Strain Name:
C57BL/6J-MtgxR8948Btlr/Mmmh
Stock Number:
068786-MU
Citation ID:
RRID:MMRRC_068786-MU
Other Names:
R8948 (G1)
Major Collection:

Strain Information

Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74200
Homologene: 41761
Polr1f
Name: RNA polymerase I subunit F
Synonyms: D16Wsu83e, 2810024J17Rik, Twistnb
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 28071
VEGA: 12
Homologene: 45411
Sf3b3
Name: splicing factor 3b, subunit 3
Synonyms: 5730409A01Rik, 1810061H24Rik, SAP130, RSE1, D8Ertd633e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 101943
Homologene: 6579
Kif11
Name: kinesin family member 11
Synonyms: Eg5, Knsl1, Kifl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: 6330503C17Rik, Zfp262
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67785
Homologene: 35470
Ctc1
Name: CTS telomere maintenance complex component 1
Synonyms: 1500010J02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68964
Homologene: 11830
Osbpl8
Name: oxysterol binding protein-like 8
Synonyms: ORP-8, D330025H14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237542
VEGA: 10
Homologene: 68813
Bmpr1a
Name: bone morphogenetic protein receptor, type 1A
Synonyms: ALK3, Bmpr, BMPR-IA, 1110037I22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12166
HGNC: HGNC:1076
Homologene: 20911
Ago3
Name: argonaute RISC catalytic subunit 3
Synonyms: argonaute 3, eIF2C3, C130014L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214150
Homologene: 49799
Smchd1
Name: SMC hinge domain containing 1
Synonyms: 4931400A14Rik, MommeD1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Akap1
Name: A kinase anchor protein 1
Synonyms: S-AKAP84, AKAP84, AKAP121, DAKAP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11640
HGNC: HGNC:367
Homologene: 31165
Kcnk5
Name: potassium channel, subfamily K, member 5
Synonyms: TASK-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16529
VEGA: 14
HGNC: HGNC:6280
Homologene: 2773
Zfyve1
Name: zinc finger, FYVE domain containing 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217695
VEGA: 12
Homologene: 10945
Plpp1
Name: phospholipid phosphatase 1
Synonyms: mPAP, Lipid phosphate phosphatase 1, LPP1, LPP-1, Hpic53, Ppap2a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19012
VEGA: 13
HGNC: HGNC:9228
Homologene: 134049
Camkv
Name: CaM kinase-like vesicle-associated
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235604
Homologene: 56983
Lrrn2
Name: leucine rich repeat protein 2, neuronal
Synonyms: NLRR-2, 5730406J09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16980
Homologene: 21274
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, Mtap2, repro4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930516E05Rik, D330038K10Rik, 4930543C13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Atad2b
Name: ATPase family, AAA domain containing 2B
Synonyms: 1110014E10Rik, D530031C13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320817
VEGA: 12
Homologene: 86351
Stk32b
Name: serine/threonine kinase 32B
Synonyms: 2510009F08Rik, YANK2, STKG6, Stk32
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 64293
Homologene: 48654
Pak2
Name: p21 (RAC1) activated kinase 2
Synonyms: PAK-2, A130002K10Rik, D16Ertd269e, 5330420P17Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224105
HGNC: HGNC:8591
Homologene: 99711
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, E030034C22Rik, B230373P09Rik, Dnahc1, G1-415-19, ferf1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Itga2
Name: integrin alpha 2
Synonyms: VLA-2 receptor, alpha 2 subunit, CD49B, DX5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Zfyve9
Name: zinc finger, FYVE domain containing 9
Synonyms: Madhip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230597
HGNC: HGNC:6775
Homologene: 3527
Slc35e1
Name: solute carrier family 35, member E1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270066
Homologene: 49075
Cdkn3
Name: cyclin dependent kinase inhibitor 3
Synonyms: 2410006H10Rik, KAP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72391
VEGA: 14
HGNC: HGNC:1791
Homologene: 3805
Epas1
