to C, chromosome 6 at 65,072,049 bp
  • G to T, chromosome 6 at 68,542,386 bp
  • T to G, chromosome 6 at 115,786,928 bp
  • C to A, chromosome 6 at 128,494,738 bp
  • T to C, chromosome 7 at 14,490,089 bp
  • C to A, chromosome 7 at 27,191,609 bp
  • T to A, chromosome 7 at 27,535,861 bp
  • A to T, chromosome 7 at 85,415,675 bp
  • A to G, chromosome 7 at 97,311,960 bp
  • T to C, chromosome 7 at 97,312,063 bp
  • A to T, chromosome 7 at 140,955,748 bp
  • A to G, chromosome 8 at 86,531,584 bp
  • C to T, chromosome 9 at 7,137,087 bp
  • A to T, chromosome 9 at 30,943,188 bp
  • T to A, chromosome 9 at 95,867,531 bp
  • G to A, chromosome 9 at 103,162,626 bp
  • T to C, chromosome 10 at 14,718,126 bp
  • T to C, chromosome 10 at 78,611,864 bp
  • T to A, chromosome 10 at 123,153,048 bp
  • T to C, chromosome 10 at 129,351,325 bp
  • C to A, chromosome 11 at 45,884,351 bp
  • G to T, chromosome 11 at 67,283,377 bp
  • T to A, chromosome 11 at 79,425,616 bp
  • G to T, chromosome 11 at 119,499,554 bp
  • A to G, chromosome 12 at 16,993,480 bp
  • G to A, chromosome 12 at 40,213,077 bp
  • T to C, chromosome 12 at 81,591,260 bp
  • A to T, chromosome 12 at 103,108,254 bp
  • A to C, chromosome 13 at 27,849,406 bp
  • G to T, chromosome 13 at 27,849,407 bp
  • A to G, chromosome 14 at 48,451,913 bp
  • A to C, chromosome 15 at 100,587,805 bp
  • A to T, chromosome 16 at 11,147,283 bp
  • T to C, chromosome 16 at 29,629,632 bp
  • A to G, chromosome 16 at 56,260,248 bp
  • T to A, chromosome 17 at 20,042,726 bp
  • C to T, chromosome 17 at 25,393,564 bp
  • C to T, chromosome 17 at 29,204,688 bp
  • A to T, chromosome 17 at 45,507,672 bp
  • A to G, chromosome 18 at 10,553,739 bp
  • T to G, chromosome 19 at 6,351,610 bp
  • T to C, chromosome Y at 738,945 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8795 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068636-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.