Strain Name:
C57BL/6J-MtgxR8857Btlr/Mmmh
Stock Number:
068677-MU
Citation ID:
RRID:MMRRC_068677-MU
Other Names:
R8857 (G1)
Major Collection:

Strain Information

U2af2
Name: U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22185
Homologene: 110853
Cnst
Name: consortin, connexin sorting protein
Synonyms: 9630058J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226744
Homologene: 17139
L3mbtl2
Name: L3MBTL2 polycomb repressive complex 1 subunit
Synonyms: 4732493N06Rik, m4mbt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 214669
Homologene: 12882
Phf20l1
Name: PHD finger protein 20-like 1
Synonyms: E130113K22Rik, CGI-72
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239510
VEGA: 15
Homologene: 9341
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20467
Homologene: 81810
Prkab1
Name: protein kinase, AMP-activated, beta 1 non-catalytic subunit
Synonyms: 1300015D22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19079
HGNC: HGNC:9378
Homologene: 38160
Zc3h7b
Name: zinc finger CCCH type containing 7B
Synonyms: Scrg3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20286
VEGA: 15
Homologene: 9735
Spast
Name: spastin
Synonyms: Spg4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50850
VEGA: 17
Homologene: 8970
Tiam1
Name: T cell lymphoma invasion and metastasis 1
Synonyms: D16Ium10, D16Ium10e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21844
Homologene: 2443
Zfyve1
Name: zinc finger, FYVE domain containing 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217695
VEGA: 12
Homologene: 10945
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: Syt3-rs, 2810036I15Rik, RIM2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 116838
VEGA: 15
Homologene: 81639
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lphn1, lectomedin-2, 2900070I05Rik, Lec2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330814
Homologene: 8951
Gpsm1
Name: G-protein signalling modulator 1 (AGS3-like, C. elegans)
Synonyms: Ags3, 1810037C22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67839
Homologene: 16987
Csf2rb2
Name: colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
Synonyms: Bil3, Il3rb2, Il3r, BetaIl3, AIC2A
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12984
VEGA: 15
HGNC: HGNC:2436
Homologene: 339
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyes2, heb, eyem02Jus, crf11, QBRICK
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Tnfrsf10b
Name: tumor necrosis factor receptor superfamily, member 10b
Synonyms: Killer/Dr5, DR5, Ly98, KILLER, TRICK2A, TRAIL-R2, TRICKB, TRAILR2, TRICK2B, Trail Receptor
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21933
VEGA: 14
Homologene: 129806
Slc17a8
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
Synonyms: Vglut3, Vgt3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216227
Homologene: 13584
Adgrf3
Name: adhesion G protein-coupled receptor F3
Synonyms: LOC381628, Gpr113, PGR23
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381628
Homologene: 17826
Hsd17b13
Name: hydroxysteroid (17-beta) dehydrogenase 13
Synonyms: Pan1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243168
Homologene: 71549
Mme
Name: membrane metallo endopeptidase
Synonyms: CD10, neprilysin, 6030454K05Rik, neutral endopeptidase, NEP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Knop1
Name: lysine rich nucleolar protein 1
Synonyms: Tsg118, 2310008H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66356
Homologene: 49729
Morc2a
Name: microrchidia 2A
Synonyms: Zcwcc1, 8430403M08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74522
Homologene: 8966
Rai1
Name: retinoic acid induced 1
Synonyms: Gt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19377
HGNC: HGNC:9834
Homologene: 7508
Shtn1
Name: shootin 1
Synonyms: shootin1, 4930506M07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71653
VEGA: 19
Homologene: 41249
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hyrh, 1700034M11Rik, hy3, 4930545D19Rik, hy-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Tnr
Name: tenascin R
Synonyms: janusin, J1-tenascin, TN-R, restrictin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21960
Homologene: 124416
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Chd7, 2600010P09Rik, Mi-2 alpha, Prp7, Prp9-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Plb1