Name: endothelial PAS domain protein 1
Synonyms: MOP2, HIF-2alpha, Hif like protein, hypoxia inducible transcription factor 2alpha, HLF, HRF, HIF2A, bHLHe73
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13819
VEGA: 17
HGNC: HGNC:3374
Homologene: 1095
Sh3pxd2a
Name: SH3 and PX domains 2A
Synonyms: Fish, Sh3md1, Tks5, 2310014D11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14218
VEGA: 19
Homologene: 7317
Abca9
Name: ATP-binding cassette, sub-family A member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Vmn2r5
Name: vomeronasal 2, receptor 5
Synonyms: EG667060
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667060
Ror2
Name: receptor tyrosine kinase-like orphan receptor 2
Synonyms: Ntrkr2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26564
Homologene: 55831
Smgc
Name: submandibular gland protein C
Synonyms: Sfc21, 2310010P21Rik, DXImx49e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223809
Tmed11
Name: transmembrane p24 trafficking protein 11
Synonyms: 1810008K16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67366
Homologene: 48721
Vsig10l
Name: V-set and immunoglobulin domain containing 10 like
Synonyms: 2210412E05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75690
Homologene: 35386
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Sap30
Name: sin3 associated polypeptide
Synonyms: 30kDa
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 60406
Homologene: 2869
Ergic3
Name: ERGIC and golgi 3
Synonyms: CGI-54, NY-BR-84, 2310015B14Rik, D2Ucla1, Sdbcag84
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66366
Homologene: 5289
Csf2rb
Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Synonyms: AIC2B, common beta chain, CDw131, beta c, Bc, Il3rb1, Il5rb, Il3r, Csf2rb1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12983
VEGA: 15
HGNC: HGNC:2436
Homologene: 339
Ccdc30
Name: coiled-coil domain containing 30
Synonyms: 1700111D19Rik, 4930445I03Rik, 1700001O02Rik, 1700041C02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73332
Homologene: 137391
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Prrt4
Name: proline-rich transmembrane protein 4
Synonyms: D330027H18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101359
Homologene: 46116
D630023F18Rik
Name: RIKEN cDNA D630023F18 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98303
Homologene: 129674
Efcc1
Name: EF hand and coiled-coil domain containing 1
Synonyms: AB041550, Ccdc48
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58229
Homologene: 130011
Or3a10
Name: olfactory receptor family 3 subfamily A member 10
Synonyms: M5, GA_x6K02T2P1NL-4202012-4201065, MOR255-2, Olfr139
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259005
Homologene: 77386
Rsbn1
Name: rosbin, round spermatid basic protein 1
Synonyms: Rsbp, C230004D03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229675
Homologene: 10154
Or5b99
Name: olfactory receptor family 5 subfamily B member 99
Synonyms: GA_x6K02T2RE5P-3328502-3329434, MOR202-1, Olfr1451
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258700
HGNC: HGNC:8323
Homologene: 128082
Ergic2
Name: ERGIC and golgi 2
Synonyms: 4930572C01Rik, 1200009B18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67456
Homologene: 6574
Trappc6a
Name: trafficking protein particle complex 6A
Synonyms: 4930519D19Rik, 1810073E21Rik, TRS33
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67091
Homologene: 69370
Telo2
Name: telomere maintenance 2
Synonyms: 1200003M09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71718
Homologene: 41107
Sult2a2
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2
Synonyms: mSTa2, Sth2, C730007P19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043194
Ccin
Name: calicin
Synonyms: 4933417A14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 442829
HGNC: HGNC:1568
Homologene: 4306
Perp
Name: PERP, TP53 apoptosis effector
Synonyms: PIGPC1, KCP1, 1110017A08Rik, KRTCAP1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64058
VEGA: 10
Homologene: 11098
Znhit2
Name: zinc finger, HIT domain containing 2
Synonyms: ORF6, Znhit2-ps
