Strain Name:
C57BL/6J-MtgxR8863Btlr/Mmmh
Stock Number:
068679-MU
Citation ID:
RRID:MMRRC_068679-MU
Other Names:
R8863 (G1)
Major Collection:

Strain Information

Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233765
Homologene: 52172
Trnt1
Name: tRNA nucleotidyl transferase, CCA-adding, 1
Synonyms: 2610044E04Rik, CGI-47, 2410043H24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70047
Homologene: 9333
Axin1
Name: axin 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12005
HGNC: HGNC:903
Homologene: 2614
Ppp6r3
Name: protein phosphatase 6, regulatory subunit 3
Synonyms: 9130026N02Rik, D19Bwg1430e, 4930528G08Rik, D19Ertd703e, Pp6r3, Pptcs3, Saps3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52036
VEGA: 19
HGNC: HGNC:1173
Homologene: 115911
Ccm2
Name: cerebral cavernous malformation 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216527
Homologene: 12868
Ptpn6
Name: protein tyrosine phosphatase, non-receptor type 6
Synonyms: SHP-1, Ptp1C, hcp, Hcph
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15170
HGNC: HGNC:9658
Homologene: 56589
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Mxi1
Name: MAX interactor 1, dimerization protein
Synonyms: Mad2, bHLHc11
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17859
VEGA: 19
HGNC: HGNC:7534
Homologene: 4351
C2cd5
Name: C2 calcium-dependent domain containing 5
Synonyms: C030008B15Rik, CDP138, 5730419I09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74741
Homologene: 8873
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Thap1
Name: THAP domain containing, apoptosis associated protein 1
Synonyms: 4833431A01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73754
Homologene: 10005
Igfbp3
Name: insulin-like growth factor binding protein 3
Synonyms: IGFBP-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16009
HGNC: HGNC:5472
Homologene: 500
Pon2
Name: paraoxonase 2
Synonyms: 6330405I24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330260
HGNC: HGNC:9205
Homologene: 385
Gtpbp1
Name: GTP binding protein 1
Synonyms: GP-1, GTPBP1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14904
VEGA: 15
HGNC: HGNC:4669
Homologene: 3165
Pop4
Name: processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: Rpp29, 1110023P21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66161
Homologene: 31392
Aasdhppt
Name: aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Synonyms: 2810407B07Rik, AASD-PPT, CGI-80, LYS5, LYS2, 2010309J24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67618
Homologene: 9130
Ebf1
Name: early B cell factor 1
Synonyms: Olf-1, O/E-1, Olf1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13591
HGNC: HGNC:3126
Homologene: 7297
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, bob, nmf112, nmf181, nmf252, sals
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: Idh-2, IDPm
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Lysmd4
Name: LysM, putative peptidoglycan-binding, domain containing 4
Synonyms: 4930506D23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75099
Homologene: 45123
Ttf1
Name: transcription termination factor, RNA polymerase I
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22130
Homologene: 137223
Camk2g
Name: calcium/calmodulin-dependent protein kinase II gamma
Synonyms: CaMK II, Ca2+/calmodulin-dependent protein kinase II, Camkg, 5930429P18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12325
VEGA: 14
HGNC: HGNC:1463
Homologene: 15596
L3mbtl4
Name: L3MBTL4 histone methyl-lysine binding protein
Synonyms: D930040M24Rik, A730037L19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320858
Homologene: 114383
Aoc1l2
Name: amine oxidase copper containing 1-like 2
Synonyms: 1600015I10Rik, Doxl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69761
HGNC: HGNC:80
Homologene: 79726
Vwc2l
Name: von Willebrand factor C domain-containing protein 2-like
Synonyms: brorin-like, Brl, A830006F12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320460
Homologene: 27945
Mpl
Name: myeloproliferative leukemia virus oncogene
Synonyms: c-mpl, thrombopoietin receptor, TPO-R, CD110, c-mpl-II, c-mpl-I, hlb219
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17480
HGNC: HGNC:7217
Homologene: 7845
Zfp696
Name: zinc finger protein 696
Synonyms: 9130023H24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043133
Or2q1
Name: olfactory receptor family 2 subfamily Q member 1
