Strain Name:
C57BL/6J-MtgxR8848Btlr/Mmmh
Stock Number:
068671-MU
Citation ID:
RRID:MMRRC_068671-MU
Other Names:
R8848 (G1)
Major Collection:

Strain Information

Il4i1
Name: interleukin 4 induced 1
Synonyms: Fig1-ps, Fig1, H46, H4, H-46, H-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14204
Homologene: 22567
Nms
Name: neuromedin S
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 433292
Homologene: 67775
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Arhgef18
Name: Rho/Rac guanine nucleotide exchange factor 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102098
Homologene: 32254
Abcc8
Name: ATP-binding cassette, sub-family C member 8
Synonyms: SUR1, Sur, D930031B21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Snd1
Name: staphylococcal nuclease and tudor domain containing 1
Synonyms: p100 co-activator, Tudor-SN
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56463
Homologene: 8665
Acbd3
Name: acyl-Coenzyme A binding domain containing 3
Synonyms: Pap7, 8430407O11Rik, Gocap1, D1Ertd10e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170760
Homologene: 11227
Polr3a
Name: polymerase (RNA) III (DNA directed) polypeptide A
Synonyms: RPC155, RPC1, 9330175N20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218832
VEGA: 14
Homologene: 5124
Tbc1d5
Name: TBC1 domain family, member 5
Synonyms: 1600014N05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72238
VEGA: 17
Homologene: 8834
Zfp407
Name: zinc finger protein 407
Synonyms: LOC381139, LOC240469, 6430585N13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240476
Homologene: 86402
Usp53
Name: ubiquitin specific peptidase 53
Synonyms: Sp6, Phxr3, mbo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99526
Homologene: 34521
Bmal1
Name: basic helix-loop-helix ARNT like 1
Synonyms: Arnt3, MOP3, bHLHe5, Arntl
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11865
HGNC: HGNC:701
Homologene: 910
Lix1
Name: limb and CNS expressed 1
Synonyms: 5730466L18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66643
Homologene: 12004
Cdhr1
Name: cadherin-related family member 1
Synonyms: Prcad, Pcdh21
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 170677
VEGA: 14
Homologene: 13215
Brf2
Name: BRF2, RNA polymerase III transcription initiation factor 50kDa subunit
Synonyms: 2700059M06Rik, BRFU, TFIIIB50, 5730512K07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66653
Homologene: 10127
Rab11a
Name: RAB11A, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53869
HGNC: HGNC:9760
Homologene: 37903
1110059G10Rik
Name: RIKEN cDNA 1110059G10 gene
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66202
Homologene: 10791
Slc15a4
Name: solute carrier family 15, member 4
Synonyms: C130069N12Rik, PTR4, PHT1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100561
Homologene: 26432
Stag3
Name: STAG3 cohesin complex component
Synonyms: stromalin 3, SA-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50878
Homologene: 40844
Vps37d
Name: vacuolar protein sorting 37D
Synonyms: Wbscr24
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 194309
Homologene: 45580
Ppara
Name: peroxisome proliferator activated receptor alpha
Synonyms: Nr1c1, PPAR-alpha, PPARalpha, Ppar, 4933429D07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19013
HGNC: HGNC:9232
Homologene: 21047
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Pkp1
Name: plakophilin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18772
HGNC: HGNC:9023
Homologene: 253
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, D430038H04Rik, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, erythroid, ihj, Spna1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2.3, NaG, Nav2, 1110034K09Rik, Scn6a, Nax
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20272
Homologene: 55706
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: D-LTCC, Cchl1a, Cchl1a2, Cacnl1a2, 8430418G19Rik, Cav1.3alpha1, C79217
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
C7
Name: complement component 7
Synonyms: LOC383055
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109828