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 29805
HGNC: HGNC:1177
Homologene: 8477
Or7g29
Name: olfactory receptor family 7 subfamily G member 29
Synonyms: GA_x6K02T2PVTD-13113073-13112135, MOR149-2, Olfr847
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258518
Homologene: 17281
Preb
Name: prolactin regulatory element binding
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50907
HGNC: HGNC:9356
Homologene: 40877
Sult2a1
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Synonyms: mSTa1, Std, Sth1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20859
Homologene: 37741
Eddm3b
Name: epididymal protein 3B
Synonyms: Fam12
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219026
VEGA: 14
Homologene: 75184
Abat
Name: 4-aminobutyrate aminotransferase
Synonyms: 9630038C02Rik, GABA-T
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268860
HGNC: HGNC:23
Homologene: 542
Krtap5-25
Name: keratin associated protein 5-25
Synonyms: Gm45337
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 115486481
Rpl36-ps4
Name: ribosomal protein L36, pseudogene 4
Synonyms: Gm6716
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 626888
VEGA: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 65,108,740 bp
  • G to T, chromosome 1 at 66,380,525 bp
  • A to C, chromosome 1 at 132,938,366 bp
  • T to C, chromosome 2 at 31,354,729 bp
  • T to C, chromosome 2 at 156,011,240 bp
  • A to T, chromosome 3 at 64,491,101 bp
  • G to T, chromosome 3 at 88,709,912 bp
  • A to T, chromosome 3 at 103,961,514 bp
  • G to A, chromosome 4 at 43,984,064 bp
  • A to T, chromosome 4 at 108,642,091 bp
  • T to C, chromosome 4 at 119,324,161 bp
  • T to C, chromosome 4 at 126,350,322 bp
  • C to T, chromosome 4 at 126,864,267 bp
  • C to A, chromosome 4 at 152,138,821 bp
  • A to G, chromosome 5 at 30,958,327 bp
  • A to T, chromosome 5 at 37,454,997 bp
  • C to T, chromosome 5 at 108,777,427 bp
  • T to C, chromosome 6 at 29,177,666 bp
  • A to G, chromosome 6 at 87,751,786 bp
  • A to T, chromosome 6 at 148,202,507 bp
  • A to T, chromosome 7 at 13,733,559 bp
  • A to G, chromosome 7 at 13,796,417 bp
  • G to A, chromosome 7 at 19,515,998 bp
  • A to T, chromosome 7 at 43,468,199 bp
  • A to G, chromosome 7 at 85,957,361 bp
  • A to T, chromosome 7 at 105,759,005 bp
  • A to G, chromosome 7 at 142,144,080 bp
  • C to A, chromosome 8 at 57,487,422 bp
  • A to T, chromosome 8 at 72,492,198 bp
  • T to C, chromosome 8 at 110,823,443 bp
  • C to T, chromosome 9 at 18,647,233 bp
  • A to G, chromosome 9 at 19,374,966 bp
  • C to T, chromosome 9 at 107,947,097 bp
  • A to T, chromosome 10 at 18,853,578 bp
  • C to T, chromosome 10 at 76,610,693 bp
  • T to C, chromosome 10 at 111,267,669 bp
  • T to G, chromosome 11 at 69,026,349 bp
  • A to G, chromosome 11 at 74,044,956 bp
  • G to T, chromosome 11 at 88,844,273 bp
  • T to C, chromosome 11 at 110,163,380 bp
  • C to A, chromosome 12 at 4,991,012 bp
  • T to A, chromosome 12 at 33,433,527 bp
  • A to C, chromosome 12 at 83,548,028 bp
  • T to A, chromosome 13 at 53,131,996 bp
  • A to T, chromosome 13 at 112,856,977 bp
  • C to T, chromosome 13 at 114,873,330 bp
  • T to C, chromosome 14 at 20,141,978 bp
  • T to C, chromosome 14 at 31,290,439 bp
  • G to T, chromosome 14 at 34,441,191 bp
  • C to T, chromosome 14 at 46,767,323 bp
  • T to A, chromosome 14 at 51,116,653 bp
  • A to T, chromosome 15 at 78,348,320 bp
  • C to T, chromosome 15 at 91,838,362 bp
  • T to C, chromosome 16 at 8,600,941 bp
  • A to T, chromosome 16 at 32,033,911 bp
  • A to G, chromosome 17 at 25,113,111 bp
  • C to T, chromosome 17 at 71,436,772 bp
  • A to G, chromosome 17 at 86,827,492 bp
  • A to G, chromosome 17 at 87,921,146 bp
  • A to T, chromosome 19 at 6,061,773 bp
  • A to T, chromosome 19 at 12,999,081 bp
  • A to G, chromosome 19 at 16,745,976 bp
  • T to A, chromosome 19 at 37,398,154 bp
  • T to C, chromosome 19 at 47,373,443 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8948 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068786-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.