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Strain Name:
C57BL/6J-MtgxR8947Btlr/Mmmh
Stock Number:
068785-MU
Citation ID:
RRID:MMRRC_068785-MU
Other Names:
R8947 (G1)
Major Collection:

Strain Information

Itpk1
Name: inositol 1,3,4-triphosphate 5/6 kinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217837
HGNC: HGNC:6177
Homologene: 8588
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Osbpl1a
Name: oxysterol binding protein-like 1A
Synonyms: LOC328902, G430090F17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 64291
Homologene: 84746
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 319765
Homologene: 4774
Fastk
Name: Fas-activated serine/threonine kinase
Synonyms: 0610011K02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66587
Homologene: 4884
Gmps
Name: guanine monophosphate synthetase
Synonyms: Gm9479
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229363
HGNC: HGNC:4378
Homologene: 68367
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,158,148 bp
  • A to G, chromosome 1 at 51,181,793 bp
  • A to T, chromosome 1 at 55,000,285 bp
  • T to A, chromosome 1 at 128,174,957 bp
  • T to A, chromosome 1 at 153,755,031 bp
  • A to T, chromosome 1 at 154,402,150 bp
  • A to T, chromosome 1 at 177,131,079 bp
  • T to G, chromosome 1 at 179,716,755 bp
  • G to A, chromosome 2 at 31,388,208 bp
  • T to C, chromosome 2 at 59,948,239 bp
  • C to T, chromosome 2 at 111,489,697 bp
  • T to C, chromosome 2 at 119,210,809 bp
  • A to T, chromosome 2 at 121,304,969 bp
  • C to T, chromosome 2 at 121,370,989 bp
  • A to T, chromosome 2 at 156,148,356 bp
  • T to C, chromosome 3 at 33,815,460 bp
  • T to A, chromosome 3 at 59,077,022 bp
  • T to C, chromosome 3 at 62,472,966 bp
  • T to A, chromosome 3 at 63,784,126 bp
  • T to A, chromosome 3 at 63,998,677 bp
  • T to A, chromosome 3 at 73,701,428 bp
  • T to C, chromosome 3 at 105,914,238 bp
  • C to T, chromosome 3 at 126,942,747 bp
  • C to T, chromosome 3 at 142,811,913 bp
  • C to T, chromosome 4 at 21,678,817 bp
  • T to C, chromosome 4 at 34,811,835 bp
  • T to A, chromosome 4 at 42,972,097 bp
  • T to C, chromosome 4 at 104,822,129 bp
  • T to C, chromosome 4 at 129,137,136 bp
  • T to A, chromosome 4 at 141,246,307 bp
  • C to A, chromosome 5 at 24,441,651 bp
  • T to G, chromosome 5 at 48,249,798 bp
  • C to T, chromosome 5 at 83,313,307 bp
  • T to G, chromosome 5 at 109,086,656 bp
  • T to C, chromosome 5 at 123,786,978 bp
  • G to T, chromosome 5 at 143,977,134 bp
  • T to G, chromosome 6 at 41,062,707 bp
  • T to G, chromosome 6 at 48,448,570 bp
  • T to G, chromosome 6 at 52,202,796 bp
  • T to A, chromosome 6 at 91,485,380 bp
  • A to G, chromosome 6 at 102,437,903 bp
  • C to A, chromosome 6 at 115,924,407 bp
  • C to A, chromosome 6 at 121,780,594 bp
  • G to T, chromosome 6 at 128,552,256 bp
  • C to G, chromosome 6 at 129,733,779 bp
  • A to G, chromosome 7 at 6,480,247 bp
  • T to C, chromosome 7 at 11,669,880 bp
  • T to C, chromosome 7 at 97,681,852 bp
  • T to A, chromosome 7 at 103,052,108 bp
  • T to G, chromosome 7 at 143,847,222 bp
  • T to A, chromosome 8 at 70,102,521 bp
  • T to A, chromosome 8 at 80,045,156 bp
  • C to T, chromosome 8 at 109,863,332 bp
  • T to C, chromosome 8 at 119,625,713 bp
  • T to G, chromosome 8 at 125,671,100 bp
  • T to C, chromosome 9 at 21,586,453 bp
  • T to A, chromosome 9 at 38,473,389 bp
  • T to C, chromosome 9 at 58,017,455 bp
  • T to A, chromosome 9 at 82,846,793 bp
  • C to T, chromosome 9 at 105,945,634 bp
  • T to A, chromosome 10 at 62,432,339 bp
  • T to A, chromosome 10 at 63,169,377 bp
  • T to C, chromosome 10 at 79,469,039 bp
  • C to A, chromosome 10 at 81,199,705 bp
  • A to G, chromosome 11 at 29,200,758 bp
  • G to A, chromosome 11 at 48,868,748 bp
  • A to T, chromosome 11 at 77,953,527 bp
  • T to C, chromosome 11 at 102,314,976 bp
  • A to G, chromosome 11 at 106,768,344 bp
  • A to G, chromosome 11 at 116,221,338 bp
  • C to T, chromosome 11 at 116,649,819 bp
  • T to G, chromosome 12 at 83,954,657 bp
  • A to T, chromosome 12 at 102,570,323 bp
  • C to A, chromosome 13 at 60,782,190 bp
  • T to C, chromosome 13 at 64,367,026 bp
  • A to G, chromosome 14 at 6,773,326 bp
  • A to T, chromosome 14 at 30,935,909 bp
  • T to C, chromosome 14 at 53,488,127 bp
  • T to C, chromosome 14 at 75,278,187 bp
  • T to G, chromosome 14 at 79,201,112 bp
  • T to A, chromosome 15 at 82,029,665 bp
  • C to T, chromosome 15 at 91,702,270 bp
  • T to A, chromosome 16 at 4,847,428 bp
  • C to A, chromosome 16 at 22,078,723 bp
  • T to A, chromosome 16 at 32,981,829 bp
  • T to C, chromosome 16 at 58,926,070 bp
  • T to A, chromosome 17 at 15,544,008 bp
  • T to A, chromosome 17 at 24,721,253 bp
  • A to T, chromosome 17 at 33,241,981 bp
  • A to G, chromosome 17 at 34,908,304 bp
  • A to T, chromosome 17 at 44,242,261 bp
  • T to A, chromosome 17 at 71,204,876 bp
  • T to C, chromosome 17 at 84,691,818 bp
  • A to G, chromosome 18 at 12,766,801 bp
  • A to T, chromosome 18 at 37,853,701 bp
  • T to C, chromosome 18 at 38,199,020 bp
  • T to C, chromosome 19 at 34,941,229 bp
  • A to T, chromosome 19 at 37,174,966 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8947 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068785-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.