VEGA: 15
HGNC: HGNC:1346
Homologene: 489
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Ulk3
Name: unc-51-like kinase 3
Synonyms: 1200015E14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71742
VEGA: 9
Homologene: 68482
Kcnk7
Name: potassium channel, subfamily K, member 7
Synonyms: Mlk3, Knot, Kcnk8, 2310014G03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16530
HGNC: HGNC:6282
Homologene: 43131
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Lingo4
Name: leucine rich repeat and Ig domain containing 4
Synonyms: A530050P17Rik, Lrrn6d, LERN4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320747
Homologene: 18563
Or5p81
Name: olfactory receptor family 5 subfamily P member 81
Synonyms: GA_x6K02T2PBJ9-10997715-10998659, MOR204-34, Olfr510
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258308
Speg
Name: SPEG complex locus
Synonyms: BPEG, SPEGbeta, SPEGalpha, D1Bwg1450e, SPEG, Apeg1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72277
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Pgbd1
Name: piggyBac transposable element derived 1
Synonyms: 4921509E05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319207
Homologene: 130030
F11
Name: coagulation factor XI
Synonyms: plasma thromboplastin antecedent, FXI, Cf11, 1600027G01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109821
HGNC: HGNC:3529
Homologene: 86654
Slc28a2
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
Synonyms: CNT2, 2010208B10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269346
Homologene: 20891
Zfp455
Name: zinc finger protein 455
Synonyms: Rslcan-10, 3732412P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218311
Homologene: 110878
Svop
Name: SV2 related protein
Synonyms: 1110030H18Rik, msvop
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68666
Homologene: 41283
Cyp2c40
Name: cytochrome P450, family 2, subfamily c, polypeptide 40
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13099
Homologene: 74936
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Casr-rs3, EG637898, Gprc2a-rs3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637898
Homologene: 129683
Eif2b4
Name: eukaryotic translation initiation factor 2B, subunit 4 delta
Synonyms: Eif2b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13667
HGNC: HGNC:3260
Homologene: 5976
Vmn1r72
Name: vomeronasal 1 receptor 72
Synonyms: V1rg1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252905
Homologene: 74318
Gm12185
Name: predicted gene 12185
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 620913
Homologene: 83188
Or8k25
Name: olfactory receptor family 8 subfamily K member 25
Synonyms: MOR188-1, GA_x6K02T2Q125-47883395-47882454, MOR188-9, MOR188-1, MOR188-7, Olfr1515, Olfr1061
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259022
Homologene: 79468
Adh1
Name: alcohol dehydrogenase 1 (class I)
Synonyms: ADH-AA, class I alcohol dehydrogenase, Adh-1-t, Adh-1t, Adh-1, Adh1-t, Adh1-e, Adh1tl, Adh-1e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11522
Homologene: 73888
Upb1
Name: ureidopropionase, beta
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103149
Homologene: 9471
Ehd3
Name: EH-domain containing 3
Synonyms: Ehd2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57440
HGNC: HGNC:3244
Homologene: 81837
Fbxl7
Name: F-box and leucine-rich repeat protein 7
Synonyms: Fbl6, FBL7, D230018M15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 448987
VEGA: 15
Homologene: 69121
Grin3b
Name: glutamate receptor, ionotropic, NMDA3B
Synonyms: NR3B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 170483
Homologene: 15606
Hao2
Name: hydroxyacid oxidase 2
Synonyms: Hao3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56185
HGNC: HGNC:4810
Homologene: 97412
Nom1
Name: nucleolar protein with MIF4G domain 1
Synonyms: LOC381627, D5Kng1, Gm1040
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433864
Homologene: 39776
Erlec1
Name: endoplasmic reticulum lectin 1
Synonyms: 4933407N01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66753
Homologene: 9247
Lpo
Name: lactoperoxidase
