Strain Name:
C57BL/6J-MtgxR8899Btlr/Mmmh
Stock Number:
068756-MU
Citation ID:
RRID:MMRRC_068756-MU
Other Names:
R8899 (G1)
Major Collection:

Strain Information

Sparcl1
Name: SPARC-like 1
Synonyms: mast9, hevin, Sc1, Ecm2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13602
Homologene: 3438
Lgi1
Name: leucine-rich repeat LGI family, member 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56839
HGNC: HGNC:6572
Homologene: 3737
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50492
Homologene: 55726
Csrnp3
Name: cysteine-serine-rich nuclear protein 3
Synonyms: CSRNP-3, mbu1, A330102K23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77771
Homologene: 11803
Usp1
Name: ubiquitin specific peptidase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230484
Homologene: 2528
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Trim36
Name: tripartite motif-containing 36
Synonyms: Haprin, D18Wsu100e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 28105
VEGA: 18
Homologene: 10275
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: Ascc3l1, A330064G03Rik, HELIC2, U5-200KD
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320632
Homologene: 5859
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: G431004K08Rik, GCN1L, Gcn1l1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Fbxl10, Cxxc2, Jhdm1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 30841
Homologene: 13069
Snx6
Name: sorting nexin 6
Synonyms: 2010006G21Rik, 2810425K19Rik, 2610032J07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72183
VEGA: 12
Homologene: 12304
Polr2d
Name: polymerase (RNA) II (DNA directed) polypeptide D
Synonyms: RBP4, 2310002G05Rik, 2610028L19Rik, HSRBP4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69241
VEGA: 18
HGNC: HGNC:9191
Homologene: 37968
Cdc40
Name: cell division cycle 40
Synonyms: EHB3, 1200003H23Rik, PRP17
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71713
VEGA: 10
Homologene: 5716
Srbd1
Name: S1 RNA binding domain 1
Synonyms: D530025C17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78586
VEGA: 17
Homologene: 9994
Kifbp
Name: kinesin family binding protein
Synonyms: 2510003E04Rik, Kif1bp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72320
Homologene: 9223
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Tmem245
Name: transmembrane protein 245
Synonyms: D730040F13Rik, A630051L19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Ate1
Name: arginyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11907
HGNC: HGNC:782
Homologene: 31420
Arel1
Name: apoptosis resistant E3 ubiquitin protein ligase 1
Synonyms: 1110018G07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68497
Homologene: 8885
Sgo2a
Name: shugoshin 2A
Synonyms: 1110007N04Rik, Sgol2, Tripin, 5730576N04Rik, Sgol2a, D1Ertd8e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68549
Homologene: 51867
Grm4
Name: glutamate receptor, metabotropic 4
Synonyms: Gprc1d, mGluR4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268934
HGNC: HGNC:4596
Homologene: 20230
Icam5
Name: intercellular adhesion molecule 5, telencephalin
Synonyms: TLN, CD50, Tlcn, Icam3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15898
VEGA: 9
HGNC: HGNC:5348
Homologene: 2447
Rsbn1l
Name: round spermatid basic protein 1-like
Synonyms: C330002G24Rik, 8430412F05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242860
Homologene: 19435
Spag9
Name: sperm associated antigen 9
Synonyms: 3110018C07Rik, Mapk8ip4, 4831406C20Rik, syd1, JLP, 4733401I23Rik, JIP4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70834
Homologene: 2954
Zfp799
Name: zinc finger protein 799
Synonyms: 6030490I01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240064
Homologene: 107106
Cenpe
Name: centromere protein E
Synonyms: Kif10, 312kDa, CENP-E, N-7 kinesin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Cul1
Name: cullin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26965
HGNC: HGNC:2551
Homologene: 2663
Atl2
Name: atlastin GTPase 2
Synonyms: 2010110I21Rik, Aip-2, Arl6ip2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56298
VEGA: 17
Homologene: 56949
Lhx8
Name: LIM homeobox protein 8
Synonyms: Lhx7, L3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16875
Homologene: 62661
Zfp831
Name: zinc finger protein 831
Synonyms: ENSMUSG00000050600, OTTMUSG00000017459
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100043757
Homologene: 19013
Colgalt1
Name: collagen beta(1-O)galactosyltransferase 1
Synonyms: Glt25d1, 2810024B22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234407