Synonyms: GA_x6K02T2P3E9-4742413-4741481, MOR257-3, Olfr450
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258437
Homologene: 51720
Vmn1r172
Name: vomeronasal 1 receptor 172
Synonyms: V3R9, V1rd9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81010
Homologene: 79577
Cyp2c29
Name: cytochrome P450, family 2, subfamily c, polypeptide 29
Synonyms: AHOH, AHOHase, P450-2C, Ahh-1, Ah-2, Cyp2c
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13095
Homologene: 117948
Piwil4
Name: piwi-like RNA-mediated gene silencing 4
Synonyms: 9230101H05Rik, Miwi2, MIWI2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330890
Homologene: 45122
Ncf2
Name: neutrophil cytosolic factor 2
Synonyms: NADPH oxidase subunit (67kDa), p67phox, Ncf-2, NOXA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17970
HGNC: HGNC:7661
Homologene: 374
Or8c17
Name: olfactory receptor family 8 subfamily C member 17
Synonyms: GA_x6K02T2PVTD-31962461-31963411, MOR170-1, Olfr895
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258875
Homologene: 74253
Oas1a
Name: 2'-5' oligoadenylate synthetase 1A
Synonyms: L3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246730
HGNC: HGNC:8086
Homologene: 1903
Tpp1
Name: tripeptidyl peptidase I
Synonyms: Cln2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12751
HGNC: HGNC:2073
Homologene: 335
Or5ac15
Name: olfactory receptor family 5 subfamily AC member 15
Synonyms: GA_x54KRFPKG5P-55348161-55347241, MOR182-7P, MOR182-13, Olfr194
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 433031
Homologene: 122781
Rfk
Name: riboflavin kinase
Synonyms: ATP:riboflavin 5'-phosphotransferase, flavokinase, 0610038L10Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54391
Homologene: 115690
Asb16
Name: ankyrin repeat and SOCS box-containing 16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217217
Homologene: 76813
Mocs2
Name: molybdenum cofactor synthesis 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17434
HGNC: HGNC:7193
Homologene: 32193
Tcf15
Name: transcription factor 15
Synonyms: bHLH-EC2, paraxis, Meso1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21407
Homologene: 37943
Tmem160
Name: transmembrane protein 160
Synonyms: 1810008O21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69094
Homologene: 9881
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 70,728,904 bp
  • A to G, chromosome 1 at 152,836,113 bp
  • T to C, chromosome 2 at 29,079,480 bp
  • A to T, chromosome 2 at 152,144,103 bp
  • C to A, chromosome 4 at 118,457,405 bp
  • T to C, chromosome 5 at 110,289,367 bp
  • C to T, chromosome 5 at 120,905,880 bp
  • C to T, chromosome 6 at 5,265,480 bp
  • A to T, chromosome 6 at 42,817,846 bp
  • T to C, chromosome 6 at 48,930,108 bp
  • T to C, chromosome 6 at 106,774,482 bp
  • T to A, chromosome 6 at 124,732,346 bp
  • T to C, chromosome 6 at 143,041,362 bp
  • T to C, chromosome 7 at 16,452,964 bp
  • A to T, chromosome 7 at 23,659,785 bp
  • A to G, chromosome 7 at 28,131,581 bp
  • G to A, chromosome 7 at 38,263,225 bp
  • T to C, chromosome 7 at 67,223,745 bp
  • TCCCAGG to T, chromosome 7 at 80,098,331 bp
  • C to T, chromosome 7 at 105,749,607 bp
  • T to A, chromosome 7 at 116,154,640 bp
  • A to G, chromosome 7 at 128,236,951 bp
  • CAGCATCTGCTCGGAGCA to CAGCA, chromosome 8 at 26,160,856 bp
  • C to A, chromosome 9 at 4,309,424 bp
  • T to C, chromosome 9 at 14,720,087 bp
  • T to C, chromosome 9 at 38,269,359 bp
  • G to T, chromosome 10 at 5,099,527 bp
  • G to T, chromosome 10 at 60,376,834 bp
  • A to G, chromosome 11 at 6,585,211 bp
  • A to G, chromosome 11 at 7,213,568 bp
  • T to A, chromosome 11 at 44,883,839 bp
  • T to C, chromosome 11 at 102,277,232 bp
  • T to A, chromosome 11 at 115,985,072 bp
  • A to G, chromosome 13 at 114,826,279 bp
  • A to G, chromosome 14 at 20,760,176 bp
  • C to T, chromosome 15 at 44,569,986 bp
  • A to G, chromosome 15 at 79,707,061 bp
  • A to T, chromosome 16 at 32,751,462 bp
  • G to T, chromosome 16 at 59,119,349 bp
  • T to C, chromosome 17 at 26,143,401 bp
  • T to A, chromosome 17 at 68,679,424 bp
  • T to A, chromosome 19 at 3,471,030 bp
  • T to A, chromosome 19 at 17,395,226 bp
  • A to G, chromosome 19 at 39,273,366 bp
  • G to A, chromosome 19 at 53,371,695 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8863 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068679-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.