Synonyms: 5830499B15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76113
HGNC: HGNC:6678
Homologene: 21240
Cox7c
Name: cytochrome c oxidase subunit 7C
Synonyms: COXVIIc, Cox7c1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12867
HGNC: HGNC:2292
Homologene: 81691
Or2t43
Name: olfactory receptor family 2 subfamily T member 43
Synonyms: GA_x6K02T2NKPP-858022-858862, GA_x6K02T00261-652-347, MOR275-3, MOR275-10_p, Olfr327-ps1, Olfr224
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258198
Homologene: 133015
Mymx
Name: myomixer, myoblast fusion factor
Synonyms: minion, myomerger
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 653016
Rwdd1
Name: RWD domain containing 1
Synonyms: 2700069A07Rik, 2610002D06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66521
Homologene: 41082
Cox8c
Name: cytochrome c oxidase subunit 8C
Synonyms: 1700007F21Rik, COXVIII-3, COX8-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75483
VEGA: 12
Homologene: 83496
Vmn2r34
Name: vomeronasal 2, receptor 34
Synonyms: ENSMUSG00000070841
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042636
Homologene: 113703
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 38,939,310 bp
  • T to C, chromosome 1 at 75,427,438 bp
  • T to C, chromosome 1 at 135,879,914 bp
  • G to A, chromosome 1 at 174,197,744 bp
  • T to A, chromosome 1 at 180,734,519 bp
  • G to A, chromosome 2 at 66,700,049 bp
  • T to C, chromosome 2 at 86,413,477 bp
  • A to G, chromosome 2 at 122,460,421 bp
  • A to T, chromosome 3 at 94,403,533 bp
  • T to A, chromosome 3 at 98,877,212 bp
  • C to T, chromosome 3 at 122,949,176 bp
  • T to C, chromosome 3 at 122,949,586 bp
  • G to T, chromosome 3 at 138,280,501 bp
  • A to G, chromosome 5 at 29,440,139 bp
  • A to T, chromosome 5 at 31,190,866 bp
  • T to A, chromosome 5 at 96,781,348 bp
  • G to T, chromosome 5 at 114,045,626 bp
  • T to G, chromosome 5 at 127,601,957 bp
  • A to G, chromosome 5 at 135,073,665 bp
  • A to G, chromosome 5 at 138,290,266 bp
  • C to A, chromosome 6 at 23,344,257 bp
  • T to A, chromosome 6 at 28,874,963 bp
  • C to T, chromosome 7 at 7,672,308 bp
  • T to A, chromosome 7 at 11,670,342 bp
  • T to C, chromosome 7 at 42,136,745 bp
  • C to A, chromosome 7 at 44,839,751 bp
  • A to T, chromosome 7 at 46,117,345 bp
  • T to A, chromosome 7 at 108,667,722 bp
  • T to C, chromosome 7 at 113,306,120 bp
  • T to C, chromosome 8 at 3,427,481 bp
  • T to C, chromosome 8 at 27,126,112 bp
  • G to T, chromosome 8 at 45,242,244 bp
  • T to C, chromosome 9 at 15,967,102 bp
  • T to C, chromosome 9 at 57,589,607 bp
  • T to C, chromosome 9 at 64,716,982 bp
  • T to C, chromosome 9 at 73,525,981 bp
  • T to C, chromosome 9 at 107,514,656 bp
  • T to C, chromosome 9 at 122,949,041 bp
  • A to G, chromosome 10 at 34,008,991 bp
  • T to A, chromosome 10 at 39,846,709 bp
  • T to A, chromosome 10 at 75,428,344 bp
  • A to T, chromosome 10 at 79,973,833 bp
  • T to C, chromosome 11 at 30,948,411 bp
  • T to A, chromosome 11 at 48,915,453 bp
  • T to A, chromosome 11 at 58,567,076 bp
  • T to A, chromosome 11 at 87,817,777 bp
  • C to A, chromosome 11 at 103,080,620 bp
  • T to A, chromosome 12 at 102,899,318 bp
  • A to G, chromosome 13 at 21,422,882 bp
  • A to G, chromosome 13 at 67,208,025 bp
  • A to T, chromosome 13 at 86,045,781 bp
  • A to T, chromosome 14 at 24,450,766 bp
  • C to T, chromosome 14 at 30,123,326 bp
  • T to A, chromosome 14 at 37,080,574 bp
  • A to G, chromosome 15 at 5,059,429 bp
  • T to A, chromosome 15 at 26,552,816 bp
  • T to A, chromosome 15 at 85,788,987 bp
  • A to G, chromosome 15 at 99,940,153 bp
  • G to A, chromosome 17 at 17,443,693 bp
  • A to T, chromosome 17 at 45,602,009 bp
  • A to T, chromosome 17 at 50,919,054 bp
  • A to T, chromosome 17 at 73,829,916 bp
  • T to A, chromosome 18 at 84,560,694 bp
  • T to A, chromosome 19 at 5,706,715 bp
  • G to A, chromosome 19 at 39,812,800 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8848 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068671-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.