Homologene: 23465
Fyco1
Name: FYVE and coiled-coil domain containing 1
Synonyms: ZFYVE7, Mem2, 2810409M01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17281
Homologene: 11561
Tbc1d17
Name: TBC1 domain family, member 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233204
Homologene: 11656
Fbxo44
Name: F-box protein 44
Synonyms: Fbxo6a, FBX30, Fbx6a, FBG3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230903
Homologene: 13232
Ucp1
Name: uncoupling protein 1 (mitochondrial, proton carrier)
Synonyms: Slc25a7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22227
Homologene: 22524
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: tomosyn-2, A830015P08Rik, insulin level locus 1, LLGL4, t2md1, T2dm1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207227
Homologene: 18173
Or11j4
Name: olfactory receptor family 11 subfamily J member 4
Synonyms: MOR106-5, GA_x6K02T2PMLR-6089963-6090901, Olfr736
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258660
Homologene: 64902
Fbxw10
Name: F-box and WD-40 domain protein 10
Synonyms: SM2SH2, SM25H2, Fbw10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 213980
Homologene: 32757
Zfp521
Name: zinc finger protein 521
Synonyms: B930086A16Rik, Evi3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225207
VEGA: 18
Homologene: 9151
Cd209e
Name: CD209e antigen
Synonyms: SIGNR4, mSIGNR4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170780
HGNC: HGNC:1641
Homologene: 128353
Tas2r143
Name: taste receptor, type 2, member 143
Synonyms: mt2r36, Tas2r43
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387514
Homologene: 74285
Sh3bp4
Name: SH3-domain binding protein 4
Synonyms: BOG25
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98402
Homologene: 8726
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18080
Homologene: 40632
Pip5kl1
Name: phosphatidylinositol-4-phosphate 5-kinase-like 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227733
Homologene: 45457
Mefv
Name: Mediterranean fever
Synonyms: marenostrin, FMF, pyrin, TRIM20
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 54483
VEGA: 16
HGNC: HGNC:6998
Homologene: 32441
Ugt1a6a
Name: UDP glucuronosyltransferase 1 family, polypeptide A6A
Synonyms: Ugt1a6, UGT1.6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 94284
Homologene: 85959
Agxt2
Name: alanine-glyoxylate aminotransferase 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268782
Homologene: 12887
Fut10
Name: fucosyltransferase 10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 171167
Homologene: 32790
Spmap2l
Name: sperm microtubule associated protein 2 like
Synonyms: Thegl, 1700023E05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71868
Homologene: 128474
Fap
Name: fibroblast activation protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14089
HGNC: HGNC:3590
Homologene: 48282
Or10h1
Name: olfactory receptor family 10 subfamily H member 1
Synonyms: GA_x6K02T2KN0P-2543-1596, Olfr239, MOR267-10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100038860
Homologene: 110515
Tmem67
Name: transmembrane protein 67
Synonyms: b2b1163.1Clo, b2b1291.1Clo, 5330408M12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329795
Homologene: 71886
Kcnk3
Name: potassium channel, subfamily K, member 3
Synonyms: cTBAK-1, Task-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16527
HGNC: HGNC:6278
Homologene: 1692
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: Trs4, 4932408B21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214704
Homologene: 44790
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: 2410012C07Rik, very-kind, VKIND, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Gabrg2
Name: gamma-aminobutyric acid type A receptor, subunit gamma 2
Synonyms: Gabrg-2, GABAA-R, gamma2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14406
HGNC: HGNC:4087
Homologene: 22443
Ddx19b
Name: DEAD box helicase 19b
Synonyms: 2810457M08Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b, 4921519L13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234733
HGNC: HGNC:2742
Homologene: 56032
Tas2r136
Name: taste receptor, type 2, member 136
Synonyms: Tas2r36, mt2r52
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353165
Homologene: 136304
Or8b3b
Name: olfactory receptor family 8 subfamily B member 3B
Synonyms: Olfr918, MOR164-3, GA_x6K02T2PVTD-32375756-32374818
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258372
VEGA: 9
Or5t16
Name: olfactory receptor family 5 subfamily T member 16
Synonyms: Olfr1101, MOR179-3, GA_x6K02T2Q125-48475870-48474938