Name: phospholipase B1
Synonyms: 4930433E17Rik, 4632413E21Rik, 4930539A06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665270
Homologene: 82108
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Fbn2
Name: fibrillin 2
Synonyms: sy, Fib-2, Sne
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Or5ac25
Name: olfactory receptor family 5 subfamily AC member 25
Synonyms: MOR182-6, GA_x54KRFPKG5P-55580232-55579315, Olfr208, MOR182-9, GA_x54KRFPKG5P-55570276-55569359, Olfr209, Olfr207, MOR182-6, GA_x54KRFPKG5P-55590495-55589578
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 404311
Homologene: 133040
Uroc1
Name: urocanase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243537
Homologene: 76629
Arhgef5
Name: Rho guanine nucleotide exchange factor 5
Synonyms: 2210412D05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54324
Homologene: 66300
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: 4930449A08Rik, 4930538D17Rik, Tmem180
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75146
Homologene: 12592
Hltf
Name: helicase-like transcription factor
Synonyms: Smarca3, Snf2l3, P113
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20585
Homologene: 30136
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Rev, Sez4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Trp63
Name: transformation related protein 63
Synonyms: deltaNp63, KET protein, p51/p63, Trp53rp1, TAp63, p63, p73L
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22061
Homologene: 31189
Ablim1
Name: actin-binding LIM protein 1
Synonyms: abLIM-M, 4833406P10Rik, abLIM-L, Limab1, abLIM-S, 2610209L21Rik, 2210411C18Rik, 9330196J19Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226251
HGNC: HGNC:78
Homologene: 40994
Bdh1
Name: 3-hydroxybutyrate dehydrogenase, type 1
Synonyms: 2310032J20Rik, Bdh
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71911
HGNC: HGNC:1027
Homologene: 20860
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap-1, Mtap1a, Mtap1, 6330416M19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70381
Homologene: 9120
Hic1
Name: hypermethylated in cancer 1
Synonyms: HIC-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15248
HGNC: HGNC:4909
Homologene: 4740
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319734
Homologene: 26544
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244810
HGNC: HGNC:6658
Irf2bpl
Name: interferon regulatory factor 2 binding protein-like
Synonyms: 6430527G18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238330
VEGA: 12
Homologene: 11555
Tmem174
Name: transmembrane protein 174
Synonyms: 0610009B10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68344
VEGA: 13
Homologene: 17711
P2rx1
Name: purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms: RP-2, Pdcd3, P2X1 receptor, P2x
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18436
HGNC: HGNC:8533
Homologene: 1921
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: 4930544G21Rik, A930009L15Rik, SKIP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77629
Homologene: 18172
Disc1
Name: disrupted in schizophrenia 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244667
HGNC: HGNC:2888
Homologene: 10257
Fbln5
Name: fibulin 5
Synonyms: EVEC
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23876
VEGA: 12
HGNC: HGNC:3602
Homologene: 38170
Apba2
Name: amyloid beta precursor protein binding family A member 2
Synonyms: X11-like, X11L, Mint 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11784
HGNC: HGNC:579
Homologene: 4021
Padi4
Name: peptidyl arginine deiminase, type IV
Synonyms: Pad4, PAD type IV, Pdi4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18602
Homologene: 7883
Slc7a11
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Synonyms: xCT, 9930009M05Rik, System xc, sut, xc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26570
Homologene: 22684
Zfp488
Name: zinc finger protein 488
Synonyms: LOC382867
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 382867
Homologene: 17688
Zp1
Name: zona pellucida glycoprotein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22786
Homologene: 33483
Selenoi
Name: selenoprotein I
Synonyms: C79563, D5Wsu178e, 4933402G07Rik, Ept1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 28042
Homologene: 100935
Polr1g
Name: RNA polymerase I subunit G
Synonyms: PAF49, Ase1, 2610103M17Rik, Cd3eap