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258584
Homologene: 74087
Gnl1
Name: guanine nucleotide binding protein-like 1
Synonyms: Gna-rs1, Gnal1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14670
HGNC: HGNC:4413
Homologene: 3862
Lim2
Name: lens intrinsic membrane protein 2
Synonyms: MP19, 19kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233187
HGNC: HGNC:6610
Homologene: 12744
Septin8
Name: septin 8
Synonyms: Sepl, Sept8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20362
Homologene: 57205
Rnf146
Name: ring finger protein 146
Synonyms: 2610509H23Rik, Iduna
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68031
Homologene: 12227
Rdh12
Name: retinol dehydrogenase 12
Synonyms: A930033N07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77974
Homologene: 110830
Prss53
Name: serine protease 53
Synonyms: BC039632
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330657
Homologene: 80097
Tff2
Name: trefoil factor 2 (spasmolytic protein 1)
Synonyms: SP, mSP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21785
Homologene: 3956
Otop3
Name: otopetrin 3
Synonyms: 2310011E08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69602
Homologene: 26091
Pate9
Name: prostate and testis expressed 9
Synonyms: Gm5615
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434396
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 58,019,663 bp
  • T to A, chromosome 1 at 88,139,081 bp
  • C to T, chromosome 1 at 89,145,575 bp
  • A to G, chromosome 2 at 32,579,070 bp
  • A to G, chromosome 2 at 62,518,473 bp
  • G to A, chromosome 2 at 66,022,643 bp
  • A to G, chromosome 2 at 86,988,366 bp
  • A to G, chromosome 2 at 127,236,597 bp
  • A to T, chromosome 2 at 174,644,185 bp
  • T to C, chromosome 3 at 36,988,280 bp
  • A to G, chromosome 3 at 135,239,883 bp
  • A to G, chromosome 3 at 154,328,016 bp
  • A to G, chromosome 4 at 12,055,038 bp
  • A to C, chromosome 4 at 56,903,916 bp
  • A to G, chromosome 4 at 98,931,110 bp
  • A to G, chromosome 4 at 123,475,059 bp
  • A to T, chromosome 4 at 148,153,621 bp
  • A to T, chromosome 5 at 20,896,867 bp
  • A to G, chromosome 5 at 30,622,236 bp
  • T to A, chromosome 5 at 77,037,353 bp
  • T to C, chromosome 5 at 104,092,724 bp
  • T to C, chromosome 5 at 115,579,161 bp
  • T to A, chromosome 5 at 122,987,788 bp
  • C to T, chromosome 6 at 24,505,769 bp
  • T to A, chromosome 6 at 42,400,954 bp
  • T to A, chromosome 6 at 47,497,312 bp
  • T to C, chromosome 6 at 132,777,360 bp
  • T to C, chromosome 7 at 43,433,631 bp
  • C to T, chromosome 7 at 44,842,904 bp
  • T to C, chromosome 7 at 127,889,021 bp
  • T to C, chromosome 7 at 130,394,659 bp
  • C to T, chromosome 7 at 139,927,795 bp
  • C to T, chromosome 8 at 3,851,212 bp
  • T to C, chromosome 8 at 31,236,486 bp
  • T to C, chromosome 8 at 71,623,662 bp
  • T to C, chromosome 8 at 83,290,587 bp
  • A to T, chromosome 8 at 111,011,297 bp
  • T to C, chromosome 9 at 21,037,119 bp
  • A to T, chromosome 9 at 36,534,958 bp
  • C to T, chromosome 9 at 38,672,851 bp
  • T to C, chromosome 9 at 67,934,501 bp
  • A to C, chromosome 9 at 123,826,581 bp
  • G to A, chromosome 10 at 29,347,758 bp
  • G to A, chromosome 10 at 40,841,813 bp
  • T to C, chromosome 10 at 62,563,503 bp
  • T to C, chromosome 10 at 81,080,606 bp
  • G to A, chromosome 11 at 41,976,550 bp
  • G to A, chromosome 11 at 53,536,035 bp
  • T to A, chromosome 11 at 62,857,741 bp
  • T to C, chromosome 11 at 94,092,869 bp
  • T to C, chromosome 11 at 115,341,060 bp
  • A to T, chromosome 12 at 54,765,638 bp
  • A to G, chromosome 12 at 70,030,936 bp
  • A to G, chromosome 12 at 79,222,028 bp
  • A to G, chromosome 12 at 84,934,243 bp
  • T to C, chromosome 14 at 50,392,812 bp
  • A to T, chromosome 15 at 10,378,814 bp
  • G to A, chromosome 16 at 3,710,900 bp
  • ATTTT to ATTTTT, chromosome 16 at 37,216,052 bp
  • T to C, chromosome 17 at 27,434,780 bp
  • C to T, chromosome 17 at 31,143,139 bp
  • G to T, chromosome 17 at 32,820,374 bp
  • A to T, chromosome 17 at 33,199,744 bp
  • T to C, chromosome 17 at 35,988,716 bp
  • T to C, chromosome 17 at 79,876,040 bp
  • T to A, chromosome 17 at 85,985,457 bp
  • A to G, chromosome 18 at 3,295,370 bp
  • C to A, chromosome 18 at 13,846,080 bp
  • T to A, chromosome 18 at 31,789,173 bp
  • T to G, chromosome 18 at 46,169,197 bp
  • C to T, chromosome 19 at 38,306,090 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8899 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068756-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.