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70333
Homologene: 17107
C130073F10Rik
Name: RIKEN cDNA C130073F10 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242574
Tomm34
Name: translocase of outer mitochondrial membrane 34
Synonyms: 2610100K07Rik, TOM34
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67145
Homologene: 4956
Mptx2
Name: mucosal pentraxin 2
Synonyms: Gm11062
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100504232
Homologene: 134535
Nutm1
Name: NUT midline carcinoma, family member 1
Synonyms: Nut, BC125332
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213765
Homologene: 18185
Qsox1
Name: quiescin Q6 sulfhydryl oxidase 1
Synonyms: b2b2673Clo, QSOX, 1300003H02Rik, Qscn6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 104009
HGNC: HGNC:9756
Homologene: 37690
Adra1b
Name: adrenergic receptor, alpha 1b
Synonyms: alpha1B-adrenergic receptor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11548
HGNC: HGNC:278
Homologene: 55477
Krtap19-5
Name: keratin associated protein 19-5
Synonyms: Krtap8-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16704
VEGA: 16
Trav15-1-dv6-1
Name: T cell receptor alpha variable 15-1-DV6-1
Synonyms: Gm16591
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 386446
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 83,280,567 bp
  • T to A, chromosome 1 at 90,775,763 bp
  • A to G, chromosome 1 at 155,782,587 bp
  • A to G, chromosome 1 at 159,886,158 bp
  • T to C, chromosome 1 at 173,274,885 bp
  • T to C, chromosome 1 at 179,610,313 bp
  • G to C, chromosome 2 at 26,340,445 bp
  • A to G, chromosome 2 at 112,251,178 bp
  • G to A, chromosome 2 at 121,307,617 bp
  • G to A, chromosome 2 at 164,054,459 bp
  • T to C, chromosome 3 at 20,105,661 bp
  • A to G, chromosome 3 at 50,438,856 bp
  • A to T, chromosome 3 at 63,348,649 bp
  • T to A, chromosome 4 at 83,004,043 bp
  • G to A, chromosome 4 at 101,890,358 bp
  • A to G, chromosome 4 at 140,774,161 bp
  • A to T, chromosome 5 at 30,197,067 bp
  • C to A, chromosome 5 at 30,256,162 bp
  • T to C, chromosome 5 at 32,364,212 bp
  • A to G, chromosome 5 at 103,977,197 bp
  • T to C, chromosome 5 at 116,020,088 bp
  • T to C, chromosome 5 at 144,216,299 bp
  • T to C, chromosome 6 at 43,287,624 bp
  • T to C, chromosome 6 at 90,357,528 bp
  • A to T, chromosome 6 at 119,271,948 bp
  • T to A, chromosome 7 at 5,062,291 bp
  • C to T, chromosome 7 at 19,359,430 bp
  • T to A, chromosome 7 at 64,750,191 bp
  • T to C, chromosome 7 at 118,852,726 bp
  • T to C, chromosome 8 at 72,756,895 bp
  • C to A, chromosome 8 at 83,931,028 bp
  • T to C, chromosome 8 at 110,571,955 bp
  • A to C, chromosome 8 at 125,165,131 bp
  • G to C, chromosome 9 at 39,600,535 bp
  • T to A, chromosome 10 at 39,794,969 bp
  • A to G, chromosome 10 at 89,591,160 bp
  • T to A, chromosome 11 at 3,677,484 bp
  • C to G, chromosome 11 at 43,836,265 bp
  • A to G, chromosome 11 at 60,186,567 bp
  • G to A, chromosome 11 at 69,362,320 bp
  • A to G, chromosome 11 at 73,012,371 bp
  • A to G, chromosome 11 at 75,165,402 bp
  • A to T, chromosome 11 at 115,981,027 bp
  • T to A, chromosome 12 at 83,551,600 bp
  • T to C, chromosome 12 at 86,882,585 bp
  • C to A, chromosome 12 at 101,760,731 bp
  • G to T, chromosome 13 at 98,636,925 bp
  • A to C, chromosome 14 at 33,970,803 bp
  • T to A, chromosome 14 at 53,560,158 bp
  • G to A, chromosome 14 at 69,775,094 bp
  • T to A, chromosome 15 at 39,679,648 bp
  • T to C, chromosome 15 at 66,641,932 bp
  • T to C, chromosome 15 at 78,294,413 bp
  • T to A, chromosome 15 at 81,687,119 bp
  • G to A, chromosome 15 at 81,772,480 bp
  • A to T, chromosome 16 at 25,820,476 bp
  • A to T, chromosome 16 at 31,446,632 bp
  • A to T, chromosome 16 at 59,361,678 bp
  • A to T, chromosome 16 at 88,896,251 bp
  • A to T, chromosome 16 at 89,865,257 bp
  • T to A, chromosome 17 at 74,368,943 bp
  • G to A, chromosome 18 at 58,153,861 bp
  • T to G, chromosome 19 at 10,916,524 bp
  • A to G, chromosome 19 at 46,368,128 bp
  • G to A, chromosome 19 at 57,130,855 bp
  • T to C, chromosome 19 at 58,990,368 bp
  • T to C, chromosome 19 at 61,127,563 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8857 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068677-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.